[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"facial-pain\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:facial-pain":34},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,52,87,115,155,178],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":22,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":35,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100651108","headache-ear-auditory-dizziness-sinus-heads-registry-100651108",false,"NCT07754266","Headache Ear Auditory Dizziness Sinus (HEADS) Registry","HEADS","Inclusion Criteria:\n\n* Resident of the United States of America\n* Age of Majority (18+ in 47 states and Washington, D.C., 19+ in Alabama and Nebraska, 21+ in Puerto Rico and Mississippi)\n* Fluent in English OR Spanish.\n* Experience sinus, vestibular auditory, and\u002For headache symptoms, with and without diagnosis of migraine.\n\nExclusion Criteria:\n\n* Under 18 years of age, under age of Majority. Minors are not the population of interest for the study at this time.",true,"ALL","18 Years",{"count":20,"type":21},10000,"ESTIMATED","10 Years","OBSERVATIONAL","The Headache, Ear, Auditory, Dizziness, Sinus (HEADS) Registry is a study over time of individuals living in the United States who experience sinus, vestibular, auditory, and headache symptoms. Through an online portal, participants are asked questions about their symptoms, how they have affected their lives, and how effectively they have managed them. This information is then used to better understand these symptoms and to improve patient diagnosis and treatment.\n\nSome potential research benefits of the HEADS Registry include:\n\n* Improving healthcare professionals' understanding of the causes of specific head and neck symptoms.\n* Reducing delays in diagnosis and the use of inappropriate tests, medications, and surgeries.\n* Finding the most effective treatments for sinus, vestibular, and auditory disorders.\n* Providing participants the opportunity to be contacted for additional important research related to sinus, vestibular, and auditory disorders.\n\nAll U.S. residents over the age of majority who experience sinus, vestibular, and auditory symptoms, with or without migraine, are eligible to participate. Enrollment is voluntary, confidential, and free of charge.",[26,27,28,29,30,31,32,33,34],"Headache Disorders","Dizziness","Vestibular Diseases","Sinus Disease","Vestibular Disorder","Migraine Disorders","Headache","Migraine","Facial Pain",[36,31,37,38,34,32],"Registries","Ear Diseases","Paranasal Sinus Diseases","RECRUITING","2026-08-04",{"date":42,"type":43},"2026-08-10","ACTUAL",{"date":45,"type":43},"2023-07-06",{"date":47,"type":21},"2033-12-31",{"name":49,"class":50},"Association of Migraine Disorders","OTHER",1,{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":59,"enrollmentInfo":60,"targetDuration":4,"studyType":62,"phases":63,"briefSummary":65,"conditions":66,"keywords":69,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":4},"100649633","arthrocentesis-versus-botulinum-toxin-injection-in-patients-with-temporomandibular-joint-disorders-a-randomized-controlled-trial-100649633","NCT07736521","Arthrocentesis Versus Botulinum Toxin Injection in Patients With Temporomandibular Joint Disorders: A Randomized Controlled Trial","RCT","Inclusion Criteria:\n\n* Clinically and radiographically confirmed temporomandibular joint (TMJ) disorder, diagnosed according to Wilkes staging or the Research Diagnostic Criteria for Temporomandibular Disorders (RDC\u002FTMD)\n* Age 18 years or older\n* Symptom duration of at least 3 months\n* Unresponsive to conservative therapy\n* Willing and able to provide written informed consent\n\nExclusion Criteria:\n\n* Previous TMJ surgery\n* Systemic rheumatic\u002Finflammatory joint disease (e.g., rheumatoid arthritis, ankylosing spondylitis)\n* Bony ankylosis of the TMJ\n* Pregnancy\n* Known allergy or contraindication to botulinum toxin\n* Concurrent use of muscle relaxants, corticosteroids, or anticoagulant medication that may confound treatment effects\n* Unwillingness or inability to attend scheduled follow-up visits","64 Years",{"count":61,"type":21},66,"INTERVENTIONAL",[64],"NA","The goal of this clinical trial is to learn if arthrocentesis works as well as botulinum toxin (Botox) injection to treat pain and jaw dysfunction in adults with temporomandibular joint (TMJ) disorders.\n\nThe main questions it aims to answer are:\n\n* Does arthrocentesis reduce pain more, less, or the same as Botox injection?\n* Does arthrocentesis improve jaw opening and function more, less, or the same as Botox injection?\n* What side effects do participants have with each treatment?\n\nResearchers will compare arthrocentesis to Botox injection to see which treatment works better for reducing pain and improving jaw movement in patients with TMJ disorders.\n\nParticipants will:\n\n* Be randomly assigned to receive either arthrocentesis (a joint-washing procedure) or a Botox injection into the jaw muscles\n* Visit the clinic at 1, 3, and 6 months after treatment for checkups and assessments - Rate their pain and have their jaw movement measured at each visit\n* Complete short questionnaires about their jaw function and quality of life",[67,68,34],"Temporomandibular Joint Disorders","Temporomandibular Joint Dysfunction Syndrome",[67,70,71,72,73,74,75,76],"Arthrocentesis","Botulinum Toxin","TMJ Pain","Randomized Controlled Trial","Botox","Maximum Mouth Opening","Visual Analog Scale","NOT_YET_RECRUITING","2026-07-26",{"date":80,"type":43},"2026-07-30",{"date":82,"type":21},"2026-08-15",{"date":84,"type":21},"2027-05-01",{"name":86,"class":50},"Mudher MB Alsunbuli",{"id":88,"slug":89,"hasResults":11,"nctId":90,"briefTitle":91,"officialTitle":92,"acronym":4,"eligibilityCriteria":93,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":94,"enrollmentInfo":95,"targetDuration":4,"studyType":62,"phases":97,"briefSummary":98,"conditions":99,"keywords":102,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":109,"completionDateStruct":111,"leadSponsor":113,"locationsCount":51},"100647134","comparative-analysis-of-dry-needling-techniques-for-orofacial-myofascial-pain-100647134","NCT07706153","Comparative Analysis of Dry Needling Techniques for Orofacial Myofascial Pain","Comparative Analysis of the Effectiveness and Comfort of Different Dry Needling Techniques in the Treatment of Orofacial Myofascial Pain: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Clinical diagnosis of Myofascial Pain (with or without referred pain) in the masseter and\u002For temporalis muscles according to the Diagnostic Criteria for Temporomandibular Disorders (DC\u002FTMD) Axis I\n* Presence of at least one active trigger point in a taut band reproducing the chief complaint\n* Baseline pain intensity ≥ 2 on the VAS in the last two weeks\n* Confirmed pressure pain threshold (PPT ≤ 1.5 kg\u002Fcm²)\n* Signed informed consent form\n\nExclusion Criteria:\n\n* TMD treatment in the last 3 months (physical therapy, needling, laser therapy) or Botulinum Toxin injection in the orofacial region within 12 months\n* Continuous systemic use of analgesics, anti-inflammatories, or muscle relaxants\n* Diagnosis of fibromyalgia, systemic rheumatic diseases, neurological disorders, or neuropathic pain\n* Needle phobia (belonephobia), coagulation disorders, or use of anticoagulant drugs\n* Active skin or odontogenic infections in the application area\n* History of recent facial trauma or orthognathic\u002Fjoint surgery\n* Pregnancy","80 Years",{"count":96,"type":21},45,[64],"This study aims to compare the clinical effectiveness and individual comfort of three distinct dry needling techniques (dynamic, static, and hybrid) for managing orofacial myofascial pain. Myofascial pain is a highly prevalent manifestation of temporomandibular disorders (TMD), characterized by painful trigger points in the masticatory muscles, such as the masseter and temporalis, which cause pain, muscle tenderness, and jaw movement limitations. While dry needling is widely recognized as an effective minimally invasive therapy to deactivate these trigger points, there is still a lack of consensus in scientific literature regarding the standardization of application protocols.\n\nTo address this gap, this randomized, triple-blind, parallel-group clinical trial will enroll 45 individuals diagnosed with myofascial pain according to the Diagnostic Criteria for Temporomandibular Disorders (DC\u002FTMD). Participants will be randomly allocated into three equal groups (15 individuals per group): Group 1 will receive dynamic dry needling (fanning technique); Group 2 will receive static dry needling (needle kept in situ for 10 minutes); and Group 3 will receive a hybrid approach (combining an initial static period followed by dynamic manipulation).\n\nThe primary outcome will evaluate changes in self-reported pain intensity using a Visual Analog Scale (VAS) from baseline to 7 days post-intervention. Secondary outcomes will assess changes in pressure pain thresholds (PPT) via digital algometry, mandibular range of motion via digital caliper measurements, and the subjective perception of comfort and acceptability of each technique. Evaluations will be conducted at baseline, immediately post-intervention, at 7 days, and at 15 days of follow-up. The findings are expected to contribute to the standardization of more effective and comfortable clinical protocols for managing orofacial pain.",[100,34,101],"Myofascial Pain Syndromes","Trigger Points",[103,104,105],"dry needling","orofacial pain","myofascial pain syndromes","2026-07-21",{"date":108,"type":43},"2026-07-23",{"date":110,"type":21},"2026-08-01",{"date":112,"type":21},"2027-04-01",{"name":114,"class":50},"Flávio Magno Gonçalves",{"id":116,"slug":117,"hasResults":11,"nctId":118,"briefTitle":119,"officialTitle":119,"acronym":120,"eligibilityCriteria":121,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":122,"targetDuration":124,"studyType":23,"phases":4,"briefSummary":125,"conditions":126,"keywords":132,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":145,"lastUpdatePostDateStruct":146,"startDateStruct":148,"completionDateStruct":150,"leadSponsor":152,"locationsCount":154},"100603323","prospective-register-study-to-assess-eligibility-for-and-efficacy-of-surgical-treatment-in-patients-with-neurovascular-conflict-100603323","NCT07135024","Prospective Register Study to Assess Eligibility for and Efficacy of Surgical Treatment in Patients With nEuRovascular Conflict","PETER registry","Inclusion Criteria:\n\n* suspected neurovascular conflict\n* signed consent for further use of routine clinical data as accepted by local regulations\n\nExclusion Criteria:\n\n* refusal of further use of routine clinical data",{"count":123,"type":21},5001,"5 Years","The aim of the registry is a multicenter, prospective long-term data collection of patients suspected neurovascular conflict and referred for possible microvascular decompression (Jannetta procedure). The registry relies exclusively on routinely collected clinical data, which are gathered in a standardized and privacy-compliant manner as part of everyday clinical practice. By systematically compiling this information across multiple centers, valuable insights into the effectiveness, potential side effects, and long-term outcomes of this surgical treatment can be gained. The registry will serve as a foundation for future scientific analyses and is intended to help answer relevant research questions regarding the treatment of trigeminal neuralgia based on solid evidence.",[127,128,34,129,130,131],"Trigeminal Neuralgia","Tic Douloureux","Glossopharyngeal Neuralgia","Hemifacial Spasm","Neurovascular Conflict",[127,133,134,135,136,137,138,139,140,141,142,143,144],"Registry","prospective study","eligibility determination","efficacy, treatment","Follow-Up Studies","indication","microvascular decompression","Jannetta","tic douloureux","hemifacial spasm","neurovascular conflict","glossopharyngeal neuralgia","2025-08-13",{"date":147,"type":43},"2025-08-21",{"date":149,"type":21},"2025-10-01",{"date":151,"type":21},"2033-10-01",{"name":153,"class":50},"Gerrit A Schubert",2,{"id":156,"slug":157,"hasResults":11,"nctId":158,"briefTitle":159,"officialTitle":160,"acronym":4,"eligibilityCriteria":161,"healthyVolunteers":11,"sex":17,"minAge":162,"maxAge":163,"enrollmentInfo":164,"targetDuration":4,"studyType":62,"phases":166,"briefSummary":167,"conditions":168,"keywords":4,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":169,"lastUpdatePostDateStruct":170,"startDateStruct":172,"completionDateStruct":174,"leadSponsor":176,"locationsCount":4},"100595365","effects-of-photobiomodulation-with-superpulsed-laser-and-dual-wavelengths-in-children-and-adolescents-100595365","NCT07031505","Effects of Photobiomodulation With Superpulsed Laser and Dual Wavelengths in Children and Adolescents","Effects of Photobiomodulation With Superpulsed Laser and Dual Wavelength (810 + 980 NM) in Children and Adolescents With Facial Muscle Pain and Headache: Protocol for a Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* Children and adolescents 6 to 17 years of age enrolled at the medical and dental clinic of Universidade Nove de Julho (UNINOVE), Vergueiro Campus;\n* Children and adolescents who present with at least one symptom of orofacial pain and\u002For headache, according to the Faces Pain Scale and the childhood and adolescence headache questionnaire based on the ICHD-3\n\nExclusion Criteria:\n\n* Pregnant adolescents;\n* Having taken corticoids, non-steroidal anti-inflammatory drugs or analgesics in the previous 30 days;\n* Having taken isotretinoin;\n* Individuals who report photosensitivity to laser or LED in previous treatments.","6 Years","17 Years",{"count":165,"type":21},60,[64],"This randomized clinical trial evaluates the effects of photobiomodulation with a superpulsed diode laser (810 + 980 nm) on orofacial pain and tension-type headache in children and adolescents. Sixty participants will be assigned to receive active PBM or sham therapy over eight sessions. Pain and anthropometric variables will be assessed.",[34,32],"2025-06-12",{"date":171,"type":43},"2025-06-22",{"date":173,"type":21},"2025-07-01",{"date":175,"type":21},"2026-04-30",{"name":177,"class":50},"University of Nove de Julho",{"id":179,"slug":180,"hasResults":11,"nctId":181,"briefTitle":182,"officialTitle":183,"acronym":4,"eligibilityCriteria":184,"healthyVolunteers":16,"sex":17,"minAge":185,"maxAge":186,"enrollmentInfo":187,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":189,"conditions":190,"keywords":191,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":195,"lastUpdatePostDateStruct":196,"startDateStruct":198,"completionDateStruct":200,"leadSponsor":202,"locationsCount":51},"100555925","emotion-and-memory-in-chronic-neuropathic-pain-100555925","NCT06518421","Emotion and Memory in Chronic Neuropathic Pain","The Role of Limbic Subcortical Structures and Cognition in Chronic Neuropathic Pain","Inclusion Criteria (for HC and TN):\n\n* Age between 35 and 60 years old\n* Absence of other active major neurological or psychiatric disorders\n* Absence of MRI contraindications\n* Able to communicate sufficiently to complete tasks and questionnaires\n* Montreal Cognitive Assessment (MoCA) score greater than 23\u002F30 (MoCA ≤23\u002F30 could indicate severe cognitive impairment)\n\nInclusion Criteria for TN:\n\n* Experiencing TN pain over a period of 6 months\n* Stable medication use\n* Meet established diagnostic criteria for TN (ICHD-3)\n\nExclusion Criteria (both HC and TN):\n\n* Presence of other chronic pain\u002Fheadache conditions\n* Untreated hypertension or diabetes mellitus\n* History of chronic drug or substance use disorder, chronic use of opioids or steroids, head trauma affecting cognitive performance,\n* History\u002Fpresence of active psychiatric illness and\u002For current use of psychoactive medication\n* History of multiple sclerosis, skull base injury or tumours","35 Years","60 Years",{"count":188,"type":21},400,"Chronic pain affects one in four Canadians, leading to severe personal and societal costs. Over 70% of chronic pain patients report memory difficulties and fear having unexpected pain. Abnormalities in brain structures associated with emotion and memory, including the hippocampus and amygdala, can be affected by chronic pain. Understanding the relationship between chronic pain, structural brain changes, and cognitive functioning will lead to improved diagnosis, treatment, and outcomes in chronic pain disorders. In this project, the investigators will use advanced brain imaging techniques that assess the structure and function of the brain along with cognitive assessments to examine the overlap between chronic pain and emotion-memory processes. The study team will conduct the study using an excellent model of chronic pain-trigeminal neuralgia, a severe form of facial pain that responds well to surgical treatment. Brain images and cognitive data will be collected from participants before and after surgical treatment for pain. This information will be analyzed and compared with age- and sex-matched healthy individuals. This study will be the first to thoroughly investigate relationships between brain structure and function, cognition (memory, emotion), and promises to impact our understanding of chronic neuropathic pain conditions.",[127,34],[127,34,192,193,194],"Emotion","Cognition","Memory","2024-07-23",{"date":197,"type":43},"2024-07-24",{"date":199,"type":43},"2024-02-12",{"date":201,"type":21},"2029-02-12",{"name":203,"class":50},"University Health Network, Toronto"]