[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"facial-paralysis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:facial-paralysis":24},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,43,75,99,123,145],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":25,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100652847","video-based-facial-movement-analysis-in-facial-paralysis-100652847",false,"NCT07780370","Video-Based Facial Movement Analysis in Facial Paralysis","Investigation of the Relationship Between Video-Based Objective Facial Movement Analysis and Clinical Assessment Scales in Patients With Facial Paralysis","Inclusion Criteria:\n\n* Diagnosis of facial paralysis (e.g., Bell's palsy)\n* Age 18 years and older\n* Willing and able to provide informed consent\n\nExclusion Criteria:\n\n* Presence of other neurological or craniofacial conditions affecting facial movement\n* Prior facial surgery affecting facial musculature\n* Inability to cooperate with video recording or clinical assessment procedures","ALL","18 Years",{"count":19,"type":20},49,"ESTIMATED","OBSERVATIONAL","This study aims to evaluate facial movements in patients with facial paralysis using video-based objective analysis and to examine the relationship between these video-based measurements and standard clinical assessment scales. Participants will be asked to perform simple facial movements, such as raising the eyebrows, closing the eyes tightly, smiling, showing the teeth, pursing the lips, and puffing the cheeks, while a video recording is taken. Researchers will also evaluate participants' facial function using established clinical rating scales and questionnaires. No medication will be given, no invasive procedures will be performed, and no changes will be made to participants' current treatment. The goal is to contribute to the development of more detailed, objective, and standardized methods for evaluating facial function in patients with facial paralysis.",[24],"Facial Paralysis",[24,26,27,28,29],"Video-Based Analysis","Facial Movement Analysis","Objective Facial Assessment","Clinical Assessment Scales","NOT_YET_RECRUITING","2026-08-19",{"date":33,"type":34},"2026-08-21","ACTUAL",{"date":36,"type":20},"2026-09-01",{"date":38,"type":20},"2027-06-20",{"name":40,"class":41},"Biruni University","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":16,"minAge":49,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":53,"phases":54,"briefSummary":56,"conditions":57,"keywords":60,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":42},"100651169","combined-effects-of-proprioceptive-neuromuscular-facilitation-pnf-and-neural-mobilization-on-improving-facial-symmetry-in-patients-with-bells-palsy-100651169","NCT07758543","Combined Effects of Proprioceptive Neuromuscular Facilitation (PNF) and Neural Mobilization on Improving Facial Symmetry in Patients With Bells Palsy","Inclusion Criteria:\n\n* Age 15-60 years.\n* Both male and female.\n* Patient diagnosed with bells palsy by neurologist or relevant specialist.\n* Patients with moderate to severe Bell's palsy evaluated by Modified House-Brackman SCALE\n* Patient without exposure to any other rehabilitation program\n* Patients within the acute or subacute phases (within 6 months of onset)\n\nExclusion Criteria:\n\n* Patients with a history of recurrent Bell's palsy or other neurological disorders (e.g., stroke, multiple sclerosis)\n* Patients with pacemakers, metal implants or other contraindications for electrical muscle stimulation.\n* Presence of facial trauma or surgical interventions that might interfere with rehabilitation outcomes.\n* Co-existing medical conditions (e.g., diabetes mellitus, infections, or malignancies) that might impair nerve recovery or affect study outcomes","15 Years","60 Years",{"count":52,"type":20},38,"INTERVENTIONAL",[55],"NA","Bell's palsy is an acute,unilateral facial paresis that significantly affects patient's facial symmetry,motor function and quality of life.The primary goal of this randomized controlled trial is to determine if integrating the targeted neural mobilization with proprioceptive neuromuscular facilitation improves facial symmetry and motor function more effectively than using pnf alone.participants allocated to either experimental group receiving neural mobilization and pnf or control group receiving pnf alone.after approval from ERC FUSH, participants are assessed using housebrackman scale and sunnybrook facial grading system(scales to asses the degree of severity of facial paralysis) at first and fourth week of intervention application.data will be analysed using spss v.22.",[58,24,59],"Bell's Palsy","Facial Asymmetry",[61,62,63,64],"Bell's palsy","facial paralysis","neural mobilization","proprioceptive neuromuscular facilitation","RECRUITING","2026-08-06",{"date":68,"type":34},"2026-08-11",{"date":70,"type":34},"2025-09-14",{"date":72,"type":20},"2027-01-10",{"name":74,"class":41},"Foundation University Islamabad",{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":79,"acronym":4,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":81,"targetDuration":4,"studyType":53,"phases":83,"briefSummary":84,"conditions":85,"keywords":86,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":42},"100602707","mindfulness-in-nonflaccid-facial-paralysis-100602707","NCT07127016","Mindfulness in Nonflaccid Facial Paralysis","Inclusion Criteria:\n\n\\- Diagnosed with non-flaccid facial paralysis (NFFP) due to Bell's Palsy, Ramsay Hunt syndrome, Lyme disease, or post-acoustic neuroma resection, at least 8 months from the initial diagnosis\n\nExclusion Criteria:\n\n* Received treatments such as botox or physical therapy for facial paralysis\n* History of malignancy or facial surgery",{"count":82,"type":20},24,[55],"The purpose of this study is to learn more about how mindfulness techniques can help reduce anxiety, depression and body image disturbance as well as improve synkinesis in individuals with non-flaccid facial paralysis.",[24],[87,88,89],"non-flaccid facial paralysis","synkinesis","mindfulness","2026-08-04",{"date":92,"type":34},"2026-08-05",{"date":94,"type":20},"2026-08",{"date":96,"type":20},"2027-01",{"name":98,"class":41},"Wake Forest University Health Sciences",{"id":100,"slug":101,"hasResults":11,"nctId":102,"briefTitle":103,"officialTitle":103,"acronym":104,"eligibilityCriteria":105,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":106,"targetDuration":4,"studyType":53,"phases":108,"briefSummary":109,"conditions":110,"keywords":111,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":117,"completionDateStruct":119,"leadSponsor":121,"locationsCount":42},"100294615","morphometric-study-of-the-muscles-of-the-skin-in-mri-3-tesla-in-patients-with-facial-paralysis-100294615","NCT03115203","Morphometric Study of the Muscles of the Skin in MRI 3 Tesla in Patients With Facial Paralysis.","SIMOVI IRM 2","Inclusion Criteria:\n\n* Subject, for which a diagnosis of facial paralysis has been made, female or male, over 18 years of age.\n\nExclusion Criteria:\n\n* Pregnancy and lactation,\n* a patient with a contra-indication to MRI (Claustrophobia, Pace Maker, Neurosurgical Clips, Vascular Clips, Cardiac Valves, V.peritoneal Valves, Cochlear Implant, Neuro-Stimulator, Intra-Orbital Metal Shards (Articular Prosthesis, Dental Prosthesis, Contact Glass, Insulin Pumps, Intrauterine Device, Tattoo, Piercing \u002F Implants.))",{"count":107,"type":20},60,[55],"The problem posed is the possibility of objectively assessing facial muscle mobility.\n\nToday, in patients with facial paralysis, the assessment of the deficit is carried out using a subjective scale such as the House Brackman \\[1\\] or EMG scale of the facial nerve but does not distinguish each muscle individually . Objective measurements of skin muscles such as thickness and volume, in preoperative assessment of a facial paralysis rehabilitation surgery, would be useful in order to choose the most appropriate surgical technique. Indeed, too much amyotrophy will contraindicate hypoglosso-facial anastomosis (VII-XII) and it will be preferable to propose a temporal elongation myoplasty or a reinfused free muscle flap.\n\nSimilarly, it would be useful to be able to objectively evaluate the recovery of muscle function after facial allo-transplantation.\n\nAlthough electromyography has been developed since the work of Duchenne de Boulogne, little research has been carried out on the development of noninvasive methods to objectively characterize in vivo skin muscles (variation, position, orientation, morphometry). The main morphometric data of the skin muscles come from anatomical dissections.\n\nImaging of the skin muscles has not been specifically developed. Some studies have been carried out to visualize these muscles in MRI 1.5 Tesla in pathologies such as myasthenia gravis, facial paralysis, and labio-alveolo-palatine clefts for example.\n\nThe originality of the project is to develop a method allowing to establish a quantitative correlation between the movements of the face and the muscular changes. This correlation will be achieved by associating muscular morphological data derived from MRI acquisitions and cutaneous deformations resulting from clinical examinations. This non-invasive approach should make it possible to establish objective and reproducible indicators in patients with facial paralysis sequelae.",[24],[112,113],"muscle skin","IRM 3 tesla","2026-05-12",{"date":116,"type":34},"2026-05-13",{"date":118,"type":34},"2016-08-08",{"date":120,"type":20},"2027-08-08",{"name":122,"class":41},"Centre Hospitalier Universitaire, Amiens",{"id":124,"slug":125,"hasResults":11,"nctId":126,"briefTitle":127,"officialTitle":128,"acronym":4,"eligibilityCriteria":129,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":130,"enrollmentInfo":131,"targetDuration":4,"studyType":53,"phases":133,"briefSummary":134,"conditions":135,"keywords":4,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":136,"lastUpdatePostDateStruct":137,"startDateStruct":139,"completionDateStruct":141,"leadSponsor":143,"locationsCount":42},"100541888","intraoperative-electrical-stimulation-to-improve-nerve-grafting-outcome-100541888","NCT06335719","Intraoperative Electrical Stimulation to Improve Nerve Grafting Outcome","Intraoperative Brief Electrical Stimulation to Improve Cross-Face Nerve Grafting Outcomes","Inclusion Criteria:\n\n1. Patients 18-80 years-old with unilateral facial paralysis who are candidates for two- stage CFNG smile reanimation surgery (i.e. CFNG-driven free gracilis muscle transfer (FGMT) or dual innervation FGMT).\n2. Agree to participate in the study.\n\nExclusion Criteria:\n\n1. Bilateral facial paralysis\n2. Age less than 18 years-old or older than 80 years-old\n3. Comorbid medical condition preventing two-stage CFNG surgery","80 Years",{"count":132,"type":20},20,[55],"A research study to find out if brief intraoperative electrical stimulation therapy improves nerve regeneration and smile outcomes following two-stage cross face nerve graft facial reanimation surgery.",[24],"2025-07-28",{"date":138,"type":34},"2025-07-30",{"date":140,"type":34},"2023-03-01",{"date":142,"type":20},"2026-12-31",{"name":144,"class":41},"The Cleveland Clinic",{"id":146,"slug":147,"hasResults":11,"nctId":148,"briefTitle":149,"officialTitle":150,"acronym":4,"eligibilityCriteria":151,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":152,"enrollmentInfo":153,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":155,"conditions":156,"keywords":4,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":157,"lastUpdatePostDateStruct":158,"startDateStruct":160,"completionDateStruct":162,"leadSponsor":164,"locationsCount":42},"100434211","3d-dynamic-and-patient-centered-outcomes-of-facial-reanimation-surgery-in-patients-with-facial-paralysis-100434211","NCT04934176","3D Dynamic and Patient-Centered Outcomes of Facial Reanimation Surgery in Patients With Facial Paralysis","3D Dynamic and Patient-Centered Outcomes of Facial Reanimation","Inclusion Criteria:\n\n* Patients with unilateral facial paralysis scheduled for smile reconstruction using free gracilis muscle transfer driven by one of four neuronal inputs, specifically, the trigeminal nerve (nV), a cross-face nerve graft (nVII), dual innervation combining the trigeminal nerve, a cross face nerve graft, and patients who have midfacial modifications that involve performing direct coaptation between the trigeminal nerve and a branch to the native zygomaticus major muscle (5-7 transfer) and selective neurolysis in which several facial nerve branches that innervate muscles antagonistic to the smile animation are transected.\n* Patient\u002Fparent interest\u002Fwillingness to participate in the study\n* An ability to comprehend verbal instructions\n* An age range of 18 to 75 years\n\nExclusion Criteria:\n\n* Presence of a major facial deformity\u002Fcondition either congenital or acquired e.g. hemifacial microsomia, cancer\n* Facial movement disorders due to primary muscular dysfunction or hemifacial spasm in the absence of synkinesis\n* Mental or hearing impairment to the extent that comprehension or ability to perform the tests is hampered","75 Years",{"count":154,"type":20},125,"In this study, patients who have undergone facial paralysis surgery will be asked to participate. The goal of this study is to compare the facial disability and perception outcomes of facial reanimation surgeries in patients with extensive and permanent, unilateral paralysis using 3D analysis, and compare patient-centered outcomes of facial appearance, well-being, and satisfaction using validated questionnaires. The focus point of this study will be on outcomes of mid-facial reanimation surgeries in patients with more extensive and permanent, unilateral, paralysis of varied etiology and presentation.\n\nThe specific aims of the study are as follows. Specific Aim 1. To quantitatively determine the surgical effects\u002Fimpact on facial disability (facial impairment and disfigurement) among four surgically treated groups of patients with unilateral facial paralysis who undergo free gracilis muscle transfer driven by (1) a trigeminal nerve (nV) graft, (2) a crossface nerve graft (nVII), (3) dual innervation comprising both nerves, and (4) midfacial modification.\n\n1. We will compare the changes in facial disability among the groups before and after surgery, and the differences in facial disability between each surgery group and the controls before and after surgery.\n2. Specific Aim 2. To compare among the surgery groups the changes in self-perceptions of facial appearance and well-being that occur due to facial reanimation surgery, and to compare the surgery groups before and at 18 months to historical controls recruited during the tenure of the R21 grant.\n3. Specific Aim 3. In patients with facial paralysis, to compare surgeons' current qualitative assessment and 2D, quantitative assessment of facial impairment and disfigurement with the objective, 3D, quantitative assessments in order to determine the clinical utility of the 3D assessment approach as an outcome measure and relevance for dissemination to the surgical community.",[24],"2024-12-20",{"date":159,"type":34},"2024-12-27",{"date":161,"type":34},"2021-06-03",{"date":163,"type":20},"2026-06-03",{"name":165,"class":41},"Tufts University"]