[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"family-history-of-schizophrenia-spectrum-disorder\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:family-history-of-schizophrenia-spectrum-disorder":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":5},"100650153","developing-biomarker-supported-schizophrenia-spectrum-disorder-ssd-prevention-100650153",false,"NCT07743645","Developing Biomarker-Supported Schizophrenia Spectrum Disorder (SSD) Prevention","Developing Biomarker-Supported SSD Prevention","Inclusion Criteria:\n\n* Family history of SSD (defined as first-degree (e.g., a parent or a sibling), second-degree (e.g., an uncle or a grandparent), or other combinations of biological relatives in the family have or likely have a diagnosis of SSD or other closely related severe mental illnesses equivalent to at least 25% of genetic sharing) per medical record review and\u002For parent\u002Flegal guardian report and confirmed by a structured interview\n* screening positive for two or more risk factors targeted by the intervention\n* Participants and parent(s)\u002Flegal guardian(s) agree to participate\n* psychiatrically stable and have no major changes in antidepressant, stimulant, or antipsychotic medication in the past 4 weeks.\n\nExclusion Criteria:\n\n* Current or past history of psychotic disorders or clinical high risk for psychosis (CHR-p) per study interview\n* Current or past antipsychotic medication use to specifically treat a psychotic disorder\n* major medical and neurological conditions\n* moderate to severe intellectual disabilities or mild intellectual disabilities but expected to have difficulty completing the study assessments;\n* current drug or alcohol use that impacts functioning and study engagement;\n* Not able to give assent, permission, or consent.\n* Not able to undergo MRI.",true,"ALL","9 Years","19 Years",{"count":21,"type":22},100,"ESTIMATED","INTERVENTIONAL",[25],"NA","The purpose of this study is to compare the effect of a brief family-based psychosocial intervention that addresses modifiable SSD risk factors on persistent and distressing psychotic-like experiences in children and young adults with a family history of SSD and high versus low baseline SSD-like brain patterns",[28,29,30],"Prevention","Risk Factors for Mental Illness","Family History of Schizophrenia Spectrum Disorder",[32,28,33],"Risk Reduction Therapy (RRT)","family history of schizophrenia spectrum disorder","NOT_YET_RECRUITING","2026-07-30",{"date":37,"type":38},"2026-08-04","ACTUAL",{"date":40,"type":22},"2026-10-01",{"date":42,"type":22},"2031-04-01",{"name":44,"class":45},"The University of Texas Health Science Center, Houston","OTHER"]