[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"fasting-state\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:fasting-state":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":5},"100649851","ketosis-immune-function-and-metabolic-adaptation-in-response-to-short-term-fasting-in-critical-illness-100649851",false,"NCT07738536","Ketosis, Immune Function and Metabolic Adaptation in Response to Short-term Fasting in Critical Illness","KETOsis, Immune Function and Metabolic Adaptation in Response to Short-Term Fasting in Critical Illness (KETO-FAST): A Translational Substudy of the FAST-ICU Cluster-randomized Cross-over Trial.","KETO-FAST","Inclusion Criteria:\n\n1. Adult (≥18 years).\n2. ICU admission (index admission to the participating ICU).\n\nExclusion Criteria:\n\n1. The patient requires intravenous glucose infusion, enteral nutrition or parenteral nutrition according to the attending clinician's assessment,\n2. Acute or acute-on-chronic liver failure\n3. Moderate hypernatremia ( \\>150 mmol\u002FL)\n4. Diabetic ketoacidosis or hyperosmolar hyperglycemic state at admission,\n5. Pregnancy,\n6. Exclusive end-of-life care (no other treatment goal than comfort care for end of life),\n7. Organ donor,\n8. Prior enrolment in this trial during the same hospitalisation,\n9. Patients with a metabolic disease requiring specific diet and patients with clinical need for a ketogenic diet.\n10. Patients already enrolled in other interventional studies on nutrition, intravenous fluids, phosphate supplementation or hormonal therapies that influence glucose homeostasis.\n11. Inclusion not possible due to site-specific regulatory issues regarding the ethical approval or informed consent procedure.",true,"ALL","18 Years",{"count":21,"type":22},200,"ESTIMATED","INTERVENTIONAL",[25],"NA","KETO-FAST is a pre-planned translational substudy of the FAST-ICU cluster-randomized cross-over trial. The substudy will characterize ketone body production and associated metabolic, autophagy-related, and immune cellular responses during the first 72 hours after intensive care unit admission in critically ill patients exposed to delayed nutrition compared with patients receiving standard care.\n\nPatients enrolled in FAST-ICU at designated participating centers will undergo serial blood sampling during the first 72 hours after ICU admission. Plasma ketone body concentrations, targeted metabolomics, serum-induced cellular responses in vitro, leukocyte autophagy markers, and immune cell phenotypes and functional markers will be assessed. In addition, 10 healthy volunteers will perform a 72-hour fast with blood sampling to provide reference values from non-critically ill subjects.",[28,29,30,31],"Critical Illness","Fasting State","Ketosis","Nutrition",[33,34,35,30,36],"Critical Care","Intensive care","Fasting","Calorie restriction","NOT_YET_RECRUITING","2026-07-29",{"date":40,"type":41},"2026-07-31","ACTUAL",{"date":43,"type":22},"2026-08-31",{"date":45,"type":22},"2027-07-31",{"name":47,"class":48},"Karolinska University Hospital","OTHER"]