[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"fat-disorder\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:fat-disorder":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,45],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":4},"100649555","impact-of-mbs-on-body-composition-basal-metabolic-rates-and-muscle-functions-in-morbid-obese-patients-100649555",false,"NCT07737860","Impact of MBS on Body Composition, Basal Metabolic Rates and Muscle Functions in Morbid Obese Patients","Impact of Bariatric Surgery on Body Composition, Basal Metabolic Rates and Muscle Functions in Morbid Obese Patients: A Prospective Observational Study","BARCOM","Inclusion Criteria:\n\n* BMI \\> 35 with or without obesity-related comorbidities Planned for Bariatric and Metabolic Surgery\n\nExclusion Criteria:\n\n* Known endocrine disorders (Cushing's and Untreated hypothyroidism)\n* History of prior bariatric surgery\n* Inability to comply with follow-up scheduleLost to follow-up before 3 months post-treatment","ALL","18 Years","60 Years",{"count":21,"type":22},21,"ESTIMATED","OBSERVATIONAL","PRIMARY OBJECTIVE To evaluate the changes in body composition in morbid obese patients following bariatric and metabolic surgery\n\nSecondary Objectives:\n\n1. To assess changes in BMR in obese patients following bariatric surgery\n2. To evaluate muscles strength and muscle performance parameters in obese patients following bariatric surgery\n3. To assess change in inflammatory and metabolic parameters following bariatric surgery In this study, morbidly obese patients undergoing bariatric surgery will be assessed at baseline and followed by 3rd and 6 months to evaluate various physiological and biochemical changes. Anthropometric measurements including height, weight, BMI, and waist-hip ratio will be recorded. Body composition will be assessed using Bioelectrical Impedance Analysis (BIA), which will provide data on percentage body fat (PBF), segmental muscle mass (SMM), segmental fat mass (SFM), and skeletal muscle index (SMI). Basal metabolic rate (BMR) will also be measured through BIA. Muscle strength will be evaluated using a hand grip dynamometer, while muscle performance will be assessed via gait speed using the 6-meter walk test. Inflammatory markers such as high-sensitivity C-reactive protein (HsCRP), erythrocyte sedimentation rate (ESR), and interleukin-6 (IL-6) will be analyzed. Additionally, metabolic parameters including thyroid-stimulating hormone (TSH), fasting and postprandial blood glucose, HbA1c, and lipid profile will be measured to understand the systemic effects of the surgery.",[26,27,28],"Obesity, Morbid","Obesity; Endocrine","Fat Disorder",[30,31,32],"BMR","Fat composition","Muscle strength","NOT_YET_RECRUITING","2026-07-29",{"date":36,"type":37},"2026-07-30","ACTUAL",{"date":39,"type":22},"2026-09-01",{"date":41,"type":22},"2027-12",{"name":43,"class":44},"All India Institute of Medical Sciences, Bhubaneswar","OTHER",{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":52,"sex":17,"minAge":18,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":56,"phases":57,"briefSummary":59,"conditions":60,"keywords":4,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":72},"100480725","metabolism-and-sleep-apnea-treatment-100480725","NCT05539716","Metabolism and Sleep Apnea Treatment","MaST","Aim 1 Group:\n\nInclusion criteria:\n\n* Age between 18-70 years\n* Ability to provide consent\n\nExclusion criteria\n\n* Body Mass Index (BMI) \\> 40 kg\u002Fm2\n* Prevalent myocardial infarction, coronary revascularization, heart failure, and stroke\n* Type 1 or Type 2 diabetes mellitus\n* Current or prior use of PAP or oral appliance therapy for OSA\n* Use of oral corticosteroids\n* Unstable medical conditions that may preclude enrollment in the protocol such as: uncontrolled angina and\u002For congestive heart failure, uncontrolled blood pressure or resistant hypertension, severe chronic obstructive pulmonary disease, cancer, and active psychiatric disease (e.g., major depression)\n* Other sleep disorders (e.g., circadian rhythm disorder, self-reported habitual sleep duration \\\u003C 6h)\n* Use of supplemental oxygen during wakefulness or sleep\n* Central sleep apnea, obesity hypoventilation syndrome or Cheyne-Stokes respiration based on the home sleep test\n* Resting awake Oxygen Saturation (SpO2) \\\u003C 90%\n\nAim 2 Group:\n\nInclusion criteria:\n\n* Age between 18-70 years\n* Ability to provide consent\n* Moderate-to-severe OSA (AHI ≥ 15\u002Fh);\n* Demonstration of Positive Airway Pressure (PAP) use of \\> 4 h\u002Fnight on 70% of the nights during 1-week run-in period\n* Successful completion of all of the procedures for Aim 1.\n\nExclusion criteria:\n\n* BMI: ≥ 40 kg\u002Fm2\n* Type 1 or Type 2 diabetes mellitus\n* Current use of PAP or oral appliance therapy for OSA\n* Commercial driver or report of motor vehicle accident or near-miss due to sleepiness within the 2 previous years\n* Epworth sleepiness score of 18 or more\n* Use of oral corticosteroids\n* Participation in another clinical trial\n* Unstable medical conditions that may preclude enrollment in the protocol such as: uncontrolled angina and\u002For congestive heart failure, uncontrolled blood pressure or resistant hypertension, severe chronic obstructive pulmonary disease, cancer, and active psychiatric disease (e.g., major depression)\n* Other sleep disorders (e.g., circadian rhythm disorder, self-reported habitual sleep duration \\\u003C 6h)\n* Use of supplemental oxygen during wakefulness or sleep\n* Central sleep apnea, obesity hypoventilation syndrome or Cheyne-Stokes respiration based on the home sleep test\n* Resting awake SpO2 \\\u003C 90%",true,"70 Years",{"count":55,"type":22},100,"INTERVENTIONAL",[58],"NA","The purpose of this research study is to see if obstructive sleep apnea (OSA) is associated with abnormalities in fat metabolism. Through this research study, the Investigator will evaluate how fat is metabolized in people with and without sleep apnea, what substances the fat tissue releases, and how these substances might change the way the body uses energy and sugar.",[61,28],"Obstructive Sleep Apnea","RECRUITING","2026-03-18",{"date":65,"type":37},"2026-03-23",{"date":67,"type":37},"2022-05-20",{"date":69,"type":22},"2027-09-01",{"name":71,"class":44},"University of Miami",1]