[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"fatigue-symptom\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:fatigue-symptom":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,15,0,[8,58,79,108,135,171,208,240,277,304,338,370,393,421,448],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":40,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":46,"lastUpdatePostDateStruct":47,"startDateStruct":50,"completionDateStruct":52,"leadSponsor":54,"locationsCount":57},"100649918","dietary-supplements-and-middle-aged-women-collagen--omega-100649918",false,"NCT07740967","Dietary Supplements and Middle Aged Women (Collagen & Omega)","The Effects of Dietary Supplements on Health and Wellbeing in Middle Aged Women","Inclusion Criteria:\n\n* Female\n* Age 35 - 65 years old\n* Healthy, free from known disease\n* Non-smoker\n* BMI of 18 - 30 kg\u002Fm2 of\n* Classified as either recreationally physically active (meet the WHO guidelines for physical activity of completing at least 150-300 min moderate-intensity activity or 75-150 min of vigorous-intensity activity a week, plus muscle-strengthening activities 2 or more days a week) OR classified as sedentary (do not meet minimum activity guidelines but do occasional and\u002For incidental physical activity (e.g., walking to work, household activities))\n\nExclusion Criteria:\n\n* Currently have a musculoskeletal injury or diagnosed condition (e.g., cardiovascular disease, osteoarthritis, diabetes, cancer, metabolic syndrome, uncontrolled hypertension, gastrointestinal disease, blood clotting disorder)\n* Regularly taking prescription medication initiated in the last 3 months or unstable\n* Have initiated hormone replacement therapy within the last 3 months and\u002For currently unstable\n* BMI not between 18-30 kg\u002Fm2\n* Allergy to ingredients in supplements or standardized breakfasts\n* Pregnant or breastfeeding, or any other contraindications to consuming study supplements\n* Lost more than 10% of body mass in past 6 months or plan on trying to lose body mass during trial period\n* Currently consuming the supplements being investigated and unwilling to stop taking them\n* Any known cognitive or visual impairments limiting ability to perform cognitive tests\n* Unwilling to maintain current diet and physical activity levels or exercise and activity levels above recreationally active (e.g., athlete)",true,"FEMALE","35 Years","65 Years",{"count":21,"type":22},34,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study will examine the effects of combining different types of dietary supplements on various aspects of health and wellbeing in middle aged women. The main outcomes of the trial will be aspects of health and wellbeing that middle aged women report as increasingly problematic, such as joint pain, fatigue, sleep, and changes in body composition, strength, and inflammation. Participants will consume the supplement(s) or placebo for 8 weeks, and outcome measures will be assessed before and after supplementation.",[28,29,30,31,32,33,34,35,36,37,38,39],"Cognition","Inflammation Biomarkers","Bone Metabolism Biomarkers","Fatigue Symptom","Sleep","Body Composition Changes","Joint Pain","Quality of Life","Gastrointestinal Comfort","Blood Pressure and Augmentation Index","Muscle Strength","Fatty Acid Blood Profile",[41,42,43,44],"Collagen peptides","Middle aged women","Joint pain","Dietary supplements","RECRUITING","2026-07-31",{"date":48,"type":49},"2026-08-03","ACTUAL",{"date":51,"type":49},"2026-05-01",{"date":53,"type":22},"2028-08-01",{"name":55,"class":56},"Loughborough University","OTHER",1,{"id":59,"slug":60,"hasResults":11,"nctId":61,"briefTitle":62,"officialTitle":14,"acronym":4,"eligibilityCriteria":63,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":64,"targetDuration":4,"studyType":23,"phases":66,"briefSummary":26,"conditions":67,"keywords":69,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":76,"leadSponsor":78,"locationsCount":57},"100649225","dietary-supplements-and-middle-aged-women-creatine-100649225","NCT07729930","Dietary Supplements and Middle Aged Women (Creatine)","Inclusion Criteria:\n\n* Female\n* Aged 35-65 years old\n* Healthy, free from known disease\n* Non-smoker\n* BMI 18-30 kg\u002Fm2\n* Classified as recreationally active (meet the WHO guidelines for physical activity: complete at least 150-300 minutes of moderate intensity activity or 75-150 minutes of vigorous intensity activity a week, plus muscle strengthening activities 2 or more days a week) OR sedentary (do not meet the minimum activity guidelines but do occasional and\u002For incidental physical activity, e.g., walking to work, household activities).\n\nExclusion Criteria:\n\n* Currently have a musculoskeletal injury or diagnosed condition (CVD, osteoarthritis, diabetes, cancer, metabolic syndrome, uncontrolled hypertension, gastrointestinal disease, blood clotting disorder)\n* Regularly taking prescription medication initiated in the last 3 months or unstable\n* Have initiated hormone replacement therapy within the last 3 months or unstable\n* Have an allergy to ingredients in the supplements or standardised breakfast\n* Pregnant or breastfeeding, or any other contradictions to consuming the study supplements\n* Lost more than 10% of body mass in the past 6 months or plan on trying to lose body mass during trial period\n* Currently consuming the supplements being investigated and unwilling to stop\n* Any known cognitive or visual impairments limiting ability to perform cognitive tests\n* Unwilling to maintain current diet and physical activity levels and report any change in health status",{"count":65,"type":22},38,[25],[28,38,31,37,33,32,36,35,34,29,30,68],"Menopause Symptoms",[70,42,71,44],"Creatine","Cognitive function","2026-07-21",{"date":74,"type":49},"2026-07-28",{"date":51,"type":49},{"date":77,"type":22},"2028-11-01",{"name":55,"class":56},{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":83,"acronym":84,"eligibilityCriteria":85,"healthyVolunteers":16,"sex":86,"minAge":4,"maxAge":4,"enrollmentInfo":87,"targetDuration":89,"studyType":90,"phases":4,"briefSummary":91,"conditions":92,"keywords":4,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":107},"100647364","the-comet-study-a-prospective-cohort-of-medical-residents-to-assess-professional-personal-and-psychological-trajectories-of-residents-in-general-internal-medicine-100647364","NCT07707453","The COMET Study: a Prospective COhort of MEdical residenTs to Assess Professional, Personal and Psychological Trajectories of Residents in General Internal Medicine","COMET","Inclusion Criteria:\n\nResident physician in general internal medicine employed at a participating study site or annex centre during the recruitment period Written informed consent\n\nExclusion Criteria:\n\nNot providing direct patient care Severe mental or physical condition precluding informed consent or compliance with the protocol","ALL",{"count":88,"type":22},800,"5 Years","OBSERVATIONAL","Introduction.\n\nSwitzerland, like most Western countries, faces a paradox: an ageing, multimorbid population needs general internal medicine (GIM) physicians more than ever, yet fewer young doctors choose - and stay in - the specialty. Career decisions during residency are intertwined with well-being, mental and physical health, and work-life balance, and distress in training has been associated with depression, burnout, attrition and poorer patient care. Longitudinal data following GIM residents across these domains, and linking them to actual career trajectories, are lacking. The COMET study establishes a multicentre prospective cohort of GIM residents to fill this gap.\n\nMethods and analysis.\n\nCOMET is a prospective, open, multicentre cohort conducted in the departments of (general) internal medicine of Fribourg Hospital (HFR, four sites), Bern University Hospital (Inselspital) and Lausanne University Hospital (CHUV). All GIM residents providing direct patient care are eligible (≈334 residents; expected enrolment ≥267, assuming 80% participation). Participants complete an annual online survey (REDCap; French or German) at baseline and for at least four years, covering sociodemographics; job characteristics; career intentions and 24 factors for or against a GIM career; well-being (Physician Well-Being Index, Professional Fulfillment Index, quality of life, work-life balance); mental health (CES-D, Perceived Stress Scale, Maslach Burnout Inventory, Questionnaire of Cognitive and Affective Empathy); and physical health (step counts, physical activity, fatigue, sleep, healthcare utilisation). Primary endpoints are the longitudinal course of well-being and distress (PWBI, PFI, CES-D) and residents' career trajectory. Analyses combine descriptive statistics, mixed-effects and regression models, and comparisons with the population-based CoLaus\\|PsyCoLaus cohort.",[93,94,95,96,31,97],"Burnout Syndrome","Depression Disorder","Insomnia","Perceived Stress","Empathy","2026-07-15",{"date":100,"type":49},"2026-07-16",{"date":102,"type":49},"2025-08-01",{"date":104,"type":22},"2031-12-31",{"name":106,"class":56},"University of Fribourg",3,{"id":109,"slug":110,"hasResults":11,"nctId":111,"briefTitle":112,"officialTitle":113,"acronym":4,"eligibilityCriteria":114,"healthyVolunteers":16,"sex":86,"minAge":115,"maxAge":4,"enrollmentInfo":116,"targetDuration":4,"studyType":23,"phases":118,"briefSummary":119,"conditions":120,"keywords":4,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":127,"startDateStruct":129,"completionDateStruct":131,"leadSponsor":133,"locationsCount":57},"100614569","mindfulness-oriented-respiratory-distress-symptom-intervention-for-lung-cancer-100614569","NCT07281300","Mindfulness-Oriented Respiratory Distress Symptom Intervention for Lung Cancer","Mindfulness-Oriented Respiratory Distress Symptom Intervention for Patients With Lung Cancer: A Feasibility Randomized Controlled Trial","Inclusion Criteria:\n\n* HK patients who can understand Cantonese, aged 18 years or older;\n* A confirmed diagnosis of an intrathoracic malignancy, including small cell lung cancer, non-small cell lung cancer, or mesothelioma; at any stage of cancer treatment or palliative care;\n* Self-reported impact on daily life from at least two of the three symptoms, where one symptom is breathlessness;\n* Stability of COPD, if present;\n* WHO Performance Status of 0-2;\n* fMRI can be conducted;\n* Expected lifespan of more than six months.\n\nExclusion Criteria:\n\n* Cognitive impairments, severe psychotic symptoms, or other medical conditions that might hinder participation;\n* Participating in mindfulness or other psychological support interventions or symptom management interventions.","18 Years",{"count":117,"type":22},64,[25],"Lung cancer is the leading cause of cancer mortality, posing a critical public health challenge in both Hong Kong and global populations. Patients with lung cancer frequently experience a distressing symptom cluster characterized by breathlessness-driven respiratory distress, accompanied by persistent cough and fatigue, which collectively impose a substantial disease burden. While our research team leader previously developed and validated a multi-component Respiratory Distress Symptom Intervention (RDSI) in England, demonstrating clinical efficacy for lung cancer management, its impact on psychological distress (anxiety and depression) proved limited. This limitation may reflect insufficient integration of psychological components, a crucial consideration given the well-established bidirectional relationship between respiratory symptoms and psychological distress. Emerging evidence indicates that mindfulness interventions provide dual therapeutic benefits by improving patient adherence and effectively addressing both physical symptoms, such as breathlessness and fatigue, as well as psychological distress, including anxiety and depression. Meanwhile, current evaluation methodologies have mainly focused on behavioral data collection, such as self-reported questionnaires, to reflect the effect before and after the intervention. Neuroimaging data can help understand the brain mechanisms underlying breathlessness and elucidate the effectiveness of interventions, thereby improving intervention strategies.",[121,122,123,31,124,125],"Symptom Cluster","Breathlessness","Coughing","Lung Cancer Patients","Brain Activity","2026-04-14",{"date":128,"type":49},"2026-04-17",{"date":130,"type":49},"2025-08-12",{"date":132,"type":22},"2027-07-30",{"name":134,"class":56},"The Hong Kong Polytechnic University",{"id":136,"slug":137,"hasResults":11,"nctId":138,"briefTitle":139,"officialTitle":139,"acronym":140,"eligibilityCriteria":141,"healthyVolunteers":11,"sex":86,"minAge":115,"maxAge":142,"enrollmentInfo":143,"targetDuration":4,"studyType":23,"phases":145,"briefSummary":146,"conditions":147,"keywords":152,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":162,"lastUpdatePostDateStruct":163,"startDateStruct":165,"completionDateStruct":167,"leadSponsor":169,"locationsCount":57},"100576556","characterization-treatment-and-long-term-follow-up-of-fatigued-patients-in-primary-care-100576556","NCT06786832","Characterization, Treatment, and Long-term Follow-up of Fatigued Patients in Primary Care","iFAS","Inclusion Criteria:\n\n1. age 18-67\n2. enrollment at a primary care clinic in Region Stockholm\n3. severe, functionally disabling fatigue as a central symptom for at least 3 months\n4. The fatigue has an identifiable start and hence has not been life-long;\n5. The fatigue is not a direct effect of an active disease process motivating another treatment (e.g., hypo-\u002Fhyperthyroidism, anemia, cancer, dementia) or the effect of medication\n6. regular access to a computer and to the Internet\n7. ability to read and write in Swedish.\n8. ability to visit a study center for participation in potential assessments and treatment sessions (maximum 60 minutes) and to take part of written material via the internet.\n\nExclusion Criteria:\n\n1. substance abuse disorder in the past 6 months\n2. Current or past psychosis or bipolar disorder\n3. Primary psychiatric disorder of such severity that it merits evidence-based treatment (e.g., obsessive compulsive disorder, moderate to severe depression, post-traumatic stress disorder, anorexia nervosa)\n4. elevated risk for suicide\n5. deliberate self harm in the past 6-months (e.g., cutting, burning, poisoning);\n6. BMI\\>40\n7. Initiated or changed psychopharmacological medication (e.g., for depression or anxiety disorders) in the past month\n8. ongoing chemotherapy\n9. intellectual disability (e.g., severe autism) that affects ability to work with the treatment\n10. pregnancy\n11. life circumstances that complicate or make treatment impossible (e.g., domestic violence, ongoing legal disputes, disputes with social insurance agency, planed or on-going work capacity assesment regarding permanent work disability pension or planed surgery)\n12. ongoing psychological treatment and\u002For multimodal rehabilitation.\n13. working night shifts","67 Years",{"count":144,"type":22},190,[25],"The overarching purpose of this project is to further the understanding of fatigue as a symptom in primary care patients, and to build evidence for a highly accessible treatment targeting fatigue that can be readily implemented in primary care clinics.\n\nData will be collected within a randomized controlled superiority trial. The primary aim is to evaluate the effectiveness of a transdiagnostic cognitive behavioral therapy (tCBT) for fatigued patients as compared to care as usual (CAU). Primary outcome will be change in fatigue severity (as measured by the Checklist Individual Strengths, fatigue subscale) pre- to post-treatment (6 months), with long-term controlled follow-up after 12 months. A register-based follow-up will be conducted up to 60 months post baseline. Moderators and mechanisms of treatment effect will be investigated with the aim to identify potential subgroups of fatigued individuals across and within diagnostic categories that may respond differently to treatment. Lastly, a health economic evaluation of long-term treatment effects will be conducted, which incorporates much needed detailed mapping of care as usual for fatigued patients.",[148,149,150,31,151],"Fatigue","Fatigue Post Viral","Exhaustion Disorder","Fatigue Related to Cancer Treatment",[153,154,155,156,157,148,158,159,160,161],"Psychological treatment","Primary care","cognitive behavioral therapy","blended treatment","randomized controlled trial","burnout","chronic stress","register data","cognitive testing","2026-03-09",{"date":164,"type":49},"2026-03-11",{"date":166,"type":49},"2025-02-06",{"date":168,"type":22},"2033-01",{"name":170,"class":56},"Karolinska Institutet",{"id":172,"slug":173,"hasResults":11,"nctId":174,"briefTitle":175,"officialTitle":176,"acronym":177,"eligibilityCriteria":178,"healthyVolunteers":11,"sex":86,"minAge":115,"maxAge":4,"enrollmentInfo":179,"targetDuration":4,"studyType":23,"phases":180,"briefSummary":181,"conditions":182,"keywords":193,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":199,"lastUpdatePostDateStruct":200,"startDateStruct":202,"completionDateStruct":204,"leadSponsor":206,"locationsCount":57},"100617334","vr-pmr-for-post-burn-symptoms-100617334","NCT07317271","VR-PMR for Post-Burn Symptoms","Virtual Reality-Enhanced Progressive Muscle Relaxation for Symptom Management in Burn Survivors","VIBE","Inclusion criteria are:\n\n* ≥18 years old;\n* sustained a burn injury in the last 6 months or longer;\n* Score high on at least one of the following: Insomnia severity index (ISI) score of ≥8, Brief Pain Inventory Short Form (BPI-SF) Pain severity score of ≥3, or PROMIS Itch Severity of ≥55;\n* own a smartphone or computer with reliable internet connection for online visits and survey completion;\n* able to comfortably wear goggles or headsets on face as determined by self-report.\n\nExclusion criteria:\n\n* Cognitive impairment (Mini Mental Status Exam (MMSE) \\\u003C 25);\n* history of motion sickness, photosensitivity, photoinduced seizures, and claustrophobia as determined by self-report;\n* uncorrected visual or hearing impairments as determined by self-report;\n* non-English speaker.",{"count":21,"type":22},[25],"The goal of this clinical trial is to learn whether progressive muscle relaxation (PMR), delivered either alone or enhanced with virtual reality (VR), can help treat chronic symptom, such as pain, itch, anxiety, sleep disturbances, and fatigue, in adult burn survivors.\n\nThe main questions it aims to answer are:\n\n* Does VR-enhanced PMR (VR-PMR) reduce chronic pain, anxiety, itch, sleep disturbances, and fatigue more effectively than standard PMR?\n* Is VR-PMR a feasible and acceptable self-administered home-based intervention for burn survivors?\n\nResearchers will compare two self-administered intervention conditions, VR-enhanced PMR and standard PMR, using a randomized to sequence crossover design to see if VR technology enhances the therapeutic effects of PMR on chronic symptom management in burn survivors.\n\nParticipants will:\n\n* Complete home-based sessions of VR-enhanced PMR\n* Complete home-based sessions of standard PMR\n* Report symptoms such as pain, itch, anxiety, sleep disturbances, and fatigue throughout the study\n* Use VR equipment provided for the intervention period (during the VR-PMR arm)",[183,184,185,186,187,188,189,31,190,191,192],"Burn","Chronic Pain Following Thermal Burn Injury","Non-Pharmacological Interventions","Virtual Reality","Sleep Disturbance","Anxiety","Depressive Symptoms","Pruritus","Burn Injury","Progressive Muscle Relaxation",[186,194,192,195,196,197,32,148,198,191],"Burn Survivors","Chronic Symptom Management","Pain","Itch","Burns","2026-03-03",{"date":201,"type":49},"2026-03-05",{"date":203,"type":49},"2026-02-27",{"date":205,"type":22},"2026-12",{"name":207,"class":56},"Johns Hopkins University",{"id":209,"slug":210,"hasResults":11,"nctId":211,"briefTitle":212,"officialTitle":213,"acronym":214,"eligibilityCriteria":215,"healthyVolunteers":11,"sex":86,"minAge":216,"maxAge":4,"enrollmentInfo":217,"targetDuration":4,"studyType":23,"phases":219,"briefSummary":220,"conditions":221,"keywords":226,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":230,"lastUpdatePostDateStruct":231,"startDateStruct":233,"completionDateStruct":235,"leadSponsor":237,"locationsCount":239},"100614390","hemodiafiltration-versus-hemodialysis-in-older-people-100614390","NCT07278973","Hemodiafiltration Versus Hemodialysis in Older People","HemoDiafiltration Versus HemoDialysis in OLDER People: a Randomized, Multicenter, Crossover, Pragmatic Clinical Trial","HD-OLDER","Inclusion Criteria:\n\n* Signed and dated informed consent\n* Age \\>84 years\n* Diagnosed with kidney failure\n* On maintenance hemodialysis \\>3months\n* Willing to have a dialysis session of 3.5 to 4-hour duration, three times a week\n* Has a reliable vascular access\n* Is covered by the health insurance\n\nExclusion Criteria:\n\n* Patients with cognitive impairment (assessed with a mini-test if needed)\n* Hospitalized at inclusion\n* Have difficulties with French speaking\n* Terminally ill with life expectancy\\\u003C3 months\n* With active cancer","85 Years",{"count":218,"type":22},62,[25],"This study will compare the impact of two hemodialysis techniques on fatigue and post-dialysis recovery time in patients aged 85 years and older. These two techniques are high-flux hemodialysis (HD) and hemodiafiltration (HDF).\n\nPatients will receive the treatment over two periods: if period 1 is HD then period 2 will be HDF. Every patient will be his\u002Fher own control, this is why it is called cross-over. Each period will last three months. Between the two periods, patients will receive a traditional low-flux hemodialysis.\n\nThese two techniques are widely used worldwide and their side-effects are well-known and do not put the patients at risk. HDF has been shown to improve survival in patients with a mean age of 58 years. But a previous study from the investigators' group showed that HDF causes a prolonged recovery time in older patients. This randomized trial aims to elucidate this question.",[222,223,31,224,225],"Hemodialysis","Hemodiafiltration","Quality of Life of Patients","Older People",[222,223,227,148,228,229],"Older people","Patient reported outcome","Dialysis recovery time","2026-02-20",{"date":232,"type":49},"2026-02-23",{"date":234,"type":22},"2026-02-19",{"date":236,"type":22},"2026-12-19",{"name":238,"class":56},"AUB Santé",4,{"id":241,"slug":242,"hasResults":11,"nctId":243,"briefTitle":244,"officialTitle":245,"acronym":4,"eligibilityCriteria":246,"healthyVolunteers":16,"sex":86,"minAge":115,"maxAge":4,"enrollmentInfo":247,"targetDuration":4,"studyType":23,"phases":248,"briefSummary":249,"conditions":250,"keywords":263,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":268,"lastUpdatePostDateStruct":269,"startDateStruct":271,"completionDateStruct":273,"leadSponsor":275,"locationsCount":57},"100624078","the-effect-of-surgical-mask-and-n95-mask-use-on-surgical-smoke-in-operating-room-nurses-100624078","NCT07404956","THE EFFECT OF SURGICAL MASK AND N95 MASK USE ON SURGICAL SMOKE IN OPERATING ROOM NURSES","COMPARISON OF THE EFFECTS OF SURGICAL MASK AND N95 MASK USE ON PHYSICAL SYMPTOMS OF SURGICAL SMOKE IN OPERATING ROOM","Inclusion Criteria:\n\n* Willingness to participate in the study\n* Aged 18 years or older\n* Working as a sterile operating room nurse at least 4 hours per day, 5 days per week\n* Compliance with the protocol requiring continuous use of both surgical mask and N95 mask for at least 4 hours per day\n* Ability to communicate verbally and provide informed consent\n\nExclusion Criteria:\n\n* Diagnosed psychiatric disorders\n* Presence of chronic respiratory, musculoskeletal, or neurological diseases\n* Presence of chronic dermatological conditions or allergies affecting the facial or respiratory area\n* Speech or communication impairments\n* Pregnancy\n* Holding a supervisory role (e.g., charge nurse) or non-sterile nursing role\n* Planned unit change or rotation during the study period",{"count":65,"type":22},[25],"This study was conducted to compare the effect of surgical mask and N95 mask use on physical symptoms due to surgical smoke in operating theatre nurses. The study, which was conducted in a single-group prospective quasi-experimental design, was completed with 38 nurses in the operating theatre unit of a state hospital in the Western Black Sea Region. Data were collected for four weeks using the Descriptive Information Form, Numerical Rating Scale and Symptom Follow-up Form. According to the findings, muscle weakness, myalgia in the upper extremities and muscle cramps were statistically significantly less in nurses using N95 masks. Respiratory parameters, watery eyes and redness were significantly lower in nurses using surgical masks. As a result, it was determined that the type of mask was effective on the incidence of physical symptoms related to surgical smoke.",[251,252,253,254,255,31,256,257,258,259,260,261,262],"Surgical Smoke Exposure","Occupational Exposure to Surgical Smoke","Headache","Dizziness","Nause and Vomiting","Eye Allergies","Abdominal Pain (AP)","Heart Rate Determination","SpO2","Muscle Weakness | Patient","Muscle Aches","Dispnea",[264,265,266,267],"Surgical Smoke","Masks","Operating Room Nurses","Occupational Exposure","2026-02-09",{"date":270,"type":49},"2026-02-12",{"date":272,"type":49},"2024-09-15",{"date":274,"type":22},"2026-02-28",{"name":276,"class":56},"Bartın Unıversity",{"id":278,"slug":279,"hasResults":11,"nctId":280,"briefTitle":281,"officialTitle":281,"acronym":4,"eligibilityCriteria":282,"healthyVolunteers":11,"sex":86,"minAge":115,"maxAge":4,"enrollmentInfo":283,"targetDuration":4,"studyType":23,"phases":285,"briefSummary":286,"conditions":287,"keywords":289,"overallStatus":294,"whyStopped":4,"lastUpdateSubmitDate":295,"lastUpdatePostDateStruct":296,"startDateStruct":298,"completionDateStruct":300,"leadSponsor":302,"locationsCount":57},"100608791","physical-exercise-as-treatment-post-stroke-fatigue---a-feasibilty-study-100608791","NCT07206147","Physical Exercise as Treatment Post-stroke Fatigue - a Feasibilty Study.","Inclusion Criteria:\n\n\\- Stroke ≥6 months, able to move independently ≥100 meters with or without a walking aid, speak Swedish, Fatigue assessment scale (FAS) ≥24 points\n\nExclusion Criteria:\n\n* Other neurological disease. Severe impairment of vision, hearing and\u002For cognition that prevents participation in the intervention. Already performs structured strength training (e.g. gym, group training) regularly (at least 1 time\u002Fweek).",{"count":284,"type":22},16,[25],"The goal of this clinical trial is to evaluate the feasibility the treatment FaStEx (FatigueStrokeExercise) which consists of strength exercise in people with brain fatigue after stroke, referred to as post-stroke fatigue. The main questions it aims to answer are:\n\n* What is the feasibility of a study with the treatment FaStEx, structured physical training, for people with post-stroke fatigue?\n* What factors are important for people with post-stroke fatigue to be able to complete the FaStEx treatment?\n* How do people with post-stroke fatigue experience participation in the study with the FaStEx treatment?\n\nResearchers will compare FaStEx to physical activity at home to see if FaStEx can reduce post-stroke fatigue.\n\nParticipants will\n\n* Carry out strength training twice a week at a health care center.\n* Carry out physical activity for at least 150 minutes per week on their own. Participants in the control group will carry out this physical activity as well.\n* The treatment lasts for eight weeks.",[288,31],"Stroke",[290,288,291,292,293],"Post-stroke fatigue","Physical exercise","Physical activity","Physiotherapy","NOT_YET_RECRUITING","2025-09-25",{"date":297,"type":49},"2025-10-03",{"date":299,"type":22},"2026-01-01",{"date":301,"type":22},"2026-06-01",{"name":303,"class":56},"Region Örebro County",{"id":305,"slug":306,"hasResults":11,"nctId":307,"briefTitle":308,"officialTitle":309,"acronym":4,"eligibilityCriteria":310,"healthyVolunteers":11,"sex":86,"minAge":115,"maxAge":4,"enrollmentInfo":311,"targetDuration":4,"studyType":23,"phases":313,"briefSummary":314,"conditions":315,"keywords":318,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":328,"lastUpdatePostDateStruct":329,"startDateStruct":331,"completionDateStruct":333,"leadSponsor":335,"locationsCount":337},"100604604","brain-stimulation-effects-on-post-stroke-fatigue-and-aphasia-100604604","NCT07151677","Brain Stimulation Effects on Post-Stroke Fatigue and Aphasia","Pre-Frontal tDCS as a Novel Intervention to Reduce Effects of Post-Stroke Fatigue While Improving Language and Attention in Aphasia","Inclusion Criteria:\n\n1. 18 years or older.\n2. No diagnosis of neurological disorder (other than stroke).\n3. No diagnosis of psychiatric disorder, with the exception of anxiety and\u002For depression if it is managed through medication and\u002For behavioral intervention.\n4. No seizure within the past 6 months.\n5. Not pregnant.\n6. Does not currently have cardiac pacemaker\n7. In chronic phase of recovery, defined as at least 6 months post-stroke.\n8. Not undergoing speech and language therapy targeting auditory comprehension or attention for the duration of the study.\n9. No metal implants in the scalp or bone in the pre-frontal area of the head.\n10. No unhealed skull fractures.\n11. Onset of aphasia related to single, left hemisphere, ischemic stroke.\n12. Damaged brain tissue from stroke does not overlap with left hemisphere dorsolateral prefrontal cortex.\n13. Mild to moderate aphasia (as measured by WAB-R \\*\\*or QAB).\n14. Self-report of post-stroke fatigue (as measured on SF-CAT)\n15. No significant challenges with vision or hearing (with use of corrective aids if needed; eyeglasses, hearing aids).\n16. Willing to allow audio-recording of study sessions.\n\nExclusion Criteria:\n\n1. Younger than 18 years old.\n2. Diagnosis or history of neurological disorder other than stroke.\n3. Diagnosis or history of psychiatric disorder with the exception of anxiety and\u002For depression if it is managed through medication and\u002For behavioral intervention.\n4. History of seizures within the past 6 months.\n5. Pregnant.\n6. Currently has cardiac pacemaker\n7. \\\u003C6 months post-stroke (however, if this is only exclusionary criterion met, participant can be re-evaluated at the 6-month mark if still interested in the study)\n8. Currently undergoing speech and language therapy targeting auditory comprehension or attention.\n9. Metal implants in the scalp or bone in the pre-frontal area of the head.\n10. Currently has an unhealed skull fracture.\n11. Onset of aphasia related to etiology other than ischemic left hemisphere stroke.\n12. Damaged brain tissue significantly overlaps with left hemisphere dorsolateral prefrontal cortex.\n13. No aphasia or severe aphasia (as measured by WAB-R \\*\\*or QAB).\n14. Does not report experience of post-stroke fatigue (as measured on SF-CAT)\n15. Significant challenges with vision and\u002For hearing (even with use of corrective aids).\n16. Unwilling to allow audio-recording of study sessions.",{"count":312,"type":22},60,[25],"The goal of this clinical trial is to determine if electrical brain stimulation applied to the front parts of the brain can help people who have had a stroke improve their fatigue, language, and attention. The main question it aims to answer is:\n\n* Does transcranial direct current stimulation (tDCS) administered to the pre-frontal areas of the brain improve post-stroke fatigue and aphasia?\n* What kinds of participant characteristics are associated with better improvement of post-stroke fatigue and aphasia?\n\nResearchers will compare active electrical stimulation to sham stimulation to see if the active stimulation does a better job at reducing fatigue and language deficits after stroke. Participants will be asked to complete fatigue, language, and cognitive testing before and after receiving 10 sessions of tDCS plus speech and language therapy.",[316,317,31],"Aphasia Following Cerebral Infarction","Stroke Ischemic",[319,320,321,322,323,324,325,326,327],"aphasia","fatigue","post-stroke fatigue","tDCS","brain stimulation","language treatment","language therapy","speech therapy","speech-language therapy","2025-08-25",{"date":330,"type":49},"2025-09-03",{"date":332,"type":49},"2025-08-04",{"date":334,"type":22},"2029-11",{"name":336,"class":56},"Syracuse University",2,{"id":339,"slug":340,"hasResults":11,"nctId":341,"briefTitle":342,"officialTitle":343,"acronym":4,"eligibilityCriteria":344,"healthyVolunteers":16,"sex":86,"minAge":345,"maxAge":19,"enrollmentInfo":346,"targetDuration":4,"studyType":90,"phases":4,"briefSummary":348,"conditions":349,"keywords":354,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":361,"lastUpdatePostDateStruct":362,"startDateStruct":364,"completionDateStruct":366,"leadSponsor":368,"locationsCount":57},"100603382","monitoring-fatigue-in-daily-life-in-adults-with-cerebral-palsy-or-acquired-brain-injury-100603382","NCT07135791","Monitoring Fatigue In Daily Life In Adults With Cerebral Palsy or Acquired Brain Injury","Real-Time Monitoring of Fatigue In Daily Life Among Adults With Cerebral Palsy or Acquired Brain Injury: An Observational Study","Inclusion Criteria:\n\n* Score of minimum 4 on the 7-item Fatigue Severity Scale (CP and ABI only)\n* Speak, read, and write Danish\n* Living in a private residence (i.e., not in institutional care or facilities providing 24-hour assistance)\n* Able to walk independently or with assistive devices over short distances\n* Able to operate a smartphone independently\n\nAdditional inclusion criteria for CP specifically:\n\n* Self-reported diagnosis of CP\n* Gross Motor Function Classification System (GMFCS) level ≤ II\n* Communication Function Classification System level ≤ II\n\nAdditional inclusion criteria for ABI specifically:\n\n* Self-reported diagnosis of ABI, including stroke, traumatic brain injury, brain infections, toxins, anoxia, or encephalopathy (transient ischemic attack, concussion or post-concussion syndrome, intracranial tumors, or progressive brain diseases are not included)\n* Between three months and two years post-injury\n* modified Rankin Scale (mRS) score ≤ 3\n\nExclusion Criteria:\n\n* History of other neurological disorders or chronic fatigue syndrome requiring treatment\n* Current substance or alcohol abuse\n* Night shift work or travel across time zones (1 to 3 zones within the last week or 4 to 6 zones within the last two weeks or at least 7 zones within the last 4 weeks)","30 Years",{"count":347,"type":22},120,"The goal of this observational study is to learn about levels and patterns of fatigue in adults with cerebral palsy (CP) and acquired brain injury (ABI) in daily life.\n\nThe main question it aims to answer is: How do adults with CP and ABI experience fatigue in daily life?\n\nResearchers will compare data from CP and ABI with healthy volunteers to see if they experience fatigue differently.\n\nParticipants will:\n\n* Monitor their symptoms, mood, and behavior in real-time by completing a brief survey on their mobile phone 10 times a day for seven consecutive days.\n* Attend a briefing session the day prior to the seven-day period of real-time monitoring.\n* Wear an accelerometer for the seven-day period.\n* Complete a daily sleep diary for the seven-day period.\n* Receive feedback on their real-time monitoring data, sleep and activity data.",[31,350,351,352,353,148],"Fatigue Intensity","Cerebral Palsy (CP)","Acquired Brain Injury Including Stroke","Fatigue, Mental",[355,356,357,358,359,148,360],"Cerebral palsy","Acquired brain injury","ecological momentary assessment","experience sampling method","real-time monitoring","Real-time fatigue","2025-08-15",{"date":363,"type":49},"2025-08-22",{"date":365,"type":49},"2025-03-26",{"date":367,"type":22},"2026-10-31",{"name":369,"class":56},"Rigshospitalet, Denmark",{"id":371,"slug":372,"hasResults":11,"nctId":373,"briefTitle":374,"officialTitle":375,"acronym":376,"eligibilityCriteria":377,"healthyVolunteers":11,"sex":86,"minAge":115,"maxAge":4,"enrollmentInfo":378,"targetDuration":4,"studyType":23,"phases":380,"briefSummary":381,"conditions":382,"keywords":4,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":384,"lastUpdatePostDateStruct":385,"startDateStruct":387,"completionDateStruct":389,"leadSponsor":391,"locationsCount":337},"100566102","adapting-the-facets-program-to-sickle-cell-disease-100566102","NCT06650813","Adapting the FACETS Program to Sickle Cell Disease","Adapting the FACETS Fatigue Management Program to Sickle Cell Disease","Drépa-FACETS","Inclusion Criteria:\n\n* Participant having freely given his oral agreement.\n* Participant with a major sickle cell syndrome, regardless of genotype (e.g. SS, SC, Sbeta).\n* Participant with a sufficient command of spoken and written French to take the assessments, complete the questionnaires, follow the program sessions and carry out the home exercises.\n\nExclusion Criteria:\n\n* Participant with one or more severe psychiatric pathologies (e.g. severe depression, psychosis) that could interfere with the conduct of the study, in particular the primary and secondary endpoints.\n* Participants with another chronic pathology causing fatigue.\n* Participants in vaso-occlusive crisis (VOC) or hospitalization.\n* Participant under legal protection (guardianship, curatorship, safeguard of justice, deprived of liberty).",{"count":379,"type":22},24,[25],"Adaptation of a fatigue management program combining the principles of cognitive-behavioral therapy and energy conservation strategies (FACETS program) for a population of adult patients with sickle cell disease (Drépa-FACETS program).",[31,383],"Sickle Cell Disease","2025-08-14",{"date":386,"type":49},"2025-08-19",{"date":388,"type":49},"2025-01-10",{"date":390,"type":22},"2026-05-02",{"name":392,"class":56},"Versailles Hospital",{"id":394,"slug":395,"hasResults":11,"nctId":396,"briefTitle":397,"officialTitle":398,"acronym":399,"eligibilityCriteria":400,"healthyVolunteers":11,"sex":86,"minAge":115,"maxAge":4,"enrollmentInfo":401,"targetDuration":4,"studyType":90,"phases":4,"briefSummary":403,"conditions":404,"keywords":408,"overallStatus":294,"whyStopped":4,"lastUpdateSubmitDate":413,"lastUpdatePostDateStruct":414,"startDateStruct":416,"completionDateStruct":418,"leadSponsor":419,"locationsCount":4},"100584496","study-of-the-association-between-fatigue-experienced-by-patients-and-the-specific-side-effects-of-cart-cells-during-the-first-month-after-administration-for-non-hodgkins-lymphoma-100584496","NCT06890091","Study of the Association Between Fatigue Experienced by Patients and the Specific Side Effects of CART Cells, During the First Month After Administration for Non-Hodgkin's Lymphoma","Etude de l'Association Entre la Fatigue Ressentie Par Les Patients et Les Effets Secondaires spécifiques Des CART Cells, au Cours du Premier Mois après l'Administration Pour un Lymphome Non Hodgkinien","CAR-TIGUE","Inclusion Criteria:\n\n* Adult (age\\> 18year old)\n* Person hospitalised for treatment with CAR-T Cells for non-Hodgkin's lymphoma.\n* Person able to understand and read the French language.\n\nExclusion Criteria:\n\n* Patient under legal protection\n* Opposition to research",{"count":402,"type":22},100,"The incidence of cancer in 2023 is estimated at 433136 cases, according to INCa. Haemopathies account for 12% of these new cases of cancer cases of cancer, and around two-thirds are lymphoid haemopathies, in particular lymphomas. There are many treatments available for lymphoma. However, the arrival in France in 2018 of immunotherapy treatments such as CAR-T Cells have changed the paradigm of treatment options for certain non-Hodgkin's lymphomas. In these treatments can have both short-term and long-term adverse effects and long-term adverse effects. During hospitalisation for the administration of CAR-T Cells, acute side effects include CRS and ICANS. There is also another complication very specific to this treatment that has been observed in patients: cytopenias. This is despite the fact that one of the symptoms frequently mentioned and felt by patients during the first month after month after treatment is fatigue. Despite numerous studies on the prevalence of fatigue, healthcare professionals often underestimate this symptom. Nurses, and in particular the advanced practice nurse have a crucial role to play in assessing fatigue. The EORTC scale QLQ-FA12 is a multidimensional scale which assesses the physical emotional and cognitive dimensions of fatigue. The theory of symptom management, which was developed in 1994 by the California College of Nursing in San Francisco, is a relevant framework for understanding fatigue in patients. This theory places the patient's experience at the centre of care. This holistic approach provides a detailed framework for understanding this symptom. \"According to the theoretical model, measuring the symptom is an important step and characterising it is an essential element in better targeting the actions to be taken\". Although CAR-T Cell therapy is innovative and allows long-term remissions, it is important to evaluate and understand how patients live with this treatment. To our knowledge, few studies have been carried out on quality of life, particularly regarding fatigue, following the first month of CAR-T Cell administration. The research question we will address in this study is: \"Is there an association between the side effects of CAR-T Cell treatment and the state of fatigue in patients receiving this treatment for non-Hodgkin's lymphoma during the first month?\"",[31,405,406,407],"Lymphoma Non-Hodgkin","Chimeric Antigen Receptor T-cell Therapy","Adverse Events",[148,409,410,411,405,412],"CAR-T cells","Chimeric antigen receptor","Adverse events","Nurse practitionners","2025-03-17",{"date":415,"type":49},"2025-03-21",{"date":417,"type":22},"2025-04-01",{"date":51,"type":22},{"name":420,"class":56},"Assistance Publique - Hôpitaux de Paris",{"id":422,"slug":423,"hasResults":11,"nctId":424,"briefTitle":425,"officialTitle":426,"acronym":4,"eligibilityCriteria":427,"healthyVolunteers":11,"sex":86,"minAge":115,"maxAge":4,"enrollmentInfo":428,"targetDuration":4,"studyType":90,"phases":4,"briefSummary":429,"conditions":430,"keywords":432,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":439,"lastUpdatePostDateStruct":440,"startDateStruct":442,"completionDateStruct":444,"leadSponsor":446,"locationsCount":57},"100575667","chronic-fatigue-in-the-internal-medicine-outpatient-clinic-a-mixed-methods-quantitative-and-qualitative-study-100575667","NCT06775262","Chronic Fatigue in the Internal Medicine Outpatient Clinic: a Mixed-methods Quantitative and Qualitative Study","Patients with Chronic Fatigue Complaints for Whom a Consultation Including Diagnostics Do Not Reveal a Somatic Diagnosis Atthe Internal Medicine Outpatient Clinic","Cohort 1:\n\nInclusion Criteria:\n\n* Patients under 18 years of age;\n* Patients lost to follow-up.\n\nExclusion Criteria:\n\n* Patients at the internal medicine outpatient clinic with a referral for fatigue e.c.i.\n* Patients who visited the clinic after the 1st of April 2022.\n\nCohort 2:\n\nInclusion criteria\n\n* Patients at the internal medicine outpatient clinic with a referral for fatigue e.c.i. whose consultation did not bring about a somatic diagnosis\n\nExclusion criteria:\n\n* Patients under 18 years of age;\n* Patients that do not speak Dutch fluently",{"count":402,"type":22},"With this study, the investigators aim to answer the following research questions:\n\n1. In what percentage of cases does the diagnostic process conducted during a fatigue consultation at the internal medicine outpatient clinic contribute to a somatic diagnosis?\n2. What are the experiences of patients presenting with fatigue at the internal medicine outpatient clinic when a consultation, including diagnostic testing, does not lead to a diagnosis?\n\nTo address question (1), the investigators will conduct a retrospective data analysis using information from HiX, an electronic health record (EHR) system.\n\nTo answer question (2), the investigators will conduct a prospective qualitative study through interviews.",[31,148,431],"Fatigue Syndrome, Chronic",[148,433,434,435,436,437,438],"Qualitative study","Quantative study","Diagnostic efficacy","Internal medicine","Interviews","Grounded theory","2025-02-25",{"date":441,"type":49},"2025-02-27",{"date":443,"type":49},"2024-12-20",{"date":445,"type":22},"2025-07-25",{"name":447,"class":56},"Flevoziekenhuis",{"id":449,"slug":450,"hasResults":11,"nctId":451,"briefTitle":452,"officialTitle":452,"acronym":4,"eligibilityCriteria":453,"healthyVolunteers":11,"sex":86,"minAge":115,"maxAge":4,"enrollmentInfo":454,"targetDuration":4,"studyType":90,"phases":4,"briefSummary":456,"conditions":457,"keywords":4,"overallStatus":294,"whyStopped":4,"lastUpdateSubmitDate":460,"lastUpdatePostDateStruct":461,"startDateStruct":462,"completionDateStruct":464,"leadSponsor":466,"locationsCount":57},"100578488","sleep-disordered-breathing-in-the-acute-phase-after-stroke-and-neuropsychiatric-outcomes-100578488","NCT06811948","Sleep-Disordered Breathing in the Acute Phase After Stroke and Neuropsychiatric Outcomes","Inclusion Criteria:\n\n* Age \\>18 years\n* Stroke according to WHO definition (31) (ischemic stroke, intracerebral hemorrhage, or subarachnoid hemorrhage)\n* TIA with MRI-verified lesions corresponding to symptoms\n* Informed consent to participate\n\nExclusion Criteria:\n\n* Traumatic stroke\n* Tumor-associated bleeding\n* Expected survival \\\u003C3 months\n* Unconsciousness (RLS \\>3)",{"count":455,"type":22},340,"In people who have had a stroke or a transient ischemic attack (TIA), it is common to have problems with breathing patterns during sleep, particularly a condition called obstructive sleep apnea. Another common long-term problem after a stroke is post-stroke fatigue, which affects function and quality of life after stroke. There is currently no clearly effective treatment for post-stroke fatigue. We are investigating whether there might be a connection between sleep-related breathing disturbances, and the risk of developing long-term post-stroke fatigue\n\nThe project is being conducted at Blekingesjukhuset Karlskrona, and inpatients with stroke are asked to participate. Participants are equipped with a sleep analysis pad under the mattress that measures breathing patterns during the night, as well as a wrist-worn device that measures oxygen saturation in the blood. Participants are also asked about their functional level in daily life and any symptoms of obstructive sleep apnea. One year after the stroke, participants are invited for a follow-up visit where we ask about post-stroke fatigue, depressive symptoms, and treatment and investigations related to the stroke.\n\nWe will then investigate the relationship between sleep-related breathing disturbances, measured early after stroke, and the risk of significant fatigue after the stroke. This could lead to future studies with treatment trials for obstructive sleep apnea in certain individuals with post-stroke fatigue. The study could also lead to potentially increased awareness that these conditions might be connected, which could result in a higher likelihood of detecting treatable obstructive sleep apnea in certain subgroups after stroke.",[288,31,458,459],"Obstructive Sleep Apnea","Sleep Disordered Breathing (SDB)","2025-01-31",{"date":166,"type":49},{"date":463,"type":22},"2025-02-20",{"date":465,"type":22},"2027-12-20",{"name":467,"class":56},"Blekinge County Council Hospital"]