[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"fibroadenoma\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:fibroadenoma":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,40],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":39},"100456139","medical-imaging-and-thermal-treatment-for-breast-tumors-using-harmonic-motion-imaging-hmi-100456139",false,"NCT05219695","Medical Imaging and Focused Ultrasound Treatment for Breast Tumors Using Harmonic Motion Imaging (HMI)","Focused Ultrasound Surgery\n\nInclusion criteria:\n\n* Women age 18 years or older with benign tumors or early-stage, non-metastatic breast cancer (stage I without the involvement of axillary lymph nodes)\n* Scheduled to receive surgical resection of the tumor by their clinical care team\n\nExclusion criteria:\n\n* Patients who have received or are scheduled to receive thermal ablation or treatment of the tumor as part of their clinical care\n* Pregnant or lactating\n* Presence of breast implants\n* Have a history of laser or radiation therapy to the targeted breast.\n\nMicrobubble-mediated LIFU, i.e., sonoporation\n\nInclusion criteria:\n\n* Women 18 years or older\n* Deemed eligible to receive neoadjuvant systemic therapy as per the treating physician, with the dose and schedule deemed appropriate by the treating physician\n* Any stage invasive breast cancer provided the primary breast tumor size is at least 4 mm\n\nExclusion criteria:\n\n* Pregnant or lactating\n* Presence of breast implants\n* History of laser or radiation therapy to the affected breast\n* Contraindication history or hypersensitivity to ultrasound contrast agents, e.g., Definity, including polyethylene glycol (PEG) allergy.","FEMALE","18 Years",{"count":18,"type":19},82,"ESTIMATED","INTERVENTIONAL",[22],"PHASE1","This study will investigate Harmonic Motion Imaging guided Focused Ultrasound (HMIgFUS) method for ablation and sonoporation monitoring of breast tumors. The aim of this study is to evaluate the efficacy of real-time guidance\u002Fmonitoring and ablation\u002Fsonoporation method. The hypothesis behind this proposed study is that High Intensity Focused Ultrasound (HIFU) can be used to ablate tumor tissue, and microbubble-mediated Low Intensity Focused Ultrasound (LIFU) can be used to sonoporate tumor vasculature. The investigators of this study also hypothesize that HMI can be used to monitor HIFU ablation by measuring the changes in tissue stiffness that occur as a result of thermal ablation, guide LIFU sonoporation and HIFU ablation targeting stiff tumor tissue, and the HMI-monitored stiffness changes during ablation will correlate with post-treatment immune response. The ultimate goals of this study are: first, to assess whether these techniques can be used in the clinic in order to provide a well-monitored, noninvasive tumor ablation\u002Fsonoporation method for benign tumors and breast cancers, to minimize side effects due to invasiveness and enhance therapeutic effects of current methods; second, to make full use of the real-time monitoring capability of HMIgFUS for more precise, point-of-care treatment planning to ensure success of ablation\u002Fsonoporation and immune activation.",[25,26],"Fibroadenoma","Breast Cancer Stage I","RECRUITING","2026-08-11",{"date":30,"type":31},"2026-08-13","ACTUAL",{"date":33,"type":31},"2022-01-19",{"date":35,"type":19},"2031-05",{"name":37,"class":38},"Columbia University","OTHER",1,{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":4,"eligibilityCriteria":46,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":47,"targetDuration":4,"studyType":20,"phases":49,"briefSummary":51,"conditions":52,"keywords":4,"overallStatus":55,"whyStopped":4,"lastUpdateSubmitDate":56,"lastUpdatePostDateStruct":57,"startDateStruct":59,"completionDateStruct":61,"leadSponsor":63,"locationsCount":39},"100576005","regional-anesthesia-techniques-in-breast-surgery-100576005","NCT06779656","Regional Anesthesia Techniques in Breast Surgery","Regional Anesthesia Techniques in Breast Surgery: a Comparative Study","Inclusion Criteria:\n\n* American Society of Anesthesiologists (ASA) physical status classification I-III.\n* Age of 18 years or older.\n* Scheduled to undergo breast surgery, including augmentation, fibroadenoma excision, or mastectomy.\n\nExclusion Criteria:\n\n* Known allergy to local anesthetics.\n* Pregnancy or lactation.\n* Coagulation disorders.\n* Severe cardiopulmonary disease.\n* Local infection at the injection site.\n* Unstable psychiatric illness.",{"count":48,"type":19},180,[50],"NA","This clinical trial aims to evaluate the efficacy of liposomal bupivacaine and ropivacaine, when administered via paravertebral block, the rhomboid intercostal and subserratus plane (RISS) block, PECS II block, intercostal nerve block, serratus anterior plane block, or epidural block, in patients undergoing breast surgery (including augmentation, fibroadenoma excision, and mastectomy). The primary objectives are to determine:\n\n1. Whether the use of liposomal bupivacaine or ropivacaine reduces the postoperative analgesic requirements in participants.\n2. What potential adverse events participants experience when using liposomal bupivacaine or ropivacaine.\n3. Which of the following regional anesthesia techniques provides superior analgesia: paravertebral block, RISS block, PECS II block, intercostal nerve block, serratus anterior plane block, or epidural block.\n\nParticipants will undergo one of the following regional anesthesia techniques upon arrival to the surgical suite: paravertebral block, RISS block, PECS II block, intercostal nerve block, serratus anterior plane block, or epidural block. Following regional anesthesia administration, general anesthesia with endotracheal intubation will be performed. Participants' vital signs, postoperative analgesic consumption, and recovery will be recorded.",[53,25,54],"Augmentation","Mastectomy","NOT_YET_RECRUITING","2025-01-16",{"date":58,"type":31},"2025-01-17",{"date":60,"type":19},"2025-02-01",{"date":62,"type":19},"2025-05-10",{"name":64,"class":38},"Xiaguang Duan"]