[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"fine-lines-and-wrinkles\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:fine-lines-and-wrinkles":32},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,54],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":33,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":53},"100652420","a-12-week-randomized-placebo-controlled-quantitative-and-qualitative-evaluation-of-the-topical-efficacy-of-niacinamide-riboside-nr-on-signs-of-skin-aging-a-dose-response-comparison-in-women-ages-30-60-100652420",false,"NCT07774000","Efficacy of Topical Niacinamide Riboside on the Signs of Facial Skin Aging","Randomized, Placebo-controlled Clinical Study for the Evaluation and the Comparison of the Dose-response Efficacy of 4 Cosmetic Investigational Products (3 Active, 1 Placebo; 1 Tested Investigational Product Per Subject), After Repeated Applications for 12 Weeks, Under Normal Conditions of Use, in Female Adult Subjects","NR-RADIANCE","Inclusion Criteria:\n\n* Open to all races provided they meet the inclusion and exclusion criteria below:\n* Gender: Female\n* Age: 30 to 60 years old\n* Phototype: I to VI\n* Subject presenting with fines lines\u002F wrinkles as Crow's feet, inclusion grade ≥ 3 and ≤ 6 on a 10-points scale.\n* Subject presenting with one or more visible signs of skin aging on face (example of signs of skin aging: wrinkles and fine lines, lack of firmness, lack of radiance, pigmented spots, dry and rough skin, visible pores, skin sagging).\n* Subject is not currently using NAD+ or another product containing Vitamin B3 (niacin, niacinamide, nicotinamide, nicotinamide riboside, nicotinamide mononucleotide, myristyl nicotinate, etc.) administered topically, orally intravenously, or through any form of injection, as a part of their current routine or 4 weeks before starting study. The only permitted exception is the use of a multivitamin that contains niacin or nicotinamide. If this is the case, the product and dose of niacin or nicotinamide should be documented at screening and continuation of use of the product should be documented at each site visit.\n* Willingness to maintain current lifestyle, wellness and skin care routines (with the exception of the inclusion of the product requirements incorporated into the study protocol).\n\nExclusion Criteria:\n\n* Subject not providing consent;\n* Subject not complying with protocol requirements;\n* Subject of whom a health condition has changed since the inclusion visit in the I.E.C database, making the subject ineligible or places her at undue risk;\n* Active cancer diagnosis or diagnosis of cancer of any kind less than three years since remission, liver disease, kidney disease, or uncontrolled diabetes;\n* Pregnancy, actively breastfeeding, or not willing to take necessary precautions to avoid a pregnancy during the study;\n* Subject having a medical treatment, recent vaccination or expecting to be vaccinated during the study, that makes the subject ineligible or places her at undue risk, in particular, medical treatment (either oral or topical) containing tretinoin or isotretinoin during the 3 months before the starting day of the study;\n* Subject having a background of intolerance or allergy to cosmetics, NAD+ or any vitamin B3 derivative, ingredients in the auxiliary products or to other substances that makes the subject ineligible or places her at undue risk;\n* Subject having visible traces of irritation or any other abnormality on the concerned area;\n* Subject having skin recently exposed to excessive sunlight (natural or artificial) within 4 weeks preceding the inclusion;\n* Subject having undergone surgery, chemical or physical treatment to the concerned area in the last 12 months (no injection during the last 6 months);\n* Subject having applied anti-wrinkle\u002Fanti-aging\u002Ffirming products on concerned area during the 4 weeks before the starting day of the study;\n* Subject having had any cosmetic procedures performed in the last six months (including Botox, peels, laser, etc.);\n* Subject having applied NAD+\u002FB-vitamin products on the concerned area during the 4 weeks before the starting day of the study;\n* Subject having modified his\u002Fher cosmetic habits (on the concerned area by the study) during the last 2 weeks, making her ineligible;\n* Subject having applied cosmetic or pharmaceutical products (other than their usual cleanser) to the areas of concern during the 96 hours before the starting day of the study and on the day of inclusion;\n* Subject having applied any cosmetic or pharmaceutical products (only water allowed) to the areas of concern the day of inclusion.",true,"FEMALE","30 Years","60 Years",{"count":22,"type":23},140,"ESTIMATED","INTERVENTIONAL",[26],"NA","Niacinamide riboside (topical NR, also known as nicotinamide riboside) is an endogenous compound and a precursor (building block) to the essential cellular co-enzyme, nicotinamide adenine dinucleotide (NAD+). Research published by Maussudi et al. 2012 demonstrated that skin NAD+ levels were negatively correlated with age in both males and females, and aged skin was also correlated to an increase in DNA damage. Therefore, it is proposed that supporting skin NAD+ with precursors such as NR may be a strategy to combat DNA damage that leads to undesirable signs of skin aging, thus supporting skin cell resilience. The use of NR as a dietary supplement has produced effective, efficient, and reproducible increases in NAD+ in humans. However, the role of topically applied NR for skin aging requires further investigation.\n\nThough not measuring NAD+ directly, this study will explore if topically applied NR reduces the signs of skin aging that may result from cellular NAD+ deficiency. It is hypothesized that the addition of NR to a general skin care regimen will result in healthier, more youthful appearing skin over 12 weeks.\n\nThe goal of this interventional clinical trial is to identify the most effective, tolerable, and efficient dose of NR for attenuating quantitative and qualitative indicators of facial skin aging in women ages 30-60. The three primary outcome measures are\n\n* Changes in skin biological age,\n* Quantitative reduction in fine lines and wrinkles near the eye, and\n* Changes in skin firmness and tightening.\n\nSecondary quantitative and qualitative outcomes include\n\n* Changes to pores, texture, redness, skin tone evenness, radiance, plumpness, and firmness on the global face.\n* Changes in skin moisture and skin barrier integrity, and\n* Participant perception of perceived efficacy, acceptability, and irritation.\n\nSkin imaging will also be employed in the study.\n\nParticipants will be randomized into one of four test product groups:\n\n* Placebo\n* 2.5% NR,\n* 5% NR, or\n* 10% NR.\n\nThe test product will be provided in a dry nanofiber sachet, and the percentage of NR is an estimate based on the final concentration of the applied material when mixed in serum.\n\nFollowing facial cleansing with the provided cleanser, study participants will prepare the test product (immediately before application) by dissolving a single sachet in the provided standardized gel serum. Following application, participants will apply the provided moisturizer and UV serum. Product application will occur twice daily for 84 days (12 weeks). In-clinic assessments will be performed at baseline and days 28, 56, and 84. Participants will also complete at home questionnaires on days 14 and 42. Adverse events and responses will be documented in participant diaries and immediately reported to the clinical research team.",[29,30,31,32],"Skin Aging on Face","Skin Care Dermocosmetics","Skin Care","Fine Lines and Wrinkles",[34,35,36,37,38,39,40],"nicotinamide riboside","niacinamide riboside","nicotinamide adenine dinucleotide","skin aging","skin aging clock","topical","skin care","RECRUITING","2026-08-19",{"date":44,"type":45},"2026-08-21","ACTUAL",{"date":47,"type":45},"2026-08-17",{"date":49,"type":23},"2027-03-31",{"name":51,"class":52},"ChromaDex, Inc.","INDUSTRY",1,{"id":55,"slug":56,"hasResults":11,"nctId":57,"briefTitle":58,"officialTitle":58,"acronym":4,"eligibilityCriteria":59,"healthyVolunteers":17,"sex":60,"minAge":19,"maxAge":20,"enrollmentInfo":61,"targetDuration":4,"studyType":24,"phases":63,"briefSummary":64,"conditions":65,"keywords":4,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":4},"100650168","a-clinical-trial-to-evaluate-the-effects-of-nailas-collagen-marine-plus-food-supplement-on-skin-hydration-elasticity-fine-lines-and-wrinkles-and-hair-and-nail-health-100650168","NCT07746076","A Clinical Trial to Evaluate the Effects of Naila's Collagen Marine Plus Food Supplement on Skin Hydration, Elasticity, Fine Lines and Wrinkles, and Hair and Nail Health","Inclusion Criteria:\n\n* Healthy adults aged 40-60 years at the time of enrollment.\n* Self-reported visible signs of skin aging, including at least one of the following: fine lines, wrinkles, reduced skin firmness or elasticity, or skin dryness.\n* Self-reports hair shedding and a desire to improve hair health.\n* Willing to take one sachet of the study product daily for 12 weeks as directed.\n* Willing to avoid taking any other collagen-containing dietary supplements for the duration of the study.\n* Willing to maintain current diet, skincare routine, sleep patterns, and physical activity levels for the duration of the trial.\n* Willing and able to submit standardized facial and hair photographs at Baseline and Week 12.\n* Has access to a smartphone or digital camera capable of producing photographs.\n* Resides in the United States.\n* Willing to follow the study protocol and complete all required questionnaires.\n\nExclusion Criteria:\n\n* Known allergy or sensitivity to fish, marine-derived products, or any of the study product ingredients (marine collagen, hyaluronic acid, ascorbic acid, biotin).\n* Previous diagnosis of a hair loss condition such as alopecia areata, androgenetic alopecia, or telogen effluvium.\n* Currently taking any collagen-containing dietary supplements, or planning to start taking any collagen supplements in the next 12 weeks.\n* Any current uncontrolled chronic medical condition that would prevent the participant from safely completing the study protocol.\n* History of a diagnosed dermatological condition that significantly affects facial skin appearance (e.g., severe eczema, psoriasis, rosacea, or active acne) and could confound assessment of skin aging outcomes.\n* Use of prescription retinoids, injectable dermal fillers, botulinum toxin, chemical peels, laser skin treatments, or other professional aesthetic procedures on the face within 3 months prior to enrollment or planned during the study period.\n* Currently pregnant, breastfeeding, or planning to become pregnant during the study period.\n* Currently participating in another research study or planning to participate in another study during this study's duration.\n* Any condition that, in the judgment of the investigator, would make the participant unsuitable for inclusion in the study.","ALL",{"count":62,"type":23},40,[26],"This is a single-group, open-label, virtual (decentralized) clinical trial evaluating the effects of Naila's Collagen Marine Plus Food Supplement on skin hydration, elasticity, firmness, fine lines and wrinkles, and hair and nail health over 12 weeks. Forty healthy adults aged 40-60 years with self-reported mature skin showing early signs of aging will take one sachet of the supplement daily and complete questionnaires at Baseline, Week 4, Week 8, and Week 12.\n\nParticipants will also submit standardized facial and hair photographs at Baseline and Week 12 for evaluation by a board-certified dermatologist. The primary objectives are to assess changes in skin aging parameters and hair health. Secondary objectives include evaluation of nail health, hair shedding and density, participant-reported satisfaction, and product safety and tolerability.",[66,67,68,32,69,70],"Skin Aging","Skin Hydration","Skin Elasticity","Hair Health","Nail Health","NOT_YET_RECRUITING","2026-08-03",{"date":74,"type":45},"2026-08-04",{"date":76,"type":23},"2026-08",{"date":78,"type":23},"2026-11",{"name":80,"class":52},"Gulf Bird"]