[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"food-protein-induced-proctocolitis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:food-protein-induced-proctocolitis":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":32,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":5},"100398042","non-immunoglobulin-e-mediated-food-allergies-in-children-100398042",false,"NCT04462978","Non-Immunoglobulin E-mediated Food Allergies in Children","Investigating Clinical Features, Natural Course and Pathophysiology of Non-Immunoglobulin E-mediated Food Allergies in the Pediatric Age","NIGEFA","Inclusion Criteria:\n\n* subjects aged between 0-14 years\n* suggestive history of food allergy\n\nExclusion Criteria:\n\n* age \\>14 years-\n* chronic systemic diseases,\n* malignancy,\n* immunodeficiency,\n* infectious diseases,\n* autoimmune diseases,\n* inflammatory bowel diseases,\n* celiac disease,\n* metabolic and genetic diseases,\n* cystic fibrosis,\n* chronic pulmonary diseases,\n* gastrointestinal, respiratory, urinary tract and\u002For cardiovascular malformations,\n* neurologic and\u002For neuropsychiatric disorders,\n* gastrointestinal tract eosinophilic disorders,\n* use of immunomodulating drugs, steroids, pre-pro-synbiotics, antibiotics in the previous 4 months",true,"ALL","1 Day","14 Years",{"count":22,"type":23},150,"ESTIMATED","OBSERVATIONAL","Non-IgE-mediated gastrointestinal food allergies (non-IgE-GIFA) are an evolving web of clinical conditions characterized by subacute and\u002For chronic symptoms and include food protein-induced enterocolitis syndrome (FPIES), food protein-induced enteropathy (FPE), food protein-induced allergic proctocolitis (FPIAP), and food protein-induced allergic dysmotility disorders (gastroesophageal reflux disease (GERD), colic and constipation) (FPIMD).\n\nDespite the prevalence and clinical impact of these conditions, the pathogenesis as well as the natural history and the best management of these disorders are still poorly defined. These limitations could be responsible for diagnostic delays and errors, and suboptimal clinical management. We aim to evaluate clinical features, natural course and pathophysiology of non-IgE-GIFA in the pediatric age.",[27,28,29,30,31],"Non IgE Mediated Food Allergy","Food Protein-Induced Enteropathy","Food Protein-Induced Proctocolitis","Food Protein-Induced Enterocolitis Syndrome","Food Protein-induced Motility Disorders",[33,34,35,36,37,38,28,29,30,39],"Food allergy","Adverse food reactions","Immune tolerance","Atopy patch test","Atopic march","Oral food challenge","Food protein-induced motility disorders","RECRUITING","2026-08-31",{"date":43,"type":44},"2026-09-02","ACTUAL",{"date":46,"type":44},"2017-01-01",{"date":48,"type":23},"2027-12-28",{"name":50,"class":51},"Federico II University","OTHER"]