[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"foreign-bodies\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:foreign-bodies":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,52,82],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":23,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":32,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100651751","ex-vivo-thermal-damage-assessment-during-electrocautery-cutting-of-explanted-biopolymer-infiltrated-tissue-100651751",false,"NCT07765576","Ex Vivo Thermal Damage Assessment During Electrocautery Cutting of Explanted Biopolymer-Infiltrated Tissue","Prospective Ex Vivo Evaluation of Thermal Damage in Explanted Fat, Fibrotic, and Muscular Tissue From Patients Undergoing Surgical Removal of Gluteal Biopolymers Using Blunt Versus Utah Electrocautery Tips","THERM-BIOPOL","Inclusion Criteria:\n\n* Patients with clinical and\u002For imaging diagnosis of gluteal soft tissue infiltration by biopolymers or alloplastic filler material.\n* Patients scheduled for clinically indicated surgical removal of gluteal biopolymer-infiltrated tissue.\n* Ability to understand the study and provide written informed consent.\n* Availability of explanted tissue suitable for ex vivo thermal and histopathological assessment.\n\nExclusion Criteria:\n\n* Refusal or inability to provide informed consent.\n* Intraoperative finding that explanted tissue is insufficient for ex vivo thermal assessment.\n* Active severe infection requiring urgent deviation from the planned surgical protocol.\n* Extensive tissue necrosis or contamination preventing standardized ex vivo thermal assessment.\n* Specimens that cannot be processed within the predefined time window after explantation.\n* Any situation in which the surgeon determines that research handling of the specimen could interfere with clinical care, pathology required for patient management, or institutional tissue handling policies.\n* Lack of adequate thermographic recording due to technical failure.","ALL","18 Years","55 Years",{"count":21,"type":22},50,"ESTIMATED","1 Day","OBSERVATIONAL","This prospective ex vivo study will evaluate thermal damage produced during electrocautery cutting of explanted tissue from patients undergoing clinically indicated surgical removal of gluteal biopolymers. The study will focus on three tissue types: fat flap tissue, fibrotic tissue, and muscular tissue.\n\nThe clinical surgical procedure will not be modified by study participation. All experimental thermal measurements will be performed on tissue that has already been removed from the patient as part of standard surgical care.\n\nIn fat tissue, standardized blocks measuring 1.25 cm × 1 cm × 1 cm will be prepared from the explanted specimen. Thermal measurements will be performed for each combination of electrocautery tip, power setting, and electrosurgical mode. The evaluated tips will be a blunt electrocautery tip and a Utah electrocautery tip. The evaluated power settings will be 25 watts and 50 watts. The evaluated modes will be cut Blend 2 and coagulation. For each combination, three thermal measurements will be obtained.\n\nIn fibrotic and muscular tissue, due to limited tissue availability, the evaluation will be restricted to 25 watts using the blunt and Utah tips in cut Blend 2 and coagulation modes. Thermal measurements will be obtained from electrocautery cuts performed during removal of the clinically indicated specimen.\n\nThermal measurements will be recorded using a FLIR C3-X thermal camera. The camera settings will include emissivity of 0.95, reflected temperature of 20°C, operating room humidity of 57%, operating room temperature of 22°C, and a fixed measurement distance of 50 cm.\n\nHistopathological evaluation will be performed on one representative sample per experimental combination. The pathology assessor will be blinded to the electrocautery tip, power setting, and mode used for each coded sample. The primary outcome will be maximum histological depth of thermal damage.",[27,28,29,30,31],"Thermal Injury Response","Soft Tissue Disease","Granuloma, Foreign-Body","Foreign-Body Reaction","Foreign Bodies",[33,34,35,36,37,38],"Biopolymer removal","Foreign body reaction","Electrocautery","Thermal injury","Histopathology","Ex vivo study","NOT_YET_RECRUITING","2026-08-13",{"date":42,"type":43},"2026-08-14","ACTUAL",{"date":45,"type":22},"2026-08-16",{"date":47,"type":22},"2026-11-01",{"name":49,"class":50},"Research Inc","INDUSTRY",1,{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":4,"eligibilityCriteria":58,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":59,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":61,"conditions":62,"keywords":67,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":51},"100491450","a-cross-sectional-observational-study-on-retained-drug-needle-fragments-in-people-who-use-intravenous-drugs-100491450","NCT05679284","A Cross-Sectional Observational Study on Retained Drug Needle Fragments in People Who Use Intravenous Drugs","The Prevalence and Predisposing Factors to Retained Drug Needle Fragments in People Who Inject Drugs: a Protocol for a Cross-sectional Observational Study","Inclusion Criteria:\n\n* History of intravenous drug use\n* Current treatment of the drug abuse problem at a local low-threshold drug abuse service unit or primary health care centre.\n* Adherence to fill in the questionnaire\n* Participation to X-ray imaging of injection sites\n\nExclusion Criteria:\n\n* No history of intravenous drug use\n* Does not adhere to fill in the questionnaire or refuses X-ray imaging\n* Pregnancy\n* Underage (18 years old)",{"count":60,"type":22},100,"In addition to the well-known toxicological harms of intravenous drug (IVD) use, there can also be local tissue complications, including infections, venous sclerosis, tissue necrosis, and drug needle fragment retentions. Drug needle fragments in subcutaneous tissue may cause local symptoms (usually pain and infections), but they have also been identified as causing emboli to organs. The literature has described numerous case reports of people who inject drugs (PWIDs) and have retained needle fragments. The prevalence of the condition is not known, and the researchers therefore aim to perform the first cross-sectional study of PWIDs to estimate how common needle fragment retentions are and what their risk factors are in this population.",[63,64,65,66,31],"Drug Abuse, Intravenous","Substance Dependence","Needle Injury","Soft Tissue Injuries",[68,69,70],"Intravenous drug use","needle retention","needle fragment","RECRUITING","2023-05-30",{"date":74,"type":43},"2023-06-01",{"date":76,"type":43},"2023-05-25",{"date":78,"type":22},"2028-11-15",{"name":80,"class":81},"Tampere University Hospital","OTHER",{"id":83,"slug":84,"hasResults":11,"nctId":85,"briefTitle":86,"officialTitle":86,"acronym":87,"eligibilityCriteria":88,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":89,"targetDuration":91,"studyType":24,"phases":4,"briefSummary":92,"conditions":93,"keywords":4,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":51},"100335153","web-based-international-register-of-emergency-surgery-and-trauma-100335153","NCT03643718","Web-based International Register of Emergency Surgery and Trauma","WIRES-T","Inclusion Criteria:\n\n* Patients affected by an acute surgical disease\n* Patients with indication to be referred to the emergency surgeon attention\n* Patients to be operated or to be treated with non-operative approach without surgical intervention\n\nExclusion Criteria:\n\n* Patients not affected by an acute surgical disease\n* Patients without indication to be referred to the emergency surgeon attention",{"count":90,"type":22},10000,"2 Weeks","The WIRES-T project (Web-based International Registry of Emergency General Surgery and Trauma) has been set up to allow to all the EGS (Emergency General Surgery) and Trauma surgeons to register their activity and to obtain a worldwide register of traumatic and non traumatic surgical emergencies. This will give the opportunity to evaluate results on a macro-data basis and to give index allowing stratifying, evaluating and improving the outcomes.",[94,95,96,97,98,99,100,101,102,103,104,105,31,106,107],"Acute Appendicitis","Acute Cholecystitis","Acute Diverticulitis","Post-operative Complications","Acute Pancreatitis","Perforated Gastro-duodenal Ulcers","Adhesive Small Bowell Occlusion","Colonic Neoplastic Emergencies","Gynecological Emergencies","Vascular Emergencies","Intestinal Ischemia","Abdominal Wall Hernia","Caustic Ingestion","Trauma","2020-07-10",{"date":110,"type":43},"2020-07-14",{"date":112,"type":22},"2020-07",{"date":114,"type":22},"2030-09",{"name":116,"class":81},"A.O. Ospedale Papa Giovanni XXIII"]