[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"frailty\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:frailty":29},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,206,0,25,[9,54,92,115,138,167,195,227,245,285,317,354,379,402,425,459,494,520,546,571,600,630,664,690,708],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":16,"eligibilityCriteria":17,"healthyVolunteers":18,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":34,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":51,"locationsCount":4},"100652393","mitochondrial-intervention-for-resilience-in-older-adults-with-coenzyme-q10-100652393",false,"NCT07772336","MItochondrial Intervention for Resilience in Older Adults With Coenzyme Q10","Mitochondrial Intervention for Resilience in Older Adults With Coenzyme Q10","MIRO-Q","Inclusion Criteria\n\n* Age 65 years or older.\n* Community-dwelling older adult.\n* Presence of signs of reduced biological resilience or prefrailty, defined by meeting at least one of the following criteria:\n\n  * Prefrailty according to the Fried frailty phenotype, defined as the presence of 1-2 of the following criteria: unintentional weight loss, self-reported exhaustion, reduced physical activity, slow walking speed, or reduced handgrip strength; or\n  * Reduced physical performance, defined as a Short Physical Performance Battery (SPPB) score of ≤9; or\n  * Increased functional vulnerability, defined as a Clinical Frailty Scale (CFS) score of ≥4.\n* Ability to understand the study procedures and comply with the study protocol.\n* Ability and willingness to provide written informed consent before participation.\n\nExclusion Criteria\n\n* Established frailty with severe functional impairment that would interfere with study participation or outcome assessment.\n* Advanced dementia or cognitive impairment preventing informed consent or reliable participation in study assessments.\n* Active malignant disease or ongoing cancer treatment.\n* Acute inflammatory disease or acute infection at the time of enrollment.\n* Acute or unstable medical condition that could substantially affect functional performance, cognitive assessment, or the safety of the intervention.\n* Any medical condition considered by the investigator to make participation inappropriate or unsafe.\n* Current use of CoQ10 supplementation at a dose that could interfere with assessment of the study intervention, unless discontinued for the predefined washout period.\n* Known hypersensitivity or intolerance to CoQ10 or any component of the study product.\n* Participation in another interventional clinical trial that could affect the outcomes of the present study.",true,"ALL","65 Years",{"count":22,"type":23},100,"ESTIMATED","INTERVENTIONAL",[26],"NA","This randomized, double-blind, placebo-controlled clinical trial will investigate whether 10 weeks of CoQ10 supplementation can improve biological resilience and functional health in community-dwelling adults aged 65 years or older with signs of reduced biological resilience or prefrailty.\n\nParticipants will be randomly assigned in a 1:1 ratio to receive either 200 mg of CoQ10 daily or matching placebo for 10 weeks. The study will assess the effects of CoQ10 supplementation on mitochondrial functional resilience, chronic low-grade inflammation, metabolic health, physical performance, cognitive function, and objective measures of skin aging.\n\nThe study will also investigate whether baseline biological and functional characteristics can identify individuals who are more likely to benefit from CoQ10 supplementation. An exploratory aim is to develop a multidimensional composite index of biological resilience integrating molecular, biochemical, functional, and clinical measures of aging.\n\nThe study will provide evidence on whether a mitochondria-targeted intervention with CoQ10 may represent a potential strategy for improving functional resilience and reducing features of prefrailty in older adults.",[29,30,31,32,33],"Frailty","Aging","Mitochondria Health","Skin Aging","Mitochondrial Dysfunction",[35,36,37,38,39,40,41],"frailty","aging","older adults","Coenzyme Q10","mitochondrial dysfunction","geroscience","functional aging","NOT_YET_RECRUITING","2026-08-13",{"date":45,"type":46},"2026-08-19","ACTUAL",{"date":48,"type":23},"2026-09",{"date":50,"type":23},"2027-02",{"name":52,"class":53},"University Medical Centre Ljubljana","OTHER",{"id":55,"slug":56,"hasResults":12,"nctId":57,"briefTitle":58,"officialTitle":58,"acronym":59,"eligibilityCriteria":60,"healthyVolunteers":12,"sex":19,"minAge":61,"maxAge":4,"enrollmentInfo":62,"targetDuration":64,"studyType":65,"phases":4,"briefSummary":66,"conditions":67,"keywords":76,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":91},"100568904","cognitive-impact-associated-with-surgery-for-gastric-or-esophageal-cancer-100568904","NCT06687291","Cognitive Impact Associated With Surgery For Gastric Or Esophageal Cancer","CASE","Inclusion Criteria:\n\n* Patients diagnosed with esophageal or gastric cancer, treated with (or without) chemotherapy and surgery.\n* Age ≥18 at the time for inclusion.\n* Participate on a voluntary basis and can (for any reason) end its participation during the study.\n* Capable of giving informed consent.\n\nExclusion Criteria:\n\n* Patients with preoperative cognitive dysfunction such as dementia.\n* Patients who are inoperable due to metastases.\n* Patients unable to communicate due to severely impaired hearing and\u002For - seeing.\n* Patients with ongoing drug and\u002For alcohol abuse.\n* Patients who cannot give informed consent.","18 Years",{"count":63,"type":23},130,"6 Months","OBSERVATIONAL","The primary objective of this observational study is to investigate the incidence of Post Operative Delirium (POD) after gastroesophageal cancer surgery. Secondary objectives are to investigate the relationship between POD, preoperative depression, frailty, quality of life, malnutrition and sarcopenia.\n\nParticipants identified with POD will be asked (at the routine follow-up meeting after surgery) to participate in an qualitative interview, in order to understand the participant's experience of postoperative delirium.\n\nThe main objective aims to answer:\n\nWhat is the incidence of POD after gastroesophageal cancer surgery.",[68,69,70,29,71,72,73,74,75],"Gastroesophageal Cancer (GC)","Postoperative Delirium (POD)","Quality of Life (QOL)","Malnutrition","Sarcopenia","Chemobrain","Chemotherapy","Depression",[77,78,29,79,80,71,72,73,74],"postoperative delirium","gastroesophageal cancer","Quality of life","Preoperative depression","RECRUITING","2026-08-10",{"date":84,"type":46},"2026-08-11",{"date":86,"type":46},"2025-02-13",{"date":88,"type":23},"2028-11-11",{"name":90,"class":53},"Karolinska Institutet",1,{"id":93,"slug":94,"hasResults":12,"nctId":95,"briefTitle":96,"officialTitle":96,"acronym":97,"eligibilityCriteria":98,"healthyVolunteers":18,"sex":19,"minAge":20,"maxAge":99,"enrollmentInfo":100,"targetDuration":4,"studyType":24,"phases":102,"briefSummary":104,"conditions":105,"keywords":4,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":107,"startDateStruct":109,"completionDateStruct":111,"leadSponsor":113,"locationsCount":91},"100518208","phase-2-the-mito-frail-trial-effects-of-mitoq-on-vasodilation-mobility-and-cognitive-performance-in-frail-older-adults-100518208","NCT06027554","The Mito-Frail Trial: Effects of MitoQ on Vasodilation, Mobility and Cognitive Performance in Frail Older Adults","Mito-Frail","Inclusion Criteria:\n\n* men and women aged 65-80 with a slow gait speed (0.4m\u002Fs based on a 4m walk) and\u002For mild cognitive impairment.\n* good cardiovascular health (not taking any blood pressure\u002Fflow\u002Fmetabolism altering medications)\n\nExclusion Criteria:\n\n* A vaccination in past two weeks\n* Recent acute infection three weeks prior to enrollment\n* Known immunodeficiency (including HIV infection, primary immunodeficiency, any history of chemotherapy or radiotherapy\n* Use of medicines during past 6 months known to alter immune response such as high- dose corticosteroids\n* Severe autoimmune disease requiring biological therapy\n* Major severe illness and\u002For Hospitalization in past 3 months\n* On warfarin or other medications that are considered a blood thinner\n* Recent fall or other conditions that will impair ability to complete and\u002For interpret mobility performance test\n* Known bleeding disorder\n* Any conditions that would impair the function to perform grip strength test\n* include advanced neurological disease, severe co-morbid disease, terminal illness with reduced life expectancy, severe disability, unintentional weight loss in last 12 months and participation in another study.\n* Diabetes patients requiring insulin (For reducing the risk that participants will have hypoglycemic episodes when fasting for study visits)\n* Baseline ECG QTc \\>450 ms in men and QTc \\>460 ms in women\n* Prior diagnosis of ventricular arrhythmia (e.g., ventricular tachycardia, ventricular fibrillation, torsades de pointes)","80 Years",{"count":101,"type":23},60,[103],"PHASE2","The goal of this clinical trial is to test the effects of MitoQ supplementation in older adults and frail older adults with physical dysfunction and\u002For cognitive dysfunction. The main question\\[s\\] it aims to answer are:\n\n* To compare vascular function, oxidative stress levels, and physical and cognitive function among older adults and frail older adults with physical and cognitive dysfunction\n* To determine whether MitoQ supplementation has the potential to improve vascular function in central and cerebral vessels\n* To determine whether MitoQ supplementation can enhance physical and cognitive capabilities.",[29,106,30],"Mild Cognitive Impairment",{"date":108,"type":46},"2026-08-12",{"date":110,"type":46},"2024-10-07",{"date":112,"type":23},"2028-02-01",{"name":114,"class":53},"UConn Health",{"id":116,"slug":117,"hasResults":12,"nctId":118,"briefTitle":119,"officialTitle":120,"acronym":4,"eligibilityCriteria":121,"healthyVolunteers":12,"sex":19,"minAge":122,"maxAge":4,"enrollmentInfo":123,"targetDuration":4,"studyType":24,"phases":125,"briefSummary":126,"conditions":127,"keywords":4,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":130,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":91},"100649273","acupoint-stimulation-and-exercise-for-taiwanese-pre-frail-older-adults-100649273","NCT07732530","Acupoint Stimulation and Exercise for Taiwanese Pre-frail Older Adults","Exploring the Associations Among Frailty, Daily Physical Activity, Sleep, and Traditional Chinese Medicine Constitution in Taiwanese Older Adults, and Evaluating the Effects of Acupoint Stimulation Interventions","Inclusion Criteria:\n\n1. Individuals who are capable of undergoing frailty assessments.\n2. Individuals who possess effective communication skills.\n3. Aged 50 years or older.\n4. Willing to provide written informed consent, keep a 7-day sleep diary, and complete related questionnaires.\n5. Identified as pre-frail (frailty score of 1-2 points) according to the frailty phenotype criteria for the clinical trial phase.\n\nExclusion Criteria:\n\n1\\. Individuals who are unwilling or unable to wear an actigraph (wrist monitor) or undergo physical measurements.","50 Years",{"count":124,"type":23},30,[26],"This study aims to explore the relationships between frailty, daily physical activity, sleep quality, and Traditional Chinese Medicine (TCM) constitutions among older adults in Taiwan. In the trial phase, a randomized controlled trial will be conducted specifically for pre-frail older adults. Participants will be randomly assigned to either the exercise training group (Vivifrail program) or the integrated group combining exercise with daytime and sleep-improving acupoint stimulation. The study evaluates the combined efficacy of these non-invasive interventions on reducing frailty severity, improving sleep, and enhancing daily physical functions.",[29,128,30],"Sleep Quality","2026-08-04",{"date":131,"type":46},"2026-08-07",{"date":133,"type":46},"2025-06-03",{"date":135,"type":23},"2027-12-31",{"name":137,"class":53},"Tainan Hospital, Ministry of Health and Welfare",{"id":139,"slug":140,"hasResults":12,"nctId":141,"briefTitle":142,"officialTitle":143,"acronym":144,"eligibilityCriteria":145,"healthyVolunteers":12,"sex":19,"minAge":146,"maxAge":4,"enrollmentInfo":147,"targetDuration":4,"studyType":24,"phases":149,"briefSummary":150,"conditions":151,"keywords":154,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":159,"lastUpdatePostDateStruct":160,"startDateStruct":162,"completionDateStruct":163,"leadSponsor":165,"locationsCount":4},"100650083","funcional-recovery-after-minithoracotomy-or-sternotomy-for-cabg-in-frail-patients-100650083","NCT07742475","Funcional Recovery After Minithoracotomy or Sternotomy for CABG in Frail Patients","Functional Recovery After Coronary Artery Bypass Graft Surgery in Frail Patients: Randomized Clinical Trial Between Minithoracotomy Versus Sternotomy.","MINIFRAGILE","Inclusion Criteria:\n\n* Age 60 years or older.\n* Diagnosis of coronary artery disease with an established indication for coronary artery bypass grafting.\n* Coronary anatomy considered suitable for complete surgical revascularization through a left anterolateral minithoracotomy, including suitable distal coronary targets with a luminal diameter of at least 1.5 mm.;\n\n  \\> Alternatively, coronary anatomy suitable for a planned hybrid revascularization strategy, with coronary territories not treated surgically considered amenable to percutaneous coronary intervention.\n* Presence of pre-frailty or frailty, defined by at least 2 of the following Fried frailty criteria:\n\n  * Unintentional weight loss of at least 4.5 kg or at least 5% of body weight during the previous year.\n  * Self-reported exhaustion or fatigue.\n  * Reduced handgrip strength.\n  * Slow walking speed.\n  * Low level of physical activity.\n* Ability and willingness to provide written informed consent.\n\nExclusion Criteria:\n\n* Requirement for emergency cardiac surgery.\n* Planned concomitant cardiac surgical procedure in addition to coronary artery bypass grafting.\n* Clinically significant peripheral vascular disease involving the femoral vessels that prevents safe peripheral cannulation for cardiopulmonary bypass, when peripheral cannulation may be required.\n* Contraindication to left minithoracotomy, including pleural adhesions, pleural thickening, or other thoracic conditions that prevent safe access to the mediastinum through the intercostal space.\n* Severe chronic obstructive pulmonary disease or another pulmonary condition that prevents safe single-lung ventilation or temporary compression of the left lung.","60 Years",{"count":148,"type":23},194,[26],"Frailty is a major predictor of adverse outcomes following coronary artery bypass grafting (CABG), being associated with increased postoperative complications, prolonged hospitalization, delayed functional recovery, and reduced quality of life. Although minimally invasive coronary surgery (MICS) through left minithoracotomy has been associated with reduced surgical trauma and faster recovery in selected patients, its benefits have not been evaluated in a randomized trial specifically involving frail patients.\n\nThe MINI FRAGILE trial is a prospective, multicenter, randomized, open-label clinical trial designed to compare minimally invasive CABG performed through left anterior minithoracotomy with conventional median sternotomy in patients aged 60 years or older with pre-frailty or frailty undergoing surgical coronary revascularization. Eligible participants will be randomized in a 1:1 ratio to either surgical approach.\n\nThe primary objective is to determine whether minimally invasive CABG improves functional recovery, assessed by the change in the physical component of the SF-36 Health Survey 30 days after surgery. Secondary outcomes include major adverse cardiovascular events, mortality, intensive care unit and hospital length of stay, duration of mechanical ventilation, return to usual activities, surgical site infection, perioperative complications, postoperative pain, readmission, and adherence to enhanced recovery measures. The results of this trial are expected to provide high-quality evidence regarding the optimal surgical approach for frail patients requiring coronary artery bypass grafting.",[29,152,153],"Coronary Artery Disease","Coronary Artery Bypass Graft (CABG)",[155,156,157,29,158],"Coronary Artery Bypass Grafting","Minimally Invasive Coronary Surgery","Minithoracotomy","Functional Recovery","2026-08-03",{"date":161,"type":46},"2026-08-05",{"date":48,"type":23},{"date":164,"type":23},"2027-08",{"name":166,"class":53},"University of Sao Paulo General Hospital",{"id":168,"slug":169,"hasResults":12,"nctId":170,"briefTitle":171,"officialTitle":172,"acronym":173,"eligibilityCriteria":174,"healthyVolunteers":12,"sex":19,"minAge":61,"maxAge":4,"enrollmentInfo":175,"targetDuration":4,"studyType":65,"phases":4,"briefSummary":177,"conditions":178,"keywords":181,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":159,"lastUpdatePostDateStruct":188,"startDateStruct":189,"completionDateStruct":191,"leadSponsor":193,"locationsCount":91},"100643067","easix-score-and-post-induction-hypotension-in-frail-patients-undergoing-non-cardiac-surgery-100643067","NCT07642765","EASIX Score and Post-Induction Hypotension in Frail Patients Undergoing Non-Cardiac Surgery","Evaluation of the Relationship Between Endothelial Activation and Stress Index (EASIX) and Post-Induction Hypotension in Frail Patients Undergoing Non-Cardiac Surgery: A Prospective Observational Cohort Study","PIXEL","Inclusion Criteria:\n\n* Age 18 years or older\n* Scheduled for elective non-cardiac surgery under general anesthesia\n* Clinical Frailty Scale (CFS) score of 4 or above\n* Available routine preoperative laboratory values (LDH, creatinine, platelet count) within 24 hours before surgery\n\nExclusion Criteria:\n\n* Cardiac surgery\n* Emergency surgery\n* Preoperative vasopressor infusion\n* Severe hematological disease\n* Missing laboratory data required for EASIX calculation",{"count":176,"type":23},160,"Post-induction hypotension (PIH) is a common and clinically significant hemodynamic complication following general anesthesia induction. Frail patients are particularly vulnerable due to impaired vascular reactivity and endothelial dysfunction. The Endothelial Activation and Stress Index (EASIX), calculated from routine laboratory parameters (LDH, creatinine, and platelet count), may serve as a preoperative biomarker to identify patients at risk for PIH.\n\nThis prospective observational cohort study aims to evaluate the association between preoperative EASIX score and the occurrence of post-induction hypotension in frail patients undergoing elective non-cardiac surgery under general anesthesia. A total of 160 patients with a Clinical Frailty Scale (CFS) score of 4 or above will be enrolled. Mean arterial pressure will be measured every 2 minutes for the first 15 minutes after induction. PIH is defined as MAP below 65 mmHg and\u002For a decrease of 20% or more from baseline.",[179,29,180],"Hypotension on Induction","Anesthesia, General",[182,183,184,29,185,186,187],"Post-induction hypotension","EASIX","Endothelial Activation and Stress Index","Perioperative hemodynamics","Non-cardiac surgery","Clinical Frailty Scale",{"date":129,"type":46},{"date":190,"type":46},"2026-07-01",{"date":192,"type":23},"2027-03-01",{"name":194,"class":53},"Konya City Hospital",{"id":196,"slug":197,"hasResults":12,"nctId":198,"briefTitle":199,"officialTitle":200,"acronym":4,"eligibilityCriteria":201,"healthyVolunteers":12,"sex":19,"minAge":146,"maxAge":4,"enrollmentInfo":202,"targetDuration":4,"studyType":24,"phases":204,"briefSummary":205,"conditions":206,"keywords":211,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":218,"lastUpdatePostDateStruct":219,"startDateStruct":221,"completionDateStruct":223,"leadSponsor":225,"locationsCount":91},"100619531","the-effect-of-volunteer-engaged-lifestyle-optimisation-via-icope-on-sarcopenia-in-older-adults-velo-s-100619531","NCT07345832","The Effect of Volunteer-Engaged Lifestyle Optimisation Via ICOPE on Sarcopenia in Older Adults (VELO-S)","The Effect of Volunteer-Engaged Lifestyle Optimisation Via ICOPE on Sarcopenia in Older Adults (VELO-S): A Randomised Controlled Trial","Inclusion Criteria:\n\n1. aged 60 or above\n2. Pseudo-Sarcopenia as indicated by a score on SARC-CaIF ≥11, OR sarcopenia according relative BIA-based appendicular skeletal mass\u002F height (Men: \\\u003C7 kg\u002Fm2; women: \\\u003C5.7 kg\u002Fm2), OR handgrip strength on dominant hand (male \\\u003C28 kg, female \\\u003C18 kg) (Chen et al., 2025)\n3. the ability to use a smartphone, electronic tablet, or computer\n4. consent to participate\n\nExclusion Criteria:\n\n1. having medical conditions contradictory to physical activity including unstable cardiovascular and orthopaedic conditions\n2. engaging in other structured health promotion program involving physical activity and nutritional enhancement",{"count":203,"type":23},200,[26],"Sarcopenia prevention and management are highly prioritised goals in the Healthy Ageing agenda. The study aims to: 1) evaluate the effects of the digital-enhanced, volunteer-engaged collaborative care pathway to improve sarcopenia, reduce fall risk, and increase health-related quality of life (HRQL) among community-dwelling older adults with risk of, or diagnosed with, sarcopenia; 2) evaluate whether the volunteers who received health coach capacity training and supported the intervention experienced health benefits across time; 3) explore the engagement experiences and perceived effects of elderly participants with sarcopenia during the program; 4) evaluate the intervention implementation process and effects from the perspectives of social care workers.",[72,207,208,209,210,29],"Sarcopenia in Elderly","Fall Prevention in Healthy Aging","Frailty Syndrome","Malnutrition Elderly",[212,213,35,214,215,216,217],"sarcopenia","elderly","fall prevention","malnutrition","health-related quality of life","digital intervention","2026-07-30",{"date":220,"type":46},"2026-07-31",{"date":222,"type":46},"2026-02-01",{"date":224,"type":23},"2027-09-30",{"name":226,"class":53},"The University of Hong Kong",{"id":228,"slug":229,"hasResults":12,"nctId":230,"briefTitle":231,"officialTitle":231,"acronym":4,"eligibilityCriteria":232,"healthyVolunteers":12,"sex":19,"minAge":122,"maxAge":4,"enrollmentInfo":233,"targetDuration":4,"studyType":24,"phases":234,"briefSummary":235,"conditions":236,"keywords":4,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":237,"lastUpdatePostDateStruct":238,"startDateStruct":239,"completionDateStruct":241,"leadSponsor":243,"locationsCount":4},"100649780","development-of-a-frailty-risk-prediction-model-and-preliminary-evaluation-of-a-risk-stratified-social-robot-assisted-intervention-in-middle-aged-and-older-spousal-caregivers-100649780","NCT07740031","Development of a Frailty Risk Prediction Model and Preliminary Evaluation of a Risk-stratified Social Robot-assisted Intervention in Middle-aged and Older Spousal Caregivers","Inclusion Criteria:\n\n* aged 50 years or older\n* currently being a spouse caregiver\n* assessed as being at high risk level frailty by the developed online risk calculator\n* being able to use the social robot through a smartphone or tablet, either independently or with necessary guidance\n* willing to sign informed consent and participate in study\n\nExclusion Criteria:\n\n* those with acute mental disorders or disabling diseases that may limit the practice of engaging with a robot\n* acute disease attack or acute medical condition\n* currently participating in another intervention or clinical trial\n* who have limited access to electricity, which would make it hard for them to use technology at home",{"count":101,"type":23},[26],"Background With population ageing accelerating worldwide, long-term care needs are rising, and family caregivers have become an essential yet often under-recognised component of care systems. Older family caregivers are particularly susceptible to frailty because they shoulder substantial caregiving responsibilities while simultaneously experiencing their own age-related decline in health and physiological reserve. Frailty is a clinically important state of heightened vulnerability to stressors and is associated with serious adverse outcomes, including disability, hospitalisation, and mortality. In family caregivers, frailty may compromise not only health and quality of life, but also their capacity to sustain caregiving, with wider implications for the sustainability of family-based long-term care.\n\nResearch gaps A scoping review conducted by this team indicated that middle-aged and older family caregivers, particularly spousal caregivers, are vulnerable to frailty, with caregiving-related, sociodemographic, physical, psychological, and social factors contributing to this condition. However, existing evidence remains fragmented. Caregiver-specific prognostic tools for estimating future frailty risk are lacking, and risk-stratified interventions among family caregivers are sparse.\n\nAim This study aims to develop and validate an incident frailty risk prediction model for middle-aged and older spousal caregivers, identify modifiable risk factors, as well as develop and preliminarily evaluate a risk-stratified, social robot-assisted intervention to reduce the risk of frailty.\n\nMethods This study comprises four phases. Phase 1 is a completed scoping review that mapped evidence on frailty among middle-aged and older family caregivers. Phase 2 will use longitudinal data from the China Health and Retirement Longitudinal Study (CHARLS) to develop and validate an incident frailty risk prediction model for middle-aged and older spousal caregivers and to construct an online risk calculator. Phase 3 will develop social robot-assisted intervention based on the Capability, Opportunity, Motivation-Behavior (COM-B) model. Phase 4 will assess the feasibility, acceptability, and examine preliminary effects of the intervention.\n\nExpected outcomes This study is expected to provide a caregiver-specific tool for early frailty risk identification and risk stratification among middle-aged and older spousal caregivers. It will also generate a theoretically guided, risk-stratified social robot-assisted intervention targeting modifiable risk factors for frailty and provide evidence on its feasibility and acceptability, as well as preliminary effects. The findings will inform a future definitive large-scale trial and community-based caregiver support services.",[29],"2026-07-28",{"date":220,"type":46},{"date":240,"type":23},"2026-08-01",{"date":242,"type":23},"2028-06-30",{"name":244,"class":53},"The Hong Kong Polytechnic University",{"id":246,"slug":247,"hasResults":12,"nctId":248,"briefTitle":249,"officialTitle":250,"acronym":251,"eligibilityCriteria":252,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":253,"targetDuration":4,"studyType":24,"phases":255,"briefSummary":256,"conditions":257,"keywords":259,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":277,"lastUpdatePostDateStruct":278,"startDateStruct":279,"completionDateStruct":281,"leadSponsor":283,"locationsCount":91},"100649726","in-person-online-and-hybrid-healthy-aging-education-for-pre-frailty-and-frailty-in-older-adults-100649726","NCT07738393","In-Person, Online, and Hybrid Healthy-Aging Education for Pre-Frailty and Frailty in Older Adults","Effectiveness and Cost-Effectiveness of In-Person, Online, and Hybrid Healthy-Aging Education for Community-Dwelling Older Adults With Pre-Frailty or Frailty: A Four-Arm Randomized Controlled Trial (FRAGSALUD-ON)","FRAGSALUD-ON","Inclusion Criteria:\n\n* Community-dwelling adults aged 65 years or older.\n* Presence of pre-frailty or frailty according to the prespecified operationalization of the Fried frailty phenotype, defined as meeting at least one of the five Fried criteria (pre-frailty: 1-2 criteria; frailty: 3-5 criteria).\n* Ability to understand spoken and written Spanish sufficiently to follow the intervention and study procedures.\n* Access at home to Wi-Fi or mobile data and to a smartphone, tablet, or computer capable of connecting to the internet.\n* Ability to attend the study assessments and, if randomized to the in-person or hybrid intervention, the scheduled face-to-face sessions.\n* Ability to understand the study information and provide written informed consent.\n\nExclusion Criteria:\n\n* Permanent residence in a nursing home or other long-term residential care institution.\n* Robust status according to the Fried frailty phenotype, defined as meeting none of the five Fried criteria.\n* Severe dementia or any cognitive, neurological, or psychiatric condition that precludes valid informed consent or the ability to understand and follow the study procedures.\n* Use of systemic antibiotics during the 3 months preceding baseline stool-sample collection.\n* Known terminal illness or receipt of end-of-life care, with an anticipated life expectancy of less than 12 months, based on available clinical documentation or assessment by a qualified clinician.\n* Current participation in another interventional study involving an investigational medicinal product or a structured physical activity, nutritional, cognitive, or social intervention that overlaps with the FRAGSALUD-ON intervention or follow-up period.",{"count":254,"type":23},276,[26],"The goal of this clinical trial is to determine whether a 6-month healthy-aging education program delivered in person, online, or in a hybrid format reduces frailty and is cost-effective compared with usual care in community-dwelling adults aged 65 years or older with pre-frailty or frailty.\n\nThe main questions are:\n\n* Do the three educational programs, considered together, reduce the prespecified 40-item Frailty Index (40-FI) at 6 months more than usual care?\n* Are effects maintained 6 months after the programs end?\n* How do the in-person, online, and hybrid educational programs differ in multidomain frailty outcomes, implementation, costs, and quality-adjusted life-years?\n* Are changes in prespecified blood biomarkers and gut microbiota associated with changes in frailty and related outcomes?\n\nThe study will enroll 276 participants. Randomization will occur at household level so that enrolled cohabitants receive the same assignment. Households will be allocated to in-person education, online education, hybrid education, or usual care. All three educational programs address physical activity, nutrition, cognitive and emotional well-being, and social connection. Assessments will occur at baseline, 6 months, and 12 months; blood and stool samples will be collected at baseline and 6 months. The trial will compare the average effect of the three active programs with usual care and will estimate modality-specific clinical and economic outcomes.",[29,258],"Pre-Frailty",[260,261,262,263,264,265,266,267,268,269,270,271,272,273,274,275,276],"Cost-effectiveness","Digital health","Community-Dwelling Older Adults","Healthy Aging","Health Education","Online Education","Gut Microbiota","Physical activity","Frail Older Adults","Artificial Intelligence-Assisted Education","Frailty Index","Fried Frailty Phenotype","Cognitive Function","Cost-Utility Analysis","Malnutrition risk","Multidomain Health Education","Physical Function","2026-07-27",{"date":220,"type":46},{"date":280,"type":23},"2026-09-15",{"date":282,"type":23},"2028-06-15",{"name":284,"class":53},"University of Cadiz",{"id":286,"slug":287,"hasResults":12,"nctId":288,"briefTitle":289,"officialTitle":290,"acronym":291,"eligibilityCriteria":292,"healthyVolunteers":12,"sex":19,"minAge":293,"maxAge":4,"enrollmentInfo":294,"targetDuration":4,"studyType":24,"phases":296,"briefSummary":297,"conditions":298,"keywords":300,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":308,"lastUpdatePostDateStruct":309,"startDateStruct":310,"completionDateStruct":312,"leadSponsor":314,"locationsCount":316},"100649116","vivifrail-exercise-program-in-nonagenarians-effects-on-function-muscle-and-cognition-100649116","NCT07731529","Vivifrail Exercise Program in Nonagenarians: Effects on Function, Muscle, and Cognition","Effects of a Multicomponent Exercise Program Based on the Vivifrail Protocol on Functional Capacity, Muscle Morphology, and Cognition in Nonagenarians: A Randomized Clinical Trial","Vivifrail","Inclusion Criteria:\n\n* Aged 90 years or older\n* Living in the community (own or family home)\n* Able to walk independently or with a walking aid (cane or walker), without third-party assistance\n* Minimum cognitive capacity to understand and perform the exercises (MMSE, education-adjusted cutoffs)\n* Adequate home conditions to perform the program\n* Availability of a family member or caregiver to support the sessions\n* Signed informed consent (with legal guardian assistance when needed)\n\nExclusion Criteria:\n\n* \\- Total inability to walk or permanent bedridden condition\n* Severe cognitive impairment preventing safe understanding and execution of exercises\n* Severe orthopedic, neurological, or rheumatological conditions preventing exercise\n* Concurrent participation in another structured exercise program\n* Anticipated unavailability (relocation, planned hospitalization, or institutionalization) during the intervention\n* Refusal to sign informed consent or absence of a legal guardian when required","90 Years",{"count":295,"type":23},54,[26],"This randomized clinical trial investigates the effects of a home-based multicomponent exercise program (Vivifrail) on physical function, muscle morphology, and cognition in community-dwelling adults aged 90 years and older. Participants are randomized into three groups: Vivifrail at least twice a week, Vivifrail at least three times a week, or a control group. Outcomes are assessed at baseline, 12 weeks, and 24 weeks. The primary outcome is physical function measured by the Short Physical Performance Battery (SPPB).",[29,30,299],"Cognitive Decline",[291,301,302,303,304,305,306,307],"Multicomponent exercise","Nonagenarians","Physical function","Short Physical Performance Battery","Muscle quality","Muscle morphology","Home-based exercise","2026-07-24",{"date":237,"type":46},{"date":311,"type":23},"2026-07",{"date":313,"type":23},"2027-09",{"name":315,"class":53},"Federal University of Rio Grande do Sul",2,{"id":318,"slug":319,"hasResults":12,"nctId":320,"briefTitle":321,"officialTitle":322,"acronym":323,"eligibilityCriteria":324,"healthyVolunteers":12,"sex":19,"minAge":61,"maxAge":4,"enrollmentInfo":325,"targetDuration":4,"studyType":24,"phases":327,"briefSummary":328,"conditions":329,"keywords":332,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":308,"lastUpdatePostDateStruct":347,"startDateStruct":348,"completionDateStruct":350,"leadSponsor":352,"locationsCount":316},"100648963","ready-for-safe-cancer-treatment-reset-a-comprehensive-perioperative-program-for-surgical-oncology-100648963","NCT07727876","Ready for Safe Cancer Treatment (RESET): A Comprehensive Perioperative Program for Surgical Oncology","Comprehensive Tool to Improve the Quality and Optimize Hospitalization of Oncological Surgery Patients Implemented for Timely, Safe Discharge From Hospital - Ready for Safe Cancer Treatment RESET, Consisting of a Standardized Sequence of Processes -From Prehabilitation, Therapeutic Team\u002FPatient\u002FFamily Advanced Communication, Early Rehabilitation Protocol, Followed by Individual Transitional Care Program, Dedicated to Oncology Network Hospitals","RESET","ONCOLOGY GROUP\n\nInclusion Criteria:\n\n* Age ≥ 18 years\n* Qualification for admission to surgical departments with an ICD10 diagnosis for radical cancer surgery\n* Preliminary qualification for one of the procedures listed in Section II.B.23\n* Informed consent to participate in the study\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years\n* Qualification for admission to surgical departments with an ICD10 diagnosis for diagnostic procedures to identify cancer\n* Pregnancy or breastfeeding\n\nNON-ONCOLOGY GROUP\n\nInclusion Criteria:\n\n* Informed consent to participate in the study\n* Age ≥ 70 years\n* All consecutive patients referred for planned non-oncological surgical procedures, not solely diagnostic, performed under general anesthesia\n\nExclusion Criteria:\n\n\\- Diagnosis of cancer",{"count":326,"type":23},12800,[26],"The goal of this randomized controlled clinical trial is to evaluate whether the Ready for Safe Cancer Treatment (RESET) program improves perioperative care and supports safe hospital discharge in two surgical populations: adult patients undergoing planned oncological surgery and patients aged 70 years or older undergoing planned non-oncological surgery under general anesthesia.\n\nRESET is a comprehensive, multidisciplinary care pathway that combines prehabilitation, standardized perioperative care, enhanced recovery, and individualized transitional care after discharge.\n\nThe main questions it aims to answer are:\n\nDoes the RESET program reduce postoperative complications, prolonged hospitalizations, and unplanned rehospitalizations after oncological and non-oncological surgery?\n\nDoes the RESET program improve patients' overall health status, physical function, quality of life, perioperative safety, and recovery?\n\nDoes implementation of RESET improve the organization and efficiency of hospital care while reducing healthcare resource utilization and costs?\n\nResearchers will compare patients receiving the RESET program with patients receiving standard perioperative care to determine whether the comprehensive intervention leads to improved clinical, organizational, and patient-reported outcomes.\n\nParticipants assigned to the RESET intervention will:\n\nundergo a comprehensive multidisciplinary prehabilitation assessment performed by a physician, physiotherapist, dietitian, psychologist, clinical pharmacist, nurse, and study coordinator;\n\nreceive an individualized prehabilitation program that may include physical exercise, nutritional support, psychological support, medication optimization, and patient education before surgery;\n\nuse a dedicated RESET mobile application to communicate with the multidisciplinary prehabilitation team, ask questions, receive individualized recommendations and information, follow the schedule of visits and planned activities, and support adherence to the intervention;\n\nundergo reassessment of their health status, needs, and implementation of recommendations on the day of hospital admission, allowing barriers to be identified and the perioperative care plan to be optimized;\n\nreceive standardized in-hospital perioperative care incorporating Enhanced Recovery After Surgery principles, the SAFER Patient Flow Bundle, the Red2Green methodology, medication review by a clinical pharmacist, and coordinated multidisciplinary care;\n\nreceive an individualized transitional care plan after discharge, including follow-up support and monitoring for complications and rehospitalization.\n\nParticipants in the control group will receive standard perioperative care according to routine clinical practice at the participating hospitals.\n\nThe study will evaluate clinical outcomes, including postoperative complications, prolonged hospitalization, rehospitalization, recovery, overall health status, physical function, and quality of life. It will also evaluate patient satisfaction, adherence to the RESET pathway, organizational effectiveness, and costs associated with implementation of RESET.\n\nThe results are expected to support the development of an evidence-based and scalable perioperative care model that can be used in oncological surgery and in older patients undergoing major non-oncological surgery.",[330,29,331],"Neoplasms","Surgical Procedures, Operative",[333,334,335,336,337,338,339,340,341,342,343,35,344,345,346],"prehabilitation","perioperative care","surgical oncology","enhanced recovery after surgery","transitional care","hospital discharge","multidisciplinary care","postoperative complications","rehospitalization","prolonged hospitalization","patient flow","geriatric surgery","cancer surgery","supportive care",{"date":277,"type":46},{"date":349,"type":46},"2026-02-16",{"date":351,"type":23},"2031-07-31",{"name":353,"class":53},"Regional Specialist Hospital in Wroclaw",{"id":355,"slug":356,"hasResults":12,"nctId":357,"briefTitle":358,"officialTitle":359,"acronym":4,"eligibilityCriteria":360,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":361,"targetDuration":4,"studyType":24,"phases":362,"briefSummary":363,"conditions":364,"keywords":365,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":308,"lastUpdatePostDateStruct":372,"startDateStruct":373,"completionDateStruct":375,"leadSponsor":377,"locationsCount":91},"100642824","nurse-led-telehealth-frailty-management-in-older-adults-100642824","NCT07634406","Nurse-Led Telehealth Frailty Management in Older Adults","The Effect of a Nurse-Led Telehealth-Supported Multicomponent Frailty Management Program on Frailty and Functional Status in Older Adults Living at Home: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Aged 65 years or older\n* Living at home and not receiving institutional care\n* Frail or at risk of frailty\n* Having sufficient hearing and cognitive ability to communicate by telephone\n* Able to read, understand, and communicate in Turkish\n* Providing written informed consent\n\nExclusion Criteria:\n\n* Having advanced cognitive impairment such as dementia\n* Having hearing or speech problems that prevent communication\n* Being bedridden\n* Being in the terminal stage of illness\n* Participating in another intervention or education program at the same time\n* Having a serious physical or psychiatric condition that may prevent regular participation in the intervention",{"count":22,"type":23},[26],"Frailty is an important geriatric syndrome associated with reduced physiological reserve, functional decline, falls, hospitalization, and increased health care use among older adults. This randomized controlled trial aims to evaluate the effect of a nurse-led telehealth-supported multicomponent frailty management program on frailty level and functional status in older adults living at home.\n\nThe study will be conducted as a single-center, two-arm, parallel-group randomized controlled trial. A total of 100 older adults aged 65 years and older who are living at home and are frail or at risk of frailty will be randomly assigned to either the intervention group or the control group in a 1:1 ratio.\n\nParticipants in the intervention group will receive an 6-week nurse-led telehealth-supported frailty management program, including weekly telephone counseling and individualized follow-up. Participants in the control group will continue usual care. Data will be collected at baseline, at 6 weeks, and at 18 weeks. The primary outcome is frailty level measured using the FRAIL Scale. Secondary outcomes include functional status, depressive symptoms, number of falls, emergency department visits, and hospitalizations.",[29],[366,367,368,369,370,371],"Older adults","Telehealth","Nursing intervention","Frailty management","Functional status","Home care",{"date":277,"type":46},{"date":374,"type":46},"2026-06-05",{"date":376,"type":23},"2026-10-15",{"name":378,"class":53},"Kutahya Health Sciences University",{"id":380,"slug":381,"hasResults":12,"nctId":382,"briefTitle":383,"officialTitle":383,"acronym":384,"eligibilityCriteria":385,"healthyVolunteers":18,"sex":19,"minAge":61,"maxAge":4,"enrollmentInfo":386,"targetDuration":4,"studyType":65,"phases":4,"briefSummary":387,"conditions":388,"keywords":390,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":394,"lastUpdatePostDateStruct":395,"startDateStruct":396,"completionDateStruct":398,"leadSponsor":400,"locationsCount":91},"100648773","stride-strength-of-the-calf-muscles-and-their-role-in-declining-effectiveness-of-movement-with-aging-100648773","NCT07726498","STRIDE: Strength of The Calf Muscles and Their Role In Declining Effectiveness of Movement With Aging","STRIDE","Inclusion Criteria:\n\n* Participant is able and willing to provide informed consent to participate in the study\n* Aged 18 years or over\n* Ambulatory status: able to walk independently with or without aids\n* Able to attend clinic\n\nExclusion Criteria:\n\n* Participant is unwilling or unable to give informed consent.\n* Palliative\u002F end of life\n* Moderate to severe communication difficulties\u002F cognitive function\n* Immobile\n* Lower limb surgery within the last 6 months\n* Recent lower limb fracture\n* Unstable cardiopulmonary conditions\n* Severe impairments of vision or vestibular system\n* Lower limb corticosteroid injection within the last 6 months\n* No restriction on language",{"count":203,"type":23},"The calf muscles (plantarflexors) are the most important muscles for walking, running and daily activities. Weakness of these muscles through aging and disease significantly impact a person's ability to walk and complete daily activities. By assessing calf strength, it is possible to identify people at risk of falls, and a condition called sarcopenia (which means loss of muscle mass, strength and function). Unfortunately, most of the studies that have examined this have used specialist equipment unavailable to hospital staff. Our study aims to use commercially available equipment to explore the relationship between plantarflexor muscle strength and physical performance in adults living with or without sarcopenia, including those at risk of it. The study will determine if stronger\u002Fweaker calf muscles associated with sarcopenia influence the ability to walk and do things more easily. We will complete strength tests of the calf, thigh and hand, assess walking using a special camera system, use an ultrasound scan to look at the Achilles tendon, use a scan to look at how stiff your calf muscles are, assess your body composition, complete a physical performance test and some questionnaires. Each participant will complete the measures during one clinic visit",[72,30,389,29],"Muscle Weakness or Atrophy",[391,72,30,392,393],"Plantarflexors","Weakness","Multi-morbidity","2026-07-22",{"date":308,"type":46},{"date":397,"type":23},"2026-08",{"date":399,"type":23},"2028-02-29",{"name":401,"class":53},"University of Leicester",{"id":403,"slug":404,"hasResults":12,"nctId":405,"briefTitle":406,"officialTitle":407,"acronym":408,"eligibilityCriteria":409,"healthyVolunteers":12,"sex":19,"minAge":410,"maxAge":4,"enrollmentInfo":411,"targetDuration":4,"studyType":65,"phases":4,"briefSummary":413,"conditions":414,"keywords":4,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":417,"lastUpdatePostDateStruct":418,"startDateStruct":419,"completionDateStruct":421,"leadSponsor":423,"locationsCount":91},"100584454","comparison-of-preoperative-frailty-assessment-tools-100584454","NCT06889545","Comparison of Preoperative Frailty Assessment Tools","Evaluation of a Feasible Frailty Assessment Tool for Preoperative Risk Evaluation of Older Patients","PREFAS","Inclusion Criteria:\n\n* 70 years and older\n* scheduled surgery\n* estimated time of surgery 120 Minutes or more\n\nExclusion Criteria:\n\n* insufficient German language skills (for cognitive testing)\n* mental retardation\n* relevant psychiatric disorder (not allowing for cognitive testing)","70 Years",{"count":412,"type":23},584,"Frailty is a significant risk factor for postoperative complications and functional decline. Preoperative assessment of frailty is therefore recommended in all older adults. However, despite the availability of many frailty tools, few have been tested in the preoperative setting and there is little comparison of their predictive value in identifying patients at risk. The aim of this study is to investigate which of the following instruments for determining frailty has the highest predictive power with regard to the occurrence of postoperative complications: Risk Analysis Index, Clinical Frailty Scale, the Groningen Frailty Indicator, the Edmonton Frail Scale and the LUCAS-FI. The aim of this research project is to identify a suitable frailty instrument for preoperative risk stratification of older patients during the premedication visit.",[29,415,416],"Frailty in Older Adults","Frailty\u002FSarcopenia","2026-07-21",{"date":394,"type":46},{"date":420,"type":46},"2025-04-15",{"date":422,"type":23},"2028-04-01",{"name":424,"class":53},"Universitätsklinikum Hamburg-Eppendorf",{"id":426,"slug":427,"hasResults":12,"nctId":428,"briefTitle":429,"officialTitle":430,"acronym":4,"eligibilityCriteria":431,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":432,"targetDuration":4,"studyType":65,"phases":4,"briefSummary":434,"conditions":435,"keywords":439,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":451,"lastUpdatePostDateStruct":452,"startDateStruct":454,"completionDateStruct":456,"leadSponsor":457,"locationsCount":91},"100647723","analgesia-methods-and-early-mobilization-in-geriatric-icu-patients-after-major-surgery-100647723","NCT07709975","Analgesia Methods and Early Mobilization in Geriatric ICU Patients After Major Surgery","Effect of Analgesia Methods on Early Mobilization and Patient Satisfaction in Geriatric Patients Admitted to Intensive Care After Major Surgery","Inclusion Criteria:\n\n* Age 65 years or older\n* ASA physical status classification I-IV\n* Admitted to the intensive care unit (ICU) following major surgery\n* ICU stay of at least 24 hours\n\nExclusion Criteria:\n\n* Previously diagnosed advanced-stage dementia\n* Inability to assess consciousness due to severe neurological deficit\n* ICU stay of less than 24 hours\n* Incomplete or insufficient clinical data",{"count":433,"type":23},90,"This study looks at how different pain-control methods affect how quickly older adults get out of bed and start moving again after major surgery. Researchers will observe patients aged 65 and older who are admitted to the intensive care unit (ICU) after major surgery. Doctors will use their usual pain-control methods - either medication given through a vein, an epidural, or a nerve block - based on standard clinical practice; the study team will not change or choose the treatment. The study will record how long it takes for each patient to first sit up, stand, or walk after surgery, along with pain levels, confusion (delirium), how satisfied patients are with their pain control, and how long they stay in the ICU. The goal is to better understand which pain-control approaches may help older patients recover and move more quickly and safely after major surgery.",[436,437,29,438],"Postoperative Pain","Delirium - Postoperative","Postoperative Care in Geriatric Intensive Care Patients",[440,441,442,443,444,445,446,447,448,449,450,29],"Geriatric","Intensive Care Unit","Major Surgery","Postoperative Analgesia","Early Mobilization","Epidural Analgesia","Peripheral Nerve Block","Opioid Consumption","Delirium","CAM-ICU","Patient Satisfaction","2026-07-15",{"date":453,"type":46},"2026-07-17",{"date":455,"type":46},"2026-06-15",{"date":280,"type":23},{"name":458,"class":53},"Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization",{"id":460,"slug":461,"hasResults":12,"nctId":462,"briefTitle":463,"officialTitle":463,"acronym":464,"eligibilityCriteria":465,"healthyVolunteers":12,"sex":19,"minAge":466,"maxAge":4,"enrollmentInfo":467,"targetDuration":469,"studyType":65,"phases":4,"briefSummary":470,"conditions":471,"keywords":475,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":451,"lastUpdatePostDateStruct":487,"startDateStruct":489,"completionDateStruct":491,"leadSponsor":492,"locationsCount":91},"100647509","bioancient-cohort-of-centenarians-in-navarra-1926-1927-100647509","NCT07707297","BIOANCIENT: Cohort of Centenarians in Navarra (1926-1927)","BIOANCIENT","Inclusion Criteria:\n\n* Individuals aged ≥100 years\n* Residents of Navarre, Spain\n\nExclusion Criteria:\n\n* Clinical decompensation within the last month, including hemodynamic instability, acute illness, or hospitalization;\n* End-of-life condition, defined as a clinical state of irreversible deterioration with a life expectancy of days to weeks, as determined by a physician.","100 Years",{"count":468,"type":23},333,"5 Years","Demographic aging is a growing global challenge, driven by increasing life expectancy and declining birth rates, with projections indicating that more than 30% of the European population will be over 65 years old by 2100. Centenarians represent a unique biological model of extreme longevity, often exhibiting delayed onset of age-related diseases and preserved functional capacity.\n\nThis study aims to establish an intergenerational cohort of centenarians in Navarra (Spain) to investigate the biological, clinical, environmental, and lifestyle factors associated with extreme longevity. By integrating multidimensional data-including clinical assessments, functional and cognitive measures, and biological markers-this study seeks to improve understanding of aging mechanisms and identify potential determinants of healthy aging.",[30,472,473,474,29],"Cellular Senescence","Biomarkers \u002F Blood","Age-Related Diseases",[476,477,478,479,480,481,482,483,484,485,486],"Centenarians","Healthy aging","Senescence","Geroscience","Age-related diseases","Longevity","Senescence biomarkers","Personalized medicine","Preventive medicine","Artificial intelligence in healthcare","Omics technologies (genomics, proteomics, metabolomics)",{"date":488,"type":46},"2026-07-16",{"date":490,"type":46},"2026-02-04",{"date":135,"type":23},{"name":493,"class":53},"Fundacion Miguel Servet",{"id":495,"slug":496,"hasResults":12,"nctId":497,"briefTitle":498,"officialTitle":499,"acronym":4,"eligibilityCriteria":500,"healthyVolunteers":12,"sex":19,"minAge":146,"maxAge":501,"enrollmentInfo":502,"targetDuration":4,"studyType":24,"phases":504,"briefSummary":506,"conditions":507,"keywords":508,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":512,"lastUpdatePostDateStruct":513,"startDateStruct":514,"completionDateStruct":516,"leadSponsor":517,"locationsCount":4},"100647245","phase-1-safety-study-of-intravenous-miramsc-in-older-adults-with-mild-to-moderate-frailty-syndrome-100647245","NCT07705464","Safety Study of Intravenous MiraMSC in Older Adults With Mild to Moderate Frailty Syndrome","A Phase I, Open-Label Study to Evaluate the Safety and Tolerability of MiraMSC Administered Intravenously in Elderly Subjects With Mild to Moderate Frailty Syndrome","Inclusion Criteria:\n\nSubjects will be eligible for enrollment in the study only if they meet ALL the following criteria at time of Screening:\n\n1. Subjects aged ≥ 60 through ≤ 85 years old.\n2. Subjects with clinical diagnosis of mild to moderate Frailty Syndrome as assessed by the Investigator with a Clinical Frailty Scale score between 4 to\n\n6\\. 3. Subject will not start any new treatment for this condition during the study.\n\n* The new treatment refers to any clinical study of new investigational therapies or any other stem cell therapies. Subject will be allowed to continue ongoing medications and therapies that are not prohibited treatment as listed in Section 6.4.1 and are deemed necessary by the Investigator for appropriate medical care. Minor modifications or dose adjustments to ongoing frailty- related treatments that were initiated prior to study enrollment and are not prohibited by the protocol may be implemented if deemed necessary by the Investigator for appropriate care; such adjustments will not be considered the initiation of a new treatment. \\*\\* 4. Subjects with body weight between 40 to 90 kg. 5. Subject is willing to provide written informed consent to participate in the study after reading the informed consent form and the information provided.\n\nExclusion Criteria:\n\nSubjects meeting ANY of the following criteria at time of Screening will be excluded from enrollment:\n\n1. Subjects unwill ing or unable to perform any of the assessments required by endpoint analysis.\n2. Subjects who have a diagnosis of any disabling neurologic disorder including, but not limited to: Parkinson's disease, Amyotrophic Lateral Sclerosis, multiple sclerosis, stroke or dementia.\n3. Subjects who have a score on the Mini-Mental State Examination (MMSE) of 24 or below.\n4. Subjects who have a significant comorbid medical condition(s) including, but not limited to:\n\n   1. Severe kidney disease requiring hemodialysis or peritoneal dialysis;\n   2. Advanced liver disease such as severe liver cirrhosis;\n   3. Severe congestive heart failure (NYHA class 3 and 4);\n   4. Severe pulmonary dysfunction, including severe chronic obstructive pulmonary disease stage III or IV (Gold classification)\n5. Subjects who have a clinical history of malignancy within 5 years (i.e., patients with prior malignancy must be disease free for 5 years), except curatively-treated basal cell carcinoma or in situ carcinomas.\n6. Subjects using chronic immunosuppressant therapy, including corticosteroids (\\> 5 mg\u002Fday of prednisone, or equivalent), or TNF-alpha antagonists.\n7. Subjects on chronic immunosuppressive transplant therapy.\n8. Subjects who have participated in another clinical study of new investigational therapies within 6 months prior to screening.\n9. Subjects who have received any other stem cell therapy within 12 months prior to screening.\n10. Subjects with known allergy or hypersensitivity to any component of the formulation and cellular therapies (i.e., penicillin or streptomycin).\n11. Subjects who have a history of drug or alcohol abuse within the past 3 years.\n12. Subjects who are known to be infected with HIV.\n13. Subjects currently in hospital stay.\n14. Subjects who have a significant illness as judged by principal investigator (PI) including, but not limited to:\n\n    1. Psychiatric illness\n    2. Uncontrolled hypertension or hypotension\n    3. Unstable cardiac arrhythmia\n    4. Active Hepatitis B, Hepatitis C infections\n15. Subjects who have any condition that in the opinion of the Principal investigator limits lifespan to \\\u003C 1 year.\n16. Subjects who have any other condition that, in the opinion of the investigator, may compromise the safety or compliance of the patient or preclude successful completion of the study.\n17. Subjects with known or suspected bleeding disorders (including but not limited to hemophilia, von Willebrand disease, or platelet function disorders), or clinically significant coagulopathy (including abnormal PT, PTT, or INR) at screening.\n18. Subjects receiving medications that may increase the risk of bleeding or coagulopathy (such as anticoagulants, antiplatelet agents, or thrombolytics), unless medically necessary and approved by the Medical Monitor on a case- by-case basis.","85 Years",{"count":503,"type":23},12,[505],"PHASE1","The purpose of this Phase I, open-label study is to evaluate the safety and tolerability of intravenous MiraMSC-FS-001 in older adults with mild to moderate frailty syndrome. MiraMSC-FS-001 is an investigational product consisting of allogeneic umbilical cord-derived mesenchymal stem cells (UCMSCs). Eligible participants will receive intravenous administration of MiraMSC-FS-001.",[29],[509,510,511],"MiraMSC-FS-001","Mesenchymal Stem Cells (MSC)","Frailty Syndrome (FS)","2026-07-14",{"date":451,"type":46},{"date":515,"type":23},"2026-12-01",{"date":242,"type":23},{"name":518,"class":519},"Miracle Biomedical Co., Ltd.","INDUSTRY",{"id":521,"slug":522,"hasResults":12,"nctId":523,"briefTitle":524,"officialTitle":525,"acronym":526,"eligibilityCriteria":527,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":528,"targetDuration":4,"studyType":65,"phases":4,"briefSummary":530,"conditions":531,"keywords":536,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":538,"lastUpdatePostDateStruct":539,"startDateStruct":540,"completionDateStruct":542,"leadSponsor":544,"locationsCount":4},"100647742","nutritional-status-in-hospitalized-patients-over-65-years-of-age-with-mental-disorders-100647742","NCT07710456","Nutritional Status in Hospitalized Patients Over 65 Years of Age With Mental Disorders","Nutritional Status, Nutrition-Related Conditions, and Development of a Clinical Pathway for Nutritional Support in Hospitalized Patients Aged 65 Years and Older With Mental Disorders","NutriP-SI65","Inclusion Criteria:\n\n* Age 65 years and older\n* Presence of at least one psychiatric diagnosis\n* Hospitalization at the Geriatric Psychiatry Unit of the University Psychiatric Clinic Ljubljana\n\nExclusion Criteria:\n\n* Individuals who did not provide written informed consent (or whose legal representatives did not provide consent)\n* Hospitalization shorter than 48 hours\n* Presence of delirium\n* Patients receiving palliative care or who are terminally ill",{"count":529,"type":23},450,"The objective of of this observational study is to evaluate the nutritional status and the prevalence of nutrition-related conditions, as well as dysphagia, among patients aged 65 years and older with mental disorders. The study will also identify key associated factors and inform the development of targeted strategies for the prevention, early identification, and management of malnutrition and related conditions. Furthermore, a draft clinical pathway for nutritional care will be developed, and its feasibility and effectiveness will be assessed.",[71,72,532,533,29,534,535],"Obesity","Sarcopenic Obesity","Dysphagia","Mental Disorder",[71,72,29,534,532,533,535,537],"Elderly","2026-07-13",{"date":453,"type":46},{"date":541,"type":23},"2026-06",{"date":543,"type":23},"2027-12",{"name":545,"class":53},"University Psychiatric Clinic Ljubljana",{"id":547,"slug":548,"hasResults":12,"nctId":549,"briefTitle":550,"officialTitle":551,"acronym":4,"eligibilityCriteria":552,"healthyVolunteers":12,"sex":19,"minAge":61,"maxAge":4,"enrollmentInfo":553,"targetDuration":4,"studyType":24,"phases":554,"briefSummary":555,"conditions":556,"keywords":558,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":538,"lastUpdatePostDateStruct":564,"startDateStruct":565,"completionDateStruct":567,"leadSponsor":569,"locationsCount":91},"100595191","prehab-and-creatinewhey-supplementation-in-frailty-among-patients-with-cirrhosis-100595191","NCT07029243","Prehab and Creatine\u002FWhey Supplementation in Frailty Among Patients With Cirrhosis","Physical Prehabilitation With and Without Creatine\u002FWhey Protein Supplementation Effects on Frailty In Patients With Cirrhosis","Inclusion Criteria:\n\n* Confirmed diagnosis of cirrhosis by ICD-10 code, liver biopsy, abdominal imaging, or transient elastography\n* Access to digital device and internet at home\n* Ability to provide written informed consent before any study-related activities\n* Ability to remain in study for at least 3 months\n\nExclusion Criteria:\n\n* Allergy to milk protein\n* On hemodialysis\n* No English language proficiency\n* Presence of condition or abnormality that in opinion of the Investigator will compromise safety of the patient or quality of the data\n* Concomitant severe underlying systemic illness that in the opinion of the Investigator would interfere with completion of study\n* Pregnant, breastfeeding, or intention of becoming pregnant during study time frame",{"count":22,"type":23},[26],"Frailty and muscle health are important for patients with chronic liver disease. This study looks at the use of a digital prehabilitation app (HEAL-ME) plus creatine and whey protein combination supplementation on maintaining muscle health in patients with liver disease. The investigators anticipate that this combination of supplementation and nutrition\u002Fexercise prehabilitation app will maintain muscle health in patients with liver disease.",[557,29,72],"Cirrhosis",[559,560,561,562,563,35],"cirrhosis","liver","muscle","creatine","whey protein",{"date":451,"type":46},{"date":566,"type":46},"2026-04-15",{"date":568,"type":23},"2026-12",{"name":570,"class":53},"University of California, San Francisco",{"id":572,"slug":573,"hasResults":12,"nctId":574,"briefTitle":575,"officialTitle":576,"acronym":577,"eligibilityCriteria":578,"healthyVolunteers":12,"sex":19,"minAge":61,"maxAge":4,"enrollmentInfo":579,"targetDuration":4,"studyType":24,"phases":581,"briefSummary":582,"conditions":583,"keywords":587,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":593,"lastUpdatePostDateStruct":594,"startDateStruct":595,"completionDateStruct":596,"leadSponsor":598,"locationsCount":91},"100645741","remote-vs-in-person-prehabilitation-for-kidney-transplant-candidates-100645741","NCT07701382","Remote vs In-Person Prehabilitation for Kidney Transplant Candidates","Implementation of a Multimodal Prehabilitation Program for Patients With Advanced Chronic Kidney Disease Awaiting Deceased-Donor Kidney Transplantation: A Comparison of In-Person and Remote Delivery Models","KIDFIT","Inclusion Criteria:\n\n* Adults aged 18 years or older.\n* Patients with advanced chronic kidney disease on the waiting list for deceased-donor kidney transplantation.\n* Ability to perform moderate-intensity physical exercise.\n* Able and willing to provide written informed consent.\n\nExclusion Criteria:\n\n* Absolute contraindication to physical exercise.\n* Severe cognitive impairment limiting participation in the intervention or assessments.\n* Active infection at the time of enrollment.\n* Clinically unstable medical condition.\n* Physical or musculoskeletal limitations preventing participation in the exercise program.",{"count":580,"type":23},84,[26],"Patients with advanced chronic kidney disease awaiting deceased-donor kidney transplantation frequently experience progressive functional decline, frailty, reduced mobility, and poor quality of life while on the transplant waiting list. Although multimodal prehabilitation programs based on exercise, nutritional optimization, and psychological support have shown promising benefits in major surgery, their implementation in kidney transplant candidates remains limited due to barriers related to accessibility, fatigue, transportation, and treatment burden.\n\nThis randomized single-center clinical trial aims to evaluate the feasibility, adherence, and effectiveness of a multimodal prehabilitation program in patients awaiting deceased-donor kidney transplantation, comparing an in-person supervised model with a remote home-based model supported by a digital platform. The primary outcome will be the change in functional capacity measured by the 6-Minute Walk Test (6MWT). Secondary outcomes include physical activity level, frailty, nutritional status, kidney disease-specific quality of life (KDQOL-36), postoperative recovery quality (QoR-15), postoperative complications, and program adherence.\n\nThe study seeks to generate clinically applicable evidence regarding the implementation and scalability of remote prehabilitation strategies in patients with advanced chronic kidney disease, with the potential to improve accessibility, sustainability, and perioperative outcomes in kidney transplantation.",[584,585,29,586],"Chronic Kidney Disease (CKD)","Kidney Transplant","Prehabilitation",[588,589,333,590,334,591,592],"advanced chronic kidney disease","kidney transplantation","functional capacity","quality of life","multimodal prehabilitation","2026-07-08",{"date":512,"type":46},{"date":311,"type":23},{"date":597,"type":23},"2029-05",{"name":599,"class":53},"Hospital Clinic of Barcelona",{"id":601,"slug":602,"hasResults":12,"nctId":603,"briefTitle":604,"officialTitle":605,"acronym":606,"eligibilityCriteria":607,"healthyVolunteers":12,"sex":19,"minAge":61,"maxAge":4,"enrollmentInfo":608,"targetDuration":4,"studyType":65,"phases":4,"briefSummary":610,"conditions":611,"keywords":614,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":593,"lastUpdatePostDateStruct":623,"startDateStruct":624,"completionDateStruct":626,"leadSponsor":628,"locationsCount":91},"100645578","frailty-and-ultrasound-guided-central-venous-catheterization-difficulty-in-adult-cardiac-surgery-patients-100645578","NCT07701538","Frailty and Ultrasound-Guided Central Venous Catheterization Difficulty in Adult Cardiac Surgery Patients","Association Between Frailty and Central Venous Catheterization Difficulty in Adult Cardiac Surgery Patients: A Prospective Ultrasound-Based Observational Study","FRAILCVC","Inclusion Criteria\n\n* Adults aged 18 years or older.\n* Scheduled for elective cardiac surgery.\n* Planned ultrasound-guided internal jugular vein catheterization as part of routine perioperative care.\n* Able to undergo preoperative frailty assessment using the Clinical Frailty Scale (CFS).\n* Able to perform handgrip strength measurement.\n* Able to undergo ultrasound assessment of the internal jugular vein.\n* Provided written informed consent.\n\nExclusion Criteria\n\nConditions Affecting Neck Anatomy\n\n1. Previous neck surgery.\n2. History of radiotherapy to the neck region.\n3. Presence of a neck mass, infection, or any lesion that may distort neck anatomy.\n4. Known internal jugular vein thrombosis.\n5. Congenital vascular anomalies causing significant alteration of the internal jugular vein or carotid artery anatomy.\n\nClinical Conditions Affecting Catheterization\n\n1. Patients requiring emergency cardiac surgery.\n2. Presence of an existing central venous catheter.\n3. Severe coagulopathy (INR \\> 2.0 or platelet count \\\u003C 50,000\u002Fmm³).\n4. Hemodynamic instability or requirement for active cardiopulmonary resuscitation.\n\nConditions Affecting Frailty and Handgrip Strength Assessment\n\n1. Severe neurological disorders (e.g., advanced dementia or disabling sequelae of stroke).\n2. Orthopedic or neuromuscular disorders affecting upper extremity function.\n3. Inability to perform handgrip strength measurement due to severe arthritis or hand deformity.\n\nConditions Affecting Study Participation\n\n1. Cognitive impairment preventing reliable clinical assessment or informed participation.\n2. Refusal to participate in the study.\n3. Any other condition that, in the investigator's judgment, may compromise patient safety or interfere with study participation.",{"count":609,"type":23},280,"This prospective observational study aims to evaluate the association between preoperative frailty and the procedural difficulty of ultrasound-guided internal jugular vein catheterization in adult patients undergoing elective cardiac surgery.\n\nFrailty will be assessed using the Clinical Frailty Scale and handgrip strength measurements. Preprocedural ultrasound evaluation will include internal jugular vein anatomical characteristics such as anteroposterior and transverse vein diameters, cross-sectional area (CSA), common carotid artery diameter, skin-to-vein distance, overlap status, and sternocleidomastoid muscle thickness Catheterization difficulty will be assessed using the Gaber Procedural Difficulty Index.\n\nThe study seeks to determine whether frailty and ultrasound-derived anatomical parameters can predict difficult internal jugular venous catheterization and improve preprocedural risk assessment without altering routine clinical care.",[29,612,613],"Cardiac Surgery","Central Venous Catheter",[35,615,616,617,618,619,620,621,622],"central venous catheterization","ultrasound-guided catheterization","cardiac surgery","internal jugular vein","difficult catheterization","handgrip strength","venous anatomy","adult patients",{"date":512,"type":46},{"date":625,"type":23},"2026-07-25",{"date":627,"type":23},"2027-06",{"name":629,"class":53},"Ankara City Hospital Bilkent",{"id":631,"slug":632,"hasResults":12,"nctId":633,"briefTitle":634,"officialTitle":635,"acronym":636,"eligibilityCriteria":637,"healthyVolunteers":18,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":638,"targetDuration":4,"studyType":65,"phases":4,"briefSummary":640,"conditions":641,"keywords":646,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":593,"lastUpdatePostDateStruct":655,"startDateStruct":657,"completionDateStruct":659,"leadSponsor":661,"locationsCount":663},"100626159","orthopedic-procedures-and-postoperative-delirium-in-older-adults-in-the-czech-republic-100626159","NCT07432009","Orthopedic Procedures and Postoperative Delirium in Older Adults in the Czech Republic","Orthopedic Procedures and Postoperative Delirium in the Czech Republic","ORTOPODCZ","Inclusion Criteria:\n\n* Age ≥ 65 years\n* Elective total hip arthroplasty in general or regional anesthesia\n* ASA physical status I-III\n* Ability to understand and cooperate during testing; no severe sensory impairment (compensatory aids allowed)\n* Expected postoperative hospitalization in ICU, PACU, or standard ward\n\nExclusion Criteria:\n\n* Glasgow Coma Scale ≤ 14\n* Limited legal capacity\n* Active psychiatric disorder (e.g., psychotic disorder, bipolar disorder)\n* Active oncological disease\n* Chronic use of strong opioids\n* Premedication with anxiolytics or antipsychotics during preanesthetic evaluation\n* Acute reoperation within 3 months of primary surgery\n* Refusal to participate or withdrawal of consent",{"count":639,"type":23},400,"This multicenter, prospective, non-interventional observational study (ORTOPODCZ) investigates the association between preoperative cognitive impairment and postoperative delirium (POD) in older adults undergoing elective total hip arthroplasty in the Czech Republic. Postoperative delirium is a frequent and serious neurocognitive complication in senior surgical patients and is associated with increased morbidity, mortality, prolonged hospitalization, and impaired functional and cognitive outcomes. Despite international recommendations, routine preoperative cognitive screening remains insufficiently implemented.\n\nThe study evaluates the predictive value of the ALBA test, a brief cognitive screening tool, performed during the pre-anesthetic assessment. Postoperative delirium will be assessed using the validated CAM-ICU instrument for up to 72 hours after surgery. Secondary objectives include assessing the relationship between POD and frailty, polypharmacy, comorbidities, type of anesthesia, intraoperative hemodynamics, blood loss, vasoactive support, and postoperative complications.\n\nApproximately 300-400 participants aged ≥65 years will be enrolled across seven centers. No additional procedures, biological sampling, or deviations from standard clinical care are required. Data will be collected in REDCap and analyzed according to a predefined statistical analysis plan. The study aims to provide robust evidence supporting the integration of cognitive screening into routine preoperative evaluation and to describe feasibility and implementation requirements for the ALBA test in clinical practice.",[29,642,643,644,645],"Cognitive Impairment","Older Adults","Hip Arthroplasty","Postoperative Delirium",[647,449,648,649,650,651,187,652,653,654],"ALBA test","Cognitive Screening","Geriatric Patients","Perioperative Neurocognitive Disorders","Polypharmacy","Total Hip Replacement","Observational Study","Prospective Cohort",{"date":656,"type":46},"2026-07-09",{"date":658,"type":46},"2026-04-24",{"date":660,"type":23},"2030-03-31",{"name":662,"class":53},"Tomas Bata Hospital, Czech Republic",7,{"id":665,"slug":666,"hasResults":12,"nctId":667,"briefTitle":668,"officialTitle":668,"acronym":669,"eligibilityCriteria":670,"healthyVolunteers":12,"sex":19,"minAge":671,"maxAge":4,"enrollmentInfo":672,"targetDuration":4,"studyType":24,"phases":674,"briefSummary":675,"conditions":676,"keywords":678,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":681,"lastUpdatePostDateStruct":682,"startDateStruct":684,"completionDateStruct":686,"leadSponsor":688,"locationsCount":91},"100644894","sage-heart--senior-assessment-fragility-and-post-operative-qalys-1-year-after-emergency-heart-surgery-for-patients-aged-75-and-older-100644894","NCT07677319","SAGE-Heart : Senior Assessment fraGility and Post-opErative QALYs 1 Year After Emergency HEART Surgery for Patients Aged 75 and Older","SAGE-Heart","Inclusion Criteria:\n\n* Patients aged ≥ 75 years who are affiliated with or beneficiaries of a social security scheme and undergoing emergency cardiac surgery under cardiopulmonary bypass, either immediate or urgent (relative) :\n\n  * Immediate emergency surgery: intervention performed before the start of the next working day following the decision to operate,\n  * Urgent (relative) emergency surgery: patients not admitted electively for surgery but requiring an intervention during the current hospital stay for medical reasons, and who cannot be discharged without undergoing a definitive procedure\n\nExclusion Criteria:\n\n* Patients requiring preoperative cardiopulmonary resuscitation\n* Scheduled (elective) surgery\n* Lack of informed consent\n* Impaired consciousness at the time of inclusion (defined by a Glasgow Coma Scale score \\\u003C 15)\n* Individuals under legal guardianship or judicial protection\n* Individuals participating in another interventional research protocol","75 Years",{"count":673,"type":23},265,[26],"The hypothesis is that the preoperative Clinical Frailty Score (CFS) is a predictive factor for a loss in quality-adjusted life years (QALYs) one year after emergency cardiac surgery under cardiopulmonary bypass (CPB) in patients aged 75 years and older.",[29,612,677],"QALYs",[29,537,612,679,677,187,680],"Cardio-pulmonary Bypass","EuroQol, postoperative","2026-06-29",{"date":683,"type":46},"2026-06-30",{"date":685,"type":46},"2025-12-03",{"date":687,"type":23},"2028-12-03",{"name":689,"class":53},"University Hospital, Bordeaux",{"id":691,"slug":692,"hasResults":12,"nctId":693,"briefTitle":694,"officialTitle":695,"acronym":4,"eligibilityCriteria":696,"healthyVolunteers":12,"sex":19,"minAge":122,"maxAge":4,"enrollmentInfo":697,"targetDuration":4,"studyType":24,"phases":699,"briefSummary":700,"conditions":701,"keywords":4,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":681,"lastUpdatePostDateStruct":702,"startDateStruct":703,"completionDateStruct":704,"leadSponsor":706,"locationsCount":91},"100514366","perioperative-prehabilitation-on-markers-of-fitness-and-frailty-in-patients-undergoing-elective-surgery-100514366","NCT05977556","Perioperative Prehabilitation on Markers of Fitness and Frailty in Patients Undergoing Elective Surgery","The Effect of Perioperative Prehabilitation on Markers of Fitness and Frailty in Patients Undergoing Elective Surgery: a Pilot, Pragmatic, Randomized Controlled Trial","Inclusion Criteria:\n\n* 50 years of age or older\n* score of 4-6 (vulnerable, mildly or moderately frail) on the clinical frailty scale (CFS)\n* scheduled for elective surgery\n* ambulatory (indoor and\u002For outdoor) with or without gait aids\n\nExclusion Criteria:\n\n* Unstable medical conditions that limit exercise tolerance such as ME\u002FCFS",{"count":698,"type":23},50,[26],"A growing body of evidence suggests that patients who receive good perioperative care (i.e. care prior to surgery, during surgery, and after surgery) tend to have fewer complications, quicker recovery times, and shorter hospital stays. A key component of good perioperative care is recognizing individuals who have diminished physiological reserves (i.e. those who are vulnerable or frail). The stress of an invasive procedure can exhaust the diminished reserves of patients who are frail, which can in turn lead to perioperative complications, mortality and an increase burden to the healthcare system.\n\nEarly interventions in patients with diminished reserves can be applied to reduce the risk of complications and poor outcomes. There are emerging studies that show promising benefits of perioperative interventions, such as prehabilitation, though with some mixed findings. Exercise has been shown to reverse or modify the molecular driving factors of frailty, which involve dysregulation of cytokine and endocrine pathways.\n\nPhysical inactivity and prolonged sedentary behaviors are also emerging concerns in frailty because of the implicated deleterious health effects. Sedentary behaviors are associated with prevalence and severity of frailty. Among pre-frail and frail inactive adults, sedentary time is associated with higher mortality. Increasing physical activity is recommended as the most feasible approach to prevent and treat frailty. The aim of this study is to determine if a prehabilitation intervention that combines neuromuscular strength training and intervention to reduce sedentary behavior reduces complications, length of stay, and patient recovery, thereby also reducing the burden on the healthcare system.",[29],{"date":190,"type":46},{"date":311,"type":23},{"date":705,"type":23},"2028-06",{"name":707,"class":53},"University of Alberta",{"id":709,"slug":710,"hasResults":12,"nctId":711,"briefTitle":712,"officialTitle":713,"acronym":714,"eligibilityCriteria":715,"healthyVolunteers":18,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":716,"targetDuration":4,"studyType":65,"phases":4,"briefSummary":717,"conditions":718,"keywords":4,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":722,"lastUpdatePostDateStruct":723,"startDateStruct":724,"completionDateStruct":726,"leadSponsor":728,"locationsCount":91},"100433358","impact-of-auditory-stimulation-in-eating-pleasure-edere-2021-100433358","NCT04923087","Impact of Auditory Stimulation in Eating Pleasure (EDERE 2021)","Impact of Auditory Stimulation in Eating Pleasure : Multicentric Study With Biscuits With Crunchy Texture vs Soft Texture in 100 Seniors Affected or at Risk of Presbyacusis","EDERE 2021","Inclusion Criteria:\n\nSubjects 65 years of age or older, hospitalized in geriatrics or EHPAD residents.\n\nExclusion Criteria:\n\nrisk of false route when eating cookies, allergy to an ingredient in cookies",{"count":22,"type":23},"Background. Decreased taste and smell contribute to loss of appetite (anorexia), and the resulting protein-energy malnutrition increases the frailty of the elderly. The risk of falls, disability, infections and depression often requires them to be institutionalized. Elderly, undernourished and toothless patients often complain about the monotony of a soft, mixed-texture diet. In a previous study, some participants highlighted the pleasure of crunching cookies that have a solid texture that can be eaten in any dental condition. However, the age-related decrease in hearing (presbyacusis) is frequent and progressive from the age of 60. The hypothesis of this work is that older patients may perceive a crunchy food crunching in their mouth, despite presbycusis. If the hypothesis is verified, this would make geriatric caregivers aware of the possibility of diversifying the texture of food, in order to stimulate the pleasure of eating and increase the dietary intake in this population of patients who are often undernourished, dysphagic, edentulous and hearing impaired. The originality of this study is to share the expertise of geriatricians and specialists in mastication\u002Fswallowing (dental surgeon, speech-language pathologist), hearing (ENT doctor, hearing care professional) and nutrition (dietician).\n\nType of study. Type of study MR-004 \"Research not involving the human person\". Protocol. Compare the noise and pleasure of crunching between two hyperprotein nutritional supplements: a soft filled cookie (Nutra Cake™, Délical, France) and a crunchy cookie of the Breton type (Protibis™, Solidages, France). Blind study impossible: each subject will eat a cookie then the other in a random order and will be his own control. The tests will be performed without the possible hearing aids, but with or without the dentures according to the patient's preference. Indeed, some patients have dental prostheses that are no longer suitable for chewing, and that they wear only for aesthetics. Objective. Validate the evaluation criteria \"Do you hear the biscuit crunch?\" and \"Is it a pleasure?\" If so, encourage diversification with crunchy foods with a suitable texture, as well as dental and prosthetic rehabilitation of dependent elderly people.",[29,71,719,720,721],"Anorexia","Presbycusis","Edentulism Nos","2026-06-25",{"date":681,"type":46},{"date":725,"type":46},"2021-06-01",{"date":727,"type":23},"2027-06-25",{"name":729,"class":53},"Centre Hospitalier Universitaire de Nice"]