[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"gait-impairment-following-orthopedic-surgery\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:gait-impairment-following-orthopedic-surgery":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":5},"100649645","zepu-ai5-strength-training-study-zepuai5rct-100649645",false,"NCT07735702","ZEPU-AI5 Strength Training Study (ZEPUAI5RCT)","Safety, Feasibility and Efficacy of ZEPU AI5 Lower Limb Muscle Strength Training and Evaluation Robot","Inclusion Criteria:\n\n* Lower-limb motor dysfunction due to one of the following: (a) stroke (onset 2-24 months), (b) incomplete spinal cord injury (neurological level T12 or below, ASIA Impairment Scale C or D), or (c) orthopedic surgery (e.g., knee\u002Fhip replacement) with persistent gait impairment more than 3 months post-surgery\n* Age greater than 18 years and up to 60 years\n* Medically stable and able to provide informed consent\n* Able to meet device anthropometric criteria for use of the ZEPU-AI5 system\n\nExclusion Criteria:\n\n* Complete spinal cord injury with inability to bear any weight\n* Severe cognitive impairment (Mini-Mental State Examination score less than 24) preventing safe participation\n* Severe spasticity of the lower limbs (Modified Ashworth Scale greater than 3)\n* Unstable fractures, severe hip\u002Fknee contractures (greater than 30 degrees fixed flexion), or severe osteoarthritis requiring imminent surgery\n* Uncontrolled cardiac arrhythmia, pacemaker incompatibility, or any implanted electronic device incompatible with the robot's sensors\n* Pregnancy","ALL","18 Years","60 Years",{"count":20,"type":21},36,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to learn if robot-assisted lower-limb strength and gait training can improve safety, feasibility, and functional recovery in adults aged 18-60 years with lower-limb motor dysfunction due to stroke, incomplete spinal cord injury, or persistent gait impairment following orthopedic surgery. The main questions it aims to answer are:\n\nIs robot-assisted training using the ZEPU-AI5 device safe and well-tolerated, with an acceptable rate of device-related adverse events? Does adding ZEPU-AI5-assisted training to standard-of-care rehabilitation improve functional outcomes (such as walking distance, muscle strength, balance, and mobility) compared to standard-of-care rehabilitation alone?\n\nResearchers will compare an intervention group receiving standard-of-care rehabilitation combined with ZEPU-AI5-assisted training to a control group receiving standard-of-care rehabilitation alone, to see if the addition of robotic training leads to greater improvements in safety, functional recovery, and quality of life.\n\nParticipants will:\n\nUndergo a baseline assessment before starting the study Receive either robot-assisted training plus standard-of-care rehabilitation, or standard-of-care rehabilitation alone, three times per week for 12 weeks Complete follow-up assessments every two weeks to evaluate safety, functional outcomes, and durability of any benefits",[27,28,29],"Stroke","Incomplete Spinal Cord Injury","Gait Impairment Following Orthopedic Surgery",[31,32,33],"Robotic Rehabilitation","Neurorehabilitation","Muscle Strength","NOT_YET_RECRUITING","2026-07-29",{"date":37,"type":38},"2026-07-31","ACTUAL",{"date":40,"type":21},"2026-07",{"date":42,"type":21},"2026-11",{"name":44,"class":45},"Bangladesh Medical University","OTHER"]