[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"gaming-performance\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:gaming-performance":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":5},"100650853","investigation-on-the-chronic-effects-of-nepalese-pepper-zanthoxylum-armatum-dc-on-cognitive-function-mood-and-gaming-performance-in-young-healthy-action-video-gamers-100650853",false,"NCT07752329","Investigation on the Chronic Effects of Nepalese Pepper (Zanthoxylum Armatum DC) on Cognitive Function, Mood and Gaming Performance in Young, Healthy, Action Video Gamers","Inclusion Criteria:\n\n* Aged 16 to 39 years inclusive\n* Males and females\n* Self-report of good health\n* Usually a regular (at least 5 hours per week on average) player of action video games, including but not limited to First-Person Shooters (FPS) and Massive Online Battle Arenas (MOBA), (prospective participants will be asked to contact the researchers to discuss their gaming habits if uncertain that they meet the criteria).\n\nExclusion Criteria:\n\n* Have any pre-existing medical condition\u002Fillness which will impact taking part in the study (i.e. participants may be allowed to progress to screening if they have a condition\u002Fillness which would not interact with the active treatments or impede performance).\n* Are currently taking prescription medications. NOTE: the explicit exceptions to this are contraceptive treatments for female participants, and those taken 'as needed' in the treatment of asthma and hay fever. There may be other instances of medication use which, where no interaction with the active treatments is likely, and which would not be expected to have any impact on brain function, participants may be able to progress to screening.\n* Have high blood pressure (systolic over 139 mm Hg or diastolic over 89 mm Hg); or have low blood pressure (systolic below 90 mm Hg or diastolic below 60 mm Hg)\n* Have a Body Mass Index (BMI) outside of the range 18.5-35 kg\u002Fm2\n* Are pregnant, seeking to become pregnant or lactating\n* Have learning and\u002For behavioural diagnoses such as dyslexia or ADHD\n* Have a visual impairment that cannot be corrected with glasses or contact lenses (including colour-blindness)\n* Smoke tobacco or vape nicotine or use nicotine replacement products\n* Excessive caffeine intake (\\> 500 mg per day). If participants consume energy drinks they will be asked to refrain from this for 24 hours prior to attending testing.\n* Have relevant food intolerances\u002Fsensitivities.\n* Have taken antibiotics within the past 4 weeks\n* Have taken dietary supplements e.g. Vitamins, omega 3 fish oils etc. in the last 4 weeks (Note: participation is possible following a 4-week supplement washout prior to participating and for the duration of the study on the proviso that the supplements taken are out of choice and not medically prescribed or advised)\n* Have any health condition that would prevent fulfilment of the study requirements (this includes non-diagnosed conditions for which no medication may be taken)\n* Are unable to complete all of the study assessments\n* Are currently participating in other clinical or nutrition intervention studies, or have done so in the past 4 weeks\n* Has been diagnosed with\u002F undergoing treatment for alcohol or drug abuse in the last 12 months\n* Have been diagnosed with\u002F undergoing treatment for a psychiatric disorder in the last 12 months\n* Suffers from frequent migraines that require medication (more than or equal to 1 per month)\n* Sleep disorders or are taking sleep aid medication\n* Any known active infections\n* Are non-compliant with regards treatment consumption",true,"ALL","16 Years","39 Years",{"count":20,"type":21},70,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to learn if daily supplementation with a Nepalese Pepper Extract (Zanthoxylum Armatum, ZA) can improve cognitive performance and gaming performance in action video gamers aged 16 to 39, when taken over an extended period. The main questions it aims to answer are:\n\nDoes chronic (42-day) daily ZA supplementation improve speed of cognitive performance and reduce subjective mental fatigue? Do these effects translate into objective and self-reported improvements in gaming performance? Are there additional acute (within-session) effects at the end of a chronic supplementation period, on top of any chronic effect?\n\nResearchers will compare 275mg daily ZA supplementation to placebo to see if chronic ZA produces better cognitive performance and lower fatigue than placebo. Participants will:\n\nComplete a screening call and a training visit on the computerised cognitive tasks and gaming tasks Take a daily capsule (either ZA or placebo, depending on treatment order) each morning with food for 42 days, then switch to the other treatment for a further 42 days after a 2-week washout Attend four testing visits at the research centre: a baseline and an endpoint visit for each 42-day treatment period Avoid alcohol and energy drinks for 24 hours before each testing visit, and caffeine from waking Complete cognitive tests before dosing and 1 hour after dosing at each testing visit Complete mood and sleep questionnaires Wear a heart rate monitor at rest on arrival at each visit Complete gaming-specific tasks (aim training, MOBA character control, multi-tasking, finger tapping, Fitts' Law, multiple object tracking, collision prediction) Play their action video game of choice at home throughout each 42-day period and complete performance questionnaires",[27,28,29,30],"Cognition","Mood","Gaming Performance","Fatigue",[27,28,32,33,34,35,36,37,30,38],"Gaming","Performance","Esports","Nepalese Pepper","Timut Pepper","Zanthoxylum Armatum","Chronic Supplementation","NOT_YET_RECRUITING","2026-08-03",{"date":42,"type":43},"2026-08-07","ACTUAL",{"date":45,"type":21},"2026-08-20",{"date":47,"type":21},"2027-09",{"name":49,"class":50},"Northumbria University","OTHER"]