[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"gamma-oscillations\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:gamma-oscillations":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,51],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100646521","investigating-the-effectiveness-of-personalized-optimal-gamma-auditory-frequency-stimulation-intervention-on-cognitive-function-enhancement-100646521",false,"NCT07690865","Investigating the Effectiveness of Personalized Optimal Gamma Auditory Frequency Stimulation Intervention on Cognitive Function Enhancement","Investigating the Effectiveness of Personalized Optimal Gamma Auditory Frequency Stimulation Intervention on Cognitive Function Enhancement: An Intervention Study","Inclusion Criteria:\n\n1. Age between 18 to 40 years old.\n2. The Cognitive Abilities Screening Instrument (CASI) score is within normal ranges adjusted for age and education.\n3. Participants have no history of severe neurological or psychiatric disorders (such as stroke, epilepsy, depression, migraine, etc.) that could affect cognitive function.\n4. Participants have not used drugs that may affect cognitive function (e.g., benzodiazepines, anticholinergic medications, etc.).\n5. Participants with normal or corrected vision (e.g., glasses or contact lenses) to normal levels.\n6. Auditory stimuli induce significant neural entrainment.\n7. Self-reported normal hearing\n\nExclusion Criteria:\n\n1. Participants enrolled in any cognitive enhancement study within the past two months.\n2. Participants with a history of disease that could affect cognitive function (e.g., cancer, autoimmune diseases, etc.).\n3. Individuals with tinnitus or hyperacusis",true,"ALL","18 Years","40 Years",{"count":21,"type":22},20,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study aims to evaluate whether personalized gamma-frequency auditory stimulation enhances cognitive function and brain synchronization. While 40 Hz auditory stimulation has been widely studied, recent evidence suggests optimal frequencies vary by individual. Using a cross-over design with 20 healthy adults, the research compares \"optimal\" versus \"non-optimal\" frequencies over one-month intervention periods. Effectiveness is measured through EEG recordings and executive function tasks. The goal is to determine if personalized sensory intervention provides a more effective, non-invasive strategy for enhancing cognitive performance.",[28,29,30,31],"Gamma Oscillations","Healthy Adults","Alzheimer's Disease (AD)","Gamma Entrainment Using Sensory Stimuli (GENUS)",[33,34,35,36,37],"Gamma stimulation","Alzheimer's disease","EEG","cognitive function","intervention","NOT_YET_RECRUITING","2026-07-15",{"date":41,"type":42},"2026-07-16","ACTUAL",{"date":44,"type":22},"2026-08",{"date":46,"type":22},"2027-12",{"name":48,"class":49},"Chang Gung Memorial Hospital","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":59,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":61,"conditions":62,"keywords":75,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":4},"100629619","non-invasive-detection-and-preservation-of-neurocognitive-signals-in-the-peri-death-period-using-brain-computer-interface-and-artificial-intelligence-100629619","NCT07477028","Non-Invasive Detection and Preservation of Neurocognitive Signals in the Peri-Death Period Using Brain-Computer Interface and Artificial Intelligence","Feasibility of Non-Invasive Detection and Preservation of Neurocognitive Signals in the Peri-Death Period Using Brain-Computer Interface and Artificial Intelligence: A Prospective Observational Study (NeuroCogPresv)","NeuroCogPresv","Inclusion Criteria:\n\n1. Adults ≥18 years with terminal illness or severe acute trauma\n2. Do-not-resuscitate (DNR\u002FDNI) order in place\n3. Surrogate decision-maker available and willing to provide informed consent\n4. Expected survival ≤7 days (physician estimate)\n\nExclusion Criteria:\n\n1. Brain death already declared \\> 24 hours prior to enrollment\n2. Contraindication to EEG\u002FBCI headset placement (e.g., severe scalp injury)\n3. Patient lacks a legally authorized representative",{"count":21,"type":22},"OBSERVATIONAL","Background: Recent electroencephalography (EEG) data indicate that the transition from clinical death to cellular death is marked by highly organized neurophysiological events, including significant surges in gamma-band power, cross-frequency coupling, and distinct spreading depolarization waves. This prospective, observational feasibility study utilizes rapid-deployment, high-density, noninvasive BCI hardware paired with proprietary AI analytics to detect, classify, and securely archive these terminal neurocognitive signals.\n\nObjectives: (1) Quantify transient gamma-band activity and cross-frequency connectivity post-clinical death; (2) Validate the efficacy of machine learning models for real-time signal classification in high-noise clinical environments; (3) Establish a highly secure, encrypted bio-informational archive of peri-life EEG data.\n\nDesign: Prospective, open-label, multicenter, observational cohort (n\\>20).",[63,64,65,66,67,68,69,28,70,71,72,73,35,74],"Terminal Illness","End-of-Life Care","Death","Brain Death","Death Anxiety","Consciousness","Electroencephalography","Near-Death Phenomena","Cognitive","Cognition","Memory","Severe Acute Trauma",[76,77,78,65,28,72,68,79,80,81,73,82,83,84,85],"AI","BCI","Brain Computer Interface","Pefi-death","Brain death","Reservation","Life","Life experience","Transfer","Convergence","2026-03-12",{"date":88,"type":42},"2026-03-17",{"date":90,"type":22},"2026-09-01",{"date":92,"type":22},"2035-09-30",{"name":94,"class":95},"Noah Tech, Corp.","INDUSTRY"]