[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"gastroenteritis-acute\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:gastroenteritis-acute":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,44,78],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":27,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100645737","antimicrobial-stewardship-effects-of-interpretive-comments-for-faecal-pcr-tests-100645737",false,"NCT07701135","Antimicrobial Stewardship Effects of Interpretive Comments for Faecal PCR Tests","Inclusion Criteria:\n\n* Age over six months\n* Stool sample submitted to Awanui Labs for faecal bacterial pathogen testing from a community health provider during the study period\n* Test results report the detection of: Campylobacter spp, Shigella spp\u002FEntero-invasive Escherichia coli, Salmonella spp, Yersinia spp, or Aeromonas spp.\n\nExclusion Criteria:\n\n* Samples where only Clostridioides difficile or Helicobacter pylori testing has been requested will be excluded\n* Samples sent for Public Health testing (e.g. testing for clearance of Salmonella spp) will be excluded.","ALL","6 Months",{"count":18,"type":19},10000,"ESTIMATED","INTERVENTIONAL",[22],"NA","Bacterial gastroenteritis is a common condition seen in Aotearoa New Zealand, which is typically diagnosed by PCR testing on a stool sample. Most causes of bacterial gastroenteritis (e.g. Campylobacter spp, Salmonella spp, Yersinia spp) cause a self-limiting illness and antibiotic therapy is not required. Indeed, guidelines available for community healthcare providers in Aotearoa (e.g. Community HealthPathways, recently released national antimicrobial guidelines Te Whata Kura) recommend against antibiotic therapy for the vast majority of cases.\n\nA recent internal analysis at Awanui Laboratories of community faecal pathogen PCR testing revealed that antibiotic prescribing was very common after a positive result (ranging between 20-40% for the various individual pathogens), which suggests many community healthcare providers may not be following the recommended approach for the management of these infections. Given how common infectious gastroenteritis is in Aotearoa, and the volume of tests performed (approximately 100,000 through the Awanui network per year), this prescribing behaviour may represent a large volume of unnecessary antibiotic use in our communities, with resultant potential harmful effects at the individual patient level and population level via side effects, disruption to the faecal microbiome, and impacts on antimicrobial resistance (AMR).\n\nIn previous work we have demonstrated that interpretive comments, when added to laboratory reports, can have a significant positive effect on prescriber behaviour (https:\u002F\u002Fdoi.org\u002F10.1093\u002Fjac\u002Fdkad384), but this has not been examined in relation to faecal pathogen testing.",[25,26],"Gastroenteritis Acute","Diagnostic Communication",[28,29,30],"Bacterial gastroenteritis","Laboratory diagnosis","Antimicrobial stewardship","RECRUITING","2026-07-08",{"date":34,"type":35},"2026-07-14","ACTUAL",{"date":37,"type":35},"2026-06-02",{"date":39,"type":19},"2027-09-17",{"name":41,"class":42},"Medical Research Institute of New Zealand","OTHER",4,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":54,"phases":4,"briefSummary":55,"conditions":56,"keywords":61,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":77},"100640255","balanced-crystalloid-vs-normal-saline-in-pediatric-acute-gastroenteritis-100640255","NCT07610382","Balanced Crystalloid vs Normal Saline in Pediatric Acute Gastroenteritis","Comparison of Early Biochemical and Clinical Outcomes of Balanced Versus Unbalanced Isotonic Crystalloid in Children Aged 6 Months to 5 Years Who Require Intravenous Rehydration for Acute Gastroenteritis: A Single-Center Prospective Observational Cohort Study","Inclusion Criteria:\n\n* Age: 6 months to 5 years (60 months) inclusive\n* Clinical diagnosis of acute gastroenteritis: acute diarrhoea (3 or more loose stools per 24 hours) with or without vomiting; symptom duration 7 days or less\n* Clinician-initiated indication for intravenous rehydration\n* IV fluid order placed and treatment initiated independently by the treating physician, without research team influence\n\nExclusion Criteria:\n\n* Chronic systemic disease (congenital heart disease, chronic kidney disease, chronic lung disease, inborn errors of metabolism, primary immunodeficiency)\n* Hypernatraemic dehydration (serum sodium \\>= 150 mEq\u002FL at baseline)\n* Diabetic ketoacidosis, primary metabolic crisis, or suspected surgical abdomen\n* Bloody diarrhoea or suspected invasive enteric infection requiring alternative management algorithm\n* Hypoglycaemia (blood glucose \\\u003C 60 mg\u002FdL) at presentation\n* Symptom duration exceeding 7 days\n* Receipt of 20 mL\u002Fkg or more of IV fluid in the 24 hours preceding enrolment","5 Years",{"count":53,"type":19},180,"OBSERVATIONAL","Acute gastroenteritis (AGE) is among the most common reasons for paediatric emergency visits. Children with significant dehydration often require intravenous (IV) fluid therapy. Two main types of IV crystalloid solutions are currently used in clinical practice: 0.9% sodium chloride (normal saline, NS) and balanced crystalloids such as Isolyte-S, which contain acetate and gluconate as bicarbonate precursors.\n\nNormal saline has a high chloride content (154 mEq\u002FL), which may worsen the metabolic acidosis already present in many children with acute gastroenteritis. Balanced crystalloids have a chloride content closer to that of plasma (98 mEq\u002FL) and additionally contain acetate and gluconate, which are metabolised in peripheral tissues to consume hydrogen ions and thereby raise serum bicarbonate - a mechanism distinct from simply avoiding chloride overload.\n\nThis study prospectively observes and compares early biochemical and clinical outcomes in children with acute gastroenteritis who receive one of these two fluid types as part of their routine clinical care. The treating physician independently decides which fluid to use; the research team does not influence this decision and does not order any additional tests or procedures. Laboratory values used as outcomes are drawn solely from blood tests obtained as part of standard care.\n\nThe primary aim is to determine whether, at approximately 4 hours after IV fluid start, serum bicarbonate has changed more in children who received a balanced crystalloid compared with those who received normal saline. Secondary aims include comparing blood pH, chloride levels, need for additional IV boluses, time to first oral fluid intake, hospitalisation rate, and 72-hour return visits.",[25,57,58,59,60],"Dehydration","Acidosis, Metabolic","Diarrhea","Vomiting",[62,63,64,65,66,67,57],"balanced crystalloid","normal saline","bicarbonate","metabolic acidosis","pediatric emergency","Acute Gastroenteritis","2026-05-22",{"date":70,"type":35},"2026-05-28",{"date":72,"type":35},"2026-05-15",{"date":74,"type":19},"2027-03",{"name":76,"class":42},"Aydin Adnan Menderes University",1,{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":84,"eligibilityCriteria":85,"healthyVolunteers":11,"sex":15,"minAge":4,"maxAge":86,"enrollmentInfo":87,"targetDuration":4,"studyType":20,"phases":89,"briefSummary":90,"conditions":91,"keywords":95,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":4},"100614517","diagnostic-pcr-panel-in-children-with-acute-gastrointestinal-symptoms-100614517","NCT07280624","Diagnostic PCR Panel in Children With Acute Gastrointestinal Symptoms","Clinical Significance of Real Time PCR Panel in Children With Acute Gastrointestinal Symptoms","RealCAGI RCT","Inclusion Criteria:\n\n* Child or adolescent \\\u003C 16 years of age\n* Visiting pediatric ED\n* Presence of gastrointestinal symptom or symptoms (diarrhea, vomiting or abdominal pain)\n\nExclusion Criteria:\n\n* Need of cardiopulmonary resuscitation at the ED\n* Need of immediate transfer to the intensive care unit\n* Hemato-oncological disease\n* Severe immunosuppression\n* Bloody diarrhea\n* Clinical suspicion of typhoid\u002Fparatyphoid fever","16 Years",{"count":88,"type":19},526,[22],"This investigator-initiated randomized controlled trial compares the clinical impact of real time PCR of fecal samples in children with acute gastrointestinal symptoms at a pediatric emergency room. Specifically, the trial compares immediate testing of fecal samples using a multiplex PCR panel to a a control group with delayed test results.",[25,92,93,94],"Gastrointestinal Symptoms","Abdominal Pain\u002F Discomfort","Vomiting in Infants and\u002For Children",[96,97,98,59,60,99,100,101,102,103],"Multiplex PCR","Fecal samples","Diagnostic stewardship","Abdominal pain","Gastrointestinal symptoms","Pediatrics","Children","Emergency department","NOT_YET_RECRUITING","2025-12-09",{"date":107,"type":35},"2025-12-12",{"date":109,"type":19},"2025-12-15",{"date":111,"type":19},"2028-02-15",{"name":113,"class":42},"University of Oulu"]