[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"gastroesophageal-varices\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:gastroesophageal-varices":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,45],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":29,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100624139","cirrhotic-and-non-cirrhotic-patients-with-clinically-significant-portal-hypertension-100624139",false,"NCT07405749","Cirrhotic and Non-cirrhotic Patients With Clinically Significant Portal Hypertension","Incidence and Predictive Factors of Elective Procedure-Related Bleeding in Cirrhotic and Non-Cirrhotic Patients With Clinically Significant Portal Hypertension","PREDIBLEED","Inclusion Criteria:\n\n* Age \\> 18 years;\n* Ability to provide informed consent;\n* Specific signs of CSPH (gastroesophageal varices, porto-systemic collaterals, liver stiffness measurement (LSM) \\> 25 KPa or spleen stiffness measurement (SSM) \\> 50 KPa);\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years;\n* Life expectancy \\\u003C 6 months;\n* Patients unable to sign informed consent.","ALL","18 Years",{"count":20,"type":21},2500,"ESTIMATED","OBSERVATIONAL","Alterations in conventional coagulation tests in patients with cirrhosis and\u002For portal hypertension do not reliably predict bleeding risk, as hemostatic balance is complex and often compensated. Many procedure-related bleeding events are driven by non-coagulatory factors, such as portal hypertension or technical aspects of the procedure. Most commonly performed procedures carry a low risk of bleeding even in the presence of elevated INR or thrombocytopenia, and no validated laboratory thresholds support prophylactic correction. Risk assessment should therefore be based on procedural factors, severity of liver disease, and systemic patient conditions, with correction of modifiable risk factors particularly before high-risk elective procedures.",[25,26,27,28],"Cirrhosis, Liver","Portal Hypertension","Clinically Significant Portal Hypertension(CSPH)","Gastroesophageal Varices",[30,31],"Thrombotic events","porto-systemic collaterals","NOT_YET_RECRUITING","2026-02-05",{"date":35,"type":36},"2026-02-12","ACTUAL",{"date":38,"type":21},"2026-02",{"date":40,"type":21},"2030-02",{"name":42,"class":43},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":55,"conditions":56,"keywords":58,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":4},"100602894","feasibility-and-safety-evaluation-of-endoscopic-treatment-of-esophagogastric-varices-in-cirrhosis-on-the-day-care-unit-100602894","NCT07129447","Feasibility and Safety Evaluation of Endoscopic Treatment of Esophagogastric Varices in Cirrhosis on the Day-care Unit","Feasibility and Safety Assessment of Endoscopic Treatment of Esophagogastric Variceal Bleeding in Cirrhosis on the Day Unit: a Single-centre, Prospective-historical Controlled Study","Inclusion Criteria:\n\n1. aged 18-75 years;\n2. diagnosis of cirrhosis and portal hypertension by clinical manifestations, laboratory tests, imaging tests and histologic examinations;\n3. gastroscopic grading of esophagogastric varices as moderate or severe;\n4. no ruptured esophagogastric varices bleeding in the last 5 days;\n5. endoscopic treatment of esophagogastric varices during hospitalization.\n\nExclusion Criteria:\n\n1. first endoscopic treatment of esophagogastric varices;\n2. this is an acute esophagogastric variceal rupture and bleeding;\n3. previous TIPS or liver transplantation;\n4. isolated fundal varices or ectopic varices;\n5. primary hepatocellular carcinoma or acute or chronic hepatic failure, Child-pugh class C, hepatic encephalopathy stage 2 or higher;\n6. spontaneous abnormally large shunts, uncontrolled infections and sepsis, uncontrolled hypertension;\n7. combined cardiac, pulmonary, cerebral, renal and other serious complications or other reasons for not being able to tolerate the examination;\n8. pregnant women and lactating women;\n9. failure to sign the informed consent or refusal to participate.","75 Years",{"count":54,"type":21},330,"The goal of this observational study is to learn about the feasibility and safety evaluation of endoscopic treatment of esophagogastric varices in cirrhosis on the day-care ward. The main question it aims to answer is:\n\nIs inpatient endoscopic treatment on day wards also feasible and safe for patients with esophagogastric variceal bleeding in cirrhosis when compared to inpatient endoscopy on a general ward? Participants undergoing inpatient endoscopic treatment for cirrhotic esophagogastric variceal bleeding on day wards and general wards will answer online survey questions about their postoperative period over a 1-year period.",[57,28],"Liver Cirrhosis",[59,60,61,62,63],"Esophagogastric variceal bleeding","Liver cirrhosis","Endoscopic therapy","Day ward","Variceal rebleeding","2025-08-11",{"date":66,"type":36},"2025-08-19",{"date":68,"type":21},"2025-09-01",{"date":70,"type":21},"2029-12-30",{"name":72,"class":43},"Qilu Hospital of Shandong University"]