[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"general-anesthesia-induced-altered-consciousness\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:general-anesthesia-induced-altered-consciousness":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":5},"100657188","phase-4-brain-activity-and-changes-in-consciousness-during-general-anesthesia-100657188",false,"NCT07836205","Brain Activity and Changes in Consciousness During General Anesthesia","Mechanism Exploration of General Anesthesia-Induced Altered Consciousness Via Cortical-Thalamic Network Modulation and Development of a Precision Anesthesia Depth Monitoring Device","Inclusion Criteria:\n\n1. Participants must belong to one of the following prespecified age groups: children aged 6-12 years, young adults aged 20-40 years, or older adults aged 65-80 years.\n2. Children must be surgical patients undergoing general anesthesia. Young adult and older adult participants will be healthy volunteers.\n3. American Society of Anesthesiologists (ASA) physical status I; older adult participants may have ASA physical status II.\n4. Written informed consent must be obtained from all adult participants and surgical patients as applicable. For pediatric participants, written informed consent must be provided by a parent or legal guardian.\n\nExclusion Criteria:\n\n1. History of neuropsychiatric disorders, including epilepsy, dementia, or other relevant neurological or psychiatric diseases.\n2. Known hearing impairment or physical impairment that may interfere with completion of the study procedures or tasks.\n3. History of allergy to propofol, benzodiazepines, or other anesthetic agents used in the study.\n4. Long-term use of sedative or analgesic medications for more than 1 month. Disturbed sleep pattern within 14 days before the study, including shift work or insomnia.\n5. Communication difficulties or inability to cooperate with EEG data acquisition.",true,"ALL","6 Years","80 Years",{"count":21,"type":22},320,"ESTIMATED","INTERVENTIONAL",[25],"PHASE4","This study aims to investigate how general anesthetics alter brain activity and consciousness across different age groups. The study will evaluate four anesthetic agents with different mechanisms of action: propofol, remimazolam, esketamine, and dexmedetomidine. Electroencephalography (EEG) will be recorded during wakefulness, anesthetic induction, loss of responsiveness, and recovery of responsiveness to characterize changes in brain activity and brain network dynamics.\n\nThe study includes children aged 6-12 years undergoing surgery, healthy young adults aged 20-40 years, and healthy older adults aged 65-80 years. Resting-state EEG will be used to examine changes in brain rhythms, temporal and spatial brain dynamics, and network organization across different levels of consciousness. In a subgroup of young adult participants, auditory stimuli will also be presented continuously to investigate how the brain processes sounds and meaningful information as consciousness decreases and subsequently recovers.\n\nThe study will compare EEG changes across anesthetic agents, age groups, and states of consciousness. It will also evaluate the timing of loss and recovery of responsiveness, anesthetic dose-response relationships, and adverse events. The overall goal is to identify brain activity patterns associated with anesthesia-induced changes in consciousness and to provide a scientific basis for improved monitoring of consciousness and anesthetic depth.",[28],"General Anesthesia-Induced Altered Consciousness","NOT_YET_RECRUITING","2026-09-19",{"date":32,"type":33},"2026-09-23","ACTUAL",{"date":35,"type":22},"2026-09",{"date":37,"type":22},"2028-12",{"name":39,"class":40},"Beijing Chao Yang Hospital","OTHER"]