[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"general-anesthesia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:general-anesthesia":32},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,46,0,25,[9,51,85,114,145,168,196,221,263,296,319,349,370,400,424,451,475,507,532,560,583,606,629,654,680],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":16,"eligibilityCriteria":17,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":33,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":4},"100634903","comparison-of-5-vs-8-cmho-peep-on-respiratory-mechanics-in-prone-lumbar-surgery-100634903",false,"NCT07545733","Comparison of 5 vs 8 cmH₂O PEEP on Respiratory Mechanics in Prone Lumbar Surgery","The Effect of Different PEEP Levels Accompanied by PCV-VG Mode on Respiratory Mechanics and Gas Exchange in Lumbar Surgeries Performed in the Prone Position Under TIVA","PROPEEP","Inclusion Criteria:\n\n* Patients aged between 18 and 65 years\n* American Society of Anesthesiologists (ASA) physical status I-II\n* Scheduled for elective lumbar spine surgery in the prone position\n* Planned general anesthesia with total intravenous anesthesia (TIVA)\n* Ability to provide informed consent\n\nExclusion Criteria:\n\n* Body mass index (BMI) ≥ 30 kg\u002Fm²\n* History of significant pulmonary disease (e.g., COPD, asthma)\n* Severe cardiovascular disease\n* Pregnancy\n* Known difficult airway\n* Requirement for intraoperative vasopressor infusion due to hemodynamic instability\n* Conversion to different surgical position or change in surgical plan\n* Incomplete data or protocol deviation","ALL","18 Years","65 Years",{"count":22,"type":23},60,"ESTIMATED","INTERVENTIONAL",[26],"NA","This randomized controlled clinical trial aims to compare the effects of two different positive end-expiratory pressure (PEEP) levels (5 cmH₂O and 8 cmH₂O) on respiratory mechanics in patients undergoing lumbar spine surgery in the prone position under total intravenous anesthesia (TIVA). Prone positioning may adversely affect lung compliance and gas exchange, making optimal ventilatory strategies essential. Driving pressure and mechanical power are considered key determinants of ventilator-induced lung stress. This study will evaluate the impact of different PEEP levels on respiratory parameters and intraoperative physiological changes.",[29,30,31,32],"Lumbar Disc Herniation","Spinal Surgery","Prone Position","General Anesthesia",[34,35,36,37,31,38],"PEEP","Driving Pressure","Mechanical Power","PCV-VG Ventilation","Lung Protective Ventilation","NOT_YET_RECRUITING","2026-08-10",{"date":42,"type":43},"2026-08-11","ACTUAL",{"date":45,"type":23},"2026-08-15",{"date":47,"type":23},"2026-10-03",{"name":49,"class":50},"Harran University","OTHER",{"id":52,"slug":53,"hasResults":12,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":4,"eligibilityCriteria":57,"healthyVolunteers":12,"sex":18,"minAge":20,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":61,"conditions":62,"keywords":66,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":84},"100650457","remimazolam-versus-midazolam-for-general-anesthesia-induction-in-elderly-patients-undergoing-non-cardiac-surgery-100650457","NCT07746505","Remimazolam Versus Midazolam for General Anesthesia Induction in Elderly Patients Undergoing Non-Cardiac Surgery","Effectiveness and Safety of Remimazolam Compared With Midazolam for General Anesthesia Induction in Elderly Patients Undergoing Non-Cardiac Surgery: A Prospective Observational Cohort Study","Inclusion Criteria:\n\n1. Age 65 years or older.\n2. Scheduled for elective non-cardiac surgery under general anesthesia.\n3. American Society of Anesthesiologists physical status I to IV.\n4. Planned airway management with tracheal intubation or a laryngeal mask airway.\n5. Written informed consent provided by the participant or the participant's legally authorized representative.\n\n   \\-\n\nExclusion Criteria:\n\n1. Long-term preoperative benzodiazepine use.\n2. Known allergy or contraindication to benzodiazepines, flumazenil, opioids, naloxone, or related drugs.\n3. History of drug abuse or alcoholism within the past 2 years.\n4. No preoperative cognitive assessment available.\n5. Preoperative cognitive impairment, defined as a Mini-Mental State 6.Examination score less than 18.\n\n7.Refusal to provide informed consent.\n\n\\-",{"count":59,"type":23},1000,"OBSERVATIONAL","This prospective observational cohort study evaluates the effectiveness and safety of two benzodiazepine sedatives-remimazolam and midazolam-used for general anesthesia induction in elderly patients (≥65 years) undergoing elective non-cardiac surgery. Elderly patients have reduced organ reserve and altered pharmacokinetics\u002Fpharmacodynamics, increasing their susceptibility to anesthesia-related complications such as intraoperative hypotension, delayed emergence, and postoperative delirium. Remimazolam, an ultra-short-acting benzodiazepine metabolized by organ-independent tissue esterases, is hypothesized to offer greater hemodynamic stability, faster recovery, and a more favorable safety profile than midazolam in this vulnerable population. Investigators prospectively observe and collect data without altering routine clinical care; the choice of sedative is made by the attending anesthesiologist according to standard practice. Propensity score methods will be used to reduce confounding by indication.",[32,63,64,65],"Aged","Intraoperative Hypotension","Anxiety",[67,68,69,70,71,72,73],"Remimazolam","Midazolam","Elderly","Non-cardiac surgery","Anesthesia induction","Hemodynamic stability","Quality of recovery","RECRUITING","2026-08-03",{"date":77,"type":43},"2026-08-05",{"date":79,"type":43},"2026-06-15",{"date":81,"type":23},"2027-07-15",{"name":83,"class":50},"Second Affiliated Hospital, Zhejiang University, School of Medicine",1,{"id":86,"slug":87,"hasResults":12,"nctId":88,"briefTitle":89,"officialTitle":90,"acronym":4,"eligibilityCriteria":91,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":92,"enrollmentInfo":93,"targetDuration":4,"studyType":24,"phases":95,"briefSummary":97,"conditions":98,"keywords":101,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":84},"100649728","phase-4-low-dose-versus-standard-dose-remimazolam-for-prevention-of-emergence-agitation-after-nasal-surgery-100649728","NCT07740655","Low-dose Versus Standard-dose Remimazolam for Prevention of Emergence Agitation After Nasal Surgery","Low-dose Versus Standard-dose Remimazolam for Prevention of Emergence Agitation After Nasal Surgery Under Sevoflurane Anesthesia: A Randomized Double-blind Non-inferiority Trial","Inclusion Criteria:\n\n* Adults aged 18 to 79 years.\n* Scheduled to undergo elective nasal surgery under sevoflurane-based general anesthesia at Jeju National University Hospital.\n* Able to provide written informed consent.\n\nExclusion Criteria:\n\n* Contraindications to remimazolam.\n* History of allergy or hypersensitivity to benzodiazepines.\n* Inability to provide informed consent due to cognitive impairment.\n* Preexisting psychiatric disorders.\n* History of alcohol or substance abuse.\n* Inability to assess the Riker Sedation-Agitation Scale (SAS).\n* Body mass index (BMI) \\> 40 kg\u002Fm².","79 Years",{"count":94,"type":23},138,[96],"PHASE4","Emergence agitation (EA) is a common complication during recovery from sevoflurane anesthesia, particularly after nasal surgery. Although remimazolam 0.1 mg\u002Fkg has been shown to reduce the incidence of EA, this dose may produce excessive sedation and increase the risk of intraoperative burst suppression.\n\nThis randomized, double-blind, non-inferiority trial will compare low-dose remimazolam (0.03 mg\u002Fkg) with the standard dose (0.1 mg\u002Fkg) administered at the end of surgery in adult patients undergoing nasal surgery under sevoflurane anesthesia. The primary objective is to determine whether low-dose remimazolam is non-inferior to the standard dose in preventing emergence agitation. Secondary outcomes include burst suppression, recovery profiles, and safety outcomes.",[99,32,100],"Emergence Agitation","Nasal Surgical Procedures",[67,102,103,104],"Emergence Agitation Sevoflurane","Nasal Surgery","Non-inferiority Trial","2026-07-28",{"date":107,"type":43},"2026-07-31",{"date":109,"type":23},"2026-07-24",{"date":111,"type":23},"2027-07-31",{"name":113,"class":50},"Jeju National University School of Medicine",{"id":115,"slug":116,"hasResults":12,"nctId":117,"briefTitle":118,"officialTitle":119,"acronym":4,"eligibilityCriteria":120,"healthyVolunteers":121,"sex":18,"minAge":19,"maxAge":122,"enrollmentInfo":123,"targetDuration":125,"studyType":60,"phases":4,"briefSummary":126,"conditions":127,"keywords":130,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":135,"lastUpdatePostDateStruct":136,"startDateStruct":138,"completionDateStruct":140,"leadSponsor":142,"locationsCount":4},"100607911","effect-of-operating-room-noise-on-bis-and-hemodynamics-under-general-anesthesia-100607911","NCT07194707","Effect of Operating Room Noise on BIS and Hemodynamics Under General Anesthesia","The Effect of Operating Room Environmental Noise on BIS and Hemodynamics in Patients Under General Anesthesia: A Prospective Observational Study","Inclusion Criteria:\n\n* Adults aged 18-70\n* ASA (American Society of Anesthesiologists) physical status score I-II\n* Scheduled for elective surgery\n* To be undergoing general anesthesia\n* Having signed the informed consent form to participate in the study\n\nExclusion Criteria:\n\n* Hearing impairment or ear pathology\n* History of neurological disease (epilepsy, stroke, dementia, etc.)\n* Use of psychiatric medications (anxiolytics, antidepressants, antipsychotics, etc.)\n* Indications for emergency surgery\n* Planned spinal or epidural anesthesia\n* Conditions unsuitable for BIS monitoring\n* Cognitive impairment preventing informed consent",true,"70 Years",{"count":124,"type":23},70,"1 Day","This prospective observational study aims to evaluate the impact of operating room noise on bispectral index (BIS) and hemodynamic parameters in patients undergoing general anesthesia. Environmental noise in operating rooms, often overlooked, may influence anesthesia depth, patient safety, and physiological stability. A total of 70 adult patients (ASA I-II, 18-65 years, elective surgery under general anesthesia) will be enrolled at Başakşehir Çam and Sakura City Hospital. Patients will be categorized into two groups based on intraoperative average noise levels: noisy group (\\>65 dB) and quiet group (\\\u003C55 dB). Noise levels will be measured every 10 minutes using a CEM DT-8850 sound level meter, BIS will be recorded every 10 minutes, and hemodynamic variables (systolic, diastolic, mean arterial pressure, and heart rate) will be recorded every 5 minutes.\n\nPrimary outcome is the correlation between mean intraoperative noise levels (LAeq) and BIS values during the maintenance phase of anesthesia. Secondary outcomes include the relationship between noise characteristics (e.g., device-related, human-related, alarms, media) and hemodynamic stability, as well as surgical branch-related noise classifications (high, moderate, low). The study is non-interventional, with no additional risk to participants beyond standard clinical monitoring. Findings are expected to provide evidence on the role of environmental noise in anesthesia quality, inform operating room organization, and contribute to patient safety improvements.",[32,128,129],"Hemodynamics","Noise Exposure",[131,132,133,128,134,129],"Anesthesia, General","Operating Rooms","Monitoring, Intraoperative","Bispectral Index (BIS)","2026-07-21",{"date":137,"type":43},"2026-07-22",{"date":139,"type":23},"2026-08-01",{"date":141,"type":23},"2026-12-01",{"name":143,"class":144},"Başakşehir Çam & Sakura City Hospital","OTHER_GOV",{"id":146,"slug":147,"hasResults":12,"nctId":148,"briefTitle":149,"officialTitle":149,"acronym":4,"eligibilityCriteria":150,"healthyVolunteers":121,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":151,"targetDuration":4,"studyType":24,"phases":153,"briefSummary":154,"conditions":155,"keywords":157,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":160,"lastUpdatePostDateStruct":161,"startDateStruct":162,"completionDateStruct":164,"leadSponsor":166,"locationsCount":84},"100648136","effect-of-pre-injection-of-rocuronium-on-neuromuscular-blockade-onset-time-and-hemodynamics-during-general-anesthesia-induction-100648136","NCT07716891","Effect of Pre-injection of Rocuronium on Neuromuscular Blockade Onset Time and Hemodynamics During General Anesthesia Induction","Inclusion Criteria:\n\n* Aged from 18 to 65 years old\n* American Society of Anesthesiologists (ASA) physical status classification Ⅰ, Ⅱ or Ⅲ\n* Elective surgery requiring general anesthesia with tracheal intubation\n* Able to understand the study and voluntarily sign written informed consent\n* Male or female, no gender restriction\n\nExclusion Criteria:\n\n* Severe hepatic dysfunction (ALT\u002FAST \\> 3 times the upper limit of normal) or renal dysfunction (creatinine \\> 2 times the upper limit of normal)\n* Central nervous system diseases or severe neuromuscular disorders\n* Severe arrhythmia or cardiac dysfunction (NYHA class Ⅲ-Ⅳ, or ejection fraction EF \\\u003C 30%)\n* Known hypersensitivity or allergy to rocuronium, midazolam, propofol or other study-related drugs\n* Refusal to participate in this clinical trial\n* Pregnant or breastfeeding women\n* History of predicted difficult airway requiring awake tracheal intubation\n* Contraindications to rapid sequence induction",{"count":152,"type":23},108,[26],"This is a single-center, prospective, randomized, controlled trial comparing pre-injection versus standard bolus administration of rocuronium bromide for general anesthesia induction. A total of 108 adult patients (18-65 years, ASA I-III) scheduled for elective surgery requiring endotracheal intubation will be enrolled and randomized 1:1 to either the pre-injection group or control group.\n\nThe pre-injection group will receive rocuronium 0.06 mg\u002Fkg as a priming dose followed by 0.54 mg\u002Fkg 3 minutes later. The control group will receive rocuronium 0.6 mg\u002Fkg as a single bolus. All patients will receive standardized anesthesia induction with midazolam and propofol.\n\nThe primary outcome is neuromuscular blockade onset time (seconds). Secondary outcomes include hemodynamic parameters (SBP, DBP, MAP, HR, CO, SV, SVR), injection pain incidence, and adverse events.\n\nThis study aims to investigate whether pre-injection of rocuronium can shorten neuromuscular blockade onset time while maintaining hemodynamic stability compared to standard bolus administration.",[32,156],"Elective Surgery",[158,159,128],"Rocuronium bromide","Onset time","2026-07-16",{"date":135,"type":43},{"date":163,"type":23},"2026-07",{"date":165,"type":23},"2026-12",{"name":167,"class":50},"General Hospital of Ningxia Medical University",{"id":169,"slug":170,"hasResults":12,"nctId":171,"briefTitle":172,"officialTitle":173,"acronym":4,"eligibilityCriteria":174,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":175,"targetDuration":4,"studyType":24,"phases":177,"briefSummary":178,"conditions":179,"keywords":182,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":188,"lastUpdatePostDateStruct":189,"startDateStruct":191,"completionDateStruct":192,"leadSponsor":194,"locationsCount":84},"100645990","comparison-of-three-airway-intubation-devices-for-first-attempt-success-in-general-anesthesia-patients-100645990","NCT07699653","Comparison of Three Airway Intubation Devices for First-Attempt Success in General Anesthesia Patients","Application of SPHJ-II, Visual Lighted Stylet, and Visual Intubation Fiberscope in Endotracheal Intubation in Patients Under General Anesthesia","Inclusion Criteria:\n\n* Age 18 to 65 years, inclusive. American Society of Anesthesiologists (ASA) physical status I to III. Scheduled for surgery under general anesthesia requiring endotracheal intubation.\n\nThe participant or legally authorized representative is fully informed of the purpose, methods, potential risks, and possible benefits of the study and provides written informed consent.\n\nExclusion Criteria:\n\n* Anticipated severe difficulty with mask ventilation, such as severe obesity (BMI \\> 35 kg\u002Fm²) with obstructive sleep apnea syndrome, history of neck radiotherapy, craniofacial malformation, or other conditions judged by the attending anesthesiologist to confer high risk for mask ventilation, and patients requiring awake tracheal intubation.\n\nCervical spine instability, cervical trauma, rheumatoid arthritis involving the cervical spine, ankylosing spondylitis, or any condition requiring absolute cervical immobilization during the procedure.\n\nSignificant airway involvement identified preoperatively, including imaging evidence of tracheal narrowing with minimal diameter \\\u003C 5 mm, severe tracheal compression, displacement or collapse, stridor at rest or after activity, vocal cord paralysis with dyspnea, giant thyroid mass with orthopnea, or other oral, pharyngeal, or laryngeal tumor, edema, stenosis, abscess, or severe upper airway anatomical abnormality affecting glottic exposure or endotracheal tube passage.\n\nHigh risk of reflux and aspiration. Severe cardiovascular disease, severe respiratory disease, severe hepatic or renal dysfunction, severe coagulation disorder, frailty, pregnancy or breastfeeding, or known allergy.\n\nAny other condition making the patient unsuitable for participation in the study, such as psychiatric illness, communication disorder, or poor compliance.",{"count":176,"type":23},549,[26],"The goal of this clinical trial is to compare three airway intubation devices in adult patients undergoing general anesthesia who require tracheal intubation. The main questions it aims to answer are:\n\n* Does the SPHJ-II video-assisted adjustable red-light fluoroscopic tracheal intubation scope improve first-attempt intubation success compared with a visual lighted stylet and a visual intubation fiberscope?\n* How do the three devices compare in intubation efficiency, intubation-related complications, and peri-intubation physiological responses?\n\nResearchers will compare the SPHJ-II, the visual lighted stylet, and the visual intubation fiberscope to evaluate their performance during tracheal intubation.\n\nParticipants will be randomly assigned to one of the three device groups and undergo tracheal intubation during general anesthesia using the assigned device.",[180,32,181],"Airway Management","Tracheal Intubation",[183,184,185,186,187],"SPHI-II","Visual lighted stylet","Visual intubation fiberscope","First-attempt intubation success","Randomized controlled trial","2026-07-08",{"date":190,"type":43},"2026-07-13",{"date":163,"type":23},{"date":193,"type":23},"2026-12-31",{"name":195,"class":50},"Guangzhou University of Chinese Medicine",{"id":197,"slug":198,"hasResults":12,"nctId":199,"briefTitle":200,"officialTitle":201,"acronym":4,"eligibilityCriteria":202,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":203,"targetDuration":4,"studyType":24,"phases":204,"briefSummary":205,"conditions":206,"keywords":4,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":213,"lastUpdatePostDateStruct":214,"startDateStruct":216,"completionDateStruct":218,"leadSponsor":219,"locationsCount":84},"100644957","hemodynamic-effect-of-dexmedetomidine-versus-magnesium-sulphate-as-an-adjuvant-to-lidocaine-in-preemptive-peribulbar-block-in-patients-undergoing-dacryocystorhinostomy-under-general-anesthesia-100644957","NCT07675616","Hemodynamic Effect of Dexmedetomidine Versus Magnesium Sulphate as an Adjuvant to Lidocaine in Preemptive Peribulbar Block in Patients Undergoing Dacryocystorhinostomy Under General Anesthesia","Hemodynamic Effect of Dexmedetomidine Versus Magnesium Sulphate as an Adjuvant to Lidocaine in Preemptive Peribulbar Block in Patients Undergoing Dacryocystorhinostomy Under General Anesthesia: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age ≥ 18 years.\n* Both sexes.\n* American Society of Anesthesiologists (ASA) physical status I or II.\n* Undergoing elective Dacryocystorhinostomy (DCR) surgery under general anesthesia.\n\nExclusion Criteria:\n\n* Patients have local infection.\n* Allergic reaction or complications of the local anaesthesia (LA).\n* Coagulopathy defined as international normalized ratio (INR) \\> 1.5, platelet count \\\u003C 100,000\u002Fmm³, or ongoing anticoagulant therapy not adequately discontinued.\n* Uncontrolled systemic disease, defined as poorly controlled hypertension \\[systolic blood pressure (SBP) \\> 160 mmHg\\], uncontrolled diabetes mellitus (HbA1c \\> 8.5%), unstable ischemic heart disease, or decompensated hepatic or renal disease.\n* Uncooperative patients.",{"count":22,"type":23},[26],"This study aims to compare the hemodynamic effect of dexmedetomidine and magnesium sulphate as an adjuvant to lidocaine in preemptive peribulbar block in patients undergoing Dacryocystorhinostomy (DCR) under general anaesthesia (GA) .",[207,208,209,210,211,212,32],"Hemodynamic Effect","Dexmedetomidine","Magnesium Sulphate","Lidocaine","Peribulbar Block","Dacryocystorhinostomy","2026-06-27",{"date":215,"type":43},"2026-06-30",{"date":217,"type":43},"2026-05-16",{"date":141,"type":23},{"name":220,"class":50},"Cairo University",{"id":222,"slug":223,"hasResults":12,"nctId":224,"briefTitle":225,"officialTitle":226,"acronym":227,"eligibilityCriteria":228,"healthyVolunteers":12,"sex":229,"minAge":4,"maxAge":4,"enrollmentInfo":230,"targetDuration":4,"studyType":24,"phases":232,"briefSummary":233,"conditions":234,"keywords":243,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":255,"lastUpdatePostDateStruct":256,"startDateStruct":258,"completionDateStruct":259,"leadSponsor":261,"locationsCount":84},"100644265","hyperangulated-vs-macintosh-style-blades-for-intubation-in-obstetric-patients-100644265","NCT07667010","Hyperangulated vs. Macintosh Style Blades for Intubation in Obstetric Patients","HyperANGulated Versus Macintosh styLE blaDes for INtubation in OBstetric Patients: a Cluster Randomized Feasibility Study","ANGLED","Inclusion Criteria:\n\n1\\. Pregnant patients undergoing emergency or urgent cesarean delivery under general anesthesia requiring tracheal intubation.\n\nExclusion Criteria:\n\n1. No tracheal intubation performed and (ii) patient refusal of consent.\n2. Patients not receiving general anesthesia.\n3. Patients that previously participated in the study.","FEMALE",{"count":231,"type":23},100,[26],"Cesarean section under general anesthesia requires intubation (insertion of a tube through the mouth into the breathing pipe to support breathing during the surgery). A device called a video laryngoscope is used, which has a smooth, curved, or less curved component called 'a blade' that helps the doctor gently see the voice box and guide the breathing tube safely into place during anesthesia; it is not a sharp tool blade.\n\nThere are two types of video laryngoscopes blades: a Macintosh- style blade with a gentle curve, approximately 90 degrees) and a hyperangulated blade (with a more pronounced curve).\n\nAlthough video laryngoscopes are safe and both types have been used for around 20 years, it is not known whether one type works better that the other in patients undergoing cesarean delivery under general anesthesia. Because general anesthesia is used in only a small proportion (about 5%) of all cesarean deliveries, research in this area is limited.\n\nThe main purpose of the study is to assess if a study comparing these two types of blades in the obstetric population is feasible. This is also known as a feasibility study, which aims to test the study plan and determine whether enough participants will join a larger study and accept the study procedures. The results will be used as a guide for a larger study.",[235,236,237,238,239,240,241,242,32],"Obstetric","Cesarean Birth","Airway Anesthesia","Intubation","General Anesthesia; Tracheal Intubation","Video Laryngoscopy","Obstetric Anesthesia","Obstetric Anesthesia Problems",[244,245,246,247,248,249,250,251,252,253,254],"obstetric","obstetric anesthesia","intubation","airway safety in OB patients","video laryngoscopy","cesarean delivery","general anesthesia in cesarean delivery","macintosh blade","hyperangulated blade","intubation in OB patients","general anesthesia","2026-06-19",{"date":257,"type":43},"2026-06-24",{"date":79,"type":23},{"date":260,"type":23},"2028-06-30",{"name":262,"class":50},"Samuel Lunenfeld Research Institute, Mount Sinai Hospital",{"id":264,"slug":265,"hasResults":12,"nctId":266,"briefTitle":267,"officialTitle":268,"acronym":4,"eligibilityCriteria":269,"healthyVolunteers":12,"sex":229,"minAge":270,"maxAge":4,"enrollmentInfo":271,"targetDuration":4,"studyType":24,"phases":273,"briefSummary":274,"conditions":275,"keywords":278,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":287,"lastUpdatePostDateStruct":288,"startDateStruct":290,"completionDateStruct":292,"leadSponsor":294,"locationsCount":84},"100644453","phase-4-remimazolam-flumazenil-versus-sevoflurane-for-hysteroscopic-day-surgery-100644453","NCT07663877","Remimazolam-Flumazenil Versus Sevoflurane for Hysteroscopic Day Surgery","Remimazolam With Planned Flumazenil Reversal Versus Sevoflurane-based Balanced Anesthesia for Hysteroscopic Day Surgery: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Female patients aged 20 years or older.\n* Scheduled to undergo ambulatory hysteroscopic surgery under general anesthesia.\n* Able to provide written informed consent.\n* American Society of Anesthesiologists (ASA) physical status I-III.\n\nExclusion Criteria:\n\n* Known hypersensitivity to benzodiazepines, remimazolam, or flumazenil.\n* Chronic use of benzodiazepines or opioids.\n* Severe hepatic dysfunction (Child-Pugh class B or C).\n* Severe renal dysfunction (estimated glomerular filtration rate \\\u003C30 mL\u002Fmin\u002F1.73 m²).\n* Epilepsy or other significant neurologic disorders.\n* Pregnancy or breastfeeding.\n* Body mass index (BMI) ≥35 kg\u002Fm².\n* Severe obstructive sleep apnea.\n* Uncontrolled serious systemic disease that may preclude ambulatory surgery.\n* Refusal or inability to provide informed consent.","20 Years",{"count":272,"type":23},124,[96],"This prospective, single-center, randomized controlled trial aims to compare remimazolam anesthesia with planned flumazenil reversal and sevoflurane-based balanced anesthesia in adult women undergoing ambulatory hysteroscopic surgery.\n\nParticipants will be randomly assigned in a 1:1 ratio to receive either remimazolam for induction and maintenance followed by flumazenil reversal or propofol induction followed by sevoflurane-based balanced anesthesia. The primary outcome is anesthesia-controlled time, defined as the sum of induction time and emergence time. Secondary outcomes include recovery profiles, postoperative symptoms, quality of recovery, hemodynamic stability, and the incidence of re-sedation. The study will evaluate whether a remimazolam-flumazenil strategy can improve operating room efficiency while maintaining recovery quality and safety comparable to conventional sevoflurane-based anesthesia in the ambulatory surgery setting.",[276,277,32],"Hysteroscopy","Ambulatory Surgery",[279,280,281,282,283,284,254,285,286],"remimazolam","flumazenil","sevoflurane","ambulatory surgery","day surgery","hysteroscopy","recovery profile","anesthesia controlled time","2026-06-17",{"date":289,"type":43},"2026-06-23",{"date":291,"type":23},"2026-06",{"date":293,"type":23},"2028-06",{"name":295,"class":50},"Chung-Ang University Gwangmyeong Hospital",{"id":297,"slug":298,"hasResults":12,"nctId":299,"briefTitle":300,"officialTitle":300,"acronym":4,"eligibilityCriteria":301,"healthyVolunteers":121,"sex":229,"minAge":302,"maxAge":303,"enrollmentInfo":304,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":306,"conditions":307,"keywords":4,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":309,"lastUpdatePostDateStruct":310,"startDateStruct":312,"completionDateStruct":314,"leadSponsor":316,"locationsCount":318},"100518401","the-society-for-obstetric-anesthesia-and-perinatology-research-network-general-anesthesia-registry-100518401","NCT06030063","The Society for Obstetric Anesthesia and Perinatology Research Network General Anesthesia Registry","Inclusion Criteria:\n\n-Pregnant women aged 15-55 who have had a general anesthetic for Cesarean delivery","15 Years","55 Years",{"count":305,"type":23},5000,"The SOAP registry is a prospective, multicenter, electronic registry. The goal is to investigate the indications, mode of airway management, predisposing factors, and obstetric and anesthetic outcomes of pregnant patients who receive general anesthesia for cesarean delivery.",[308,32],"Cesarean Delivery","2026-06-03",{"date":311,"type":43},"2026-06-04",{"date":313,"type":43},"2024-02-22",{"date":315,"type":23},"2028-12",{"name":317,"class":50},"Yale University",35,{"id":320,"slug":321,"hasResults":12,"nctId":322,"briefTitle":323,"officialTitle":324,"acronym":325,"eligibilityCriteria":326,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":327,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":329,"conditions":330,"keywords":333,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":340,"lastUpdatePostDateStruct":341,"startDateStruct":343,"completionDateStruct":345,"leadSponsor":347,"locationsCount":84},"100639599","pain-assessment-during-rapid-sequence-induction-100639599","NCT07588165","Pain Assessment During Rapid Sequence Induction","Nociception Assessment During Rapid Sequence Induction: A Prospective Observational Study of Practices and Complications - The NARSI Study","NARSI","Inclusion Criteria:\n\n* Age \\>= 18 years\n* Patient requiring tracheal intubation after rapid sequence induction in the visceral surgery operating room\n* Pain monitoring by Analgesia Nociception Index (ANI) as part of general anesthesia\n\nExclusion Criteria:\n\n* Patient with atrial fibrillation at the time of intubation following rapid sequence induction\n* Patient on long-term beta-blocker therapy",{"count":328,"type":23},150,"Rapid sequence induction (RSI) is a standard anesthesia technique used in patients at risk of aspiration. Although tracheal intubation following RSI is a frequent and painful procedure, no study has yet evaluated nociception using the Analgesia Nociception Index (ANI) during this procedure.\n\nThis monocentric prospective observational study aims to describe the impact of RSI on pain measured by ANI, and to explore early complications (desaturation, hypotension, regurgitation) and factors associated with pain and complications. 150 patients undergoing RSI in the visceral surgery operating room at CHPG Monaco will be analyzed.",[331,181,332,32],"Rapide Sequence Induction","Nociception",[334,335,336,337,338,339],"Analgesia Nociception Index (ANI)","Rapid Sequence Induction (RSI)","Pain monitoring","Tracheal intubation","Hemodynamic response","General anesthesia","2026-05-22",{"date":342,"type":43},"2026-05-27",{"date":344,"type":43},"2026-05-21",{"date":346,"type":23},"2028-05",{"name":348,"class":50},"Centre Hospitalier Princesse Grace",{"id":350,"slug":351,"hasResults":12,"nctId":352,"briefTitle":353,"officialTitle":354,"acronym":4,"eligibilityCriteria":355,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":122,"enrollmentInfo":356,"targetDuration":4,"studyType":24,"phases":357,"briefSummary":358,"conditions":359,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":362,"lastUpdatePostDateStruct":363,"startDateStruct":365,"completionDateStruct":367,"leadSponsor":369,"locationsCount":4},"100638700","effects-of-two-anesthesa-technques-on-inflammatory-response-and-amno-acd-metabolsm-n-thyrod-surgery-100638700","NCT07592832","EFFECTS OF TWO ANESTHESİA TECHNİQUES ON INFLAMMATORY RESPONSE AND AMİNO ACİD METABOLİSM İN THYROİD SURGERY","THE EFFECT OF TWO DİFFERENT ANESTHESİA APPROACHES ON PERİOPERATİVE INFLAMMATORY RESPONSE AND AMİNO ACİD METABOLİSM İN THYROİD SURGERY","Inclusion Criteria:\n\n* This includes patients aged 18-70 years\n* classified as ASA I-III\n* who have undergone elective thyroidectomy.\n\nExclusion Criteria:\n\n* Patients who did not wish to participate in the study voluntarily\n* patients for whom superficial cervical block was contraindicated\n* pregnant and breastfeeding women\n* patients in ASA IV-V groups were excluded from the study.",{"count":22,"type":23},[26],"The main aim of this study is to compare the effects of two different anesthesia methods-(1) general anesthesia alone and (2) combination of general anesthesia with cervical plexus block-on postoperative inflammatory process and amino acid metabolism in patients undergoing thyroidectomy.",[32,360,361],"Cervical Plexus Block","Thyroid Surgery","2026-05-15",{"date":364,"type":43},"2026-05-18",{"date":366,"type":23},"2026-07-30",{"date":368,"type":23},"2027-02-20",{"name":49,"class":50},{"id":371,"slug":372,"hasResults":12,"nctId":373,"briefTitle":374,"officialTitle":375,"acronym":4,"eligibilityCriteria":376,"healthyVolunteers":12,"sex":18,"minAge":377,"maxAge":378,"enrollmentInfo":379,"targetDuration":4,"studyType":24,"phases":381,"briefSummary":382,"conditions":383,"keywords":386,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":391,"lastUpdatePostDateStruct":392,"startDateStruct":394,"completionDateStruct":396,"leadSponsor":398,"locationsCount":84},"100639649","phase-4-effective-dose-of-alfentanil-combined-with-propofol-for-laryngeal-mask-airway-insertion-in-children-100639649","NCT07581665","Effective Dose of Alfentanil Combined With Propofol for Laryngeal Mask Airway Insertion in Children","Effective Dose of Alfentanil Combined With Propofol for Laryngeal Mask Airway Insertion in Children: A Prospective, Up-and-Down Sequential Allocation Study","Inclusion Criteria:\n\n* Aged 7 to 12 years\n* Undergoing elective day surgery\n* ASA physical status I-II\n* Body Mass Index (BMI) between 14 and 24 kg\u002Fm²\n* Accompanied by a fully capable guardian within 24 hours after discharge\n\nExclusion Criteria:\n\n* Allergy to opioids\n* Unresolved upper respiratory tract infection within the past 1 week\n* Abnormal heart, lung, liver, or kidney function, or metabolic diseases\n* Airway anatomical abnormalities (e.g., micrognathia, laryngomalacia, macroglossia) or OSAHS (Obstructive Sleep Apnea-Hypopnea Syndrome)\n* Use of analgesics, sedatives, or other psychotropic drugs within the past 2 weeks\n* Refusal to sign the informed consent form","7 Years","12 Years",{"count":380,"type":23},40,[96],"This study uses a prospective, up-and-down sequential allocation method to determine the median effective dose (ED50) and 95% effective dose (ED95) of alfentanil combined with propofol for successful laryngeal mask airway (LMA) insertion in children aged 7-12 undergoing elective day surgery.",[384,180,32,385],"Pediatric Anesthesia","LMA",[387,388,384,385,389,390],"Alfentanil","Propofol","Dixon Method","Effective dose","2026-05-05",{"date":393,"type":43},"2026-05-12",{"date":395,"type":23},"2026-05-01",{"date":397,"type":23},"2027-03-30",{"name":399,"class":50},"Zhongshan Ophthalmic Center, Sun Yat-sen University",{"id":401,"slug":402,"hasResults":12,"nctId":403,"briefTitle":404,"officialTitle":405,"acronym":4,"eligibilityCriteria":406,"healthyVolunteers":12,"sex":18,"minAge":407,"maxAge":408,"enrollmentInfo":409,"targetDuration":4,"studyType":24,"phases":410,"briefSummary":411,"conditions":412,"keywords":4,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":416,"lastUpdatePostDateStruct":417,"startDateStruct":419,"completionDateStruct":421,"leadSponsor":423,"locationsCount":84},"100636766","sphenopalatine-ganglion-block-as-adjuvant-to-general-anesthesia-regarding-the-quality-of-surgical-field-in-trans-sphenoidal-endoscopic-hypophysectomy-100636766","NCT07569952","Sphenopalatine Ganglion Block as Adjuvant to General Anesthesia Regarding the Quality of Surgical Field in Trans-Sphenoidal Endoscopic Hypophysectomy","The Efficacy of Ultrasound Guided Sphenopalatine Ganglion Block as Adjuvant to General Anesthesia Regarding the Quality of Surgical Field in Trans-Sphenoidal Endoscopic Hypophysectomy: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age between 21 and 60 years.\n* American Society of Anesthesiologists (ASA) Physical Status I or II.\n* Undergoing elective endoscopic trans-nasal resection of pituitary adenoma.\n\nExclusion Criteria:\n\n* Patient's refusal\n* ASA Physical Status III or IV patients\n* Patients receiving drugs influencing blood coagulation\n* Allergy to any of the drugs utilized in this study\n* History of chronic pain therapy\n* Inadvertent intra-operative vascular injury","21 Months","60 Years",{"count":124,"type":23},[26],"This study aims to evaluate the efficacy of ultrasound guided sphenopalatine ganglion block (SPGB) through the suprazygomatic approach in optimizing the quality of surgical field as well as its effect on postoperative pain relief in patients undergoing transsphenoidal pituitary surgeries under general anesthesia.",[413,32,414,415],"Sphenopalatine Ganglion Block","Quality of Surgical Field","Trans-Sphenoidal Endoscopic Hypophysectomy","2026-04-29",{"date":418,"type":43},"2026-05-06",{"date":420,"type":43},"2025-06-01",{"date":422,"type":23},"2026-06-01",{"name":220,"class":50},{"id":425,"slug":426,"hasResults":12,"nctId":427,"briefTitle":428,"officialTitle":429,"acronym":4,"eligibilityCriteria":430,"healthyVolunteers":121,"sex":18,"minAge":19,"maxAge":431,"enrollmentInfo":432,"targetDuration":4,"studyType":24,"phases":433,"briefSummary":434,"conditions":435,"keywords":436,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":441,"lastUpdatePostDateStruct":442,"startDateStruct":444,"completionDateStruct":446,"leadSponsor":448,"locationsCount":450},"100579562","lma-i-gel-versus-lma-protector-during-minor-urological-procedures-under-general-anesthesia-in-adult-patients-100579562","NCT06825910","LMA I-Gel Versus LMA Protector During Minor Urological Procedures Under General Anesthesia in Adult Patients","Laryngeal Mask Airway I-Gel and Laryngeal Mask Airway Protector for Minor Urological Procedures Under General Anesthesia in Adult Patients: A Randomized Comparative Study","Inclusion Criteria:\n\n* ASA I-II\n* Patients older than 18 years\n* Procedures in supine and lithotomy position\n\nExclusion Criteria:\n\n* Tumors or anatomical anomalies of the upper airway\n* Known history of difficult intubation\n* Limited mouth opening less than 2cm\n* Decreased compliance of the lungs or the thoracic cage\n* Need of mechanical ventilation after the surgery","90 Years",{"count":231,"type":23},[26],"This will be a randomized comparative study comparing the two supraglottic devices i-gel and Protector, intraoperatively, during minor urological procedures under general anesthesia in adult patient.",[180,32],[385,437,438,439,440],"Protector","Airway Device Evaluation","iGel","Airway Device Comparison","2026-04-24",{"date":443,"type":43},"2026-04-27",{"date":445,"type":43},"2025-02-01",{"date":447,"type":23},"2026-12-30",{"name":449,"class":50},"Nikolopoulou Maria Zozefin",2,{"id":452,"slug":453,"hasResults":12,"nctId":454,"briefTitle":455,"officialTitle":456,"acronym":4,"eligibilityCriteria":457,"healthyVolunteers":12,"sex":18,"minAge":20,"maxAge":4,"enrollmentInfo":458,"targetDuration":4,"studyType":24,"phases":460,"briefSummary":461,"conditions":462,"keywords":4,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":468,"lastUpdatePostDateStruct":469,"startDateStruct":471,"completionDateStruct":472,"leadSponsor":474,"locationsCount":84},"100634198","sublingual-caffeine-on-reducing-recovery-time-and-postoperative-agitation-in-elderly-patients-undergoing-general-anesthesia-100634198","NCT07536568","Sublingual Caffeine on Reducing Recovery Time and Postoperative Agitation in Elderly Patients Undergoing General Anesthesia","Efficacy of Sublingual Caffeine on Reducing Recovery Time and Postoperative Agitation in Elderly Patients Undergoing General Anesthesia: A Double-Blind Randomized Controlled Trial","Inclusion Criteria:\n\n* Age ≥ 65 years.\n* Both sexes.\n* American Society of Anesthesiologists (ASA) physical status II.\n* Scheduled for elective ophthalmology surgery under general anesthesia.\n\nExclusion Criteria:\n\n* History of severe cardiac arrhythmias or uncontrolled hypertension.\n* ASA III patients were excluded to reduce the risk of adverse events in elderly patients with severe systemic diseases.\n* Known allergy or hypersensitivity to caffeine.\n* Pre-existing cognitive impairment or dementia (All patients will undergo preoperative cognitive screening using the online Mini-Cog test or Montreal Cognitive Assessment \\[MoCA\\]).\n* History of seizures or epilepsy.\n* History of alcohol or drug abuse.\n* Chronic use of CNS stimulants or sedatives.\n* Emergency surgeries.\n* Prolonged procedures for more than 3 hours.",{"count":459,"type":23},50,[26],"This study aims to evaluate the efficacy of sublingual caffeine in reducing recovery time and incidence of postoperative agitation in elderly patients undergoing general anesthesia.",[463,464,465,466,467,32],"Sublingual","Caffeine","Recovery Time","Postoperative Agitation","Elderly Patients","2026-04-18",{"date":470,"type":43},"2026-04-21",{"date":468,"type":43},{"date":473,"type":23},"2026-08-30",{"name":220,"class":50},{"id":476,"slug":477,"hasResults":12,"nctId":478,"briefTitle":479,"officialTitle":480,"acronym":481,"eligibilityCriteria":482,"healthyVolunteers":12,"sex":18,"minAge":483,"maxAge":484,"enrollmentInfo":485,"targetDuration":4,"studyType":24,"phases":487,"briefSummary":488,"conditions":489,"keywords":492,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":499,"lastUpdatePostDateStruct":500,"startDateStruct":502,"completionDateStruct":503,"leadSponsor":505,"locationsCount":84},"100631035","video-versus-direct-laryngoscopy-for-tracheal-intubation-in-pediatric-surgery-100631035","NCT07495436","Video Versus Direct Laryngoscopy for Tracheal Intubation in Pediatric Surgery","Videolaryngoscopy Versus Direct Laryngoscopy for Tracheal Intubation in Pediatric Surgery: The VIDEOKIDS Pragmatic Multicentre Randomized Trial","VIDEOKIDS","Inclusion Criteria:\n\n* Paediatric patients (age 0-16 years),\n* Undergoing elective or scheduled surgery under general anaesthesia requiring orotracheal intubation,\n* Planned tracheal intubation using either videolaryngoscopy or direct laryngoscopy as the initial technique,\n* Informed or general consent given, according to the relevant ethics committee statement,.\n\nExclusion Criteria:\n\n* Known upper airway anatomical abnormalities or clinical conditions requiring a specific intubation technique (e.g., fibreoptic intubation),\n* Requirement for emergent tracheal intubation that does not allow adequate randomisation,\n* Refusal of parents or legal guardians to participate in the study.","0 Days","16 Hours",{"count":486,"type":23},5562,[26],"Tracheal intubation in paediatric patients is a high-risk procedure in which failure to achieve successful intubation on the first attempt is associated with an increased risk of complications, including hypoxaemia and airway trauma. Videolaryngoscopes have been increasingly adopted in clinical practice because they improve glottic visualisation; however, evidence of their benefit in paediatric patients remains inconsistent.\n\nThe VIDEOKIDS trial is a large, pragmatic, international, multicentre, randomised controlled trial designed to compare videolaryngoscopy with direct laryngoscopy as the initial technique for tracheal intubation in paediatric patients undergoing surgery under general anaesthesia. The primary objective is to determine whether videolaryngoscopy increases the rate of successful intubation on the first attempt compared with direct laryngoscopy.",[181,490,32,491],"Videolaryngoscopy","Difficult Airway Intubation",[493,494,495,496,497,498],"tracheal intubation","videolaryngoscopy","laryngoscopy","Paediatric airway","Airway management","Randomised controlled trial","2026-04-17",{"date":501,"type":43},"2026-04-22",{"date":395,"type":23},{"date":504,"type":23},"2027-12-30",{"name":506,"class":50},"Hospital Clinico Universitario de Santiago",{"id":508,"slug":509,"hasResults":12,"nctId":510,"briefTitle":511,"officialTitle":512,"acronym":4,"eligibilityCriteria":513,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":514,"targetDuration":4,"studyType":24,"phases":516,"briefSummary":517,"conditions":518,"keywords":522,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":523,"lastUpdatePostDateStruct":524,"startDateStruct":526,"completionDateStruct":528,"leadSponsor":530,"locationsCount":84},"100616680","phase-4-impact-of-perioperative-dexmedetomidine-and-esketamine-on-postoperative-quality-of-recovery-100616680","NCT07308756","Impact of Perioperative Dexmedetomidine and Esketamine on Postoperative Quality of Recovery","Impact of Perioperative Dexmedetomidine and Esketamine on Postoperative Quality of Recovery in Patients Undergoing General Anesthesia and Surgery: A 2×2 Factorial Randomized Trial","Inclusion Criteria:\n\n* Aged 18 years or over;\n* Scheduled to undergo surgery under general anesthesia, with an expected surgical duration of at least 1 hour;\n* Required patient-controlled intravenous analgesia after surgery.\n\nExclusion Criteria:\n\n* Unable to communicate preoperatively due to visual, auditory, or verbal barriers or other reasons;\n* Severe bradycardia (heart rate \\\u003C50 bpm), sick sinus syndrome, or grade 2 or higher atrioventricular block without pacemaker;\n* History of hyperthyroidism or pheochromocytoma;\n* History of schizophrenia, epilepsy, Parkinson's disease, myasthenia gravis, or intracranial hypertension;\n* Intracranial tumor or neurosurgery;\n* Severe liver dysfunction (Child-Pugh class C), renal failure (requiring renal replacement therapy), or American Society of Anesthesiologists class IV or higher;\n* Enrolled in other clinical studies.",{"count":515,"type":23},316,[96],"For patients after surgery, quality of recovery has significant impacts on the prognosis, quality of life, and rational allocation of medical resources. Dexmedetomidine and esketamine have each been used during the perioperative period and improved postoperative analgesia and subjective sleep quality. This 2x2 factorial trial is designed to explore the effects of dexmedetomidine, esketamine, and their combination on the quality of recovery in patients recovering from surgery under general anesthesia.",[32,519,208,520,521],"Surgery","Esketamine","Quality of Recovery",[339,519,208,520,73],"2026-04-08",{"date":525,"type":43},"2026-04-13",{"date":527,"type":43},"2026-01-05",{"date":529,"type":23},"2027-04",{"name":531,"class":50},"Peking University First Hospital",{"id":533,"slug":534,"hasResults":12,"nctId":535,"briefTitle":536,"officialTitle":537,"acronym":4,"eligibilityCriteria":538,"healthyVolunteers":121,"sex":18,"minAge":539,"maxAge":378,"enrollmentInfo":540,"targetDuration":125,"studyType":60,"phases":4,"briefSummary":542,"conditions":543,"keywords":545,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":551,"lastUpdatePostDateStruct":552,"startDateStruct":554,"completionDateStruct":556,"leadSponsor":558,"locationsCount":84},"100617807","effects-of-different-inspiratoryexpiratory-ratios-on-respiratory-and-recovery-outcomes-during-dental-procedures-under-general-anesthesia-in-pediatric-patients-100617807","NCT07323420","Effects of Different Inspiratory:Expiratory Ratios on Respiratory and Recovery Outcomes During Dental Procedures Under General Anesthesia in Pediatric Patients","A Clinical Study on the Effects of Different Inspiratory:Expiratory Ratios on Respiratory Function and Recovery in Pediatric Patients Undergoing Dental Procedures Under General Anesthesia","Inclusion Criteria:\n\n* Pediatric patients scheduled for dental procedures under general anesthesia at our faculty.\n* American Society of Anesthesiologists (ASA) Physical Status I or II.\n* Age between 2 and 12 years.\n* Written informed consent obtained from parents or legal guardians.\n\nExclusion Criteria:\n\n* Patients whose parents or legal guardians decline participation.\n* Presence of adenoid hypertrophy \\>30%.\n* Macroglossia or retrognathia.\n* Severe obesity or developmental delay.\n* History of delayed emergence from anesthesia.\n* ASA Physical Status III or higher.\n* Anesthesia duration less than 1 hour or more than 3 hours.\n* Patients with difficult airway management or ventilation.\n* Known pulmonary or airway diseases or anomalies.\n* Use of pharmacological agents that may affect spontaneous respiratory quality.\n* Presence of neuromuscular disorders affecting respiratory function.\n* Age \\\u003C2 years or \\>12 years.\n* Administration of medications intraoperatively or preoperatively that may influence respiratory dynamics during emergence (e.g., atropine, lidocaine, steroids).","2 Years",{"count":541,"type":23},75,"This observational study aims to evaluate the effects of different inspiratory to expiratory (I:E) ratios (1:2 vs. 1:3) during mechanical ventilation in pediatric patients undergoing dental procedures under general anesthesia. Due to behavioral challenges, dental phobia, or medical conditions, general anesthesia is often required to ensure immobility and cooperation during dental treatments in children.\n\nIn the clinic where the study will be conducted, the I:E ratio is routinely adjusted approximately 20-30 minutes before the end of the procedure to facilitate a smoother transition to spontaneous breathing during emergence from anesthesia. While 1:2 is commonly used, the 1:3 ratio may improve respiratory efficiency and recovery by prolonging the expiratory phase.\n\nThe study aims to compare vital signs, respiratory parameters (heart rate, blood pressure, SpO₂, EtCO₂, respiratory rate), recovery quality, and respiratory complications between the two I:E ratios. The findings aim to optimize ventilation strategies and improve patient comfort and safety during emergence from anesthesia.",[544,384,32],"Respiratory Function",[32,546,547,548,549,550],"Anesthesia Recovery","Emergence from Anesthesia","Mechanical Ventilation","I:E Ratio","Recovery Quality","2026-04-03",{"date":553,"type":43},"2026-04-09",{"date":555,"type":43},"2026-04-01",{"date":557,"type":23},"2026-11-30",{"name":559,"class":50},"Kırıkkale University",{"id":561,"slug":562,"hasResults":12,"nctId":563,"briefTitle":564,"officialTitle":565,"acronym":4,"eligibilityCriteria":566,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":567,"targetDuration":4,"studyType":24,"phases":568,"briefSummary":569,"conditions":570,"keywords":572,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":576,"lastUpdatePostDateStruct":577,"startDateStruct":578,"completionDateStruct":580,"leadSponsor":581,"locationsCount":84},"100617991","effects-of-periodic-recruitment-maneuvers-on-atelectasis-and-respiratory-mechanics-during-elective-spine-surgery-assessed-by-lung-ultrasonography-100617991","NCT07325812","Effects of Periodic Recruitment Maneuvers on Atelectasis and Respiratory Mechanics During Elective Spine Surgery Assessed by Lung Ultrasonography","Evaluation of the Effects of Periodic Recruitment Maneuvers on Atelectasis and Respiratory Mechanics in Elective Spine Surgery Using Lung Ultrasonography","Inclusion Criteria:\n\n* Adults aged 18 to 65 years\n* Scheduled for elective lumbar spine surgery under general anesthesia\n* Surgery planned to be performed in the prone position\n* Expected surgical duration of at least 2 hours\n* American Society of Anesthesiologists (ASA) physical status I-II\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Body mass index (BMI) greater than 30 kg\u002Fm²\n* History of thoracic surgery\n* Known or suspected chronic pulmonary disease (e.g., chronic obstructive pulmonary disease, restrictive lung disease)\n* Clinically significant cardiac disease\n* Pregnancy or breastfeeding\n* Known airway anomalies\n\nIntraoperative surgical duration shorter than 2 hours\n\nRefusal or inability to provide informed consent",{"count":22,"type":23},[26],"During general anesthesia, particularly in patients undergoing spine surgery in the prone (face-down) position, increased intrathoracic and abdominal pressure may reduce lung compliance and promote the development of atelectasis (partial lung collapse). Atelectasis can impair intraoperative oxygenation and may increase the risk of postoperative pulmonary complications. Alveolar recruitment maneuvers (ARM) are routinely used in anesthesia practice to reopen collapsed lung regions; however, it remains unclear whether periodic application of ARM throughout surgery provides additional benefit compared with standard single-time application.\n\nThis prospective, randomized controlled clinical study aims to evaluate whether periodic alveolar recruitment maneuvers applied during elective spine surgery in the prone position reduce intraoperative atelectasis and improve respiratory mechanics compared with the standard approach of performing ARM only after positioning and before extubation. Adult patients undergoing elective spine surgery under general anesthesia will be randomly assigned to either a periodic ARM group or a standard ARM group.\n\nLung aeration will be assessed using lung ultrasound, a non-invasive and radiation-free bedside imaging method. The primary outcome is the incidence of intraoperative atelectasis assessed before extubation. Secondary outcomes include lung ultrasound aeration scores, respiratory mechanics parameters (such as airway pressures and compliance), oxygenation indices, and the occurrence of transient intraoperative respiratory or hemodynamic events.\n\nThe findings of this study may help optimize intraoperative ventilation strategies in prone spine surgery and contribute to improved perioperative respiratory safety.",[571,548,32,31],"Atelectasis",[571,573,574,31,575],"Alveolar Recruitment Maneuver","Lung Ultrasound","Respiratory Mechanics","2026-04-02",{"date":523,"type":43},{"date":579,"type":23},"2026-04",{"date":163,"type":23},{"name":582,"class":50},"Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization",{"id":584,"slug":585,"hasResults":12,"nctId":586,"briefTitle":587,"officialTitle":587,"acronym":4,"eligibilityCriteria":588,"healthyVolunteers":12,"sex":18,"minAge":589,"maxAge":92,"enrollmentInfo":590,"targetDuration":4,"studyType":24,"phases":592,"briefSummary":593,"conditions":594,"keywords":595,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":599,"lastUpdatePostDateStruct":600,"startDateStruct":602,"completionDateStruct":603,"leadSponsor":604,"locationsCount":84},"100632280","comparison-of-sevoflurane-and-desflurane-on-ani-in-patients-undergoing-general-anesthesia-a-prospective-randomized-controlled-study-100632280","NCT07511634","Comparison of Sevoflurane and Desflurane on ANI in Patients Undergoing General Anesthesia: a Prospective Randomized Controlled Study","Inclusion Criteria:\n\n* Adults aged 19 to 79 years\n* Patients undergoing general anesthesia\n* American Society of Anesthesiologists (ASA) physical status I or II\n\nExclusion Criteria:\n\n* History of taking medications that may affect the central nervous system or autonomic nervous system (e.g., anticholinergics, beta-blockers, antidepressants, anxiolytics, hypnotics, or analgesics)\n* Known hypersensitivity to sevoflurane, desflurane, or other halogenated anesthetics, or a personal or family history of malignant hyperthermia\n* Neurologic or psychiatric disorders (e.g., depression, dementia, or cerebral infarction)\n* Arrhythmia\n* Diabetes mellitus\n* Drug abuse or alcohol abuse\n* Vulnerable subjects\n* Patients aged 80 years or older\n* Patients with impaired consciousness or those judged to lack the capacity to provide informed consent","19 Years",{"count":591,"type":23},80,[26],"This prospective randomized controlled study will compare the effects of sevoflurane and desflurane on the Analgesia Nociception Index (ANI) in adult patients undergoing general anesthesia. Participants will be randomized to maintenance anesthesia with either sevoflurane or desflurane, and ANI responses to a standardized nociceptive stimulus will be measured under equi-minimum alveolar concentration (age-adjusted 1.0 MAC) conditions. The primary objective is to compare the change in ANI before and after tetanic stimulation between the two anesthetic groups. Secondary measurements will include bispectral index, blood pressure, heart rate, and end-tidal anesthetic concentration around the time of stimulation.",[32],[596,597,598],"Analgesia Nociception Index","ANI","Sevoflurane","2026-03-30",{"date":601,"type":43},"2026-04-06",{"date":555,"type":23},{"date":193,"type":23},{"name":605,"class":50},"Pusan National University Yangsan Hospital",{"id":607,"slug":608,"hasResults":12,"nctId":609,"briefTitle":610,"officialTitle":610,"acronym":4,"eligibilityCriteria":611,"healthyVolunteers":121,"sex":18,"minAge":19,"maxAge":612,"enrollmentInfo":613,"targetDuration":4,"studyType":24,"phases":615,"briefSummary":616,"conditions":617,"keywords":4,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":620,"lastUpdatePostDateStruct":621,"startDateStruct":623,"completionDateStruct":625,"leadSponsor":627,"locationsCount":84},"100608571","phase-4-risk-of-acute-complications-with-rocuronium-vs-cisatracurium-in-patients-with-chronic-kidney-disease-100608571","NCT07203287","Risk of Acute Complications With Rocuronium vs Cisatracurium in Patients With Chronic Kidney Disease","Inclusion Criteria:\n\n* The subject is able and willing to provide and sign informed consent\n* The subject must be between 18 and 80 years of age\n* The subject should have chronic kidney disease as defined by glomerular filtration rate\n* The surgery must require general anesthesia with endotracheal intubation and neuromuscular blockade\n\nExclusion Criteria:\n\n* Any patient under the age of 18\n* Any patient over the age of 80\n* Any patient with end stage renal disease\n* Any patient requiring dialysis\n* Patients presenting for Renal Transplantation\n* Pregnant Female\n* Any patient in the correctional system\n* Urgent or Emergent procedure\n* The surgery requires intubation post-operatively\n* Documented allergy to Rocuronium, Sugammadex, Cisatracurium or Neostigmine","80 Years",{"count":614,"type":23},490,[96],"The purpose of the study is to determine which combination of neuromuscular blocking agent and reversal agent is safer to use during anesthesia for patients with chronic kidney disease. The main question it aims to answer is\n\n\"The use of Cisatracurium with neostigmine leads to less post-operative pulmonary complications than Rocuronium with sugammadex.\"",[618,619,32],"Post Operative Pulmonary Complications","Neuromuscular Blockade","2026-02-19",{"date":622,"type":43},"2026-02-23",{"date":624,"type":43},"2025-08-26",{"date":626,"type":23},"2027-08-26",{"name":628,"class":50},"The University of Texas Medical Branch, Galveston",{"id":630,"slug":631,"hasResults":12,"nctId":632,"briefTitle":633,"officialTitle":634,"acronym":635,"eligibilityCriteria":636,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":637,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":639,"conditions":640,"keywords":643,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":646,"lastUpdatePostDateStruct":647,"startDateStruct":649,"completionDateStruct":651,"leadSponsor":652,"locationsCount":84},"100585202","prevention-of-postoperative-respiratory-complications-100585202","NCT06899295","Prevention of Postoperative Respiratory Complications","Data From Advanced Respiratory Monitoring During Alveolar Recruitment Maneuvers (ARM). A Prospective Observational Study","RAMAGE","Inclusion Criteria:\n\n1. Patients ≥ 18 years of age\n2. undergoing :\n\n   * scheduled surgery at Hospital Lariboisière.\n   * scheduled to last more than 2 hours under general anesthesia for abdominal surgery under laparoscopy or surgery in the prone position, or for obese patients with a BMI \\>35.\n   * And for whom the ventilator used includes advanced monitoring\n   * for whom placement of a gastric tube is indicated either because of the duration of the procedure or because it is necessary for the surgery.\n3. Patient informed and expressing non-opposition to participation in this study\n\nExclusion Criteria:\n\n* \\- Patients under 18 years of age.\n* Contraindications to esophageal tube placement\n* Contraindications to ARMs\n* Patient opposed to protocol participation\n* Pregnant, parturient or breast-feeding women\n* Patient under legal protection",{"count":638,"type":23},34,"Given the huge number of patients mechanically ventilated during general anaesthesia, optimizing alveolar recruitment by limiting pulmonary and systemic aggression is a key objective for further progress in perioperative patient management.\n\nDuring general anaesthesia, ventilation disorders with atelectasis, derecruitment of posteroinferior zones and reduced functional residual capacity (FRC) occur in relation to the operative position, the effect of neuromuscular block and general anaesthesia. These conditions of poor pulmonary aeration favor postoperative respiratory complications and are responsible for excess mortality in the perioperative period.\n\nAlveolar recruitment maneuvers (ARMs) are ventilatory strategies used during general anesthesia that aim to restore lung aeration with Positive End Expiratory Pressure (PEEP) sufficient to keep the lungs open afterwards. This pulmonary hyperinflation not only has a major impact on hemodynamics but also presents a risk of barotrauma. ARM is currently performed without precise measurement of the pressures prevailing in the lung.\n\nAdvanced monitoring is now available and integrated into the latest-generation ventilators and includes the combination of Transpulmonary pressure (TPP) and Electro-Impedance Tomography \" (EIT) measurements.\n\nThe aim of this observational study is to measure and record advanced respiratory monitoring data in a minimally invasive way, during alveolar recruitment tests routinely performed for the target population (obese, prone, laparoscopic surgery). Describe and a posteriori analyze the recorded data and establish a relationship between the PEEP values set by conventional ARM and those determined by advanced monitoring combining EIT and PTP for the same patient.",[32,641,642],"Ventilator-Induced Lung Injuries","Postoperative Respiratory Complications",[644,645],"Ventilator optimization","Ventilator induced lung injury","2026-02-17",{"date":648,"type":43},"2026-02-18",{"date":650,"type":23},"2026-05",{"date":346,"type":23},{"name":653,"class":50},"Assistance Publique - Hôpitaux de Paris",{"id":655,"slug":656,"hasResults":12,"nctId":657,"briefTitle":658,"officialTitle":659,"acronym":4,"eligibilityCriteria":660,"healthyVolunteers":121,"sex":18,"minAge":19,"maxAge":661,"enrollmentInfo":662,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":664,"conditions":665,"keywords":4,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":671,"lastUpdatePostDateStruct":672,"startDateStruct":674,"completionDateStruct":676,"leadSponsor":678,"locationsCount":84},"100623627","preoperative-evaluation-of-ivc-collapsibility-index-and-caval-aorta-index-after-induction-of-general-anesthesia-100623627","NCT07399093","Preoperative Evaluation of IVC Collapsibility Index and Caval Aorta Index After Induction of General Anesthesia","Preoperative Evaluation of IVC Collapsibility Index and Caval Aorta Index for Prediction of Hypotension After Induction of General Anesthesia in Patients Undergoing Craniotomy Surgeries","Inclusion Criteria:\n\n* Age from 18 to 40 years.\n* Both sexes.\n* Body Mass Index\\\u003C 40 kg\u002Fm².\n* American Society of Anesthesiologists (ASA) physical status I, II.\n* Fasted according to the ASA guidelines: 2 hours for clear fluids, 6 hours after light meal, 8 hours after a full meal with high calorie or fat content.\n* Scheduled for elective craniotomy surgeries before induction of general anesthesia.\n\nExclusion Criteria:\n\n* Current or recent pregnancy (within 3 months).\n* Pre-existing cardiac disease or hypertension.\n* On medications affecting blood pressure \\[Beta-blockers (BBs) and calcium channel blockers (CCBs)\\] .\n* Refusing to undergo the study.","40 Years",{"count":663,"type":23},36,"This study aims to assess the accuracy, repeatability, and reproducibility of preoperative evaluation of Inferior Vena Cava (IVC) collapsibility index and caval aorta index for prediction of hypotension after induction of general anesthesia.",[666,667,668,669,32,670],"Inferior Vena Cava","Collapsibility Index","Caval Aorta Index","Induction","Craniotomy","2026-02-05",{"date":673,"type":43},"2026-02-10",{"date":675,"type":43},"2024-01-14",{"date":677,"type":23},"2026-03-01",{"name":679,"class":50},"Ain Shams University",{"id":681,"slug":682,"hasResults":12,"nctId":683,"briefTitle":684,"officialTitle":684,"acronym":685,"eligibilityCriteria":686,"healthyVolunteers":12,"sex":18,"minAge":270,"maxAge":4,"enrollmentInfo":687,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":689,"conditions":690,"keywords":693,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":699,"lastUpdatePostDateStruct":700,"startDateStruct":702,"completionDateStruct":704,"leadSponsor":706,"locationsCount":84},"100614511","analysis-of-breath-sounds-during-surgery-100614511","NCT07280546","Analysis of Breath Sounds During Surgery","BREATHSOUND","Inclusion Criteria:\n\n* Age ≥ 20 years\n* American Society of Anesthesiologists (ASA) physical status I-III\n* Scheduled for elective surgery under general anesthesia\n* Provided written informed consent\n\nExclusion Criteria:\n\n* History of respiratory disease (e.g., COPD, severe asthma)\n* Previous airway surgery or anatomical abnormalities that interfere with breath sound assessment\n* Refusal to participate or inability to comply with study procedures",{"count":688,"type":23},30,"This study aims to analyze breath sounds during surgery by using electronic stethoscope sensors attached to patients under general anesthesia. The study will evaluate whether breath sound monitoring can provide useful information for respiratory management, assist anesthesiologists in early detection of abnormal breathing events, and support safer perioperative care. A total of 30 adult patients undergoing elective surgery under general anesthesia will be enrolled.",[32,691,692],"Intraoperative Monitoring","Respiratory Sounds",[694,695,696,697,698],"Breath sounds","Perioperative care","Airway monitoring","Respiratory complications","Double-lumen endotracheal tube (DLT)","2025-12-09",{"date":701,"type":43},"2025-12-12",{"date":703,"type":43},"2025-09-03",{"date":705,"type":23},"2026-09-30",{"name":707,"class":144},"Taipei Veterans General Hospital, Taiwan"]