[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"gilles-de-la-tourette-syndrome\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:gilles-de-la-tourette-syndrome":34},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,53],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":35,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":5},"100648797","integrating-exposure-and-response-prevention-and-habit-reversal-techniques-to-treat-a-tourettic-subtype-of-obsessive-compulsive-disorder-tourettic-ocd-100648797",false,"NCT07725926","Integrating Exposure and Response Prevention and Habit Reversal Techniques to Treat a Tourettic Subtype of Obsessive-Compulsive Disorder (Tourettic OCD)","TORCH","Inclusion Criteria:\n\n1. Age 18 years or older\n2. All genders\n3. Confirmation of a primary diagnosis of either:\n\na. Tourettes Disorder \u002F Tourette Syndrome b. Persistent Motor or Vocal Tic Disorder \u002F Chronic Motor or Vocal Tic Disorder c. Provisional Tic Disorder \u002F Transient Motor Tics d. Other Specified Tic Disorder e. Unspecified Tic Disorder f. Obsessive-Compulsive Disorder \\[d\\] Participants taking psychotropic medication are eligible provided medication type and dose remain stable throughout the intervention period \\[e\\] Ability to provide sustained informed consent \\[f\\] A minimum score of 16 on YBOCS \\[g\\] A minimum score of 5 on the Premonitory Urge for Tics Scale (PUTS)\n\nExclusion Criteria:\n\n1. Substance misuse\n2. Current diagnosis of a personality disorder\n3. Schizophrenia\n4. Bipolar disorder\n5. Contraindications to participation in a trial (i.e., active suicidal ideations and\u002For requirement of an interpreter)\n6. Any psychiatric or neurological condition that, in the opinion of the investigators, would interfere with participation or interpretation of study outcomes.","ALL","18 Years","65 Years",{"count":20,"type":21},40,"ESTIMATED","INTERVENTIONAL",[24],"NA","Obsessive-Compulsive Disorder and Tic Disorders frequently co-occur, and a subgroup of patients - those with a Tourettic Subtype of OCD (TOCD) - present with concurrent obsessive-compulsive and tic symptoms. Existing psychological interventions typically target one condition or the other, but rarely both together. This study aims to test whether a combined psychological therapy integrating Exposure and Response Prevention (ERP) and Habit Reversal (HbRT) is more effective at reducing symptoms than either therapy delivered alone, in adults with TOCD.",[27,28,29,30,31,32,33,34],"Obsessive - Compulsive Disorder","Tic Disorder, Chronic Motor or Vocal","Tic Disorders","Tic Disorder, Combined Vocal and Multiple Motor","Tourette Disease","Tourette Disorder","Tourettes Syndrome","Gilles de la Tourette Syndrome",[36,29,37,38,39,40],"Obsessive-Compulsive Disorder","Tourette Syndrome","Tourettic Obsessive-Compulsive Disorder","Exposure and Response Prevention","Habit Reversal Training","RECRUITING","2026-07-23",{"date":44,"type":45},"2026-07-27","ACTUAL",{"date":47,"type":45},"2026-07-08",{"date":49,"type":21},"2030-02-01",{"name":51,"class":52},"University College London Hospitals","OTHER",{"id":54,"slug":55,"hasResults":11,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":4,"eligibilityCriteria":59,"healthyVolunteers":11,"sex":16,"minAge":60,"maxAge":18,"enrollmentInfo":61,"targetDuration":4,"studyType":22,"phases":63,"briefSummary":64,"conditions":65,"keywords":67,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":84},"100519962","objective-characterizatoion-of-repetitive-behaviors-100519962","NCT06050369","Objective Characterizatoion of Repetitive Behaviors","Actimetric and Electrophysiological Analyses of Repetitive Behaviors (Tics and Compulsions)","Inclusion Criteria:\n\n* To be more of 15 years old or less than 65 years old\n* To suffer from OCD and\u002For GTS (depressive, anxious and attention deficit hyperactivity disorder (ADHD) comorbidities are accepted)\n* To be registered to the french social security (or something equivalent)\n* To give written consent to participate to the research\n* To have contraception for women participants (or to not have any sexual activity)\n\nExclusion Criteria:\n\n* Patients with any other psychiatric disorders than those mentioned in the inclusion criteria\n* Patients with any other neurological disorder than GTS\n* Patients who are not able to take decisions for themselves\n* Pregnant women\n* Patients not allowed to get MRI due to contraindication\n* Patients not speaking french","15 Years",{"count":62,"type":21},50,[24],"Introduction:\n\nRepetitive behaviors (RB) constitute a broad range of symptoms across different psychiatric\u002Fneurologic disorders. The most famous are stereotypies (found in autism), compulsions (found in obsessive-compulsive-disorder, OCD) and tics (found in Gilles de la Tourette syndrome, GTS). For some patients, it is sometime difficult to distinguish the nature of the repetitive behaviors presented, however this distinction is crucial in order to chose the appropriate treatment.\n\nAim:\n\nIn our study, the investigators will try to define electrophysiological and accelerometric marker of both OCD and tics to allow objective distinction between both tics and compulsions.\n\nMethod:\n\nSubjects: Both OCD and GTS patients will be recruited, 25 patients in each group.\n\nProtocol: our study protocol will involve two step: a step in laboratory, another step at patient home.\n\n* first step: both patients group will be recorded through a high density EEG and a portative EEG while doing a task of symptom provocation. Then they will get an anatomical MRI for source recontruction. Finally, the patients will have to mimic their symptom while wearing an accelerometer (a smartwatch).\n* second step: both patient groups will be recorded at home through a portative EEG while tagging their symptom through a smartwatch (also used for accelerometry). After the recording, the patients will keep the smartwatch for 2 weeks, still tagging their sympoms (compulsions or tics).",[66,29,34],"OCD",[68,69,70,71,72,73],"Electrophysiology","Electroencephalogram","EEG","Accelerometer","Biomarker","Symptom provocation","2026-02-10",{"date":76,"type":45},"2026-02-12",{"date":78,"type":45},"2023-12-28",{"date":80,"type":21},"2027-12-27",{"name":82,"class":83},"Institut National de la Santé Et de la Recherche Médicale, France","OTHER_GOV",3]