[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"gingivitis-and-periodontal-diseases\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:gingivitis-and-periodontal-diseases":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,42,75,112,138,168],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100616470","evaluation-of-toothbrush-bristles-100616470",false,"NCT07306026","Evaluation of Toothbrush Bristles","Evaluation of Toothbrush Bristles in Reduction of Plaque, Inflammation, Bleeding, and Abrasion: A Comparative Study of Tapered vs. End-Rounded Bristles","Inclusion Criteria:\n\n* Must have read, understood and signed an informed consent prior to being entered into the study.\n* Must be 18 to 70 years of age, male or female.\n* Have at least 20 natural or restored teeth, not including implants.\n* Must have average Plaque Index of greater than 2 at screening.\n* Must have more than 20% of pockets with bleeding on probing at screening.\n* Agree not to have a dental prophylaxis or any other elective, non-emergency dental procedures any time during the study.\n* Agree to refrain from regular oral hygiene regimen for 24 hours and eating for 4 hours before the appointment in the study.\n* Agree to abstain from the use of any dental products other than those provided in the study.\n* Agree to comply with the conditions and schedule of the study.\n\nExclusion Criteria:\n\n* Physical limitations or restrictions that might preclude normal tooth brushing.\n* Evidence of gross oral pathology\n* Periodontal probing pocket depths (PPD) ≥ 5mm.\n* Evidence of major soft tissue lesions or trauma at the baseline visit as determined by the examiner.\n* Chronic disease with concomitant oral manifestations\n* Subjects who are currently undergoing, or require, extensive dental work, orthodontic treatment or periodontal surgery, or orthodontic treatment in the preceding 3 months\n* Currently using bleaching trays\n* Eating disorders\n* Recent history of substance abuse\n* Smoking \\>10 cigarettes\u002Fday\n* Participation in other clinical studies within 14 days of screening\n* Pregnancy",true,"ALL","18 Years","70 Years",{"count":21,"type":22},70,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this randomized clinical trial is to investigate two different types of toothbrush bristles.\n\nThe main questions it aims to answer are the effects of two different bristle types on:\n\n* how much plaque is on the teeth\n* how deep the space is between gums and teeth\n* how much gum and bone are attached to the teeth\n* whether the gums bleed when checked\n* if the gums get scratched or irritated\n\nResearchers will compare toothbrushes with tapered bristles to those with regular round bristles.\n\nParticipants will be randomly assigned toothbrush A or B to use at home during the study.",[28],"Gingivitis and Periodontal Diseases","RECRUITING","2026-08-18",{"date":32,"type":33},"2026-08-20","ACTUAL",{"date":35,"type":33},"2025-10-21",{"date":37,"type":22},"2026-11-30",{"name":39,"class":40},"State University of New York at Buffalo","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":23,"phases":52,"briefSummary":53,"conditions":54,"keywords":57,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":4},"100646439","bio-descaling-toothpaste-for-dental-calculus-reduction-100646439","NCT07689071","Bio-Descaling Toothpaste for Dental Calculus Reduction","Efficacy of a Novel Toothpaste Containing a Bio-Descaling Powder (BDP) in Reducing Dental Calculus: A Double Blind Randomized Controlled Clinical Trial","AntiCal","Inclusion Criteria:\n\nPatients with a healthy but reduced periodontium undergoing a supportive periodontal care (SPC) program and\u002For patients with biofilm induced gingivitis, fulfilling the following criteria:\n\n1. Aged 18 years and older;\n2. Systemically healthy, following the criteria of American Society of Anesthesiology (ASA), type I or II;\n3. Having at least 10 opposing teeth units with presence of at least three natural lower anterior teeth;\n4. Presenting at least 1.5 mm of calculus width on the lingual surface of at least one mandibular anterior teeth (Volpe-Manhold index of at least 1.5 in the lingual side of at least one of the lower anterior teeth) ;\n5. For patients in SPC, for at least 6 months, and the last tooth cleaning at least 3 months before, fulfilling the end point criteria of periodontal therapy \\[no pockets ≥ 6 mm or \\> 4 mm with bleeding on probing (BOP)\\] . Localized pockets of 6 mm, without bleeding on probing, are allowed, except in the anterior-inferior sextant.\n6. Agree to follow the study instructions, including adherence to study arm treatment, for the study timeline.\n\nExclusion Criteria:\n\nSubjects will be excluded from participating in the study if:\n\n1. Pregnancy: pregnant women at high risk of developing gum inflammation that usually occurs during pregnancy, which could introduce bias to the study;\n2. Any physical handicap, psychological or health conditions that might jeopardize the ability of the patient to brush his\u002F her teeth, these complications may cause bias in the study. Smokers of 10 or more cigarettes per day will be excluded (Dietrich, Bernimoulin, \\& Glynn, 2004);\n3. Antibiotics or anti-inflammatory drugs taken within 1 month prior to the study, to avoid bias when assessing the gum health;\n4. Currently using chlorhexidine or other antiseptic products, since these products can affect biofilm and calculus formation, therefore they can introduce bias in the assessment of calculus removal by our toothpaste;\n5. Sensitivity to tartar-control toothpastes;\n6. Unable to return for evaluations\u002Fstudy recalls, to avoid the significant loss in the number of participants.",{"count":51,"type":22},100,[25],"Dental calculus is a calcified mineralized plaque composed primarily of calcium phosphate salts covered by an unmineralized bacterial biofilm layer. It provides a substrate for bacterial colonization and soft biofilm retention, promoting the growth of pathogenic plaque, further calculus formation, gingival tissue inflammation, that could progress to periodontitis and tooth loss. Therefore, removal of dental calculus and prevention of its formation are important for maintaining periodontal health.\n\nProfessional mechanical removal remains the most effective approach to control existing dental calculus; however, it is labor-intensive and represents a burden for patients in terms of costs and access to oral health professionals. Several toothpastes have been developed to dissolve and soften mineralized deposits using abrasive and\u002For chemical agents. Nevertheless, highly abrasive formulations may damage tooth structures and only reduce approximately 30-50% of dental calculus, while dentifrices containing mineralization and crystallization inhibitors can prevent calculus formation but are unable to remove already formed deposits.\n\nTo address these limitations, a Bio-Descaling Powder (BDP) toothpaste has recently been introduced with the aim of removing existing dental calculus. Preliminary clinical evidence showed that the amount of calculus removed with D-Tart toothpaste was five times greater than that achieved with Colgate Total® toothpaste.\n\nGiven the high prevalence of periodontal diseases and the potential role of dental calculus in their initiation and progression, effective strategies for calculus removal and prevention are of considerable clinical interest. The use of an effective toothpaste could reduce the need for professional periodontal interventions or shorten treatment time, thereby decreasing costs and patient burden.\n\nThe aim of this study is to evaluate the efficacy of a Bio-Descaling Powder (BDP)-containing toothpaste, compared with a placebo toothpaste, in decreasing the presence of already formed dental calculus.",[55,28,56],"Dental Calculus","Periodontal Diseases",[58,59,60,61,62,63,64],"dental calculus","calculus removal","Bio-descaling powder toothpaste","Periodontal Maintenance","Gingival inflammation","Supportive Periodontal Care","Periodontal diseases","NOT_YET_RECRUITING","2026-07-04",{"date":68,"type":33},"2026-07-08",{"date":70,"type":22},"2026-07",{"date":72,"type":22},"2027-01",{"name":74,"class":40},"Universidad Complutense de Madrid",{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":83,"enrollmentInfo":84,"targetDuration":4,"studyType":86,"phases":4,"briefSummary":87,"conditions":88,"keywords":91,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":41},"100641785","salivary-biomarkers-in-periodontal-disease-progression-100641785","NCT07661784","Salivary Biomarkers in Periodontal Disease Progression","Evaluation of Salivary Biomarkers Associated With Bone Remodeling in the Transition From Periodontal Health to Disease","PERIO-BIO","Inclusion Criteria:\n\nAdults aged 18-65 years Systemically healthy individuals Individuals classified as periodontally healthy, gingivitis, or periodontitis according to clinical periodontal examination Ability and willingness to provide informed consent\n\nExclusion Criteria:\n\nPresence of systemic diseases affecting periodontal status (e.g., diabetes mellitus, immunological disorders) Use of antibiotics or anti-inflammatory drugs within the last 3 months History of periodontal treatment within the last 6 months Pregnancy or lactation Smoking (optional ) Any condition that may affect salivary biomarker levels","65 Years",{"count":85,"type":22},240,"OBSERVATIONAL","This study aims to evaluate salivary biomarkers associated with bone remodeling during the transition from periodontal health to disease. Periodontal diseases are characterized by chronic inflammation that can lead to connective tissue destruction and alveolar bone loss. Although diagnosis is primarily based on clinical and radiographic findings, these methods may not fully reflect disease activity or progression.\n\nIn this observational study, individuals with periodontal health, gingivitis, and periodontitis will be included. Salivary levels of IL-17, IL-23, IL-6, TGF-β, RANKL, and OPG will be measured using ELISA. The relationship between these biomarkers and periodontal disease stage and grade will be analyzed.\n\nThe results are expected to improve understanding of the biological mechanisms underlying periodontal disease progression and to assess the potential role of salivary biomarkers in early diagnosis and personalized treatment approaches.",[89,28,90],"Periodontal Disease","Periodontitis",[89,92,90,93,94,95,96,97,98,99,100,101,102],"Gingivitis","Salivary Biomarkers","Bone Remodeling","Interleukin-17 (IL-17)","Interleukin-23 (IL-23)","Interleukin-6 (IL-6)","Transforming Growth Factor Beta (TGF-β)","RANKL","Osteoprotegerin (OPG)","ELISA","Non-invasive Diagnosis","2026-06-16",{"date":105,"type":33},"2026-06-22",{"date":107,"type":33},"2025-07-10",{"date":109,"type":22},"2026-08-30",{"name":111,"class":40},"Suleyman Demirel University",{"id":113,"slug":114,"hasResults":11,"nctId":115,"briefTitle":116,"officialTitle":117,"acronym":4,"eligibilityCriteria":118,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":119,"targetDuration":121,"studyType":86,"phases":4,"briefSummary":122,"conditions":123,"keywords":124,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":130,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":41},"100635317","association-between-periodontal-status-and-the-prevalence-of-entamoeba-gingivalis-and-trichomonas-tenax-100635317","NCT07551115","Association Between Periodontal Status and the Prevalence of Entamoeba Gingivalis and Trichomonas Tenax","Prevalence of Entamoeba Gingivalis and Trichomonas Tenax in Saliva and Subgingival Plaque Samples Among Periodontology Patients: A Prospective Observational Study","Inclusion Criteria:\n\n* Participants aged 18 years or older.\n* Having at least 10 natural teeth.\n* Willingness to undergo periodontal examination and providing written informed consent.\n* Includes both periodontally healthy individuals and patients with gingivitis or periodontitis.\n\nExclusion Criteria:\n\n* Use of systemic antibiotics within the last 3 months.\n* Use of chlorhexidine or similar antiseptic mouthwashes within the last month.\n* Having received any periodontal treatment within the last 3 months.\n* Receiving immunosuppressive therapy or having a serious systemic immune deficiency.\n* Pregnancy or breastfeeding.",{"count":120,"type":22},120,"1 Day","This prospective observational study aims to investigate the prevalence and clinical significance of two oral protozoa, Entamoeba gingivalis and Trichomonas tenax, among patients attending the Bolu Abant İzzet Baysal University Faculty of Dentistry, Department of Periodontology. While the oral microbiome typically maintains a delicate balance, disruptions in this ecosystem are thought to trigger periodontal diseases. Recent evidence suggests that these parasites may contribute to increased inflammation and tissue destruction, potentially playing a role in the etiology of gingivitis and periodontitis.\n\nThe study will include 120 participants aged 18 and older who meet the inclusion criteria. Following the collection of demographic data and oral hygiene habits via a questionnaire, a single calibrated examiner will perform comprehensive clinical periodontal examinations. Measurements will include plaque index (PI), gingival index (GI), bleeding on probing (BOP), probing pocket depth (PPD), clinical attachment loss (CAL), and gingival recession (GR) based on the 2017 World Workshop Classification of Periodontal and Peri-Implant Diseases and Conditions.\n\nTo detect the presence of parasites, unstimulated whole saliva samples and subgingival plaque samples from the deepest periodontal pockets will be collected from each participant. These samples will be analyzed immediately at the Parasitology Laboratory using light microscopy (10X and 40X magnification) to identify live trophozoites. By evaluating the relationship between parasite prevalence and periodontal status, this research aims to contribute to the limited literature on oral protozoa in Turkey and increase clinical awareness regarding their impact on oral health.",[28,90],[125,126,127,128],"gingivitis","periodontitis","Entamoeba Gingivalis","Trichomonas Tenax","2026-05-04",{"date":131,"type":33},"2026-05-08",{"date":133,"type":33},"2025-12-22",{"date":135,"type":22},"2026-09",{"name":137,"class":40},"Abant Izzet Baysal University",{"id":139,"slug":140,"hasResults":11,"nctId":141,"briefTitle":142,"officialTitle":143,"acronym":4,"eligibilityCriteria":144,"healthyVolunteers":16,"sex":145,"minAge":18,"maxAge":146,"enrollmentInfo":147,"targetDuration":149,"studyType":86,"phases":4,"briefSummary":150,"conditions":151,"keywords":153,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":159,"lastUpdatePostDateStruct":160,"startDateStruct":162,"completionDateStruct":164,"leadSponsor":166,"locationsCount":41},"100597106","metabolic-profiling-of-saliva-in-pregnancy-and-periodontal-disease-100597106","NCT07054177","Metabolic Profiling of Saliva in Pregnancy and Periodontal Disease","Salivary Metabolomics of Pregnancy and Periodontal Disease Related Metabolic Pathways","Inclusion Criteria:\n\n* Age between 18 and 40 years\n* No history of systemic disease or chronic infection\n* No use of antibiotics or anti-inflammatory drugs in the last 3 months\n* Non-smoker and non-alcohol user\n* Willingness to participate by signing the informed consent form\n\nAdditional Criteria for Pregnant Volunteers:\n\n* Singleton pregnancy (no multiple gestation)\n* Pregnancy progressing without complications (e.g., no diagnosis of preeclampsia, gestational diabetes, or threatened preterm labor)\n* Gestational age confirmed by ultrasound\n\nAdditional Criteria for Non-Pregnant Control Group:\n\n* No history of pregnancy in the past 6 months\n* Regular menstrual cycles\n* No history of hormonal disorders (e.g., polycystic ovary syndrome, thyroid dysfunction)\n\nExclusion Criteria:\n\n* Use of anti-inflammatory or antimicrobial treatments in the past 3 months\n* Smoking or alcohol consumption\n* Body mass index (BMI) \\> 30 kg\u002Fm²\n* Presence of systemic diseases including diabetes mellitus, hyperprolactinemia, congenital adrenal hyperplasia, androgen-secreting tumors, thyroid dysfunction, Cushing's syndrome, hypertension, liver or kidney dysfunction\n* Use of medications that may affect metabolic or hormonal parameters, such as oral contraceptives, steroid hormones, antihypertensives, or insulin-sensitizing drugs\n* Periodontal treatment in the past 6 months\n* Use of medications known to affect periodontal status (e.g., phenytoin, calcium channel blockers, cyclosporine, warfarin, NSAIDs, aspirin \\> 81 mg)\n* Active infectious diseases such as hepatitis, HIV, or tuberculosis","FEMALE","40 Years",{"count":148,"type":22},30,"9 Months","This study aims to better understand how pregnancy affects the health of the gums and tissues that support the teeth. During pregnancy, hormone levels (like estrogen and progesterone) increase significantly. These hormonal changes can cause many changes in the body, including in the mouth. Some pregnant women may notice that their gums become swollen, red, or bleed more easily - this is called pregnancy gingivitis. It happens more often during the second and third trimesters and usually improves after birth. Even if a pregnant person has good oral hygiene, hormonal changes may still make the gums more sensitive to plaque and bacteria. Scientists believe that these changes in gum health are linked to how the body responds to hormones, bacteria in the mouth, and changes in the immune system. To explore this further, saliva samples will be collected from:\n\n* Pregnant women during their 1st, 2nd, and 3rd trimesters\n* The same women again 6-8 weeks after giving birth\n* A group of non-pregnant, healthy women as a comparison group The investigators will use a scientific method called untargeted metabolomics to study these saliva samples. This method helps looking at small substances (called metabolites) in saliva to see if there are any patterns related to pregnancy and gum health.\n\nThe goal is to identify biological changes that happen during pregnancy and understand how they might affect the gums. This research will help improve early detection and prevention of gum problems during pregnancy in the future.",[152,28],"Pregnancy",[154,125,155,156,157,158],"pregnancy","periodontal disease","saliva","metabolomics","LC-MS\u002FMS","2025-07-18",{"date":161,"type":33},"2025-07-23",{"date":163,"type":33},"2025-06-24",{"date":165,"type":22},"2026-04",{"name":167,"class":40},"Bezmialem Vakif University",{"id":169,"slug":170,"hasResults":11,"nctId":171,"briefTitle":172,"officialTitle":173,"acronym":174,"eligibilityCriteria":175,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":176,"targetDuration":4,"studyType":86,"phases":4,"briefSummary":178,"conditions":179,"keywords":180,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":184,"lastUpdatePostDateStruct":185,"startDateStruct":187,"completionDateStruct":189,"leadSponsor":191,"locationsCount":41},"100576401","investigating-the-periodontal-status-of-traditional-and-heated-tobacco-product-users-100576401","NCT06784817","Investigating the Periodontal Status of Traditional and Heated Tobacco Product Users","Investigating the Periodontal Status of Traditional and Heated Tobacco Product Users: A Cross-sectional Observational Study","INPER-THT","Inclusion Criteria:\n\n* Smokers who smoke at least one cigarette daily for the past 12 months.\n* Exclusive users of heated tobacco products (e.g., IQOS), using them at least once daily for the past 12 months and not regular traditional cigarette smokers.\n* Non-smokers who have never consumed tobacco in any form.\n\nExclusion Criteria:\n\n* Users of electronic cigarettes, smokeless tobacco, waterpipes, or any other tobacco products.\n* Dual users of tobacco products.\n* Individuals diagnosed with systemic diseases.\n* Edentulousness or severe tooth loss (fewer than 20 remaining teeth).\n* Individuals who have taken antibiotics, steroids, or non-steroidal anti-inflammatory drugs in the past 90 days.\n* Pregnant or breastfeeding women.\n* History of periodontitis.\n* Individuals refusing to sign the written informed consent form.\n* Third molars are excluded from examination.",{"count":177,"type":22},90,"This cross-sectional observational study aims to compare the clinical and radiographic periodontal status, as well as gingival crevicular fluid volume, among cigarette smokers, heated-tobacco product users, and non-smokers. Specifically, the aim is to determine whether tobacco product users exhibit worse clinical parameters-such as probing pocket depth, bleeding on probing, plaque index, clinical attachment loss-along with greater radiographic bone loss and higher gingival crevicular fluid volume than non-smokers.",[28],[181,182,183],"smoking","heated tobacco products","periodontal diseases","2025-01-15",{"date":186,"type":33},"2025-01-20",{"date":188,"type":33},"2023-09-01",{"date":190,"type":22},"2025-03-01",{"name":192,"class":40},"Semmelweis University"]