[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"global-health\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:global-health":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,51,106,132],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":33,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100591839","khanya-ekhaya-a-home-based-intervention-100591839",false,"NCT06985641","Khanya Ekhaya: A Home-Based Intervention","Home-Based Community Health Worker Support for Mental Health Among People Living With HIV in South Africa: A Hybrid Effectiveness Implementation Trial","Inclusion Criteria:\n\n* at least 18 years old\n* must be a CHW who conducts home visits for people with HIV newly initiating or re-initiating ART at the approved clinic site\n\nExclusion Criteria:\n\n-Unable or unwilling to complete informed consent and study procedures in English, isiXhosa, or Afrikaans","ALL","18 Years",{"count":19,"type":20},119,"ESTIMATED","INTERVENTIONAL",[23],"NA","Mental health conditions, such as depression, anxiety, and harmful alcohol use are prevalent among people with chronic diseases, including HIV, and contribute to poor engagement in care. There is a need to address untreated mental health problems. Community health workers (CHWs) are frontline workers who play a central role in supporting vulnerable individuals to stay in care, including seeking people living with HIV who are newly initiating antiretroviral therapy (ART) or re-initiating after a period of care disengagement. CHW-delivered interventions are promising for improving engagement and retention in care. Yet, these programs rarely address mental health -a significant barrier to chronic disease care engagement and treatment. An approach that moves beyond providing care in the clinic setting is needed.\n\nCommunity-delivered mental health care shows promise for integration into broader community health care services for people with chronic conditions, such as HIV. However, as CHWs are taking on more mental health care roles and community-based work, our team's preliminary research has demonstrated that high levels of stress and burnout are important considerations for successful implementation of these models.",[26,27,28,29,30,31,32],"Mental Health","Community Health Workers","Training","Global Health","Burnout","Well-being","Natured-informed Therapy",[27,34,29,35,36,30,31,37],"Health Personnel","Health Care Seeking Behavior","Attitude of Health Personnel","Nature-informed therapy","NOT_YET_RECRUITING","2026-08-14",{"date":41,"type":42},"2026-08-18","ACTUAL",{"date":44,"type":20},"2026-08-17",{"date":46,"type":20},"2026-11-23",{"name":48,"class":49},"University of Maryland, College Park","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":59,"sex":60,"minAge":17,"maxAge":4,"enrollmentInfo":61,"targetDuration":4,"studyType":21,"phases":63,"briefSummary":64,"conditions":65,"keywords":80,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":50},"100649333","prostate-cancer-risk-calculator-for-actionable-clinical-decision-making-in-nigeria-100649333","NCT07733440","PROstate Cancer Risk Calculator for ACTionable Clinical Decision-making in Nigeria","Clinical Risk Calculator Validation and Implementation to Optimize Prostate Cancer Early Detection in Nigeria","PROACT","Inclusion Criteria:\n\n1. Training - Eligible primary care providers (for the training surveys) will be healthcare practitioners at community-level hospitals.\n2. Supported Risk Assessment\n\n(i) Eligible key informants will be eligible primary care providers who were trained and implemented the supported risk assessment and the targeted population of patient participants who received the supported risk assessment.\n\n(ii) Eligible patient participants (for the collection of observation data) will be the target population of adult males 40 - 79 years accessing provider services.\n\nExclusion Criteria:\n\n\\-",true,"MALE",{"count":62,"type":20},89,[23],"This study is a pilot trial that builds on findings from the validation of prostate cancer risk calculators in Nigerian men. The goal of the overall study is to improve the early detection of prostate cancer in a high-risk population.\n\nThe main questions the validation study aims to answer are:\n\n1. How accurately do existing prostate cancer risk calculators identify Nigerian men with clinically significant prostate cancer?\n2. Will a new risk calculator designed for Nigerian men more accurately identify those with clinically significant prostate cancer?\n\nThe main questions the intervention study aims to answer is:\n\nWill the primary care provider-facing risk calculator be feasible and acceptable for primary care providers to implement?\n\nThe intervention trial will be piloted among participants in community-level hospitals in order to primarily assess implementation outcomes",[66,67,68,69,70,71,72,73,74,75,76,77,29,78,79],"Prostate Cancer","Risk Assessment","Clinical Decision Support Systems","Predictive Value of Tests","Models","Algorithms","Evidence-Based Practice","Implementation Research","Community Health Services","Primary Health Care","Biomarker","Prostate Specific Antigen","Africa","Nigeria",[81,82,83,84,85,86,87,88,89,90,91,92,78,93,94,95,96,79],"Prostate cancer","early detection","prostate cancer screening","early diagnosis","prostate specific antigen","risk calculator","risk prediction model","diagnostic accuracy","validation","prostate biopsy","primary care","implementation science","precision prevention","clinically significant prostate cancer","clinical prediction model","community oncology","2026-07-24",{"date":99,"type":42},"2026-07-29",{"date":101,"type":20},"2029-03",{"date":103,"type":20},"2029-08",{"name":105,"class":49},"Ahmadu Bello University",{"id":107,"slug":108,"hasResults":11,"nctId":109,"briefTitle":110,"officialTitle":111,"acronym":4,"eligibilityCriteria":112,"healthyVolunteers":59,"sex":16,"minAge":4,"maxAge":113,"enrollmentInfo":114,"targetDuration":4,"studyType":21,"phases":116,"briefSummary":117,"conditions":118,"keywords":4,"overallStatus":121,"whyStopped":4,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":125,"completionDateStruct":127,"leadSponsor":129,"locationsCount":131},"100515307","rapid-research-in-diagnostics-development-for-tb-network-r2d2-kids-and-assessing-diagnostics-at-poc-for-tb-in-children-adapt-for-kids-100515307","NCT05989802","Rapid Research in Diagnostics Development for TB Network (R2D2 Kids) and Assessing Diagnostics At POC for TB in Children (ADAPT for Kids)","Rapid Research in Diagnostics Development for Tuberculosis Network (R2D2 Kids) and Assessing Diagnostics At Point-of-care for Tuberculosis in Children (ADAPT for Kids)","Participant eligibility criteria:\n\nParticipants will include children (age \\\u003C15 years) who present to care with:\n\nA. 2 or more of the following:\n\n* Unexplained cough for any duration\n* TB contact or tuberculin skin test or interferon gamma release assay positive\n* Abnormal chest X-ray (any abnormality) OR\n\nB. Any one of criteria A AND any one of the following:\n\n* Unexplained weight loss OR unexplained failure to thrive OR Severe Acute Malnutrition\n* Unexplained fever ≥2 weeks\n* Unexplained lethargy or reduced playfulness ≥2 weeks\n\nThe study will exclude participants who:\n\n1. Completed preventive or active TB treatment within the past 12 months (to increase TB prevalence and reduce false-positive results, respectively);\n2. Have taken any medication with anti-mycobacterial activity for any reason for greater than 3 days at the time of enrollment (to reduce false-negatives);\n3. Are unable to return for follow-up visits; or\n4. Whose parents\u002Fguardians are unwilling to provide informed consent or who are unwilling to provide assent if applicable (age determined by local IRB)\n\nAssessment of the usability of novel TB tests:\n\nThe study will also include health workers at each clinical site who are 1) aged ≥18 years and 2) involved in routine TB testing (collecting specimens for or performing TB tests). Personnel who are unwilling to provide informed consent will be excluded.","65 Years",{"count":115,"type":20},2100,[23],"Every year there are an estimated 230,000 childhood deaths from TB. There is an urgent need for novel tests for TB diagnosis in children under 15 years. The Rapid Research in Diagnostics Development for TB Network (R2D2 Kids) and the Assessing Diagnostics at Point-of-care for Tuberculosis in children (ADAPT for Kids) studies seek to reduce the burden of TB worldwide by evaluating faster, simpler, and less expensive TB triage and diagnostic tests for use in children.",[119,120,29],"Tuberculosis","Diagnostics","RECRUITING","2026-03-09",{"date":124,"type":42},"2026-03-11",{"date":126,"type":42},"2024-01-26",{"date":128,"type":20},"2026-09-01",{"name":130,"class":49},"University of California, San Francisco",3,{"id":133,"slug":134,"hasResults":11,"nctId":135,"briefTitle":136,"officialTitle":137,"acronym":138,"eligibilityCriteria":139,"healthyVolunteers":59,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":140,"targetDuration":4,"studyType":142,"phases":4,"briefSummary":143,"conditions":144,"keywords":146,"overallStatus":121,"whyStopped":4,"lastUpdateSubmitDate":150,"lastUpdatePostDateStruct":151,"startDateStruct":153,"completionDateStruct":155,"leadSponsor":157,"locationsCount":50},"100464593","pvri-godeep-global-deep-phenotyping-meta-registry-for-pulmonary-hypertension-100464593","NCT05329714","PVRI GoDeep Global Deep Phenotyping Meta-Registry for Pulmonary Hypertension","PVRI Global Deep Phenotyping Meta-Registry for Pulmonary Hypertension","PVRI GoDeep","Inclusion Criteria:\n\n* Clinical Diagnosis of Pulmonary Hypertension\n\nExclusion Criteria:\n\n* none",{"count":141,"type":20},40000,"OBSERVATIONAL","PVRI-GoDeep is a PH Meta-Registry, run under the umbrella of the Pulmonary Vascular Research Institute (PVRI). It merges anonymized PH patient related data from various local registries around the world run under the responsibility of PVRI members. It will be operated under the auspices of the University of Giessen\u002FGiessen PH center. Combining deep phenotyping with worldwide outreach, PVRI-GoDeep aims to offer insights into specific geographical and ethnical profiles of PH, to deepen the epidemiological, clinical and molecular understanding of this disease and to promote strategies for improved individualized treatment of PH patients.",[145,29],"Pulmonary Hypertension",[145,147,148,29,149],"Data Integration","Standardization","Quality Indicators","2025-04-01",{"date":152,"type":42},"2025-04-04",{"date":154,"type":42},"2020-01-30",{"date":156,"type":20},"2055-01-30",{"name":158,"class":49},"University of Giessen"]