[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"gonorrhea-female\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:gonorrhea-female":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,44],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":4},"100647125","phase-4-a-randomized-controlled-trial-of-doxycycline-post-exposure-prophylaxis-to-prevent-incident-bacterial-stis-among-women-in-the-united-states-100647125",false,"NCT07704957","A Randomized Controlled Trial of Doxycycline Post Exposure Prophylaxis to Prevent Incident Bacterial STIs Among Women in the United States","Inclusion Criteria:\n\n* Female\n* Aged 18-35\n* Reporting condomless vaginal sex with men AND least one of the following:\n\n  1. diagnosis of CT, gonorrhea, syphilis, or trichomonas in the past year\n  2. reporting 2 or more sexual partners in the past 6 months\n* Plan to continue to be sexually active over the next year\n* Have smartphone and be willing to engage with an app\n* If HIV+: Viral load\\\u003C200 copies\u002Fml and CD4 count \\>200 cells\u002Fmm3\n\nExclusion Criteria:\n\n* Pregnant, nursing, or intending to become pregnant\n* Reported allergy to tetracyclines\n* Liver disease or end-stage renal disease\n* Non-English Speaking\n* Taking concomitant medications which may impact doxycycline metabolism (e.g., systemic retinoids, antacids, barbiturates, carbamazepine, phenytoin, iron, warfarin, rifampin)\n* Not willing to take doxy PEP or comply with study procedures\n* Unable to provide informed consent","FEMALE","18 Years","35 Years",{"count":19,"type":20},519,"ESTIMATED","INTERVENTIONAL",[23],"PHASE4","The bacterial sexually transmitted infections (STIs) chlamydia, gonorrhea, and syphilis cause multiple adverse outcomes in women, and prevention strategies are critically needed. This project will determine the efficacy of doxycycline post-exposure prophylaxis (doxy PEP) to prevent STIs among women through a phase IV, open-label, randomized controlled trial.",[26,27,28,29,30,31],"Chlamydia Females","Gonorrhea Female","Syphilis Female","Adherence","Prophylaxis","Prevention","NOT_YET_RECRUITING","2026-07-10",{"date":35,"type":36},"2026-07-15","ACTUAL",{"date":38,"type":20},"2027-01-01",{"date":40,"type":20},"2032-04-01",{"name":42,"class":43},"Tulane University","OTHER",{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":51,"sex":15,"minAge":52,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":21,"phases":56,"briefSummary":58,"conditions":59,"keywords":63,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":81},"100573201","the-integrated-female-sexually-transmitted-infection-testing-for-hiv-epidemic-control-through-prep-in-step-study-100573201","NCT06743204","The Integrated Female Sexually Transmitted Infection Testing for HIV Epidemic Control Through PrEP (IN-STEP) Study","IN-STEP","Inclusion criteria:\n\n* Sexually active females aged 15-39 years,\n* resident in Rakai Community Cohort Study (RCCS) communities and who have participated in the most recent RCCS survey will be eligible to participate irrespective of their HIV serostatus.\n* Pregnant women will be included in this study\n* Additionally, eligibility criteria include participation in the most recent RCCS with consent to store and test plasma specimens collected during the RCCS visit,\n* consent to be re-contacted for future studies, and\n* willingness to be randomized in IN-STEP.\n\nExclusion criteria:\n\n* Individuals incapable of providing consent or\n* not meeting the above criteria will be excluded from the study.",true,"15 Years","39 Years",{"count":55,"type":20},5560,[57],"NA","Globally, new HIV infections are concentrated in eastern and southern Africa where the infections are largely acquired by women outside of known key populations. Identifying African women at high risk for HIV acquisition and successfully engaging them in HIV prevention services, particularly pre-exposure prophylaxis (PrEP) programs, is an urgent global health priority. The U.S. President's Emergency Plan for AIDS Relief program in Africa typically relies on self-reported risk screening tools (SRST) to target HIV testing and refer individuals for PrEP. However, these tools have low to moderate sensitivity, missing many women at high risk for HIV. This is partly due to underreporting of risk factors, but also because many African women are at heightened HIV risk solely through relationships with high-risk male partners. Moreover, many African women enrolled into PrEP programs stop using PrEP within months of initiation. Decades of research shows that curable sexually transmitted infections (cSTI) are objective markers of future HIV risk, but cSTI testing largely has been omitted from African HIV programs. With the advent of lower cost multiplex cSTI testing and point of care diagnostics, there is new opportunity to determine whether integrating female cSTI testing services into HIV programs can improve HIV epidemic control. Here, the investigators will conduct an individually randomized effectiveness implementation trial of SRST plus cSTI diagnostic testing for chlamydia, gonorrhea, trichomonas, and syphilis compared to SRST alone to increase PrEP use among cis-gender African women aged 15-39 years. The investigators hypothesize that cSTI testing will increase PrEP use primarily through (i) improved identification of women at high risk for HIV and (ii) enhancement of self-perceived HIV risk. The proposed research will be nested within the Rakai Community Cohort Study, a population-based HIV surveillance cohort in Uganda. In Aim 1, \\~4,500 HIV-negative women will be individually randomized 1:1 to PrEP screening based on SRST plus cSTI diagnostic testing (intervention) versus PrEP screening based on SRST alone (control arm). Both arms will be offered syndromic case management for cSTIs and syphilis testing for pregnant women (standard of care). The primary outcomes will be PrEP uptake, adherence, and persistence, assessed through clinical records and drug level testing. In Aim 2, the investigators will perform a mixed-methods, implementation science evaluation of female cSTI testing for HIV prevention and control. The investigators will use qualitative and quantitative methods to assess the mechanisms, barriers, and facilitators to improving PrEP outcomes through cSTI testing and how this varies by cSTI pathogen, SRST outcomes, and demographic profiles. In Aim 3, the investigators will use mathematical models to evaluate different cSTI testing approaches to reduce HIV incidence at a population level by considering what cSTIs to screen for, in what health care settings, and at what cost thresholds. The investigators will also model broader health benefits of cSTI testing. Results from this study will provide actionable, population-level information to inform strategic delivery of high impact HIV prevention through integrated HIV and cSTI programming in Africa.",[27,26,28,60,61,62],"Trichomonas Vaginalis","HIV","PrEP Uptake",[64,65,61,66,67,68,69,70],"Sexually Transmitted Infections (STI)","Diagnostics","Women","Africa","Uganda","PrEP","Adolescent Girls and Young Women (AGYW)","RECRUITING","2025-09-09",{"date":74,"type":36},"2025-09-15",{"date":76,"type":36},"2025-09-08",{"date":78,"type":20},"2029-01-31",{"name":80,"class":43},"Johns Hopkins University",1]