[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hamstring-injuries\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hamstring-injuries":32},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,56],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":39,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":44,"lastUpdatePostDateStruct":45,"startDateStruct":48,"completionDateStruct":50,"leadSponsor":52,"locationsCount":55},"100648278","acute-effects-of-neurodynamics-on-strength-and-endurance-in-athletes-100648278",false,"NCT07721220","Acute Effects of Neurodynamics on Strength and Endurance in Athletes","Acute Effects of Neurodynamics on Strength and Endurance in Athletes: A Randomized Control Trial","Inclusion Criteria:\n\n* Participants must be between 18 and 30 years of age.\n* Must be able to read, understand, and provide informed consent, in English.\n* Must be currently participating in an organized sport (e.g. collegiate, club, or competitive recreational level) or engaging in structured resistance training and athletic conditioning for recreational sports events (e.g 5k, marathon, Crossfit, Hyrox, etc).\n* Medically stable with no known contraindications to physical exertion.\n* Cleared for participation in strength or maximal-effort isometric testing.\n* Be able to perform lower extremity isometric testing without pain that limits maximal effort.\n* Must have 2 lower extremities capable to producing full range knee flexion and extension range of motion.\n* No medical condition that significantly alters lower extremity neuromuscular performance.\n* No history of lower extremity surgery in the past 12 months.\n\nExclusion Criteria:\n\n* Individuals younger than 18 or older than 30.\n* Acute lower extremity injury in the last 12 weeks.\n* Lower extremity surgery within the last 12 months.\n* Pain in either lower extremity that would limit maximal physical exertion.\n* History of neurological disorders, including but not limited to: Neuropathy, Stoke, MS, Parkinson's Disease, etc.\n* Use of medications that significantly impact neuromuscular performance, strength or fatigue.\n* No supplementation that affects neuromuscular performance, strength, or fatigue.\n* Unable to read and understand English.\n* Not in a vulnerable population: Pregnant, mentally or physically challenged, cognitively impaired.",true,"ALL","18 Years","30 Years",{"count":21,"type":22},45,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study explores the acute effects of neurodynamics, an intervention commonly used by physical therapist to improve nerve mobility and decrease pain, on the strength and muscular endurance in the athletic population. This study aims to find if these interventions can maintain or promote strength and endurance in the hamstrings. The studies results will help physical therapist better prescribe exercise and hands-on treatment for hamstring and sciatic nerve related conditions and injuries.",[28,29,30,31,32,33,34,35,36,37,38],"Sciatic Leg Pain","Hamstring Muscle Tightness","Hamstring Muscle Strain","Hamstring Muscle Strength","Hamstring Injuries","Hamstring Injury Prevention","Hamstring Rupture","Sciatic Nerve Injury","Sciatic Radiculopathy","Lumbar Disc Herniation With Radiculopathy","Lumbar Disc Herniation",[40,41,42],"hamstring","sciatic nerve","athlete","RECRUITING","2026-07-20",{"date":46,"type":47},"2026-07-22","ACTUAL",{"date":49,"type":47},"2026-06-15",{"date":51,"type":22},"2026-07",{"name":53,"class":54},"High Point University","OTHER",1,{"id":57,"slug":58,"hasResults":11,"nctId":59,"briefTitle":60,"officialTitle":60,"acronym":4,"eligibilityCriteria":61,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":62,"enrollmentInfo":63,"targetDuration":4,"studyType":23,"phases":65,"briefSummary":66,"conditions":67,"keywords":71,"overallStatus":86,"whyStopped":4,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":55},"100596413","thermal-therapies-in-the-treatment-of-muscle-injuries-100596413","NCT07045129","Thermal Therapies in the Treatment of Muscle Injuries","Inclusion Criteria:\n\n* Participant reported a sudden event\n* Acute onset pain located on the posterior thigh\n* Clinical diagnosis of an acute muscle injury defined as:\n\nLocalized pain during palpation of the area, Increasing pain during isometric contraction, Localized pain during specific tests.\n\n* MRI confirmed acute muscle lesion grade 1 - 2 - 3 (Pollock et al., 2014) of hamstring muscles\n* Available for physiotherapy treatment 4-5 days a week\n* MRI of the injury performed in Aspetar within 7 days from the injury\n* Available for follow-up\n* Compliant with heat or cold-water immersion\n\nExclusion Criteria:\n\n* Chronic condition, diabetes, or immune compromised state\n* Neurological, cardiovascular, pulmonary, or muscular pathology\n* Pacemaker wearer\n* Metallic prosthesis\n* Skin infection\n* Under medication: anti-inflammatory treatment, pain killer drugs, fluoroquinolone antibiotics\n* Contraindication to MRI\n* Previous verified or suspected lower limb muscle injury for the same leg and the same muscle within the last 6 months\n* Chronic lower limb muscle problems on the same muscle\n* Grade 0 and 4 muscle injury determined by MRI (Pollock et al., 2014)\n* Do not have an intention to return to full sport activity\n* Do not want to receive one of the therapies \u002F Noncompliance with heat or cold therapies\n* Contraindication to heat\n* Do not want to comply with follow-up\n* Pregnancy","40 Years",{"count":64,"type":22},135,[25],"Muscle strain injuries represent one of the most prevalent injuries in athletes. Despite this high injury prevalence, there is no evidence to support some of the currently used therapeutic strategies. Amongst them, thermal therapies and especially cryotherapy modalities (Ice, Cold water immersion, perfused garments) have been extensively used on soft tissue injuries to reduce pain perception and decrease inflammation. However, recent findings in humans and in animals have reported conflictual results on the effects of cold on muscle regeneration. On the other hand, recent studies in humans suggest that passive heat exposure can impact positively muscle protein synthesis, mitochondrial content and muscle torque in injured, immobilized and healthy participants. Furthermore, preliminary results from our group have shown a faster removal of muscle damages from the muscle and suggest a better muscle regeneration after a localized heat exposure. As such, our preliminary results confirmed that local heating may represent a promising tool to accelerate muscle regeneration. This randomized controlled trial will investigate the therapeutic effect of two thermal interventions (Hot or cold-water immersion) in the management of acute lower limbs muscle injuries. 135 patients will be distributed in a counterbalanced way into 3 groups: Hot, Cold and Control. All the groups will receive the same physiotherapy treatment. The thermal intervention will consist in 10 sessions of either, 60-minute hot water bath (42°C) for the hot group or, 15-minute Cold water bath (12°C) for the cold group realized after the 10 first physiotherapy session. All thermal interventions will be performed after the testing and physiotherapy treatment.",[32,68,69,34,70],"Hamstring Muscle Repair","Hamstring Muscles","Muscle Tear",[72,73,40,74,75,76,77,78,79,80,81,82,83,84,85],"muscle injury","muscle injuries","muscle repair","regeneration","muscle recovery","thermal therapy","CWI","HWI","cold water immersion","hot water immersion","cryotherapy","heat therapy","HD EMG","muscle tear","NOT_YET_RECRUITING","2025-06-22",{"date":89,"type":47},"2025-07-01",{"date":91,"type":22},"2025-09",{"date":93,"type":22},"2028-09",{"name":95,"class":54},"Aspetar"]