[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"headaches-associated-with-subarachnoid-hemorrhage-sah\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:headaches-associated-with-subarachnoid-hemorrhage-sah":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,47],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":4},"100655616","phase-2-mma-infusion-of-lidocaine-for-treatment-of-headache-in-patients-with-aneurysmal-sah-100655616",false,"NCT07816159","MMA Infusion of Lidocaine for Treatment of Headache in Patients With Aneurysmal SAH","Middle Meningeal Artery Infusion of Lidocaine for Treatment of Headache in Patients With Aneurysmal Subarachnoid Hemorrhage","MIL-SAH","Inclusion criteria\n\n1. Age ≥ 18 years\n2. Imaging showing a SAH and intracranial aneurysm\n3. Undergo endovascular therapy within 72 hours\\*\n4. Glasgow coma scale (GCS) score of 14-15\n5. Maximum headache severity of NRS score ≥ 4 at a time \\> 1 hour after ictus or the ad-ministration of opioids due to headache\n\n   Exclusion criteria\n6. The patient is unable to understand information provided in the national language or English\n7. Known allergies to amide-type local anesthetics or iodinated contrast media\n8. Pregnancy or lactation\n9. Severe hepatic impairment\n10. History of epilepsy\n11. History of chronic opioid use\n12. Renal impairment with eGFR \\\u003C 30 mL\u002Fmin\u002F1.73m2\n13. Current treatment with class III antiarrhythmics (e.g. amiodarone)\n14. Atrioventricular block of II and III degree\n15. Unsuccessful endovascular aneurysm securement or procedural complications","ALL","18 Years",{"count":20,"type":21},90,"ESTIMATED","INTERVENTIONAL",[24],"PHASE2","The purpose of the MIL-SAH trial is to evaluate the efficacy and safety of middle meningeal artery (MMA) lidocaine infusion for the treatment of headache in patients with aneurysmal subarachnoid hemorrhage (SAH). The trial aims to determine whether MMA lidocaine infusion reduces headache severity during the first 72 hours following endovascular aneurysm treatment compared with placebo.",[27],"Headaches Associated With Subarachnoid Hemorrhage (SAH)",[29,30,31,32,33,34],"subarachnoid hemorrhage","lidocaine","middle meningeal artery","SAH","MMA","headache","NOT_YET_RECRUITING","2026-09-07",{"date":38,"type":39},"2026-09-11","ACTUAL",{"date":41,"type":21},"2026-12",{"date":43,"type":21},"2030-02",{"name":45,"class":46},"Rigshospitalet, Denmark","OTHER",{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":57,"briefSummary":58,"conditions":59,"keywords":60,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":78},"100597154","phase-2-ia-lidocaine-and-methylprednisolone-for-headache-associated-with-subarachnoid-hemorrhage-100597154","NCT07054801","IA Lidocaine and Methylprednisolone for Headache Associated With Subarachnoid Hemorrhage","Intra-arterial Lidocaine and Methylprednisolone Injection Into the Middle Meningeal Artery For Treatment of Headache Associated With Subarachnoid Hemorrhage","LIMSAH","Inclusion Criteria:\n\n1. Adults aged ≥18 years with confirmed SAH via computed tomography or magnetic resonance imaging\n2. Undergoing DSA as part of routine diagnostic or therapeutic care\n3. Experiencing headaches with baseline severity assessable using Headache Impact Test (HIT-6) questionnaire and 11-point Numeric Rating Scale (NRS)\n4. Conscious patients who can understand and sign informed consent form\n5. Hemodynamically stable and suitable for intra-arterial procedures\n\n5\\) Willingness to comply with study procedures and follow-ups\n\nExclusion Criteria:\n\n1. Known allergy or hypersensitivity to lidocaine or amide-type anesthetics\n2. Known allergy or hypersensitivity to Intralipid® (intravenous fat emulsion) or any of its components, including egg phospholipids or soy-based products\n3. Known allergy or hypersensitivity to methylprednisolone, corticosteroids, any component of the Solu-Medrol® formulation\n4. Diagnostic abnormalities at baseline, including ECG abnormalities (e.g., prolonged PR\u002FQTc intervals, heart block, arrhythmias)\n5. Cardiac conditions including history of heart block, Stokes-Adams syndrome, Wolff-Parkinson-White syndrome, or use of antiarrhythmics\n6. Steroid-induced psychiatric history; uncontrolled seizures; uncontrolled diabetes; glaucoma\u002Focular hypertension; current\u002Frecent high-dose systemic steroids.\n7. Previous IA lidocaine or methylprednisolone (or similar) therapy prior to enrollment\n8. Alternative headache etiology (e.g., migraines, tension-type headache)\n9. Unable to report pain reliably due to severe cognitive or communication deficits\n10. Severe hemodynamic instability precluding safe DSA participation\n11. Contraindications to IA catheterization or DSA (e.g., severe peripheral vascular disease, contrast allergies)\n12. Severe renal impairment (eGFR \\\u003C30 mL\u002Fmin\u002F1.73 m²)\n13. Severe hepatic impairment (e.g., Child-Pugh Class C)\n14. Active systemic infections\n15. Severe comorbid conditions with life expectancy \\\u003C30 days\n16. Participants who are pregnant or breastfeeding\n17. Conditions or concomitant medications listed in the USPI for study drugs that would compromise safety or data quality\n18. Current participation in another clinical trial",{"count":56,"type":21},25,[24],"Subarachnoid hemorrhage (SAH) is a type of bleeding around the brain that can cause sudden and severe headaches. These headaches can be debilitating and persist for weeks, significantly impacting a patient's comfort and recovery. Many patients require opioids for pain control, which can lead to side effects such as drowsiness, constipation, and dependency. There is a need for new treatment strategies to help relieve this pain while minimizing side effects.\n\nThis clinical study is designed to evaluate whether an injection of two medications (lidocaine and methylprednisolone) directly into the middle meningeal artery (MMA) can help reduce headache severity in patients who recently experienced a SAH. The medications will be given through a minimally invasive procedure performed during a routine angiogram, a type of imaging test already commonly used in SAH patients. The main goals of the study are to determine whether this treatment approach is safe, helps to reduce the severity of headaches, and decreases the need for opioid pain medications. Eligible patients will be those recently diagnosed with persistent headache symptoms and SAH who are undergoing routine cerebral angiogram, during which the medications are infused into the MMA. Participants will be monitored for pain levels using the Headache Impact Test (HIT-6) and 11-point Numeric Rating Scale (NRS), and for changes in their functional recovery using standard neurologic scales. The results of this study may provide early evidence to support new treatment options for patients suffering from difficult-to-control headaches after a SAH.",[27],[61,62,63,64,65,66,67],"Headache","Subarachnoid hemorrhage","Lidocaine","Methylprednisolone","Intra-arterial","Middle meningeal artery","Digital subtraction angiography","RECRUITING","2026-07-04",{"date":71,"type":39},"2026-07-08",{"date":73,"type":39},"2026-06-23",{"date":75,"type":21},"2027-06-01",{"name":77,"class":46},"Daniel Raper, MBBS",1]