[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"health-behavior-risky\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:health-behavior-risky":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,52],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":34,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":4},"100613748","french-military-firefighters-to-assess-relationships-between-exposome-and-health-100613748",false,"NCT07270627","French Military Firefighters to Assess Relationships Between Exposome and Health.","Cohorte Militaire et Son Exposome : étude Pilote rétrospective au Sein de la Population Des Sapeurs-pompiers (Actuellement en Exercice et Anciens Sapeurs-pompiers) de la Brigade Des Sapeurs Pompiers de Paris","COMITEX-BSPP","Inclusion Criteria:\n\n* Active-duty or veteran military personnel from French Paris firefighter brigade.\n* Aged at least 18.\n* Not opposed to participate to the study\n\nExclusion Criteria:\n\n* Opposition to participate\n* veterans under legal protection",true,"ALL","18 Years",{"count":21,"type":22},15000,"ESTIMATED","OBSERVATIONAL","The aim of the study is to describe professional exposures and health events among French military firefighters (both active-duty personnel and veterans) and identify potential relationships between the exposome (the total history of occupational and personal exposures) and health status in these populations. The study is based on a self-administered questionnaire that collects retrospective and present information about exposures and health conditions.",[26,27,28,29,30,31,32,33],"Health Adult Subjects","Exposure Occupational","Health Behavior, Risky","Occupational Health","Exposure","Firefighters","Military Personnel","Observational Study",[35,36,37,38,39],"Occupational exposure","health","military","exposome","occupational","NOT_YET_RECRUITING","2025-11-26",{"date":43,"type":44},"2025-12-08","ACTUAL",{"date":46,"type":22},"2026-01-01",{"date":48,"type":22},"2026-12",{"name":50,"class":51},"Direction Centrale du Service de Santé des Armées","OTHER",{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":11,"sex":18,"minAge":60,"maxAge":61,"enrollmentInfo":62,"targetDuration":64,"studyType":23,"phases":4,"briefSummary":65,"conditions":66,"keywords":70,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":83},"100528706","dementia-risk-registry-for-young-and-middle-aged-csvd-patients-in-the-next-10-years-100528706","NCT06164262","Dementia Risk Registry for Young and Middle-aged CSVD Patients in the Next 10 Years","Dementia Risk rEgistry for Young And Middle-aged CSVD Patients in the Next 10 Years（DREAM-10）","DREAM-10","Inclusion Criteria:\n\n1. Patients with any of the CSVD-related MRI imaging markers, including recent small subcortical infarcts, lacunes, white matter hyperintensities, perivascular spaces, microbleeds, and superficial cortical siderosis.\n2. Patients aged from 30 to 60 years.\n3. Sign informed consent.\n\nExclusion Criteria:\n\n1. Unable to cooperate with inspectors.\n2. Known dementia.\n3. Other cognitive diseases (such as Alzheimer's disease, Parkinson's disease, or thyroid disease).\n4. Serious systemic illness, such as heart, liver, kidney disease or major mental illness.\n5. Contraindications for imaging examination.\n\nExit Criteria:\n\n1. Not meet the inclusion criteria.\n2. For any poor adherence, not comply with the requirements of the follow-up, or safety reasons determined by investigator.\n3. Any adverse or serious adverse events during the study period judged by investigator.","30 Years","60 Years",{"count":63,"type":22},1000,"10 Years","Age-related cerebral small-vessel disease (CSVD) is a major cause of dementia, predominantly affecting individuals over 60 years of age, with a prevalence exceeding 70% in the elderly population. However, the correlation between the burden of CSVD and the progression of cognitive impairment in young and middle-aged individuals remains uncertain. DREAM-10 is an observational, prospective study that enrolled individuals aged 30-60 years, who were free from known dementia but exhibited imaging markers related to CSVD. Through prospective registration and follow-up, this study will collect data on patients with CSVD, including clinical information, neuropsychological assessments, multimodal Magnetic Resonance Images (MRI) and retinopathy characterized by Optical Coherence Tomography Angiography (OCTA). CSVD related features seen on neuroimaging include recent small subcortical infarcts, lacunes, white matter hyperintensities, perivascular spaces, microbleeds, brain atrophy, cortical superficial siderosis. Utilizing this data, the researchers aim to investigate the potential dementia risk among young and middle-aged individuals with CSVD over the forthcoming decade, along with identifying its predictive factors.",[67,68,69,28],"Cerebral Small Vessel Diseases","Dementia, Mixed","Health Behavior",[67,71,72],"Dementia","Cardiovascular health","RECRUITING","2025-05-18",{"date":76,"type":44},"2025-05-21",{"date":78,"type":44},"2024-01-01",{"date":80,"type":22},"2034-12-01",{"name":82,"class":51},"Zhejiang Provincial People's Hospital",1]