[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"healthy-adults\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:healthy-adults":30},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,46,0,25,[9,44,78,104,130,152,179,209,230,251,281,302,324,347,375,401,426,450,477,498,523,543,573,599,622],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100644851","phase-1-a-study-to-learn-how-the-study-medicine-called-atirmociclib-is-handled-by-the-body-in-people-with-normal-liver-function-and-different-levels-of-liver-disease-100644851",false,"NCT07677358","A Study to Learn How the Study Medicine Called Atirmociclib is Handled by the Body in People With Normal Liver Function and Different Levels of Liver Disease","A PHASE 1, NON-RANDOMIZED, OPEN-LABEL, SINGLE-DOSE, PARALLEL GROUP STUDY TO COMPARE THE PHARMACOKINETICS OF ATIRMOCICLIB IN ADULT PARTICIPANTS WITH VARYING DEGREES OF HEPATIC IMPAIRMENT RELATIVE TO PARTICIPANTS WITH NORMAL HEPATIC FUNCTION","Inclusion criteria including but not limited to:\n\n* BMI of 17.5-40 kg\u002Fm2; and a total body weight \\>50 kg (110 lb).\n* Willing and able to comply with all scheduled visits, treatment plan, laboratory tests, lifestyle considerations, and other study procedures.\n* Capable of giving signed informed consent.\n\nNormal hepatic function group only:\n\n\\- Overtly healthy as determined by medical evaluations including medical history, physical examination, laboratory tests, vital signs and standard 12-lead ECGs.\n\nHepatic impairment groups only:\n\n\\- Stable hepatic impairment meeting the criteria for Child-Pugh Class A, B, or C . Stable hepatic impairment is defined as no clinically significant change in disease status within the last 28 days prior to the screening visit, as documented by the participant's recent medical history.\n\nExclusion criteria including but not limited to:\n\n* Any condition or history of surgery possibly affecting drug absorption.\n* Use of prohibited prior or concomitant medications.\n\nNormal hepatic function group only:\n\n\\- Evidence or history of clinically significant hematological, renal, endocrine, pulmonary, gastrointestinal, cardiovascular, psychiatric, neurological, or allergic disease (including drug allergies, but excluding untreated, asymptomatic, seasonal allergies at the time of dosing).\n\nHepatic impairment groups only:\n\n\\- A diagnosis of hepatic dysfunction secondary to any acute ongoing hepatocellular process that is documented by medical history, PE, liver biopsy, hepatic ultrasound, CT scan, or MRI.",true,"ALL","18 Years",{"count":21,"type":22},28,"ESTIMATED","INTERVENTIONAL",[25],"PHASE1","The purpose of this study to understand how the study medicine atirmociclib behaves in the body and how safe it is for people with different levels of liver health.\n\nThe study is seeking participants who are:\n\n* Aged 18 years or older\n* Have a BMI of 17.5 to 40 kg\u002Fm2, and body weight more than 50 kg.\n* Have normal liver function or have stable mild, moderate, or severe liver disease\n\nParticipants will receive study medicine by mouth. Blood samples will be collected to see how much of the medicine is in the body over time. This will help understand whether liver disease changes how the medicine is handled.\n\nParticipants will be in the study for about 9 weeks. Those with normal liver function will stay in the clinic for about 7 days. People with liver disease will stay for about 9 days. After leaving the clinic, people may be contacted for follow-up. This may be done by phone or through a clinic visit.",[28,29,30],"Hepatic Impairment","Healthy, Hepatic Insufficiency","Healthy Adults","RECRUITING","2026-08-19",{"date":34,"type":35},"2026-08-21","ACTUAL",{"date":37,"type":35},"2026-06-29",{"date":39,"type":22},"2027-09-10",{"name":41,"class":42},"Pfizer","INDUSTRY",3,{"id":45,"slug":46,"hasResults":12,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":17,"sex":18,"minAge":51,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":55,"phases":4,"briefSummary":56,"conditions":57,"keywords":63,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":4},"100652794","an-innovative-proprioceptive-instrument-for-upper-extremities-100652794","NCT07779928","An Innovative Proprioceptive Instrument for Upper Extremities","Development, Validation, and Clinical Application of an Innovative Proprioceptive Instrument for Upper Extremities: PropArm-PosiMoF (PropArm)","1. Healthy Young Adults:\n\n   Inclusion Criteria:\n   * (1) Age between 20 and 29 years,\n   * (2) Right-hand dominance, and\n   * (3) Ability to understand three consecutive verbal instructions.\n\n   Exclusion Criteria:\n   * (1) Currently a student or faculty member of the Department of Occupational Therapy at National Cheng Kung University, or a staff member of the Department of Physical Medicine and Rehabilitation, National Cheng Kung University Hospital,\n   * (2) History of surgery on the right upper limb,\n   * (3) Presence of neuromusculoskeletal disorders that may affect sensory or motor function of the right upper limb, such as stroke or shoulder impingement syndrome, and\n   * (4) Uncorrected hearing problems, such as hearing loss.\n2. Healthy Adults:\n\n   Inclusion Criteria:\n   * (1) Age between 30 to 39, 40 to 49, or 50 to 59 years,\n   * (2) Right-hand dominance, and\n   * (3) Ability to understand three consecutive verbal instructions.\n\n   Exclusion Criteria:\n   * (1) Currently a student or faculty member of the Department of Occupational Therapy at National Cheng Kung University, or a staff member of the Department of Physical Medicine and Rehabilitation, National Cheng Kung University Hospital,\n   * (2) History of surgery on the right upper limb,\n   * (3) Presence of neuromusculoskeletal disorders that may affect sensory or motor function of the right upper limb, such as stroke or shoulder impingement syndrome, and\n   * (4) Uncorrected hearing problems, such as hearing loss.\n3. Healthy Older Adults:\n\n   Inclusion Criteria:\n   * (1) Age between 60 to 69, 70 to 79, or 80 to 89 years,\n   * (2) Right-hand dominance, and\n   * (3) Ability to understand three consecutive verbal instructions.\n\n   Exclusion Criteria:\n   * (1) Score below the 5th percentile on the Color Trails Test-Chinese Version (CTT-C),\n   * (2) Currently a student or faculty member of the Department of Occupational Therapy at National Cheng Kung University, or a staff member of the Department of Physical Medicine and Rehabilitation, National Cheng Kung University Hospital,\n   * (3) History of surgery on the right upper limb,\n   * (4) Presence of neuromusculoskeletal disorders that may affect sensory or motor function of the right upper limb, such as stroke or shoulder impingement syndrome, and\n   * (5) Uncorrected hearing problems, such as hearing loss.\n4. Stroke:\n\n   Inclusion Criteria:\n   * (1) Age between 20 and 89 years,\n   * (2) Right-hemispheric hemorrhagic or ischemic stroke with lesions involving proprioceptive pathways or the primary somatosensory cortex, potentially resulting in difficulties with body position, movement, or force perception, or with fine tactile perception (e.g., localization, two-point discrimination, object recognition),\n   * (3) Right-hand dominance, and\n   * (4) Ability to understand three consecutive verbal instructions.\n\n   Exclusion Criteria:\n   * (1) Score below the 5th percentile on the Color Trails Test-Chinese Version (CTT-C),\n   * (2) Upper limb still in acute pain stage,\n   * (3) Muscle tone severe enough to affect right upper limb movement (e.g., score ≥ 1+ on the Modified Ashworth Scale),\n   * (4) Uncorrected hearing problems, such as hearing loss.\n5. Shoulder Impingement Syndrome:\n\n   Inclusion Criteria:\n   * (1) Age between 20 and 89 years,\n   * (2) Diagnosis of shoulder impingement syndrome in the right upper limb,\n   * (3) Right-hand dominance, and\n   * (4) Ability to understand three consecutive verbal instructions.\n\n   Exclusion Criteria:\n   * (1) Score below the 5th percentile on the Color Trails Test-Chinese Version (CTT-C),\n   * (2) Upper limb still in acute pain stage,\n   * (3) Uncorrected hearing problems, such as hearing loss.\n6. Diabetes (DM):\n\nInclusion Criteria:\n\n* (1) Age between 20 and 89 years,\n* (2) Diagnosis of diabetes mellitus by a specialist physician, based on one of the following:\n\n  1. Fasting plasma glucose (FPG) ≥ 126 mg\u002FdL or 7.0 mmol\u002FL;\n  2. Hemoglobin A1C (HbA1c) ≥ 6.5%;\n  3. Plasma glucose ≥ 200 mg\u002FdL or 11.1 mmol\u002FL at 2 hours during an oral glucose tolerance test (OGTT);\n  4. Presence of hyperglycemia symptoms (polyphagia, polyuria, polydipsia, and unexplained weight loss) with a random plasma glucose ≥ 200 mg\u002FdL.\n\nDiagnosis of diabetes is confirmed if any two of items (a-c) are met, or if any one of them remains positive on repeat testing; fulfillment of item (d) alone is also sufficient for diagnosis.\n\n* (3) Right-hand dominance, and\n* (4) Ability to understand three consecutive verbal instructions.\n\nExclusion Criteria:\n\n* (1) Score below the 5th percentile on the Color Trails Test-Chinese Version (CTT-C),\n* (2) History of surgery on the right upper limb,\n* (3) Presence of other neuromusculoskeletal disorders that may affect sensory or motor function of the right upper limb, and\n* (4) Current skin infection, and\n* (5) Uncorrected hearing problems, such as hearing loss.","20 Years","89 Years",{"count":54,"type":22},280,"OBSERVATIONAL","This study aimed to develop and validate an innovative proprioceptive assessment instrument for the upper extremities, the PropArm-PosiMoF (PropArm). This observational study was conducted in three stages. The first stage focused on the development and validation of PropArm, including test-retest reliability, concurrent validity, and convergent validity. The second stage established age norms and cut-off points in healthy adults. In the final stage, PropArm was applied to patients with proprioceptive impairments (stroke, shoulder impingement syndrome, and diabetes mellitus patients) to examine its diagnostic accuracy and clinical applicability.",[58,59,60,61,30,62],"Stroke","Shoulder Impingement Syndrome","Diabetes (DM)","Healthy Young Adults","Healthy Older Adults",[64,65,66,67],"Proprioception","Upper Extremities","Instrument","Psychometric Properties","NOT_YET_RECRUITING","2026-08-18",{"date":34,"type":35},{"date":72,"type":22},"2026-09-01",{"date":74,"type":22},"2027-12-31",{"name":76,"class":77},"National Cheng-Kung University Hospital","OTHER",{"id":79,"slug":80,"hasResults":12,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":84,"eligibilityCriteria":85,"healthyVolunteers":17,"sex":18,"minAge":86,"maxAge":87,"enrollmentInfo":88,"targetDuration":4,"studyType":23,"phases":90,"briefSummary":92,"conditions":93,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":103},"100578457","evaluating-the-effects-of-an-electrical-stimulator-on-improving-the-walking-ability-of-children-with-cerebral-palsy-100578457","NCT06811545","Evaluating the Effects of an Electrical Stimulator on Improving the Walking Ability of Children With Cerebral Palsy","Exploring the Effects of Multi-Joint Neuromuscular Electrical Stimulation on Training Gait of Children With Cerebral Palsy","CP","\\*Inclusion Criteria\\*\n\nCP Group:\n\n* Age 7-18\n* Diagnosis of spastic diplegic cerebral palsy (CP)\n* GMFCS level I-III (be able to walk with or without assistive devices)\n* MIGR \\\u003C 40% femoral head covering in acetabulum\n* Crouch, equinus, or jump gait\n* At least 0° passive dorsiflexion range of motion (ROM)\n* Sufficient visuoperceptual, cognitive, and communication skills\n* Seizure-free or well-controlled seizures\n* No other neurological or musculoskeletal disorders (e.g. dystonia, severe scoliosis, hip instability\n* Ability to travel to the University of Nebraska at Omaha two times\n* Ability to communicate pain or discomfort\n* Ability to obtain child assent and obtain parent\u002Fguardian consent\n\nHealthy adults (control) group:\n\n* Adults aged 20 to 40\n* Adults with good physical health\n* Adults with the ability to follow verbal instructions\n* Adults with the ability to walk on a treadmill for 15 minutes\n* No orthopedic surgery on the lower limb within the past 3 months\n\n\\*Exclusion Criteria\\*\n\nCP Group:\n\n* Diagnosis of athetoid or ataxic cerebral palsy (CP)\n* Scoliosis with primary curve \\> 49%\n* Spinal fusions extending into the pelvis\n* Lower Extremity (LE) joint instability or dislocation\n* Severe tactile hypersensitivity\n* LE botulinum injections in the past 6 mo\n* Implanted medical device contraindicative of functional electrical stimulation (FES)\n* Pregnancy\n* Severe LE spasticity (Modified Ashworth Scale score of 4 or greater)\n* History of pulmonary disease limiting exercise tolerance (Asthma Control Test screen)\n* History of cardiac disease (American Heart Association, AH,) screen)\n* Excessive LE joint pain during walking\n* Severely limited range of joint motion\u002F irreversible muscle contractures, i.e.\\> 10° knee flexion, \\>15° hip flexion contractures, or \\>5° plantarflexion contractures\n* LE surgery or significant injury within 1 yr.\n\nHealthy adults (control) group:\n\n* Adults with any chronic illnesses or medical conditions that could impact their health.\n* Adults with significant behavioral or emotional issues that could indicate developmental disorders or psychological conditions.\n* Adults with diagnosed developmental disorders (e.g., autism, ADHD, learning disabilities)\n* Adults with surgery on their lower limb within the past 3 months.","7 Years","40 Years",{"count":89,"type":22},65,[91],"NA","The goal of this study is to see if gentle electrical stimulation can help children with cerebral palsy (CP) walk more easily. This stimulation, called neuromuscular electrical stimulation (NMES), sends small pulses to muscles to help them activate. Researchers will test different ways of using NMES to find out which method works best.\n\nParticipants will walk on a treadmill at a comfortable speed while NMES is applied to leg muscles. The study will compare different stimulation settings to see which one helps the most.",[94,30],"Cerebral Palsy Children","2026-08-17",{"date":32,"type":35},{"date":98,"type":22},"2026-09",{"date":100,"type":22},"2029-07",{"name":102,"class":77},"University of Nebraska",1,{"id":105,"slug":106,"hasResults":12,"nctId":107,"briefTitle":108,"officialTitle":108,"acronym":4,"eligibilityCriteria":109,"healthyVolunteers":17,"sex":18,"minAge":110,"maxAge":111,"enrollmentInfo":112,"targetDuration":4,"studyType":23,"phases":114,"briefSummary":116,"conditions":117,"keywords":118,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":124,"completionDateStruct":126,"leadSponsor":128,"locationsCount":103},"100649072","early-phase-1-changes-in-self-awareness-induced-by-psychoactive-substances-an-experimental-study-with-psilocybin-100649072","NCT07732166","Changes in Self-awareness Induced by Psychoactive Substances: an Experimental Study With Psilocybin.","Inclusion Criteria:\n\n* Minimum age of 21 and maximum age of 60;\n* Minimum of eight years of schooling;\n* Fluency in Portuguese;\n* Agree, one week before the experiment, to abstain from:\n\n  * Using any herbal supplements (except with prior approval from the researchers);\n  * Using any non-prescribed medication (except non-steroidal anti-inflammatory drugs or paracetamol, provided they have prior approval from the research team);\n  * Using any prescribed medication (except birth control pills, thyroid hormones, or other medications, provided they have prior approval from the research team);\n  * Using recreational psychoactive substances;\n* Agree to abstain, 24 hours before the experiment, from:\n\n  * Consuming beverages with high caffeine content (e.g., coffee, mate, cola);\n  * Consuming alcoholic beverages;\n* Agreeing not to use caffeine or nicotine for two and six hours, respectively, after the experiment;\n* Agree not to drive a motor vehicle or operate machinery for 24 hours after the experiment;\n* Be available to be contacted by telephone for all planned stages;\n* Agree to use effective contraception throughout the study;\n* Agree to inform researchers of any medical condition or procedure that may arise prior to the experiment;\n* Agree not to participate in any other interventional clinical trial for the duration of this study.\n\nExclusion Criteria:\n\n* History of traumatic brain injury, stroke, epilepsy, neurological disease, or cardiovascular disease;\n* Evidence or history of coronary or cerebral artery disease, peripheral vascular disease, liver disease with altered liver enzymes, or any other medical condition that the researchers, including the responsible physician, deem to significantly increase the risk of administering any substance;\n* Pregnant or breastfeeding women, or women who could potentially become pregnant and are not using any effective contraceptive method;\n* Women who, at the screening stage, do not have a negative pregnancy test.\n* Having a history of or currently having a primary psychotic disorder, schizophrenia spectrum disorder, bipolar affective disorder (type 1 and 2), dissociative identity disorder, major depressive disorder;\n* History of psychotic disorders in a first-degree relative;\n* Have resting blood pressure that does not exceed 140 mmHg (systolic) and 90 mmHg (diastolic) - measured in four assessments on at least two different days;\n* Have resting blood pressure below 90 mmHg (systolic) and 60 mmHg (diastolic) - measured in four assessments on at least two different days;\n* Weigh less than 48 kg;\n* Require therapy with psychiatric medications concurrently with the study;\n* Have a history of or present with gastrointestinal disease;\n* Previous use of psilocybin or similar substances;\n* Frequent use (at least once a month) of any other psychoactive substance in the last year, except for nicotine, caffeine and alcohol;\n* Have a history of disorders or problems related to the use of psychoactive substances;\n* Not be able to provide adequate informed consent;\n* Any other condition that may compromise the results or that represents any risk to the participant, according to the assessment of the research team and the responsible physician.","21 Years","60 Years",{"count":113,"type":22},100,[115],"EARLY_PHASE1","Self-awareness, the capacity of becoming the object of one's own awareness, is a frontier of scientific knowledge. Over centuries, distinct philosophical and religious traditions have grappled with the subject, but only recently has the importance of self-awareness been established as a central concept for scientific investigation, to which scientific methods can be applied to explore and characterize this phenomenon. Self-awareness has important implications, notably from a clinical perspective. Psychedelics can affect the sense of self, with 'ego dissolution' being an essential feature of the experience of substances such as psilocybin and dimethyltryptamine. Recent evidence indicates that psychedelics can rearrange brain connectivity, with these changes being linked to alterations in self-awareness. Nevertheless, the extent to which specific components of self-awareness are modified by these substances has not been fully explored. It is possible that part of the clinical benefits of psychedelics, for conditions such as depression, OCD, and anxiety, is mediated by changes in self-awareness. Given this clinical potential, the current study aims to examine the effects of psilocybin on various components of self-awareness in healthy participants. 100 participants will be allocated to receive either 15mg of psilocybin (n=50) or an active placebo (100mg niacin; n=50). Participants will be assessed one week before, immediately after, and one week after the administration of the substances, performing tasks and completing questionnaires measuring self-awareness at these time points. The neural correlates of self-awareness, before and after substance effects, will be investigated using near-infrared spectroscopy. Participants allocated to the placebo group will be invited to an open-label extension with psilocybin upon availability of the substance. It is expected that the results of the study will elucidate the brain regions involved in self-awareness, as well as the alterations induced by psilocybin in this process, opening the possibility of new therapeutic interventions for different clinical groups.",[30],[119,120],"Psilocybin","Self-awareness","2026-07-27",{"date":123,"type":35},"2026-07-28",{"date":125,"type":35},"2026-04-01",{"date":127,"type":22},"2027-12-01",{"name":129,"class":77},"Pontifícia Universidade Católica do Rio de Janeiro",{"id":131,"slug":132,"hasResults":12,"nctId":133,"briefTitle":134,"officialTitle":135,"acronym":4,"eligibilityCriteria":136,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":137,"targetDuration":4,"studyType":23,"phases":139,"briefSummary":140,"conditions":141,"keywords":142,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":146,"lastUpdatePostDateStruct":147,"startDateStruct":148,"completionDateStruct":149,"leadSponsor":151,"locationsCount":103},"100649205","phase-1-a-study-to-learn-about-how-food-affects-the-uptake-of-study-medicine-prifetrastat-into-the-blood-in-healthy-adults-100649205","NCT07731100","A Study to Learn About How Food Affects the Uptake of Study Medicine Prifetrastat Into the Blood in Healthy Adults","A PHASE 1, RANDOMIZED, OPEN-LABEL, 2-PERIOD, 2-SEQUENCE, SINGLE-DOSE, CROSSOVER STUDY IN HEALTHY PARTICIPANTS TO EVALUATE THE EFFECT OF FOOD ON THE RELATIVE BIOAVAILABILITY OF PRIFETRASTAT","Inclusion Criteria\n\n* Females of nonchildbearing potential and males ≥18 years of age at screening who are overtly healthy as determined by medical evaluation including medical history, physical examination, laboratory tests, vital signs and 12-lead ECGs.\n* Body mass Index (BMI) of 18-32 kg\u002Fm2; and a total body weight \\>50 kg (110 lb).\n\nExclusion Criteria\n\n* Use of prescription or nonprescription drugs and dietary and herbal supplements within 14 days or 5 half-lives (whichever is longer) prior to the first dose of study intervention\n* Any prior use of epigenetic modifying agents.\n* Current use or anticipated need for food or drugs that are known moderate or strong inducers or inhibitors of CYP2C9 or CYP3A4, including their administration within 14 days plus 5 half-lives of the inducers or 14 days or 5 half lives (whichever is longer) for the inhibitors of CYP2C9 or CYP3A4, prior to first dose of study intervention, during the treatment period, and within 6 days after the last dose of prifetrastat.\n* Proton pump inhibitors must be discontinued at least 14 days prior to the first dose of study medication and throughout treatment period.",{"count":138,"type":22},12,[25],"The purpose of the study is to assess the effect of food (high-fat, high-calorie meal) on the total and peak drug exposure of the planned to be marketed tablet formulation of prifetrastat.\n\nThis study is seeking participants who are:\n\n\\- Healthy males and females of nonchildbearing potential ≥18 years of age at screening\n\nThe participants will receive study medicine prifetrastat as a single tablet by mouth at study clinic under fed or fasted condition. After at least 14 days, they will receive another single tablet of prifetrastat by mouth under fasted or fed condition. The sequence of conditions (fed or fasted first) will be randomized.\n\nThe results of this study will enable data-driven guidance regarding food intake for participants enrolled in clinical studies of prifetrastat as well as patients receiving prifetrastat post-marketing. Participants will remain in clinic for about 21 days and have one follow up contact.",[30],[143,144,145],"Prifetrastat","Food Effect","PF-07248144","2026-07-24",{"date":123,"type":35},{"date":146,"type":22},{"date":150,"type":22},"2026-10-02",{"name":41,"class":42},{"id":153,"slug":154,"hasResults":12,"nctId":155,"briefTitle":156,"officialTitle":157,"acronym":4,"eligibilityCriteria":158,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":159,"targetDuration":4,"studyType":23,"phases":161,"briefSummary":162,"conditions":163,"keywords":164,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":171,"lastUpdatePostDateStruct":172,"startDateStruct":174,"completionDateStruct":175,"leadSponsor":177,"locationsCount":4},"100647982","the-effects-of-a-smartphone-based-acceptance-and-commitment-therapy-program-on-the-mental-health-and-quality-of-life-of-caregivers-working-in-long-term-care-facilities-100647982","NCT07714408","The Effects of a Smartphone-Based Acceptance and Commitment Therapy Program on the Mental Health and Quality of Life of Caregivers Working in Long-Term Care Facilities","The Effects of a Smartphone-Based Acceptance and Commitment Therapy Program on the Mental Health and Quality of Life of Caregivers Working in Long-Term Care Facilities: A Randomized Controlled Trial Study","Inclusion Criteria:\n\n* Caregivers aged 18 years or older who provide care services to older adults in long-term care facilities, own a smartphone, and have no history of depression or other mental illnesses.\n\nExclusion Criteria:\n\n* Caregivers with a history of depression or other mental illnesses, or those who do not own a smartphone.",{"count":160,"type":22},140,[91],"The aim of this study is to investigate whether a smartphone-based Acceptance and Commitment Therapy (ACT) program can improve the mental health and quality of life of care workers in long-term care facilities. The research question of this study is as follows: Among caregivers working in long-term care facilities, are there differences in mental health, quality of life, and job burnout between the experimental group that participated in a smartphone-based ACT program and the control group that participated in a document-based ACT program?\n\nParticipants in the experimental group will complete 70 daily sessions of a smartphone-based ACT program using Anzeilax-Plus, administered Monday through Friday over a 14-week period. Participants in the control group will complete 70 daily assignments from a document-based ACT program, administered Monday through Friday over the same 14-week period.",[30],[165,166,167,168,169,170],"mobile app","acceptance and commitment therapy","Randomized Controlled Trial","caregivers","long-term care facilities","mental health","2026-07-18",{"date":173,"type":35},"2026-07-21",{"date":121,"type":22},{"date":176,"type":22},"2027-02-28",{"name":178,"class":77},"Sookmyung Women's University",{"id":180,"slug":181,"hasResults":12,"nctId":182,"briefTitle":183,"officialTitle":184,"acronym":4,"eligibilityCriteria":185,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":87,"enrollmentInfo":186,"targetDuration":4,"studyType":23,"phases":188,"briefSummary":189,"conditions":190,"keywords":194,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":200,"lastUpdatePostDateStruct":201,"startDateStruct":203,"completionDateStruct":205,"leadSponsor":207,"locationsCount":103},"100646521","investigating-the-effectiveness-of-personalized-optimal-gamma-auditory-frequency-stimulation-intervention-on-cognitive-function-enhancement-100646521","NCT07690865","Investigating the Effectiveness of Personalized Optimal Gamma Auditory Frequency Stimulation Intervention on Cognitive Function Enhancement","Investigating the Effectiveness of Personalized Optimal Gamma Auditory Frequency Stimulation Intervention on Cognitive Function Enhancement: An Intervention Study","Inclusion Criteria:\n\n1. Age between 18 to 40 years old.\n2. The Cognitive Abilities Screening Instrument (CASI) score is within normal ranges adjusted for age and education.\n3. Participants have no history of severe neurological or psychiatric disorders (such as stroke, epilepsy, depression, migraine, etc.) that could affect cognitive function.\n4. Participants have not used drugs that may affect cognitive function (e.g., benzodiazepines, anticholinergic medications, etc.).\n5. Participants with normal or corrected vision (e.g., glasses or contact lenses) to normal levels.\n6. Auditory stimuli induce significant neural entrainment.\n7. Self-reported normal hearing\n\nExclusion Criteria:\n\n1. Participants enrolled in any cognitive enhancement study within the past two months.\n2. Participants with a history of disease that could affect cognitive function (e.g., cancer, autoimmune diseases, etc.).\n3. Individuals with tinnitus or hyperacusis",{"count":187,"type":22},20,[91],"This study aims to evaluate whether personalized gamma-frequency auditory stimulation enhances cognitive function and brain synchronization. While 40 Hz auditory stimulation has been widely studied, recent evidence suggests optimal frequencies vary by individual. Using a cross-over design with 20 healthy adults, the research compares \"optimal\" versus \"non-optimal\" frequencies over one-month intervention periods. Effectiveness is measured through EEG recordings and executive function tasks. The goal is to determine if personalized sensory intervention provides a more effective, non-invasive strategy for enhancing cognitive performance.",[191,30,192,193],"Gamma Oscillations","Alzheimer's Disease (AD)","Gamma Entrainment Using Sensory Stimuli (GENUS)",[195,196,197,198,199],"Gamma stimulation","Alzheimer's disease","EEG","cognitive function","intervention","2026-07-15",{"date":202,"type":35},"2026-07-16",{"date":204,"type":22},"2026-08",{"date":206,"type":22},"2027-12",{"name":208,"class":77},"Chang Gung Memorial Hospital",{"id":210,"slug":211,"hasResults":12,"nctId":212,"briefTitle":213,"officialTitle":213,"acronym":4,"eligibilityCriteria":214,"healthyVolunteers":17,"sex":18,"minAge":51,"maxAge":215,"enrollmentInfo":216,"targetDuration":4,"studyType":23,"phases":217,"briefSummary":218,"conditions":219,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":221,"lastUpdatePostDateStruct":222,"startDateStruct":224,"completionDateStruct":226,"leadSponsor":228,"locationsCount":43},"100645438","digital-course-and-precision-rehabilitation-for-knee-osteoarthritis-and-older-adults-integration-of-multisensory-stimulation-and-digital-twin-technology-100645438","NCT07695168","Digital Course and Precision Rehabilitation for Knee Osteoarthritis and Older Adults: Integration of Multisensory Stimulation and Digital Twin Technology","Inclusion Criteria:\n\n(Group A: Healthy Adults)\n\n* Participants aged 20 to 80 years.\n* Participants who have no knee discomfort symptoms, such as knee pain or muscle weakness.\n\n(Group B: Patients with Knee Osteoarthritis)\n\n* Participants aged 50 to 80 years.\n* Patients diagnosed with knee osteoarthritis, classified as Kellgren-Lawrence grade 1 to grade 3.\n\nExclusion Criteria:\n\n(Group A and B)\n\n* History of knee or hip surgery.\n* Systemic arthritis.\n* Neurological disease.\n* Malignant tumor.\n* Untreated osteomyelitis or immature skeletal development.\n* Pregnancy.\n* Inflammatory ulcer.\n* Deep vein thrombosis.\n* Excessively moist wounds.\n* Hemophilia.\n* Local infection in the treatment or assessment area.\n* Acute myocardial infarction.\n* Unstable angina.\n* Severe aortic stenosis.\n* Uncontrolled heart failure.\n* Acute pulmonary embolism.\n* Acute myocarditis or pericarditis.\n* Acute aortic dissection.","80 Years",{"count":113,"type":22},[91],"Knee osteoarthritis (OA) is a common degenerative joint disease in middle-aged and older adults and is frequently associated with pain, quadriceps weakness, reduced mobility, impaired proprioception, balance deficits, and limitations in daily functional activities. Exercise therapy is recommended as a first-line conservative treatment for early to moderate knee OA; however, conventional rehabilitation programs often rely on therapist supervision and lack objective, quantitative movement monitoring, real-time feedback, and personalized adjustment for home-based training. These limitations may reduce exercise adherence and make it difficult to ensure correct movement execution outside the clinical setting.\n\nThe overall aim of this study is to develop and evaluate a digital rehabilitation exercise program and user interface for individuals with arthritis, using a smart elastic knee brace integrated with wearable sensing technology, surface electromyography biofeedback, joint-angle monitoring, multisensory stimulation, and artificial intelligence-based musculoskeletal monitoring. The proposed system is designed to provide personalized digital rehabilitation courses, real-time visual and auditory feedback, and objective assessment of movement performance to support knee joint motor control, gait retraining, and individualized rehabilitation planning for patients with knee OA.\n\nThe investigators hypothesize that digital rehabilitation courses combined with multisensory stimulation, including neuromuscular electrical stimulation and vibration, will improve functional performance, movement quality, muscle activation, proprioception, and knee-related symptoms in patients with knee OA compared with conventional home exercise or gait retraining alone. The expected outcome of this study is to establish the feasibility, reliability, and clinical utility of a smart knee brace-based digital rehabilitation system for personalized knee OA management.\n\nThis study will achieve the following four specific aims:\n\nAim 1: To determine the feasibility of home-based exercise combined with electrical stimulation and the reliability of digital assessment for tracking exercise performance.\n\nPatients with knee OA and healthy adults will be recruited to complete selected quadriceps strengthening exercises based on exercise difficulty levels. Participants will perform a two-week home-based training program using exercise combined with electrical stimulation. Feasibility will be assessed using questionnaires, and movement performance will be tracked using inertial sensors during functional tasks. This aim will provide evidence regarding the practicality of integrating electrical stimulation into home-based rehabilitation and the reliability of digital monitoring for exercise performance.\n\nAim 2: To evaluate the effects of digital rehabilitation exercise courses combined with multisensory stimulation in patients with knee OA and healthy adults.\n\nParticipants will be randomly assigned to an experimental group or a control group. Both groups will complete a twelve-week home exercise program, three times per week for 40 minutes per session. The experimental group will follow the digital rehabilitation exercise course combined with electrical stimulation or vibration, whereas the control group will perform home exercises based on therapist education. Outcomes will be assessed at four time points: before training, after eight weeks of training, after twelve weeks of training, and six weeks after the intervention. Assessments will include pain, WOMAC scores, hemodynamic responses, muscle strength, electromyographic activity, proprioception, functional performance, body composition, knee structure, and biomechanical parameters.\n\nAim 3: To determine the immediate effects of gait retraining combined with neuromuscular electrical stimulation in patients with knee OA.\n\nPatients with knee OA will be randomly assigned to either a gait retraining group or a gait retraining combined with neuromuscular electrical stimulation group. Both groups will receive a single 15-minute gait retraining intervention focused on modifying the foot progression angle. The experimental group will receive synchronized quadriceps electrical stimulation during gait training, while the control group will receive gait retraining alone. Pre- and post-intervention assessments will be performed to examine the immediate effects on gait parameters and functional movement performance.\n\nAim 4: To develop and validate a personalized knee joint digital twin model using artificial intelligence, multisensory stimulation, and wearable sensing technology.\n\nThis aim will develop an AI-based musculoskeletal monitoring system that integrates wearable sensor data, functional movement analysis, and personalized knee joint modeling. Patients with knee OA and healthy adults will perform functional tasks such as squatting, stair stepping, and walking under different stimulation conditions, including conti",[220,30],"Knee Osteoarthristis","2026-07-12",{"date":223,"type":35},"2026-07-14",{"date":225,"type":22},"2026-07-01",{"date":227,"type":22},"2026-12-31",{"name":229,"class":77},"National Taiwan University Hospital",{"id":231,"slug":232,"hasResults":12,"nctId":233,"briefTitle":234,"officialTitle":235,"acronym":4,"eligibilityCriteria":236,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":237,"targetDuration":4,"studyType":23,"phases":239,"briefSummary":240,"conditions":241,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":242,"lastUpdatePostDateStruct":243,"startDateStruct":245,"completionDateStruct":247,"leadSponsor":249,"locationsCount":103},"100509841","the-brain-processes-underlying-speech-motor-learning-and-speech-production-100509841","NCT05918679","The Brain Processes Underlying Speech Motor Learning and Speech Production","Improving Speech Motor Learning Processes Using Augmented Behavioral Interventions","Inclusion Criteria:\n\n* 18 years and older\n* native speaker of American English\n* normal (age-appropriate) binaural pure-tone hearing threshold\n* not taking medications affecting sensorimotor functioning\n* no current or history of communication, neurological, or psychological disorders\n\nExclusion Criteria:",{"count":238,"type":22},510,[91],"The aim of this research is to develop protocols that selectively target and improve speech-motor learning processes. Participants will be asked to name pictures, read words\u002Fsentences, and listen to sounds while their speech signals will be collected during the study.",[30],"2026-07-07",{"date":244,"type":35},"2026-07-08",{"date":246,"type":35},"2023-06-01",{"date":248,"type":22},"2027-08-31",{"name":250,"class":77},"Arizona State University",{"id":252,"slug":253,"hasResults":12,"nctId":254,"briefTitle":255,"officialTitle":256,"acronym":4,"eligibilityCriteria":257,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":258,"enrollmentInfo":259,"targetDuration":4,"studyType":23,"phases":261,"briefSummary":262,"conditions":263,"keywords":267,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":274,"lastUpdatePostDateStruct":275,"startDateStruct":276,"completionDateStruct":278,"leadSponsor":280,"locationsCount":103},"100641361","phase-1-a-study-to-learn-how-different-amounts-of-the-study-medicine-called-pf-08103402-are-tolerated-and-act-in-the-body-in-healthy-adults-or-adults-with-mild-to-moderate-asthma-100641361","NCT07660731","A Study to Learn How Different Amounts of the Study Medicine Called PF-08103402 Are Tolerated and Act in the Body in Healthy Adults or Adults With Mild To-moderate Asthma","A PHASE 1 STUDY TO EVALUATE SAFETY, TOLERABILITY, PHARMACOKINETICS, PHARMACODYNAMICS, RELATIVE BIOAVAILABILITY, FOOD EFFECT, METABOLISM & EXCRETION, AND DRUG-DRUG INTERACTION POTENTIAL OF PF-08103402 IN HEALTHY ADULTS AND\u002FOR ADULTS WITH MILD TO MODERATE ASTHMA","Key Inclusion criteria (Parts A, B, C, D and F):\n\n1. Are males or females who can no longer have children,\n2. Are 18 to 65 years old,\n3. Have a body mass index (BMI) of 16 to 32 kilograms per meter squared and a total body weight of more than 50 kilograms (110 pounds).\n\nFor Part A (Optional group or cohort 3: Japanese participants only):\n\n1. A total body weight of more than 45 kg (100 pounds).\n2. Have 4 biological Japanese grandparents who were born in Japan.\n\nFor Part E only:\n\nAdults with a documented doctor's-diagnosis history of asthma for at least 12 months before entering the study.\n\n1\\. Have a body mass index (BMI) of 16 to 35 kilograms per meter squared and a total body weight of more than 50 kilograms (110 pounds).\n\nKey Exclusion criteria\n\n1. Evidence or history of clinically significant medical conditions.\n2. History of human immunodeficiency virus (HIV) infection, hepatitis B, or hepatitis C; positive testing for HIV, hepatitis B surface antigen (HBsAg), or hepatitis C antibody (HCVAb).\n3. History of alcohol abuse or binge drinking and\u002For any other illicit drug use or dependence within 6 months of Screening.\n4. Participation in studies of other investigational products (drug or vaccine) at any time during their participation in this study.\n5. Any history of parasitic infection requiring treatment within 28 days prior to screening.\n6. Positive tuberculosis infection test result.\n7. Part C only: Evidence or history of conditions interfering with the ability to taste.\n8. Part D only: History of irregular bowel movements.\n9. Part E only: Evidence of lung disease(s) other than asthma.\n10. Part E only: Asthma exacerbation within 3 months prior to screening.\n11. Part F only: History of acute narrow-angle glaucoma, untreated open-angle glaucoma, sleep apnea, respiratory insufficiency, myasthenia gravis or adverse reaction to midazolam or other benzodiazepines.","65 Years",{"count":260,"type":22},139,[25],"The purpose of this study is to learn about the safety of a new study medicine called PF-08103402 in healthy adults (do not have disease) and or in adults with mild-to-moderate asthma. This is the first time the study medicine is being given to people.\n\nFor Parts A, B, C, D and F, the study is seeking participants who:\n\n* Are healthy (do not have disease) males or females who can no longer have children,\n* Are 18 to 65 years old,\n* Have a body mass index (BMI) of 16 to 32 kilograms per meter squared and a body weight of more than 50 kilograms (110 pounds). Body mass index is a way to measure body fat by using a person's height and weight\n\nFor Part A (optional group or cohort 3: Japanese participants only):\n\n* A body weight of more than 45 kilograms (100 pounds).\n* Have 4 biological Japanese grandparents who were born in Japan.\n\nFor Part E only:\n\n* Adults with a documented history of asthma (confirmed by a doctor) for at least 12 months before entering the study.\n* Have a body mass index (BMI) of 16 to 35 kilograms per meter squared and a total body weight of more than 50 kilograms (110 pounds).\n\nThe study has six parts: Part A, Part B, Part C, Part D, Part E and Part F. The study medicine will be taken as a suspension or tablet by mouth 1 time a day (except in Parts B and E where it will be taken 1 time a day for 14 days) at the study clinic. The study will help understand:\n\n* how the body processes the study medicine in healthy participants (Parts A and B),\n* how much of the study medicine gets into the bloodstream and if food affects the amount of study medicine in the blood in healthy participants (Part C),\n* how the study medicine is broken down and leaves the body in healthy participants (Optional Part D),\n* how the study medicine is processed in adults with mild-to-moderate asthma (Optional Part E),\n* if taking the study medicine together with another medicine affects how each medicine is processed by the body in healthy participants (Optional Part F).\n\nParticipants will take part in the study for about 10 weeks (Parts A and F), 12 weeks (Part B), 9 weeks (Parts C and D), and 16 weeks (Part E).\n\nDuring this time, they will have 2 study visits at the study clinic and up to 28 overnight stays (Part A), 18 overnight stays (Parts B and E), 10 overnight stays (Part C), 11 overnight stays (Part D), and 16 overnight stays (Part F). The study team will also call participants 1 time over the phone at the end of the study to assess how they are doing.\n\nStudy measurements will be taken by body examination, monitoring side effects, blood and urine tests, heart tests (ECG), vital signs (blood pressure and pulse), questionnaires (Parts C and E), stool samples (Part D only), and breathing tests (Part E only).",[264,30,265,266],"Healthy Volunteer Study","Healthy Participants","Asthma",[268,269,270,271,272,273],"Human","Randomized","Metabolism","Excretion","Drug-Drug Interaction","Food effect","2026-06-24",{"date":37,"type":35},{"date":277,"type":35},"2026-06-17",{"date":279,"type":22},"2027-06-18",{"name":41,"class":42},{"id":282,"slug":283,"hasResults":12,"nctId":284,"briefTitle":285,"officialTitle":286,"acronym":4,"eligibilityCriteria":287,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":288,"targetDuration":4,"studyType":23,"phases":290,"briefSummary":291,"conditions":292,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":294,"lastUpdatePostDateStruct":295,"startDateStruct":297,"completionDateStruct":299,"leadSponsor":301,"locationsCount":103},"100642357","phase-1-a-study-to-learn-how-different-forms-of-the-study-medicine-called-pf-08049820-are-absorbed-and-eliminated-in-healthy-adults-100642357","NCT07597928","A Study to Learn How Different Forms of the Study Medicine Called PF-08049820 Are Absorbed and Eliminated in Healthy Adults","A PHASE 1, OPEN-LABEL, RANDOMIZED, 5-PERIOD, 6-SEQUENCE, CROSSOVER STUDY TO COMPARE THE SINGLE-DOSE PHARMACOKINETICS OF ONE IMMEDIATE RELEASE AND TWO MODIFIED-RELEASE FORMULATIONS OF PF-08049820 ADMINISTERED ORALLY UNDER FASTED AND FED CONDITIONS (PART A), AND A FIXED SEQUENCE STUDY TO ASSESS THE EFFECT OF RABEPRAZOLE ON THE PHARMACOKINETICS OF PF-08049820 (PART B), IN HEALTHY ADULTS","Inclusion Criteria:\n\n1. Healthy males and females.\n2. At least 18 years of age\n3. Body mass index (BMI) of 16-32 kg\u002Fm2; and a total body weight \\>50kg (110 lb.).\n\nExclusion Criteria:\n\n1. Evidence or history of clinically significant medical conditions.\n2. History of human immunodeficiency virus (HIV) infection, hepatitis B, or hepatitis C; positive testing for HIV, hepatitis B or hepatitis C.\n3. History of alcohol abuse or binge drinking and\u002For any other illicit drug use or dependence within 6 months of Screening.\n4. Participation in studies of other investigational products (drug or vaccine) at any time during their participation in this study.",{"count":289,"type":22},24,[25],"The purpose of this study is to learn how different forms of the study medicine called PF-08049820 are absorbed and eliminated in healthy adults. The study will assess whether the study medicine is absorbed differently when taken with or without food. It will also assess absorption when the study medicine is taken with another medicine called rabeprazole. Rabeprazole is an FDA approved medicine that reduces stomach acid.\n\nThe study has two parts. In Part A, participants will take three forms of study medicine, one after the other. They will take each form either with or without food for a total of five doses. Each dose will be separated by a few days. Participants will stay in the clinic for about two weeks. They will receive a telephone follow-up call about a month after the last dose.\n\nIn Part B, participants will take three forms of study medicine. They will take each one with or without food, and with or without another medicine called rabeprazole. This means they will take a total of six doses of study medicine. Each dose will be separated by a few days. Participants will stay at the clinic for about three weeks, and about a month after their last dose. They will get a follow-up phone call. Part B may or may not be conducted depending on the results from Part A.\n\nThe study is seeking participants who:\n\n1. Are males or females,\n2. Are at least 18 years of age,\n3. Have a body mass index (BMI) 16 to 32 kilograms per meter squared (kg\u002Fm2). Have a total body weight of more than 50 kilograms (kg) (110 pounds).",[30,293],"Healthy","2026-06-11",{"date":296,"type":35},"2026-06-15",{"date":298,"type":35},"2026-05-13",{"date":300,"type":22},"2026-09-25",{"name":41,"class":42},{"id":303,"slug":304,"hasResults":12,"nctId":305,"briefTitle":306,"officialTitle":307,"acronym":4,"eligibilityCriteria":308,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":309,"enrollmentInfo":310,"targetDuration":4,"studyType":23,"phases":312,"briefSummary":313,"conditions":314,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":315,"lastUpdatePostDateStruct":316,"startDateStruct":318,"completionDateStruct":319,"leadSponsor":321,"locationsCount":323},"100624988","validation-of-nad-measurements-for-human-clinical-studies-100624988","NCT07416786","Validation of NAD+ Measurements for Human Clinical Studies","Validation of NAD+ Measurements for Human Clinical Studies: Multi-method Inter-laboratory Standardization","* Male or female age18-35 years or 70 years or older, healthy\n* if female reproductive potential, use of highly effective contraception (at least 1 month prior to screening and during study participation).\n* No known sensitivity to NR\n* No use of niacin, blood thinners or chemotherapy agents\n* HbA1c below 8.5% and not diabetec requiring insulin.\n* Not using\u002Ftaking corticosteroids\n* No laboratory abnormalities indicating significant anemia, bleeding risk, kidney disease, or liver disease\n* No contraindication to MRI\n* Not Pregnant, lactating, or planning to become pregnant during participation\n* Not taking multivitamins or any over-the-counter supplements except calcium and vitamin D (any other supplements - discontinued 2 weeks prior to study participation).\n* not taking\u002F undergoing another investigational drug or other intervention within the past 30 days.","110 Years",{"count":311,"type":22},48,[91],"The purpose of this study is to determine nicotinamide adenine dinucleotide (NAD) levels in healthy adult subjects before and after supplementing with over-the counter nicotinamide riboside (NR) using magnetic resonance spectroscopy (MRS).",[30],"2026-06-02",{"date":317,"type":35},"2026-06-03",{"date":225,"type":22},{"date":320,"type":22},"2028-07-31",{"name":322,"class":77},"University of Pennsylvania",2,{"id":325,"slug":326,"hasResults":12,"nctId":327,"briefTitle":328,"officialTitle":328,"acronym":329,"eligibilityCriteria":330,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":258,"enrollmentInfo":331,"targetDuration":4,"studyType":23,"phases":332,"briefSummary":333,"conditions":334,"keywords":335,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":339,"lastUpdatePostDateStruct":340,"startDateStruct":341,"completionDateStruct":342,"leadSponsor":344,"locationsCount":43},"100637917","early-phase-1-an-experimental-medicine-multicenter-trial-to-evaluate-the-safety-and-immunogenicity-of-experimental-versus-authorized-sars-cov-2-vaccine-candidates-as-a-booster-dose-in-healthy-participants-previously-vaccinated-with-authorized-mrna-sars-cov-2-vaccines-100637917","NCT07605520","An Experimental Medicine Multicenter Trial to Evaluate the Safety and Immunogenicity of Experimental Versus Authorized SARS-CoV-2 Vaccine Candidates as a Booster Dose in Healthy Participants Previously Vaccinated With Authorized mRNA SARS-CoV-2 Vaccines.","SOLVE-01","Inclusion Criteria:\n\n1. Male and female subjects aged 18 to 65 years inclusive at the time of the screening visit\n2. Having received at least two doses of COVID-19 mRNA vaccines in the past with the last dose received more than 6 months prior to IMP administration in the trial\n3. In healthy condition or with stable health status which is defined as an existing disease that has not required a significant change in treatment or hospitalization for worsening before enrolment, and for which neither a significant change in treatment or hospitalization for worsening is expected in the near future.\n4. For woman of childbearing potential: a negative Beta-HCG blood test measure during the screening visit, and a negative highly sensitive pregnancy urinary test the day of the vaccination visit\n\n   * if heterosexually active female, consistently using a highly effective method of contraception with partner from at least 21 days prior to enrolment through 4 months after the IMP administration. Highly effective contraception is defined as using any of the following methods:\n\n     * Combined hormonal contraception with inhibition of ovulation (estrogen and progesterone containing);\n     * Intrauterine device (IUD);\n     * Intrauterine hormone releasing system (IUS);\n     * Hormonal contraception (progesterone only);\n     * Successful vasectomy in the male partner (considered successful if a participant reports that a male partner has (i) documentation of azoospermia by microscopy, or (ii) a vasectomy more than 2 years ago with no resultant pregnancy despite unprotected sexual activity post vasectomy);\n     * Or not be of reproductive potential, such as having reached menopause (no menses for 1 year without an alternative medical cause) or having undergone hysterectomy, bilateral oophorectomy, or tubal ligation.\n   * Agree not to seek pregnancy including through alternative methods, such as artificial insemination or in vitro fertilization until 4 months after the IMP administration.\n5. Participant who was born male, if heterosexually active male, using an effective method of contraception with their partner from the IMP administration until 4 months thereafter. All male participants also agree not to donate sperm during this period.\n6. Negative nasopharyngeal antigenic test for SARS-CoV-2 on the day of screening and before randomisation\n7. Participant who has normal biological values:\n\n   * Hemoglobin ≥ 11.0 g\u002FdL for participants who were born female, ≥ 13.0 g\u002FdL for participants who were born male;\n   * White blood cell count = 3,300 to 12,000 cells\u002Fmm3;\n   * Total lymphocyte count ≥ 800 cells\u002Fmm3;\n   * Platelets = 125,000 to 550,000\u002Fmm3;\n   * ALT, AST, and alkaline phosphatase \\\u003C 1.25 times the institutional upper limit of normal;\n   * Creatinine \\\u003C1.1x institutional upper limit of normal of the laboratory;\n   * Normal urine test: absence of glucose, protein and haemoglobin\n   * Negative HIV antigen\u002Fantibody test;\n   * Negative Hepatitis B surface antigen (HBsAg);\n   * Negative anti-Hepatitis C virus antibodies (anti-HCV), or negative HCV polymerase chain reaction (PCR) if the anti-HCV is positive;\n8. Willingness to undertake SARS-CoV-2 testing according to study protocol, and receive SARS-CoV-2 test results\n9. Willingness and availability to be followed for the planned duration of the study in one of the dedicated trial centres\n10. Informed and signed written consent form before performance of any trial-related screening procedures\n11. Agree to be registered in the French Health Ministry computerised file (for France only)\n12. Being covered by Health Insurance (for France only)\n\nExclusion Criteria:\n\n1. Acute febrile infection (body temperature ≥ 38.0°C) within the previous 72 hours and\u002For presenting symptoms suggestive of COVID-19 or SARS-CoV-2 infection within the previous 28 days or having been in contact with an infected individual for the last 14 days before the inclusion visit\n2. Any medical condition that could impair the immune response: clinically significant medical condition, physical examination findings, clinically significant abnormal laboratory results, or past medical history with clinically significant implications for current health. A clinically significant condition or process includes but is not limited to:\n\n   * A process that would affect the immune response;\n   * A process that would require medication that affects the immune response;\n   * Any contraindication to repeated injections or blood draws;\n   * A condition that requires active medical intervention or monitoring to avert grave danger to the participant's health or well-being during the study period;\n   * A condition or process for which signs or symptoms could be confused with reactions to vaccine, or\n   * Any condition specifically listed among the exclusion criteria below.\n3. Pregnancy or breastfeeding that is currently ongoing, or positive pregnancy test at screening visit and the day of the vaccination\n4. Immunodeficiency\n5. Asthma: a condition that requires active medical intervention or monitoring to avert grave danger to asthma other than mild, well-controlled asthma. (Symptoms of asthma severity as defined in the most recent National Asthma Education and Prevention Program (NAEPP) Expert Panel report). Exclude a participant who:\n\n   * Uses a short-acting rescue inhaler (typically a beta 2 agonist) daily, or\n   * Uses moderate\u002Fhigh dose inhaled corticosteroids, or\n   * In the past year has either of the following: (i) Greater than 1 exacerbation of symptoms treated with oral\u002Fparenteral corticosteroids or (ii) Needed emergency care, urgent care, hospitalization, or intubation for asthma.\n6. Diabetes type 1 or type 2, including cases controlled with diet alone. (Not excluded: history of isolated gestational diabetes).\n7. Thyroidectomy, or thyroid disease requiring medication during the last 12 months\n8. Hypertension:\n\n   * If a person has been diagnosed with hypertension, exclude for blood pressure that is not well controlled (well-controlled blood pressure is defined as consistently ≤ 140 mm Hg systolic and ≤ 90 mm Hg diastolic, with or without medication, with only isolated, brief instances of higher readings, which must be ≤ 150 mm Hg systolic and ≤ 100 mm Hg diastolic). For these participants, blood pressure must be ≤ 140 mm Hg systolic and ≤ 90 mm Hg diastolic at enrolment;\n   * If a person has NOT been diagnosed with hypertension, exclude for systolic blood pressure ≥ 150 mm Hg at enrolment or diastolic blood pressure ≥ 100 mm Hg at enrolment. (the measurement must be performed on a person who has been lying down for at least 5 minutes and repeat at the end of the consultation, if appropriated). Tension must be confirmed outside the clinical site to rule out hypertension.\n9. Contraindication to the IMPs including hypersensitivity\n10. BMI ≥ 40 kg\u002Fm2; ≤ 18 kg\u002Fm2; or BMI ≥ 35 kg\u002Fm2 with 2 or more of the following: age \\> 45, systolic blood pressure \\> 140 mm Hg, diastolic blood pressure \\> 90 mm Hg, current smoker, known hyperlipidemia\n11. Bleeding disorder diagnosed (e.g., coagulation factor deficiency, coagulopathy, or platelet disorder requiring special precautions)\n12. Malignancy (Not excluded: volunteer who has had malignancy excised surgically and who, in the investigator's estimation, has a reasonable assurance of sustained cure, or who is unlikely to experience recurrence of malignancy during the period of the study)\n13. Asplenia: any condition resulting in the absence of a functional spleen\n14. Seizure disorder: History of seizure(s) within past three years. Also excluded if volunteer has used medications in order to prevent or treat seizure(s) at any time within the past 3 years.\n15. History of hereditary angioedema, acquired angioedema, or idiopathic angioedema.\n16. History of myocarditis, pericarditis, cardiomyopathy, congestive heart failure with permanent sequelae, clinically significant arrhythmia (including arrhythmia requiring medication, treatment, or clinical follow-up)\n17. History of autoimmune disease\n18. Any medical, psychiatric, occupational, or other condition that, in the judgment of the investigator, would interfere with or serve as a contraindication to protocol adherence, assessment of safety, or a volunteer's ability to give informed consent\n19. Psychiatric condition that precludes compliance with the protocol. Specifically excluded are persons with psychoses within the past 3 years, ongoing risk for suicide, or history of suicide attempt or gesture within the past 3 years.\n20. History of serious adverse reactions to vaccines including anaphylaxis and related symptoms such as hives, respiratory difficulty, angioedema, and\u002For abdominal pain. (Not excluded: a volunteer who had a non-anaphylactic adverse reaction to pertussis vaccine as a child)\n21. Investigational research agents received within 30 days before IMP administration\n22. Experimental vaccine(s) received within the last 5 years in a prior vaccine trial\n23. Live attenuated vaccines (e.g., measles, mumps, and rubella (MMR); oral polio vaccine (OPV); varicella; yellow fever) received within 30 days before IMP administration or scheduled within 28 days after the injection scheduled within the protocol\n24. Vaccines that are not live attenuated vaccines and were received within 21 days prior to IMP administration (e.g., tetanus, pneumococcal, Hepatitis A or B)\n25. Blood-derived products or immunoglobulin received within 6 months before IMP administration\\*\n26. Current anti-tuberculosis (TB) prophylaxis or therapy received within 3 months before IMP administration \\*\n27. Allergy treatment with antigen injections within 30 days before IMP administration or that are scheduled within 14 days after IMP administration\\*\n28. Immunosuppressive medications or immunomodulators (such as cytokines or interferons) received within last three months before IMP administration. (Not excluded: (1) corticosteroid nasal spray; \\[2\\] topical corticosteroids for mild, uncomplicated dermatitis; or (2) a single course of oral\u002Fparenteral corticosteroids at doses \\\u003C 2 mg\u002Fkg\u002Fday and length of therapy \\\u003C 11 days with completion at least 30 days prior to enrolment) or low dose oral corticosteroids (≤10 mg prednisone\u002Fday) or corticosteroids for the treatment of immune-related adverse events\\*\n29. Other prohibited medications: Corticosteroids \\> 10 mg prednisone equivalent\u002Fday (not excluded: topical preparations) \\*\n30. Person participating in another research involving the human person or participating in another research involving the human person with an exclusion period still in progress at screening\n31. Intent to participate in another study of an investigational research agent during the planned duration of the study\n32. Participants who are not able to understand and to follow all required study procedures for the whole period of the study in the judgment of the investigator\n33. Under tutorship (only for France), guardianship, or deprived of liberty by a juridical or administrative decision\n34. Planned absence that could affect participation in the study (travel abroad, relocation, impending professional mutation...)\n\n    * The scheduled use of these treatments up to 6 months after the injection also represents a contraindication",{"count":311,"type":22},[115],"The SOLVE-01 trial is a study evaluating four SARS-CoV-2 vaccines as booster injections: two experimental vaccines (CD40.RBDv and CD40.Pan.CoV, both combined with the Hiltonol® adjuvant) and two authorised vaccines (Comirnaty® and NuvaxovidTM). This trial is designed for healthy adults aged 18 to 65 at the time of signing the informed consent form.\n\nThe main objectives of this trial are:\n\n* to evaluate the safety of the two experimental vaccines,\n* to determine the antibody response induced by the vaccines and its durability.\n\nParticipants will:\n\n* Receive one injection of vaccine and two intradermal skin tests\n* Come to the hospital 10 visits for medical exams and blood and saliva sample collection\n* Keep a diary of their symptoms and the treatments taken",[30],[336,337,338],"COVID19 vaccine","phase 1","experimental medicine trial","2026-06-01",{"date":315,"type":35},{"date":298,"type":35},{"date":343,"type":22},"2028-12",{"name":345,"class":346},"ANRS, Emerging Infectious Diseases","OTHER_GOV",{"id":348,"slug":349,"hasResults":12,"nctId":350,"briefTitle":351,"officialTitle":352,"acronym":353,"eligibilityCriteria":354,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":258,"enrollmentInfo":355,"targetDuration":4,"studyType":23,"phases":356,"briefSummary":357,"conditions":358,"keywords":360,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":339,"lastUpdatePostDateStruct":367,"startDateStruct":369,"completionDateStruct":371,"leadSponsor":373,"locationsCount":103},"100637075","the-effect-of-low-or-high-dietary-fiber-diet-on-volatile-organic-compounds-in-exhaled-breath-of-healthy-individuals-100637075","NCT07594600","The Effect of Low or High Dietary Fiber Diet on Volatile Organic Compounds in Exhaled Breath of Healthy Individuals","Characterization of Fiber-degrading Microbiota in Individuals Without Gastrointestinal Diseases","FIBRE-MATCH","Inclusion Criteria:\n\n1. Signed informed consent obtained prior to any study-related procedures.\n2. Willingness to refrain from regular consumption of prebiotic or probiotic products, as well as medications known to affect gastrointestinal function, for at least four weeks prior to the study visits.\n\nExclusion Criteria:\n\n1. History of complicated gastrointestinal surgery.\n2. Presence of a gastrointestinal diagnosis or any condition that, in the opinion of the principal investigator, may influence the study outcomes.\n3. Current diagnosis of a psychiatric disorder.\n4. Systemic use of antibiotics or steroid medications within the past 3 months.\n5. Frequent use of NSAIDs (non-steroidal anti-inflammatory drugs) within the 2 months preceding the study visit.\n6. Regular consumption of prebiotic or probiotic products within the past 4 weeks.\n7. Alcohol or substance abuse.\n8. Current smoking or use of nicotine pouches.\n9. Frequent use of laxatives, antidiarrheal agents, or anticholinergic medications within the 12 weeks preceding the study visit.\n10. Pregnancy or breastfeeding.\n11. Respiratory disease or infection.",{"count":187,"type":22},[91],"The aim of this crossover intervention study is to evaluate the volatile organic compounds (VOCs) present in participants at baseline and how these levels change after consuming either a low- or high-dietary fiber diet for three days. This study will involve adults, 18-65 years old, without any gastrointestinal diseases.\n\nThe primary objectives are to characterize baseline VOC profiles, assess changes in these profiles after a short-term dietary fiber intervention, determine if specific VOC patterns correlate with dietary fiber intake, and identify the time points at which VOC levels peak. This information will help establish the optimal timing for breath sampling and potentially provide insight into how VOC patterns relate to dietary fiber consumption and degradation.\n\nThe expected outcome is that a high-dietary fiber diet will produce a VOC profile enriched in metabolites associated with fiber fermentation compared to a low-dietary fiber diet, and that these VOCs will be consistent with those identified in vitro during fecal fermentation. Each participant will serve as an internal control, enabling within-subject comparisons of VOC levels at baseline and following the dietary fiber intervention.\n\nParticipants will receive a whole-food product that is rich in dietary fiber and will consume either a low-fiber diet (10 g\u002Fday) or a high-fiber diet (40 g\u002Fday) for three days. On the first day of each intervention, participants will also ingest a pH capsule to monitor gastrointestinal pH continuously throughout the three days. After a three-week washout period, participants will cross over to the other intervention arm and undergo another round of gastrointestinal pH monitoring.\n\nIn addition to the dietary intervention, participants will complete food and health questionnaires to assess habitual fiber intake and dietary habits. Fecal samples will be collected for in vitro fermentation to functionally profile the gut microbiota by assessing fecal VOCs, short-chain fatty acids (SCFA), and the microbial enzymatic activity and its pH-dependent modulation.",[30,359],"Dietary Fiber Fermentation",[361,362,363,364,365,366],"Volatile Organic Compounds","Food Intervention","Healthy participants","No gastrointestinal diseases","Without gastrointestinal diseases","Dietary Fiber",{"date":368,"type":35},"2026-06-04",{"date":370,"type":22},"2026-05-25",{"date":372,"type":22},"2027-03",{"name":374,"class":77},"Örebro University, Sweden",{"id":376,"slug":377,"hasResults":12,"nctId":378,"briefTitle":379,"officialTitle":380,"acronym":4,"eligibilityCriteria":381,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":382,"enrollmentInfo":383,"targetDuration":4,"studyType":23,"phases":385,"briefSummary":386,"conditions":387,"keywords":388,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":298,"lastUpdatePostDateStruct":393,"startDateStruct":395,"completionDateStruct":397,"leadSponsor":399,"locationsCount":103},"100600884","effects-of-isocapnic-respiratory-muscle-endurance-training-in-healthy-adults-100600884","NCT07103291","Effects of Isocapnic Respiratory Muscle Endurance Training in Healthy Adults","The Effects of Isocapnic Respiratory Muscle Endurance Training on the Multidimensional Components and Neurophysiological Mechanisms of Exertional Breathlessness in Healthy Adults","Inclusion Criteria:\n\n* 18-55 years of age (inclusive)\n* Male or Female (biological sex)\n* Body mass index greater than 18 or less than 30 kg\u002Fm2\n* Normal pulmonary function: FEV1\u002FFVC \\> 0.70 and FEV1 ≥ 80%\n* Able to read and understand English\n* Regularly trains and\u002For competes at a regional, national, or international level as a road cyclist or triathlete\n* Access to a device with the capability to download the Isocapnic app (Apple IOS or Google Play\u002FAndroid) or the ability to use the Web Based application.\n\nExclusion Criteria:\n\n* Currently smoke, vape, or use cannabis, or have a history of frequent smoking, vaping or cannabis use\n* History of, or current symptoms of cardiopulmonary (i.e., lung and\u002For heart) disease (excluding controlled asthma)\n* Heart problem; a serious infection within the body; a neuromuscular (nerve to muscle) or musculoskeletal (muscle, ligament and\u002For bone) disorder; or other health problem that will be made worse with exercise testing\n* Contraindications to exercise testing defined as anything that would prevent exercise under proper and safe conditions (e.g. a problem with the heart or lungs, muscle or bone injury, a serious infection)\n* Currently pregnant\n* Required to read and understand English due to the nature of the consent form and study materials, including questionnaires and training instructions, which are only available in English.","55 Years",{"count":384,"type":22},32,[91],"Respiratory muscle training (RMT) strengthens breathing muscles and may improve exercise performance and reduce breathlessness. However, different training methods and devices create controversy in the field. Two main types of RMT exist: inspiratory muscle training (IMT) and respiratory endurance training, like voluntary isocapnic hyperpnea (VIH). While IMT is well-studied, the impact of VIH on breathlessness remains unclear. This study will use the Canadian-developed BreathWayBetter device to examine how 5 weeks of VIH affects breathing discomfort and muscle function. Findings may help personalize RMT for athletes and clinical patients, improving respiratory care and exercise tolerance.",[30],[389,390,391,392],"Exercise physiology","Respiratory muscle training","Cycling","Competitive cyclists",{"date":394,"type":35},"2026-05-15",{"date":396,"type":35},"2025-08-04",{"date":398,"type":22},"2026-08-01",{"name":400,"class":77},"University of British Columbia",{"id":402,"slug":403,"hasResults":12,"nctId":404,"briefTitle":405,"officialTitle":406,"acronym":4,"eligibilityCriteria":407,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":258,"enrollmentInfo":408,"targetDuration":4,"studyType":55,"phases":4,"briefSummary":409,"conditions":410,"keywords":412,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":417,"lastUpdatePostDateStruct":418,"startDateStruct":420,"completionDateStruct":422,"leadSponsor":424,"locationsCount":103},"100637816","gait-adaptability-in-persons-with-ms-having-mild-disability-100637816","NCT07580820","Gait Adaptability in Persons With MS Having Mild Disability","Multidimensional Assessment of Gait Adaptability in Persons Multiple Sclerosis With no to Mild Disability","Inclusion Criteria:\n\n* Age between 18-65 years,\n* confirmed diagnosis of definite MS,\n* relapse free at least 30 days,\n* Expanded Disability Status Scale (EDSS) score between 0 and 3.5\n\nExclusion Criteria:\n\n* Diagnosed with neurological disease other than MS\n* cognitive decline that renders the patient incapable of performing tests and questionnaires.\n* Other neurological, orthopedic, or visual impairments affecting gait",{"count":384,"type":22},"Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disease of the central nervous system that frequently leads to walking impairment, balance deficits, fatigue, cognitive difficulties, and an increased risk of falls. Importantly, these problems can already be present in the early stages of the disease and may not be adequately captured by standard clinical walking tests, which primarily assess speed or distance. Such tests are often insufficient to reflect the complexity of real-life walking, which requires continuous adaptation to environmental challenges, and attention to internal and external stimuli.\n\nGait adaptability, the ability to modify walking patterns in response to changing and unpredictable demands such as obstacles or sudden perturbations, is critical for safe mobility and fall prevention. Both proactive (anticipatory) and reactive (feedback-driven) gait adaptations are essential for maintaining balance and functional independence. However, gait adaptability and its underlying neural mechanisms remain insufficiently understood in people with MS.\n\nThis study aims to provide a comprehensive assessment of gait adaptability in people with MS by evaluating both proactive and reactive gait adaptations using objective gait measurements and cortical activity recordings. The findings may contribute to the development of more sensitive outcome measures and inform targeted rehabilitation strategies that better reflect real-life mobility demands.\n\nPrimary aims:\n\n• To investigate the behavioral measures and neural correlates of reactive and proactive gait adaptability in pwMS compared to HC\n\nSecondary aims:\n\n* To investigate factors related to gait adaptability\n* To investigate changes in gait adaptability during prolonged walking conditions",[411,30],"Multiple Sclerosis",[413,414,415,416],"multiple sclerosis","gait","gait adaptability","balance","2026-05-05",{"date":419,"type":35},"2026-05-12",{"date":421,"type":35},"2025-12-05",{"date":423,"type":22},"2026-12-20",{"name":425,"class":77},"Hasselt University",{"id":427,"slug":428,"hasResults":12,"nctId":429,"briefTitle":430,"officialTitle":431,"acronym":4,"eligibilityCriteria":432,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":433,"targetDuration":4,"studyType":23,"phases":435,"briefSummary":437,"conditions":438,"keywords":439,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":441,"lastUpdatePostDateStruct":442,"startDateStruct":444,"completionDateStruct":446,"leadSponsor":448,"locationsCount":449},"100626147","phase-2-a-study-to-learn-about-mrna-vaccines-against-influenza-in-adults-100626147","NCT07431853","A Study to Learn About mRNA Vaccines Against Influenza in Adults","A PHASE 2, RANDOMIZED, DOUBLE-BLIND, CLINICAL STUDY TO EVALUATE THE SAFETY, TOLERABILITY, AND IMMUNOGENICITY OF MRNA VACCINES AGAINST INFLUENZA IN ADULTS 18 YEARS OF AGE AND OLDER","Inclusion Criteria\n\n• Healthy and medically stable participants who are determined by medical history, physical examination (if clinically required), and clinical judgment of the investigator to be eligible for inclusion in the study.\n\nExclusion Criteria\n\n* Tested positive for influenza ≤5 months (150 days) prior to Visit 1 (Day 1).\n* Vaccination with any investigational or licensed influenza vaccine ≤5 months (150 days) before Visit 1 (Day 1).\n* Receipt of antiviral therapies for influenza (eg, Tamiflu) ≤5 months (150 days) prior to Visit 1 (Day 1).",{"count":434,"type":22},770,[436],"PHASE2","The purpose of this study is to learn about safety in participants taking the study vaccine (mRNA-based vaccine) and the ability of the study vaccine to trigger the body's immune response, targeting the flu virus (influenza virus).\n\nThis study is seeking healthy participants 18 years of age or older. All participants in this study will receive only 1 dose in their arm, to deliver one of the experimental flu vaccines or one of the approved flu vaccines used for comparison.\n\nParticipants will take part in this study for about 6 months, and participants will need to visit the study site at least 3 times. A blood sample will be taken at each of the 3 planned study visits and a swab from inside the nose will be taken at the first study visit.",[30],[440],"Influenza vaccination","2026-05-04",{"date":443,"type":35},"2026-05-06",{"date":445,"type":35},"2026-02-23",{"date":447,"type":22},"2027-06-22",{"name":41,"class":42},15,{"id":451,"slug":452,"hasResults":12,"nctId":453,"briefTitle":454,"officialTitle":455,"acronym":4,"eligibilityCriteria":456,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":258,"enrollmentInfo":457,"targetDuration":4,"studyType":23,"phases":459,"briefSummary":460,"conditions":461,"keywords":462,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":469,"lastUpdatePostDateStruct":470,"startDateStruct":471,"completionDateStruct":473,"leadSponsor":475,"locationsCount":323},"100636559","efficacy-and-safety-of-repetitive-transcranial-magnetic-stimulation-and-expressive-writing-for-post-traumatic-stress-100636559","NCT07567261","Efficacy and Safety of Repetitive Transcranial Magnetic Stimulation and Expressive Writing for Post-Traumatic Stress","Efficacy and Safety of a Combined Intervention of Repetitive Transcranial Magnetic Stimulation and Expressive Writing According to Timing of Administration: A Parallel-Group Randomized Controlled Trial in Adults With Post-Traumatic Stress Symptoms","Inclusion Criteria:\n\n* Be between 18 and 65 years of age.\n* Have experienced at least one traumatic or highly stressful event, regardless of how much time has passed since the event occurred.\n* Present a score ≥ 24 on the Revised Impact of Event Scale (IES-R).\n* Have post-traumatic stress symptoms that are not better explained by another clinical condition or mental disorder.\n\nExclusion Criteria:\n\n* History of epilepsy, seizures, or convulsions.\n* Presence of intracranial or cranial metal incompatible with rTMS.\n* History of severe traumatic brain injury.\n* Pregnancy or reasonable possibility of pregnancy.\n* Cochlear implants or internal pulse generators.\n* Use of medication that lowers the seizure threshold.\n* Current suicidal ideation or behaviour, or recent suicidal ideation within the past month.\n* Other medical or psychiatric conditions that contraindicate the use of rTMS.\n* Any condition that prevents participation in any of the study interventions.\n* Currently receiving psychological and\u002For pharmacological treatment for PTSD, acute stress, or another disorder that could account for post-traumatic stress symptoms.\n* Failure to provide written informed consent.",{"count":458,"type":22},45,[91],"The goal of this clinical trial is to learn if a combined treatment using repetitive transcranial magnetic stimulation (rTMS) and expressive writing works to reduce symptoms of post-traumatic stress in adults. It will also study how safe this treatment is and whether the timing of rTMS changes how well it works.\n\nThe main questions it aims to answer are:\n\n* Does this combined treatment lower symptoms of post-traumatic stress?\n* Does it work better when rTMS is given before or after expressive writing?\n\nResearchers will compare three groups to see which approach works best:\n\n* rTMS given before expressive writing\n* rTMS given after expressive writing\n* Sham stimulation (a look-alike procedure that does not provide real stimulation)\n\nParticipants will:\n\n* Take part in sessions that include expressive writing about emotional experiences\n* Receive either real rTMS or sham stimulation\n* Complete questionnaires about post-traumatic stress, anxiety, depression, and mood\n* Have their heart rate and skin responses measured during the sessions\n* Be assessed before the study, after the sessions, and one month later\n\nThis study includes adults aged 18 to 65 who have experienced at least one traumatic or highly stressful event and report symptoms of post-traumatic stress.",[30],[463,464,465,466,467,468],"Post-traumatic stress","rTMS","randomized controlled trial","repetitive transcranial magnetic stimulation","transcranial magnetic stimulation","TMS","2026-04-28",{"date":417,"type":35},{"date":472,"type":22},"2026-06",{"date":474,"type":22},"2027-02",{"name":476,"class":77},"Servicio Canario de Salud",{"id":478,"slug":479,"hasResults":12,"nctId":480,"briefTitle":481,"officialTitle":482,"acronym":483,"eligibilityCriteria":484,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":258,"enrollmentInfo":485,"targetDuration":4,"studyType":23,"phases":487,"briefSummary":488,"conditions":489,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":490,"lastUpdatePostDateStruct":491,"startDateStruct":493,"completionDateStruct":494,"leadSponsor":496,"locationsCount":103},"100631323","a-study-on-body-posture-and-eye-movements-during-screen-usage-on-adults-aged-18-to-65-wearing-various-types-of-eyeglasses-100631323","NCT07499180","A Study on Body Posture and Eye Movements During Screen Usage on Adults Aged 18 to 65 Wearing Various Types of Eyeglasses","Etude Des Comportements Posturaux et Oculomoteurs Durant l'Utilisation d'Outils Digitaux","POEM","Inclusion Criteria:\n\n* Distance refractive error (equivalent sphere) between -3D and +3D\n* Astigmatism inferior or equal to 1D\n* Anisometropia inferior or equal to 1.5D\n* Addition (for presbyopes) between 0.75D and 2.75D\n* Minimum corrected visual acuity : 8\u002F10\n* Stable binocular vision\n\nExclusion Criteria:\n\n* Employee of Essilor, Luxottica, GrandVision and their subsidiaries\n* Aphakia, pseudophakia or ocular surgery\n* Reported systemic pathology that affects vision\n* Medical treatment or taking medications that affect vision\n* Severe ocular pathology declared, involving a loss of visual field as in glaucoma, a loss of acuity\n* Reported neurological deficit, including a history of seizure or sensorimotor coordination disorders, vestibular or cerebellar pathology\n* Binocular vision problems such as amblyopia, strabismus, or double vision\n* Vertebral or cervical troubles\n* Difficulty to move, vertigo, ocular migraine",{"count":486,"type":22},69,[91],"The goal of this clinical study is to evaluate how adults aged 18 to 65 move their bodies and eyes when they use screens, with various eyeglasses. The main questions it aims to answer are :\n\n* How the behaviour between young and presbyopes is different while performing visual tasks on digital devices ?\n* How the behaviour while performing visual tasks changes according to different types of eyeglasses ? Participants will be asked to take part in an eye exam and do simple visual tasks on digital devices.",[30],"2026-04-07",{"date":492,"type":35},"2026-04-13",{"date":490,"type":35},{"date":495,"type":22},"2026-10",{"name":497,"class":42},"Essilor International",{"id":499,"slug":500,"hasResults":12,"nctId":501,"briefTitle":502,"officialTitle":503,"acronym":504,"eligibilityCriteria":505,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":506,"targetDuration":4,"studyType":55,"phases":4,"briefSummary":508,"conditions":509,"keywords":510,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":516,"lastUpdatePostDateStruct":517,"startDateStruct":518,"completionDateStruct":519,"leadSponsor":521,"locationsCount":103},"100632421","3t-magnetic-resonance-neurography-100632421","NCT07513467","3T Magnetic Resonance Neurography","High-resolution MR Neurography Evaluation of the Cervical Spine at 3 Tesla","3T MRN","Inclusion Criteria:\n\n\\- written consent to agree to participate in this study\n\nExclusion Criteria:\n\n* \\\u003C18 years of age\n* pregnancy\n* known cervical spine pathology or history of neck surgery\n* contraindication to perform non-contrast-enhanced MRI",{"count":507,"type":22},30,"The goal of this observational study is to evaluate whether optimized high-resolution MRI can better visualize very fine nerves in the cervical spine and neck region compared to standard MRI. The main question it aims to answer is:\n\nCan high-resolution MRI reliably show small nerves and potentially detect their injuries or diseases that are often invisible on conventional MRI scans?\n\nParticipants will come once to Balgrist University Hospital for a one-hour visit. They will fill out a questionnaire and have a single 30-minute MRI scan of the cervical spine without contrast.",[30],[511,512,513,514,515],"Cervical spine","MRI","3 Tesla","Magnetic Resonance Neurograghy","Cervical nerves","2026-03-30",{"date":490,"type":35},{"date":472,"type":22},{"date":520,"type":22},"2028-06",{"name":522,"class":77},"Balgrist University Hospital",{"id":524,"slug":525,"hasResults":12,"nctId":526,"briefTitle":527,"officialTitle":528,"acronym":4,"eligibilityCriteria":529,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":530,"enrollmentInfo":531,"targetDuration":4,"studyType":23,"phases":532,"briefSummary":533,"conditions":534,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":535,"lastUpdatePostDateStruct":536,"startDateStruct":538,"completionDateStruct":540,"leadSponsor":541,"locationsCount":103},"100629353","phase-1-a-studyphase-iof-gs3-007a-dry-suspension-in-healthy-chinese-adults-100629353","NCT07473570","A Study（Phase I）of GS3-007a Dry Suspension in Healthy Chinese Adults","A Phase I Clinical Study of GS3-007a Dry Suspensions in Healthy Chinese Adults: Randomized, Double-Blind, Placebo-Controlled, Single- and Multiple-Dose, Dose-Escalation, and Food Effect Study","Inclusion Criteria:\n\n1. Age 18-45 years (inclusive), healthy adult subjects, both male and female are eligible;\n2. Body Mass Index (BMI): 19-26 kg\u002Fm² (inclusive), males weighing ≥50 kg, females weighing ≥45 kg;\n3. Fully understand the purpose, nature, and methods of the trial, as well as possible adverse reactions, voluntarily participate as subjects, sign the informed consent form (ICF) before any study procedures;\n4. From screening day to 3 months after the last dose, have no plans for conception or sperm\u002Fegg donation, and agree to use reliable non-drug contraception during the trial (such as complete abstinence, intrauterine device, partner sterilization, etc.).\n\nExclusion Criteria:\n\n1. A highly allergic constitution\n2. Individuals with a clear history of neurological or psychiatric disorders; those lacking behavioral or cognitive function.\n3. Electrocardiogram (ECG) QTcF interval abnormal, with a history of QT\u002FQTc interval prolonged; abnormal liver function; abnormal findings in physical examination, laboratory tests, or other examinations with clinical significance.\n4. Individuals with a history of hepatitis B, hepatitis C, syphilis, AIDS, or with one or more clinically significant abnormal findings in infectious disease screening.\n5. Individuals who are alcoholics or who regularly consumed alcohol within 6 months before the first dose of the trial, or those unwilling to stop drinking or consuming any alcohol-containing products during the entire trial.\n6. Individuals with a history of heavy smoking or those who smoked an average of ≥5 cigarettes per day within the 3 months before screening\n7. Individuals with immune deficiencies or immunosuppressive diseases, malignant tumors, chronic cardiovascular, liver, kidney, endocrine, respiratory, hematological (including coagulation), or digestive system diseases.\n8. Individuals who underwent major surgery within 6 months before screening or during the screening period, or those who experienced acute neurological, digestive, respiratory, circulatory, endocrine, or hematological diseases within 3 months before screening;\n9. Subjects who have donated blood (including blood components) within 3 months prior to the first dose, or have experienced blood loss ≥ 400 mL within 3 months prior to the first dose\n10. Subjects who have participated in any clinical trial and used investigational drugs, vaccines, or devices within 3 months prior to screening\n11. Subjects who have started a significantly abnormal diet within 4 weeks prior to screening or during the screening period, or have special dietary requirements, cannot comply with the standardized diet, or cannot tolerate the high-fat, high-calorie meal in postprandial trials\n12. Female subjects who are pregnant or breastfeeding","45 Years",{"count":384,"type":22},[25],"This study consists of two parts: the first part is a single-dose escalating（SAD） and food effect （FE）study, and the second part is a multiple-dose (14-day) escalating(MAD) study. Both phases are designed as randomized, double-blind, dose-escalation, placebo-controlled clinical studies.",[30],"2026-03-12",{"date":537,"type":35},"2026-03-16",{"date":539,"type":35},"2026-01-07",{"date":204,"type":22},{"name":542,"class":42},"Changchun GeneScience Pharmaceutical Co., Ltd.",{"id":544,"slug":545,"hasResults":12,"nctId":546,"briefTitle":547,"officialTitle":548,"acronym":549,"eligibilityCriteria":550,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":551,"enrollmentInfo":552,"targetDuration":4,"studyType":23,"phases":553,"briefSummary":555,"conditions":556,"keywords":557,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":564,"lastUpdatePostDateStruct":565,"startDateStruct":567,"completionDateStruct":569,"leadSponsor":571,"locationsCount":103},"100628521","phase-4-statins-against-bushfire-smoke-100628521","NCT07462715","Statins Against Bushfire Smoke","Does Short-term or Long-term Statin Use Protect the Heart and Brain During Exposure to Bushfire Smoke? A Parallel-group Statin Trial With Cross-over, Order-randomised Smoke Exposure vs Filtered Air Among Healthy Australian Adults.","SABS","Inclusion Criteria:\n\n* Good general health and, if aged 45 year or more, low to intermediate (\\\u003C10%) atherosclerotic cardiovascular disease (ASCVD) risk category, based on clinical data measured within 12 months prior to enrolment.\n\nExclusion Criteria:\n\n* History of severe chronic lung diseases such as chronic obstructive pulmonary disease or asthma as determined by participants' care providers.\n* History of chest pain, irregular heartbeats, heart failure, heart attack, heart pacemaker or coronary bypass surgery.\n* High cardiovascular risk (\\>10%) category on the ASCVD risk calculator or judged to be at high risk by study cardiologist, for those aged 45 years or older.\n* History of stroke, dementia or other neurological condition\n* Untreated high blood pressure (≥ 140 systolic, ≥ 90 diastolic)\n* History of autoimmune or inflammatory rheumatic disease (e.g., rheumatoid arthritis, systemic lupus erythematosus, spondyloarthritis). Osteoarthritis alone is not an exclusion.\n* History of immunodeficiency\n* Diabetes (any type)\n* Current medications: Long term medications that interact with atorvastatin (such as verapamil, digoxin and warfarin); Medications that affect heart rate variability including beta-blockers (such as atenolol, metoprolol, propranolol, and acebutolol), tricyclic antidepressants and selective serotonin reuptake inhibitors (such as amitriptyline, sertraline, fluoxetine or citalopram), or medications with anti-cholinergic action (such as promethazine or prochlorperazine); stimulant medications, such as those prescribed for ADHD (such as methylphenidate, dexamphetamine, lisdexamfetamine); anti-inflammatory, immunosuppressive or immune modulating medications including systemic corticosteroids (such as prednisolone, dexamethasone) and non-steroidal anti-inflammatory drugs (NSAIDS) (such as ibuprofen, naproxen or diclofenac)\n* Currently smoking, or have smoked: more than one pack of cigarettes in the past year, or have smoked more than 100 packs of cigarettes in their lifetime\n* Currently vaping or have vaped: more than 200 puffs in the last year, more than 20,000 puffs in their lifetime\n* Currently pregnant, attempting to become pregnant or breastfeeding\n* History of skin allergy to tape or electrodes\n* Inability to travel to the study site","68 Years",{"count":113,"type":22},[554],"PHASE4","The goal of this clinical trial is to test whether statins can protect the heart and brain from the biological stress and inflammatory responses caused by breathing bushfire smoke in healthy adult volunteers aged 18-64 years. The main questions it aims to answer are:\n\n1. Does short-term statin use (2 days) reduce bushfire smoke-induced changes in heart rate variability, blood pressure, arterial stiffness, inflammation and oxidative stress markers, and cognitive function?\n2. Does long-term statin use (≥12 months) reduce bushfire smoke-induced changes in heart rate variability, blood pressure, arterial stiffness, inflammation and oxidative stress markers, and cognitive function?\n\nThe study includes two streams:\n\nStream 1:short-term statin use (2 days) where participants receive either statin tablets (80mg atorvastatin) or placebo; Stream 2: long-term statin use (≥12 months) where participants include those already taking statins (≥12 months) with statin-naïve individuals.\n\nParticipants will:\n\n* Attend two 3½-hour visits to a Climate Hut, which are approximately 4 weeks apart, where they will spend 2 hours exposed to either filtered air or simulated dilute bushfire smoke (average particulate matter (PM2.5) concentration of 300μg\u002Fm\\^3) in randomised order;\n* Have continuous heart monitoring with ECG leads and blood pressure checks every 15 minutes during each visit\n* Provide urine, saliva, and nose swab samples before and after each exposure, plus follow-up samples the next morning\n* Complete cognitive tests (reaction time, memory tasks) and postural balance measurements during exposure\n* Complete questionnaires about anxiety levels, symptoms, diet, and health status\n* Have blood samples collected and pulse wave velocity measurements (assessing arterial stiffness) immediately after each exposure session.\n\nPotential risks include time commitment, muscle pain from statins, eye irritation or throat discomfort from smoke exposure, and minor discomfort from blood collection.",[30],[558,559,560,561,562,563,198],"bushfire smoke","wildfire","air pollution","cardiovascular function","statin","inflamation","2026-03-05",{"date":566,"type":35},"2026-03-10",{"date":568,"type":22},"2026-05-01",{"date":570,"type":22},"2028-12-31",{"name":572,"class":77},"Menzies Institute for Medical Research",{"id":574,"slug":575,"hasResults":12,"nctId":576,"briefTitle":577,"officialTitle":578,"acronym":4,"eligibilityCriteria":579,"healthyVolunteers":17,"sex":18,"minAge":530,"maxAge":580,"enrollmentInfo":581,"targetDuration":4,"studyType":23,"phases":583,"briefSummary":584,"conditions":585,"keywords":586,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":591,"lastUpdatePostDateStruct":592,"startDateStruct":594,"completionDateStruct":596,"leadSponsor":597,"locationsCount":103},"100610413","health-properties-of-pecan-nut-consumption-100610413","NCT07227259","Health Properties of Pecan Nut Consumption","Assessment of Systematic Health Properties of Pecan Nut Consumption: Gut, Vascular, Metabolic and Cognitive Outcomes","Inclusion Criteria:\n\nBMI of 20-35 kg\u002Fm2, ability to understand the intervention instructions, Willingness to follow the dietary intervention, Willingness to provide biological samples (blood and stool) -\n\nExclusion Criteria:\n\nAllergy to pecan or other nuts, Cognitive impairment due to dementia of any type and inability to understand or comply with intervention instructions, Use of menopausal hormone replacement therapy, Use of antibiotics or probiotics in the 2 months prior to enrollment, Uncontrolled diabetes with HbA1C of \\>9.5, Vegetarian\u002Fvegan, Any serious medical condition (such as chronic kidney disease of stage 3 or greater, heart failure, active cancer treatment, inflammatory bowel disease, etc.), Consumption of supplements that may interfere with vascular response or gut microbiome, Use of statin drugs for cholesterol lowering.\n\n\\-","75 Years",{"count":582,"type":22},40,[91],"The main goal of this clinical study is to see if consuming pecan nuts will result in improvements in overall body metabolism such as in blood lipids, markers of inflammation, blood pressure, cognitive performance and changes in bacteria living in the gut in adults 45 to 75 years of age.\n\nParticipants will take part in two 3-month intervention periods, separated by 4-6 weeks, in random order ( a total of approximately 7 months). During one intervention period, they will include pecan nuts in their diet each day, while during the other intervention period they will avoid pecans in their diet. There will be an initial screening visit to evaluate eligibility and four study visits to the clinic.\n\nParticipants will be asked to complete some questionnaires about their diet, physical and cognitive health, and provide blood and stool samples, and have their blood pressure measured.",[30],[587,588,589,590],"pecan nut","cardiovascular","gut microbiome","cognitive","2026-02-20",{"date":593,"type":35},"2026-02-24",{"date":595,"type":35},"2025-11-15",{"date":206,"type":22},{"name":598,"class":77},"University of California, Davis",{"id":600,"slug":601,"hasResults":12,"nctId":602,"briefTitle":603,"officialTitle":604,"acronym":4,"eligibilityCriteria":605,"healthyVolunteers":17,"sex":18,"minAge":606,"maxAge":111,"enrollmentInfo":607,"targetDuration":4,"studyType":23,"phases":608,"briefSummary":609,"conditions":610,"keywords":611,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":614,"lastUpdatePostDateStruct":615,"startDateStruct":617,"completionDateStruct":619,"leadSponsor":620,"locationsCount":103},"100578799","phase-1-phase-1a-single-ascending-dose-study-of-mib-725-in-healthy-adults-100578799","NCT06815991","Phase 1a Single Ascending Dose Study of MIB-725 in Healthy Adults","A Phase 1, Single Ascending Dose Administration of MIB-725 to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics in Community Dwelling Healthy Adults","Inclusion Criteria:\n\n1. Is a non-smoking healthy adult, 19 to 60 years of age, inclusive\n2. Has a body mass index (BMI) between 19 and 37.5 kg\u002Fm2, inclusive\n3. Is free from clinically significant medical problems as determined by the Investigator\n4. Is able and willing to provide written informed consent.\n5. Is able and willing to provide authorization for the use and disclosure of personal health information in accordance with the Health Insurance Portability and Accountability Act (HIPAA).\n\nExclusion Criteria:\n\n1. Is a current cigarette smoker\n2. AST or ALT \\> 1.5 times the upper limit of normal\n3. Hematocrit \\\u003C 37% or \\> 51%\n4. Diagnosis of diabetes mellitus, as indicated by use of diabetes medication, hemoglobin A1C \\> 6.4% or fasting glucose ≥126 mg\u002FdL\n5. Serum creatinine \\> 2.0 mg\u002FdL\n6. Current use of barbiturates, benzodiazepines, opiates, amphetamine, cannabinoids and cocaine\n7. Known allergy to niacin or nicotinamide mononucleotide\n8. Unwilling to refrain from drinking alcohol during the duration of the study\n9. Use of any other dietary supplement during the course of the trial\n10. Use of anabolic steroids, rhGH, DHEA, androstenedione, or any other performance enhancing drug\n11. In the judgment of the study physician, the participant is unlikely to comply with the study protocol for any reason or it may not be safe to administer the study medication\n12. Has a history of myocardial infarction, stroke, or heart failure in the preceding 6 months.\n13. Has a history of cancer other than nonmelanotic skin cancer requiring treatment in the previous 2 years.\n14. Has other medical conditions which, in the opinion of the Principal Investigator, would jeopardize the safety of the study subject or impact the validity of the study results.\n\nIn addition, female participants must:\n\n1. Be postmenopausal as indicated by cessation of menstruation at least one year before screening\n2. Not be pregnant and not planning to become pregnant over the next 6 months\n\nProhibited medications and substances:\n\n1. Current use of barbiturates, benzodiazepines, opiates, amphetamine, cannabinoids and cocaine\n2. Use of any other dietary supplement during the course of the trial. Subjects who are using a supplement containing nicotinamide, niacin, nicotinamide mononucleotide, or nicotinamide riboside may be included if they agree to stop the supplement at least 2 weeks prior to day 0 and during the entire duration of the study.\n3. Initiation of a new prescription drug during the preceding 4 weeks or during the course of the study\n4. Use of anabolic steroids, rhGH, DHEA, androstenedione, or any other performance enhancing drug\n\n   \\-","19 Years",{"count":384,"type":22},[25],"This is a single center, open label (i.e. participants and study staff will not be masked to the intervention) single ascending dose study to evaluate the safety, tolerability, pharmaokinetics and pharmacodynamics of MIB-725 in community dwelling, healthy adults. Up to 4 successive groups (cohorts) of 8 subjects each will be enrolled in this trial.\n\nThis study will determine the safety and tolerability of orally administered single ascending (increasing) doses (100, 200, 400, and 800 mg) of MIB-725 in healthy adults. The safety will be assessed by evaluating physical examination that includes an external eye examination, vital signs, adverse events, and changes in blood counts, EKG, urinalysis, coagulation measures, and blood chemistries, including but not limited to blood glucose, electrolytes, creatinine, liver function tests, uric acid, and creatine kinase.",[30],[612,613],"Phase 1","NAD Booster","2026-02-16",{"date":616,"type":35},"2026-02-19",{"date":618,"type":35},"2025-02-11",{"date":372,"type":22},{"name":621,"class":42},"Metro International Biotech, LLC",{"id":623,"slug":624,"hasResults":12,"nctId":625,"briefTitle":626,"officialTitle":627,"acronym":4,"eligibilityCriteria":628,"healthyVolunteers":17,"sex":18,"minAge":629,"maxAge":630,"enrollmentInfo":631,"targetDuration":4,"studyType":23,"phases":632,"briefSummary":633,"conditions":634,"keywords":635,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":639,"lastUpdatePostDateStruct":640,"startDateStruct":642,"completionDateStruct":644,"leadSponsor":645,"locationsCount":323},"100609607","phase-1-safety-and-efficacy-of-injectable-klotho-plasmid-gene-therapy-in-humans-100609607","NCT07216781","Safety and Efficacy of Injectable Klotho Plasmid Gene Therapy in Humans","Evaluating the Safety and Efficacy of Injectable Klotho Plasmid Gene Therapy in Humans: An Interventional, Non-Placebo-Controlled Pilot Phase Study","Inclusion Criteria:\n\n* Participant is open to morphological change\n* If female, participant agrees to maintain contraception\n* If female, participant agrees to take a pregnancy test\n* If female, participant agrees to a pregnancy waiver\n\nExclusion Criteria:\n\n* Women of childbearing potential who are unwilling or unable to use effective contraception for the duration of the study\n* History of cancer diagnosis\n* Preexisting medical issues that may be exacerbated by the treatment\n* Has received any gene therapy within the past 12 months\n* Unwilling or unable to provide written informed consent","23 Years","90 Years",{"count":289,"type":22},[25],"The purpose of this study is to investigate the safety and efficacy of a gene therapy for Klotho, delivered via a nonviral plasmid in healthy adult volunteers. Additionally, this study seeks to understand the cognitive and health benefits of the Klotho gene therapy.",[30],[636,637,638],"Klotho","plasmid","gene therapy","2026-02-15",{"date":641,"type":35},"2026-02-17",{"date":643,"type":35},"2025-10-06",{"date":204,"type":22},{"name":646,"class":42},"Minicircle"]