[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"healthy-middle-aged-subjects\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:healthy-middle-aged-subjects":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":5},"100656825","stearic-acid-and-endothelial-function-100656825",false,"NCT07831603","Stearic Acid and Endothelial Function","Inclusion Criteria:\n\n* Adults ages 40-70 years\n* BMI 25.0-40.0 kg\u002Fm2\n* Seated blood pressure \\\u003C130\u002F80 mmHg\n* Willing and able to attend laboratory visits\n\nExclusion Criteria:\n\n* Current diagnosis or history of diabetes, renal disease, liver disease, gallbladder disease, cholecystectomy, pancreatic disease, cancer, overt cardiovascular disease, or a major cardiovascular event (e.g., heart attack or stroke)\n* Current or recent use of weight loss medications\n* Significant change in bodyweight of ≥ 5% within the past 6 months\n* Current or recent use of glucose- or lipid-lowering drugs\n* Fasting LDL cholesterol ≥ 190 mg\u002FdL or fasting plasma total cholesterol \\> 7.8 mmol\u002FL (302 mg\u002FdL), or fasting plasma TAG \\> 3 mmol\u002FL (267 mg\u002FdL)\n* Current or recent use of tobacco, nicotine, or illicit drugs\n* History of bariatric surgery\n* Hysterectomy or ovarian removal (females)\n* Pregnant or lactating\n* Athlete\n* Unwilling or unable to provide consent\n* Unwilling or unable to consume study diet",true,"ALL","40 Years","70 Years",{"count":20,"type":21},40,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to evaluate the postprandial and long-term effects of dietary stearic acid on vascular function in overweight or obese adult males and females aged 40-70 years. The main questions it aims to answer are:\n\n1. Does consuming a high stearic acid-rich meal improve postprandial vascular function compared to a high oleic acid-rich meal?\n2. Does a 14-day stearic acid-rich diet improve fasting vascular function compared to an oleic acid-rich diet?\n3. Does a 14-day stearic acid-rich diet reduce the impairment of postprandial vascular function following a high palmitic-acid challenge meal?\n\nParticipants will:\n\n* Complete screening questionnaires, a 3-day food log, body composition measurements, and fasting blood and urine tests.\n* Consume a provided, 14-day controlled diet high in palmitic acid while avoiding outside food and beverages other than water.\n* Be randomly assigned to consume a provided 14-day diet high in either stearic acid (cocoa butter blend) or oleic acid (plant oil blend).\n* Attend two 5-hour testing visits at the clinic after overnight fasting.\n* Undergo intravenous (IV) catheter placement for repeated blood sampling and non-invasive vascular health assessments (ultrasound artery checks and pulse measurements).\n* Consume assigned high-fat test meals within 15 minutes and undergo hourly vascular and blood assessments over a 4-hour period.",[27,28],"Healthy Middle-aged Subjects","Obesity & Overweight","NOT_YET_RECRUITING","2026-09-15",{"date":32,"type":33},"2026-09-21","ACTUAL",{"date":35,"type":21},"2026-10-01",{"date":37,"type":21},"2027-08",{"name":39,"class":40},"Florida State University","OTHER"]