[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"heart-brain-coupling\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:heart-brain-coupling":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,48],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100650703","modulatory-effects-of-personalized-transcranial-magnetic-stimulation-tms-on-heart-brain-coupling-in-individuals-with-depressive-tendencies-100650703",false,"NCT07753473","Modulatory Effects of Personalized Transcranial Magnetic Stimulation (TMS) on Heart-Brain Coupling in Individuals With Depressive Tendencies","Study on the Regulation of Heart-Brain Coupling in Individuals With Depressive Tendencies Using Transcranial Magnetic Stimulation (TMS) Based on Personalized Functional Connectivity","Inclusion Criteria:\n\n一、Inclusion criteria for the depressed group:\n\n1. Aged 18-30 years;\n2. Recent feelings of low mood and presence of depressive symptoms;\n3. Physically healthy, with no history of neurological disorders;\n4. No participation in other neuromodulation experiments within the past month;\n5. Normal hearing and normal (or corrected-to-normal) vision;\n6. PHQ-9 score \\> 5 and BDI-II score \\> 13;\n7. Avoidance of staying up late, alcohol consumption, and excessive caffeine intake prior to the experiment;\n8. Able and willing to cooperate with the completion of scale assessments. 二、Inclusion criteria for healthy participants:\n\n(1) Aged 18-30 years; (2) No significant symptoms of depression and no history of neuropsychiatric disorders; (3) Physically healthy with no history of neurological disorders; (4) No participation in other neuromodulation experiments within the past month; (5) Normal hearing and normal (or corrected-to-normal) vision; (6) PHQ-9 score \\\u003C 5 and BDI-II score \\\u003C 13; (7) Avoidance of staying up late, alcohol consumption, and excessive caffeine intake prior to the experiment; (8) Able and willing to cooperate with the completion of scale assessments.\n\nExclusion Criteria:\n\n1. History of head trauma (including neurosurgery), stroke, elevated intracranial pressure, or other brain-related disorders;\n2. History of epileptic seizures or family history of epilepsy;\n3. Receipt of TMS or other neuromodulation stimulation within the past month;\n4. Presence of intracranial or internal metallic foreign bodies, electrodes made of silver or gold, or metal prostheses;\n5. Presence of devices potentially affected by TMS, such as pacemakers, drug pumps, cochlear implants, or implanted brain stimulators;\n6. Severe or recent cardiac, pulmonary, or hematopoietic system disorders, or other neurological diseases;\n7. Clinically diagnosed moderate-to-severe depressive disorder;\n8. Substance abuse, alcohol dependence, etc.;\n9. Current active suicidal ideation or suicidal behavior; Refusal to sign the informed consent form.",true,"ALL","18 Years","30 Years",{"count":21,"type":22},60,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study focuses on individuals with depressive tendencies and investigates the regulatory effects of Transcranial Magnetic Stimulation (TMS)-guided by personalized functional connectivity mapping-on heart-brain coupling in this population, while also exploring the underlying mechanisms.Participants will undergo 3T functional magnetic resonance imaging (fMRI) scans, followed by four different types of neurostimulation: stimulation targeting individualized Dorsolateral Prefrontal Cortex (DLPFC) -Subgenual Anterior Cingulate Cortex (sgACC) functional connectivity, stimulation targeting individualized DLPFC-insula functional connectivity, standard F3 targeting, and sham stimulation. The order of these stimulation sessions will be randomized. Researchers will simultaneously record the participants' electroencephalogram (EEG) and electrocardiography (ECG) signals before and after stimulation, and will record ECG in real-time during the stimulation. The primary objective of this study is to investigate the effects of DLPFC targeting specificity on metrics such as heart-brain coupling in individuals with depressive tendencies, thereby providing a basis for future research on objective assessment and personalized interventions for depression.",[28,29,30],"Depression Disorder","fMRI Research","Heart-Brain Coupling",[32,33,34],"Functional Connectivity","Individualized treatment","Transcranial magnetic stimulation","RECRUITING","2026-08-05",{"date":38,"type":39},"2026-08-07","ACTUAL",{"date":41,"type":22},"2026-08-01",{"date":43,"type":22},"2026-12-30",{"name":45,"class":46},"Xidian University","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":56,"minAge":18,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":23,"phases":59,"briefSummary":60,"conditions":61,"keywords":64,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":47},"100636149","effects-of-high-frequency-left-dorsolateral-prefrontal-rtms-on-heart-brain-coupling-in-women-with-recurrent-pregnancy-loss-and-elevated-bmi-100636149","NCT07561931","Effects of High-frequency Left Dorsolateral Prefrontal rTMS on Heart-brain Coupling in Women With Recurrent Pregnancy Loss and Elevated BMI","Effects of High-frequency Left Dorsolateral Prefrontal rTMS on Heart-brain Coupling in Women With Recurrent Pregnancy Loss and Elevated BMI: a Randomized, Sham-controlled Mechanistic Trial (NEURO-CARD-BMI)","NEURO-CARD-BMI","Inclusion Criteria:\n\n* 1.Female participants aged 18-45 years and right-handed.\n* 2.Fulfillment of the prespecified definition of recurrent pregnancy loss in this study, defined as at least two consecutive spontaneous miscarriages occurring before 28 weeks of gestation.\n* 3.BMI ≥24 kg\u002Fm², classified as overweight or obesity according to the Chinese adult criteria for overweight and obesity.\n* 4.Currently not pregnant and in a clinically stable condition. If there is a recent history of missed abortion, appropriate management must have been completed and obstetric assessment must confirm the absence of acute vaginal bleeding, infection, marked abdominal pain, or hemodynamic instability.\n* 5.Ability to understand the study procedures, provide written informed consent, and cooperate with scale assessment, transcranial magnetic stimulation safety screening, and the single-session rTMS-ECG protocol.\n\nExclusion Criteria:\n\n* 1.Presence of contraindications to transcranial magnetic stimulation or elevated seizure risk, including but not limited to epilepsy or a history of unexplained seizures, intracranial ferromagnetic metal implantation, or the presence of electronic or metallic implanted devices within 30 cm of the coil that are judged unsuitable for transcranial magnetic stimulation.\n* 2.Current pregnancy.\n* 3.Hemodynamic instability or cardiovascular abnormalities that may substantially affect interpretation of the primary endpoint, including systolic blood pressure \\>180 mmHg or \\\u003C90 mmHg, atrial fibrillation or other clinically significant arrhythmias, valvular heart disease, marked sinus bradycardia, symptomatic coronary artery disease, or other cardiovascular conditions judged by the research team to make participation unsuitable.\n* 4.Uncontrolled major medical or neurologic disorders, particularly those that may substantially affect autonomic state, ECG recording, or interpretation of the primary endpoint, including uncontrolled thyroid dysfunction, uncontrolled diabetes mellitus, significant cerebrovascular disease, neurologic disorders, or active pulmonary disease.\n* 5.Presence of significant suicide risk.\n* 6.Severe psychiatric disorders that may affect study safety or adherence, including schizophrenia spectrum disorders, bipolar disorder during a manic or hypomanic episode, delirium, and active substance use disorder.\n* 7.Severe anxiety or severe depression, defined as a Hamilton Anxiety Rating Scale total score of ≥25 or a 17-item Hamilton Depression Rating Scale total score of ≥24.\n* 8.Recent medication-related confounding risk, including current withdrawal from alcohol, sedative-hypnotics, or other relevant substances, or initiation, discontinuation, or dose adjustment within the preceding 2 weeks of medications that may substantially affect seizure threshold, autonomic function, ECG-related indices, or interpretation of the primary endpoint.\n* 9.Any other condition judged by the research team to make participation inappropriate.","FEMALE","45 Years",{"count":21,"type":22},[25],"This randomized, sham-controlled mechanistic trial will examine whether a single session of high-frequency repetitive transcranial magnetic stimulation, rTMS, applied to the left dorsolateral prefrontal cortex can modify heart-brain coupling in women with recurrent pregnancy loss and elevated body mass index, BMI. Women with recurrent pregnancy loss often experience reproductive, metabolic, and emotional stress at the same time, and this combined vulnerability may be associated with altered autonomic regulation and exaggerated cardiac responses to stress. The left dorsolateral prefrontal cortex is a key brain region involved in cognitive control, emotion regulation, and top-down modulation of autonomic function.\n\nEligible participants will be randomly assigned in a 1:1 ratio to receive either real or sham rTMS at the same left dorsolateral prefrontal target. The stimulation protocol will use 10 Hz rTMS at 100% motor threshold, delivered in 30 cycles of 5 s stimulation followed by 11 s inter-train interval, with simultaneous 3-lead electrocardiography recording. The primary endpoint will be the between-group difference in mean heart-brain coupling across 30 stimulation cycles. Safety and tolerability will also be monitored. This study is intended to provide mechanistic evidence and methodological support for future multi-session randomized trials in this population.",[62,63,30],"Recurrent Pregnancy Loss","Overweight , Obesity",[65,66,67,68,69,70,71],"recurrent pregnancy loss","elevated BMI","overweight","heart-brain coupling","repetitive transcranial magnetic stimulation","left dorsolateral prefrontal cortex","autonomic regulation","NOT_YET_RECRUITING","2026-04-24",{"date":75,"type":39},"2026-05-01",{"date":77,"type":22},"2026-04-28",{"date":79,"type":22},"2026-09-30",{"name":81,"class":46},"Shenyang Medical College"]