[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hepatic-resection\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hepatic-resection":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,43],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":27,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100571277","immunohistochemical-algorithm-for-the-diagnosis-and-classification-of-hepatocellular-carcinomas-with-tert-tp53-and-ctnnb1-mutation-100571277",false,"NCT06718153","Immunohistochemical Algorithm for the Diagnosis and Classification of Hepatocellular Carcinomas With TERT, TP53 and CTNNB1 Mutation","Inclusion Criteria:\n\n* Age ≥18 years\n* Patients resected for HCC\n* Availability of NGS data\n* Availability of paraffin material for immunohistochemistry investigations\n\nExclusion Criteria:\n\n* None","ALL","18 Years",{"count":18,"type":19},100,"ESTIMATED","INTERVENTIONAL",[22],"NA","The presence of certain mutations in HCC, such as TERT and TP53, have a suspected or proven prognostic role in resected patients, but lack a morphological or immunophenotypic counterpart, which would allow us to define which tumours are rationally candidate for molecular biology analysis. The identification of a histological and immunohistochemical algorithm to determine which HCCs to take to NGS for prognostic purposes will save time and economic costs in the laboratory by rationalising available resources. In the future, the application of the immunohistochemical and molecular algorithm on biopsy could allow better prognosis and predictivity even before surgery\u002Ftherapy.",[25,26],"Hepatic Cancer","Hepatic Resection",[28,29],"Molecular diagnostics","Immunohistochemistry","RECRUITING","2024-12-04",{"date":33,"type":34},"2024-12-05","ACTUAL",{"date":36,"type":34},"2024-10-23",{"date":38,"type":19},"2025-06",{"name":40,"class":41},"IRCCS Azienda Ospedaliero-Universitaria di Bologna","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":20,"phases":52,"briefSummary":54,"conditions":55,"keywords":59,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":42},"100427703","phase-4-erector-spinae-plane-block-catheters-and-intrathecal-morphine-for-hepatic-resection-100427703","NCT04849455","Erector Spinae Plane Block Catheters and Intrathecal Morphine for Hepatic Resection","Erector Spinae Plane Block Catheters: The Role in Acute Postoperative Pain After Hepatic Resection With Intrathecal Morphine","Inclusion Criteria:\n\n* undergoing hepatic resection\n* Admitting service requests APS consult\n* \\>18 years old and able to provide consent\n\nExclusion criteria:\n\n* pregnancy\n* incarceration\n* inability to communicate with the investigators and hospital staff\n* severe hepatic disease\n* chronic high-dose opioid use (defined as daily use for more than 4 weeks prior to surgery of at least the equivalent of 20 mg oxycodone);\n* BMI \\> 40 kg\u002Fm2\n* allergy to study medications (lidocaine, ropivacaine)",{"count":51,"type":19},70,[53],"PHASE4","To determine whether the addition of erector spinae plane (ESP) catheters to existing multimodal analgesic regimen with intrathecal morphine provides superior postoperative analgesia in patients undergoing hepatic resection compared with patients not receiving ESP catheters.",[26,56,57,58],"Acute Pain","Anesthesia","Anesthesia, Local",[60,61,62],"acute postoperative pain","erector spinae plane block","liver resection","2022-06-06",{"date":65,"type":34},"2022-06-07",{"date":67,"type":34},"2021-05-24",{"date":69,"type":19},"2023-05-01",{"name":71,"class":41},"University of California, San Diego"]