[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hereditary-neoplastic-syndromes\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hereditary-neoplastic-syndromes":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,48],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":30,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":4,"leadSponsor":44,"locationsCount":47},"100060106","collection-of-serum-and-tissue-samples-from-patients-with-biopsy-proved-or-suspected-malignant-disease-100060106",false,"NCT00026884","Collection of Serum and Tissue Samples From Patients With Biopsy-Proved or Suspected Malignant Disease","Collection of Serum and Tissue Samples From Patients With Biopsy-Proved or Suspected Malignant Diseases","* INCLUSION CRITERIA:\n* Individuals with biopsy-proven malignant disease\n* Individuals suspected of having a malignant disease\n* Individuals who have or are suspected of having an inherited genitourinary malignant disorder\n* Participants must be \\>= 2 years of age\n* A relative (related by blood) of an individual with a confirmed or suspected diagnosis of a malignant disease or an inherited genitourinary malignant disorder.\n* All participants and parents\u002Fguardians, for children younger than 18 years of age, must sign an informed consent document indicating their understanding of the investigational nature and the risks of this study before any protocol related studies are performed.\n\nEXCLUSION CRITERIA:\n\n-Individuals whose co-morbidities preclude surgical intervention.",true,"ALL","2 Years",{"count":20,"type":21},5950,"ESTIMATED","OBSERVATIONAL","Selected individuals suspected of having or with prior biopsy proof of malignant disease will be seen in the Urologic Oncology Branch, NCI. Blood samples may be collected at the time of the initial visit and at periodic intervals during the course of the disease. These samples will be stored in the tissue bank of the Urologic Oncology Branch. Aliquots of malignant and normal tissue will be collected at the time of surgery and stored in the tissue bank, Urologic Oncology Branch, NCI. These materials will be used in the research efforts of the Urologic Oncology Branch, NCI.",[25,26,27,28,29],"Malignant Neoplasms","Hereditary Neoplastic Syndromes","Kidney Cancer","Renal Cancer","Bladder Cancer",[31,32,33,34,35,36],"Serum","Collection of Tissue","Malignant Disease","Molecular Basis","Genome Sequencing","Natural History","RECRUITING","2026-08-14",{"date":40,"type":41},"2026-08-17","ACTUAL",{"date":43,"type":41},"1998-03-12",{"name":45,"class":46},"National Cancer Institute (NCI)","NIH",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":16,"sex":17,"minAge":56,"maxAge":4,"enrollmentInfo":57,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":59,"conditions":60,"keywords":64,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":4},"100646141","psychological-support-and-psycho-emotional-trajectories-in-cancer-genetics-100646141","NCT07695506","Psychological Support and Psycho-Emotional Trajectories in Cancer Genetics.","Apport d'un Accompagnement Psychologique au Cours du Parcours en oncogénétique : étude de la Trajectoire Psycho-émotionnelle Des Consultants","PsyOncoGen","Inclusion Criteria:\n\n* Adult individuals referred for their first genetic counselling consultation, with an indication for a genetic test;\n* Individuals capable of understanding and expressing themselves sufficiently in French (able to complete questionnaires and participate in interviews);\n* Must not present with neurocognitive or psychopathological disorders, or impairments that could compromise their understanding of the study and informed decision-making regarding participation;\n* Affected or unaffected index case or relatives.\n\nExclusion Criteria:\n\n* Individuals under guardianship, curatorship, or a legal protection order, or deprived of liberty by a judicial or administrative decision;\n* Individuals presenting with neurocognitive or psychopathological disorders and\u002For linguistic difficulties that preclude understanding the study and questionnaires, or participating in an informed manner;\n* Individuals already enrolled in a hereditary cancer testing care pathway.","18 Years",{"count":58,"type":21},220,"Undergoing a cancer genetic testing pathway and receiving results regarding a personal or familial cancer predisposition can generate substantial, multifaceted psycho-emotional distress for patients. While professional psychological support is strongly recommended in clinical guidelines, very few studies have formally quantified its actual contribution to the longitudinal psycho-emotional experiences of patients within real-world clinical practices. The primary objective of the PsyOncoGen study is to describe the longitudinal psycho-emotional trajectories of patients within the routine care pathway. It evaluates the clinical impact of psychological support by observing the natural outcomes of patients who choose to accept this systematically offered service versus those who choose to decline it. The study will follow 220 adult patients across two natural cohorts determined solely by patient choice: 110 patients utilising the clinical psychological support and 110 patients declining it.",[61,62,26,63],"Psychological Distress","Genetic Testing","Neoplasms",[65,62,61,66,67],"Hereditary Cancer Syndromes","Psychological Needs","Psycho-oncology","NOT_YET_RECRUITING","2026-07-06",{"date":71,"type":41},"2026-07-10",{"date":73,"type":21},"2026-09-01",{"date":75,"type":21},"2028-06-01",{"name":77,"class":78},"Assistance Publique - Hôpitaux de Paris","OTHER"]