[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hiatal-hernia-paraesophageal\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hiatal-hernia-paraesophageal":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,49],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100648235","laparoscopic-nissen-versus-toupet-fundoplication-for-hiatal-hernia-100648235",false,"NCT07718828","Laparoscopic Nissen Versus Toupet Fundoplication for Hiatal Hernia.","Laparoscopic Nissen Versus Toupet Fundoplication for Gastroesophageal Reflux Management in Patients With Hiatal Hernia: A Patient- and Assessor-Blinded Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients aged 18 to 90 years\n* Patients diagnosed with primary hiatal hernia by fibrogastroscopy and\u002For barium swallow examination\n* Patients with symptoms of gastroesophageal reflux disease\n* Patients scheduled for elective laparoscopic hiatal hernia repair with fundoplication\n* Patients able to provide informed consent\n\nExclusion Criteria:\n\nPatients younger than 18 years or older than 90 years Patients with recurrent hiatal hernia Patients who are not suitable for general anesthesia Patients who prefer a surgical approach other than laparoscopic surgery Patients who are unable or unwilling to provide informed consent","ALL","18 Years","90 Years",{"count":20,"type":21},200,"ESTIMATED","INTERVENTIONAL",[24],"NA","This randomized controlled trial compares laparoscopic Nissen fundoplication and laparoscopic Toupet fundoplication in patients undergoing surgical treatment for hiatal hernia associated with gastroesophageal reflux disease. Participants will be randomly assigned to one of two surgical groups. The study will evaluate postoperative pain, health-related quality of life, hospital stay, recurrence of reflux symptoms, gas-bloat symptoms, operative time, fundoplication time, and postoperative complications.",[27,28,29],"Hiatal Hernia, Paraesophageal","Hiatal Hernia Large","Hiatal Hernia With Gastroesophageal Reflux Disease",[31,32,33,34,35],"Hiatal hernia","Gastroesophageal reflux disease","Laparoscopic fundoplication","Toupet fundoplication","Antireflux surgery","RECRUITING","2026-07-17",{"date":39,"type":40},"2026-07-22","ACTUAL",{"date":42,"type":40},"2023-05-29",{"date":44,"type":21},"2027-01-31",{"name":46,"class":47},"Sofia Med Hospital","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":22,"phases":58,"briefSummary":59,"conditions":60,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":48},"100454743","sutures-versus-polyglactin-mesh-in-hiatal-hernia-repair-100454743","NCT05201508","Sutures Versus Polyglactin Mesh in Hiatal Hernia Repair","Sutures Only Versus Absorbable Polyglactin (Vicryl®) Mesh in Closure of Hiatal Defect in Laparoscopic Paraesophageal Hernia Repair: Randomized Controlled Trial.","Inclusion Criteria:\n\n* Over 18 years old\n* Type III-IV PEH with either radiologic or endoscopic confirmation\n* Scheduled for laparoscopic PEH repair\n* The informed consent is acquired\n\nExclusion Criteria:\n\n* Need for esophagus lengthening procedure (Collis gastroplasty)\n* Recurrent PEH\n* Emergency surgery\n* No written consent",{"count":57,"type":21},110,[24],"Paraesophageal hernia causes pain, heartburn, regurgitation, anemia and in extreme, life-threatening strangulation. For symptomatic patients, laparoscopic surgery is offered which includes hiatal defect closure and antireflux surgery. However, recurrence rates are high between 12 and 42%. In order to reduce recurrences, mesh has been used with various materials and techniques with conflicting results. Non-absorbable mesh has been linked with adverse events including erosion of esophageal wall. Traditionally used biological mesh materials are expensive and therefore problematic in routine use. Use of polyglactin (Vicryl®) mesh, which degrades in 6-8 week, has been reported in paraesophageal hernia surgery. Previously, no randomized controlled trial comparing sutures only and polyglactin mesh has been performed. In this trial, the aim was to randomize total of 110 patients to receive sutures only or mesh repair. Primary outcome was recurrence of paraesophageal hernia at 6 months after the repair based on computed tomography scan. Secondary outcomes included symptomatic recurrences, reoperation rate, quality of life, reoperations up to 20-years after surgery and use of proton pump inhibitors up to 20-years after surgery.",[61,62,27,63],"Paraesophageal Hernia","Hiatal Hernia","Recurrence","2023-03-24",{"date":66,"type":40},"2023-03-27",{"date":68,"type":40},"2022-01-21",{"date":70,"type":21},"2043-01-01",{"name":72,"class":47},"Oulu University Hospital"]