[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hoarseness\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hoarseness":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,45],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":4},"100648475","intraperitoneal-dexamethasone-spraying-on-vagal-nerve-rich-areas-for-prevention-of-hoarseness-after-upper-abdominal-surgery-100648475",false,"NCT07722091","Intraperitoneal Dexamethasone Spraying on Vagal Nerve-Rich Areas for Prevention of Hoarseness After Upper Abdominal Surgery","Intraperitoneal Dexamethasone Spraying on Vagal Nerve-Rich Areas for Prevention of Hoarseness After Upper Abdominal Surgery: A Prospective Randomized Controlled Trial","Inclusion Criteria:\n\n* Age 18 to 75 years, both sexes.\n* Elective abdominal surgery (including gastric, hepatobiliary, and pancreaticoduodenal surgery) under general anesthesia.\n* American Society of Anesthesiologists (ASA) physical status classification I-III.\n* Preoperative GRBAS Grade (G) score = 0 (no hoarseness).\n* Signed written informed consent.\n\nExclusion Criteria:\n\n* Need for systemic glucocorticoid therapy during hospitalization for other reasons.\n* Pre-existing hoarseness, vocal cord paralysis, or organic vocal cord lesions.\n* History of neck surgery, neck radiotherapy, or laryngeal surgery.\n* Known allergy to dexamethasone or other glucocorticoids.\n* Active peptic ulcer or gastrointestinal bleeding within 6 months prior to enrollment.\n* Uncontrolled diabetes mellitus or severe active infection.","ALL","18 Years","75 Years",{"count":20,"type":21},584,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to evaluate whether intraoperative spraying of dexamethasone onto the abdominal vagal nerve-rich areas can prevent postoperative hoarseness in patients undergoing elective upper abdominal surgery. The main questions it aims to answer are:\n\n* Does intraoperative topical dexamethasone spraying reduce the incidence of postoperative hoarseness after upper abdominal surgery?\n* Does postoperative intravenous dexamethasone accelerate recovery in patients who develop hoarseness? Researchers will compare a dexamethasone group (intraoperative spraying of 10 mg dexamethasone in 10 mL normal saline) to a placebo group (intraoperative spraying of 10 mL normal saline alone) to see if dexamethasone reduces the rate of postoperative hoarseness.\n\nParticipants will:\n\n* Undergo voice assessment (GRBAS scale) and voice recording before surgery and daily for 10 days after surgery.\n* Be randomly assigned to receive either dexamethasone or placebo sprayed onto the surgical field at the end of the operation.\n* If hoarseness develops in the placebo group, be randomly assigned again to receive either intravenous dexamethasone (5 mg daily for 3 days) or placebo.",[27,28],"Hoarseness","Post Operative Complicaiton",[30,31,32],"Dexamethasone","Postoperative Hoarseness","Upper Abdominal Surgery","NOT_YET_RECRUITING","2026-07-18",{"date":36,"type":37},"2026-07-23","ACTUAL",{"date":39,"type":21},"2026-07-27",{"date":41,"type":21},"2027-03-01",{"name":43,"class":44},"Fujian Medical University Union Hospital","OTHER",{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":52,"minAge":17,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":22,"phases":56,"briefSummary":57,"conditions":58,"keywords":63,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":77},"100619209","effect-of-cuff-pressure-assessment-methods-on-postoperative-complications-in-breast-surgery-100619209","NCT07341646","Effect of Cuff Pressure Assessment Methods on Postoperative Complications in Breast Surgery","The Effect of Endotracheal Tube Cuff Pressure Assessment Methods on Postoperative Complications in Patients Undergoing Elective Breast Surgery: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Female patients aged 18 to 65 years.\n* Patients classified as American Society of Anesthesiologists (ASA) physical status I, II, or III.\n* Patients scheduled for elective breast surgery requiring general anesthesia and endotracheal intubation.\n* Patients who provide voluntary written informed consent to participate.\n\nExclusion Criteria:\n\n* Patients with a history of Chronic Obstructive Pulmonary Disease (COPD) or an asthma attack within the last 6 months.\n* Presence of preoperative sore throat, hoarseness, or cough.\n* Patients with predicted difficult intubation or those who are difficult to intubate.\n* Patients with communication difficulties that prevent accurate assessment of symptoms.\n* Patients whose surgery duration exceeds 3 hours.\n* Patients older than 65 years.","FEMALE","65 Years",{"count":55,"type":21},90,[24],"Endotracheal intubation is a standard procedure used to secure the airway during general anesthesia. A key component of the breathing tube is the \"cuff,\" a balloon-like device that is inflated to seal the airway and prevent aspiration. However, if the pressure within this cuff is too high, it can restrict blood flow to the tracheal lining, leading to complications such as postoperative sore throat, hoarseness, and difficulty swallowing (dysphagia).\n\nCurrently, there are various methods to monitor and adjust this pressure. In many clinical practices, the pressure is adjusted subjectively or checked only once at the beginning of the surgery. These methods may allow pressure to exceed safe limits (typically 20-30 cmH₂O) or fluctuate during the procedure, potentially causing tissue irritation. This randomized controlled trial aims to compare three different methods of assessing and maintaining endotracheal tube cuff pressure to determine which is most effective at reducing postoperative complications. The study focuses on women undergoing elective breast surgery, a group chosen because the surgery typically lasts 1-3 hours and does not involve major changes in head and neck position, allowing for a clear assessment of the cuff pressure methods.\n\nParticipants will be randomly assigned to one of three groups:\n\n* Continuous Monitoring Group: Cuff pressure is monitored continuously using a pressure indicator and maintained within the 20-30 cmH₂O range throughout the surgery.\n* Manometer Group: Cuff pressure is measured and set to 20-30 cmH₂O using a manual manometer once, immediately after intubation.\n* Control Group (Minimal Occlusive Volume): The cuff is inflated with the minimum amount of air required to prevent an air leak, without using a pressure gauge.\n\nResearchers will assess patients for sore throat, cough, hoarseness, and swallowing difficulties at 0, 1, 12, and 24 hours after surgery to identify the safest and most comfortable method for airway management.",[59,60,27,61,62],"Airway Complications","Postoperative Sore Throat","Dysphagia","Cough Severity",[64,65,66,60,59,67],"Continuous Cuff Pressure Monitoring","Manometer","Endotracheal Tube Cuff Pressure","Intubation Safety","2026-01-14",{"date":70,"type":37},"2026-01-15",{"date":72,"type":21},"2026-03-01",{"date":74,"type":21},"2027-06-01",{"name":76,"class":44},"Izmir Katip Celebi University",1]