[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hormone-replacement-therapy-post-menopausal\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hormone-replacement-therapy-post-menopausal":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,47],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":5},"100623239","a-prospective-multicenter-cohort-study-of-contemporary-menopausal-hormone-therapy-and-cardiovascular-outcomes-100623239",false,"NCT07394049","A Prospective Multicenter Cohort Study of Contemporary Menopausal Hormone Therapy and Cardiovascular Outcomes","Cardiovascular Assesment Under Current Hormone Replacement Therapy in Menopause (CATCH-Menopause)","CATCH-Menopaus","Inclusion Criteria:\n\n* female sex\n* Age 45-75 years at enrollment\n* Perimenopausal or postmenopausal status documented according to prespecified clinical criteria\n* Increased cardiovascular risk, defined as SCORE \\> 5 % (age 45-69 years) or SCORE2-OP \\> 5 % (age \\> 70 years), or established disease\n* Established cardiovascular disease includes coronary artery disease, cerebrovascular disease and\u002For peripheral artery disease, as specified in the approved protocol\n* Ability to understand the study procedures and provide written informed consent\n\nExclusion Criteria:\n\n* Age \\\u003C45 years or \\> 75 years\n* Active malignancy at screening\n* Inability to provide written informed consent or to comply with study procedures\n* Severe renal impairment, defined as estimated glomerular filtrate rate \\\u003C30 ml\u002Fmin\u002F1.73m2, or dialysis dependance\n* Advanced liver disease, defined as Child-Pugh class C\n* Known genetic cardiomyopathiy",true,"FEMALE","45 Years","75 Years",{"count":22,"type":23},3408,"ESTIMATED","OBSERVATIONAL","This prospective registry study investigates the impact of new hormone replacement therapy (HRT) delivery methods, such as creams, gels, and sprays, on cardiovascular risk in postmenopausal women. Menopause-related estrogen deficiency leads to metabolic and vascular changes that increase atherosclerosis and cardiovascular events. This study hypothesizes that new HRT forms may reduce cardiovascular risk in high-risk women.\"",[27,28,29,30],"Hormone Replacement Therapy","Cardiovascular Diseases","Hormone Replacement Therapy, Post-Menopausal","Menopause",[32,33,34],"hormone replacement therapy","cardiovascular disease","menopause","NOT_YET_RECRUITING","2026-07-30",{"date":38,"type":39},"2026-07-31","ACTUAL",{"date":41,"type":23},"2026-08-01",{"date":43,"type":23},"2041-03",{"name":45,"class":46},"Heinrich-Heine University, Duesseldorf","OTHER",{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":18,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":58,"phases":59,"briefSummary":61,"conditions":62,"keywords":68,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":78},"100649535","effect-of-hormone-replacement-therapy-on-physiotherapy-outcomes-in-postmenopausal-women-with-frozen-shoulder-100649535","NCT07736027","Effect of Hormone Replacement Therapy on Physiotherapy Outcomes in Postmenopausal Women With Frozen Shoulder","The Effects of Hormone Replacement Therapy on Clinical and Functional Outcomes in Postmenopausal Women With Frozen Shoulder","Inclusion Criteria:\n\n* Postmenopausal female patients aged 40 to 60 years.\n* Shoulder pain at rest and during activities of daily living lasting for more than 3 months.\n* Clinical diagnosis of Stage I or Stage II frozen shoulder (adhesive capsulitis).\n* Passive range of motion (ROM) loss of greater than 25% compared to the unaffected shoulder in at least two movement planes (flexion, abduction, internal rotation, or external rotation).\n* Reduced range of motion of less than 50% compared to the unaffected side in at least one movement direction (flexion, abduction, internal rotation, or external rotation).\n* Increased restriction of external and internal rotation during glenohumeral abduction from 45 to 90 degrees.\n\nExclusion Criteria:\n\n* Passive external rotation range of motion of less than 30 degrees (\\\u003C30°).\n* Presence of glenohumeral arthritis confirmed by radiography.\n* History or presence of inflammatory joint disease.\n* History of malignancy or active cancer diagnosis.\n* Previous treatment for the current shoulder condition (e.g., physiotherapy and rehabilitation, intra-articular injections, or surgical intervention).\n* Baseline shoulder pain score of less than 3 (\\\u003C3) on the Numeric Pain Rating Scale (NPRS).","40 Years","60 Years",{"count":57,"type":23},56,"INTERVENTIONAL",[60],"NA","The purpose of this study is to compare the effects of a physiotherapy program on pain levels, shoulder range of motion, functional status, pain catastrophizing, perceived change, sleep quality, and quality of life in postmenopausal women diagnosed with frozen shoulder, with and without Hormone Replacement Therapy (HRT). The findings are expected to contribute to personalized treatment planning for postmenopausal women with frozen shoulder and help fill the gap in current literature.",[63,64,65,29,66,67],"Frozen Shoulder","Adhesive Capsulitis","Adhesive Capsulitis of the Shoulder","Exercise","Physical Therapy",[69],"Frozen Shoulder, Adhesive Capsulitis, Hormone Replacement Therapy, Postmenopause, Physical Therapy, Rehabilitation, Pain Catastrophizing, Range of Motion","2026-07-28",{"date":36,"type":39},{"date":73,"type":23},"2026-09-01",{"date":75,"type":23},"2027-10-01",{"name":77,"class":46},"Istanbul University - Cerrahpasa",1]