[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hyperandrogenism-21-hydroxylase-deficiency\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hyperandrogenism-21-hydroxylase-deficiency":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":27,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":5},"100648100","evaluation-of-circadian-hormonal-balance-lc-msms-measurement-of-salivary-and-serum-steroids-in-patients-with-congenital-adrenal-hyperplasia-100648100",false,"NCT07718230","Evaluation of Circadian Hormonal Balance: LC-MS\u002FMS Measurement of Salivary and Serum Steroids in Patients With Congenital Adrenal Hyperplasia","MASSALIVE","Inclusion Criteria:\n\n* Patients aged 6 years or older\n* Confirmed diagnosis of congenital adrenal hyperplasia treated with glucocorticoids\n* Signed informed consent provided by legal guardians\n* Affiliation to a national health insurance system\n\nExclusion Criteria:\n\n* Patients younger than 6 years of age\n* Lesions of the oral mucosa that could interfere with saliva sampling\n* Inability to provide the patient or legal representatives with appropriate study information (e.g., poor understanding of French)\n* Underage parents\n* Lack of affiliation with a social security\u002Fhealth insurance system","ALL","6 Years",{"count":19,"type":20},50,"ESTIMATED","OBSERVATIONAL","In congenital adrenal hyperplasia (CAH), lifelong hormone replacement therapy is required to treat adrenal insufficiency and to reduce elevated androgen levels. This is essential to ensure \"normal\" growth and puberty. Replacement therapy includes hydrocortisone and 9α-fludrocortisone acetate (as a mineralocorticoid substitute). Defining appropriate criteria for evaluating therapeutic goals is a key component of patient follow-up.\n\nCurrently, monitoring is generally limited to the quantification of serum 17-hydroxyprogesterone (17OHP), testosterone (T) and delta-4 androstenedione (D4), measured in the morning after an overnight fast and before the morning hydrocortisone dose. However, such single-point serum measurements do not take into account the circadian rhythm of these steroids.\n\nThe objective of the study is to evaluate correlations between steroid levels (21-deoxycortisol, 17-hydroxyprogesterone, testosterone, delta-4 androstenedione, and cortisol) measured by LC-MS\u002FMS in multiple at-home self-collected saliva samples and those measured in serum during routine monitoring.",[24,25,26],"Congenital Adrenal Hyperplasia","Adrenal Insufficiency","Hyperandrogenism; 21-hydroxylase Deficiency",[28,29,30,31,32,33,34,35,36,37],"Congenital adrenal hyperplasia","21-hydroxylase deficiency","pediatric endocrinology","salivary steroids","LC-MS\u002FMS","circadian rhythm","nycthemeral profile","hydrocortisone","fludrocortisone","steroid profiling","NOT_YET_RECRUITING","2026-07-17",{"date":41,"type":42},"2026-07-21","ACTUAL",{"date":44,"type":20},"2026-09",{"date":46,"type":20},"2028-09",{"name":48,"class":49},"Assistance Publique - Hôpitaux de Paris","OTHER"]