[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hyperlactatemia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hyperlactatemia":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,50],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":28,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100645477","effect-of-preoperative-prewarming-on-serum-lactate-levels-in-patients-undergoing-elective-nephrectomy-100645477",false,"NCT07702487","Effect of Preoperative Prewarming on Serum Lactate Levels in Patients Undergoing Elective Nephrectomy","Effect of Preoperative Active Prewarming on Serum Lactate Levels and Perioperative Outcomes in Patients Undergoing Elective Nephrectomy: A Prospective Observational Study","Inclusion Criteria:\n\n* Scheduled for elective nephrectomy\n* Adults aged 18-90 years\n* ASA (American Society of Anesthesiologists) physical status classification I-III\n* Signed informed consent form\n\nExclusion Criteria:\n\n* Emergency nephrectomy\n* Concurrent additional major surgical procedure planned in the same session\n* Age under 18 or over 90 years\n* ASA physical status classification IV or higher\n* Incomplete preoperative records (missing pre- or postoperative measurement of at least one primary outcome variable)","ALL","18 Years","90 Years",{"count":20,"type":21},128,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to learn whether warming patients before surgery, called \"prewarming,\" affects blood lactate levels (a marker of how well tissues are getting oxygen) and recovery in adults having planned (elective) kidney removal surgery (nephrectomy).\n\nThe main questions this study aims to answer are:\n\n* Does prewarming lower the rise in blood lactate seen during and after surgery?\n* Does prewarming affect time spent in the intensive care unit (ICU), the need for a blood transfusion, or the rate of complications after surgery?\n\nResearchers will compare two groups of adults having this surgery. One group receives brief active warming before anesthesia (the \"prewarming\" group). The other group does not receive this warming (the \"control\" group). The anesthesia team decides whether to use prewarming and for how long, as part of routine care; the study does not change this decision. Researchers will compare the two groups to see whether prewarming is linked to lower lactate levels and better recovery.\n\nParticipants will:\n\n* Receive their usual, routine surgery and anesthesia care\n* Have blood pressure, heart rate, body temperature, and blood tests, including lactate, checked before and after surgery, as already done in routine care\n* Have their ICU stay, need for blood transfusion, and any complications recorded\n\nThis study does not add any extra tests, procedures, or blood draws beyond routine clinical care.",[25,26,27],"Nephrectomy \u002F Methods","Intraoperative Hypothermia","Hyperlactatemia",[29,30,31,32,33,34,35,36],"prewarming","Preoperative warming","Perioperative hypothermia","serum lactate","Nephrectomy","Anesthesia","Intensive care unit","Postoperative complications","RECRUITING","2026-07-10",{"date":40,"type":41},"2026-07-14","ACTUAL",{"date":43,"type":41},"2025-11-15",{"date":45,"type":21},"2026-11-15",{"name":47,"class":48},"Beyzanur Aydoğdu","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":57,"sex":16,"minAge":17,"maxAge":58,"enrollmentInfo":59,"targetDuration":4,"studyType":61,"phases":62,"briefSummary":64,"conditions":65,"keywords":69,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":49},"100625710","role-of-elevated-lactate-levels-on-lipid-and-carbohydrate-metabolism-100625710","NCT07426172","Role of Elevated Lactate Levels on Lipid and Carbohydrate Metabolism.","LACTMET","Inclusion Criteria:\n\n* Men and women\n* \\>18 years of age\n* Women non-pregnant or taking contraceptive medication\n* Physically active according to WHO's guidelines\n* Metabolic syndrome as IDF 2009 criteria (Alberti et al., Circulation)\n* Written and verbal consent to participation\n\nExclusion Criteria:\n\n* Chronic illness that prevents them from exercising\n* Affected blood samples at screening, as assessed by the PI\n* Assessed as unsuitable by PI",true,"65 Years",{"count":60,"type":21},24,"INTERVENTIONAL",[63],"NA","The purpose of this study is to investigate whether the elevated circulating lactate levels of individuals with metabolic syndrome are responsible for their reduced lipolysis and glucose tolerance. The investigators will conduct an intervention study in which blood lactate levels will be elevated via intravenous infusion of sodium lactate. State of the art metabolic assessment using stable isotopes and indirect calorimetry will be used to study alterations in fat and carbohydrate metabolism.",[27,66,67,68],"Metabolic Syndrome (MetS)","Lipolysis","Exercise",[70,71,72,73,74,75,76,77,78,79],"blood lactate","lipolysis","oral glucose tolerance test","stable isotopes","indirect calorimetry","carbohydrate oxidation","fat oxidation","exercise","metabolic flexibility","metabolic syndrome","2026-02-15",{"date":82,"type":41},"2026-02-23",{"date":84,"type":41},"2026-01-20",{"date":86,"type":21},"2028-09-30",{"name":88,"class":48},"Ricardo Mora"]