[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hypoxia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hypoxia":32},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,45,0,25,[9,51,80,105,138,171,204,229,253,280,309,327,353,375,401,420,448,477,505,533,556,585,608,628,648],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":16,"eligibilityCriteria":17,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":34,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100652823","icu-succeed-for-survivors-of-acute-respiratory-failure-and-their-caregivers-100652823",false,"NCT07778004","ICU-SUCCEED for Survivors of Acute Respiratory Failure and Their Caregivers","A Pilot Randomized Trial of the Self-Management Using Couples' Coping EnhancEment in Diseases Intervention for Survivors of Acute Respiratory Failure and Their Family Caregivers","ICU-SUCCEED","Patient Inclusion Criteria\n\n* Admitted to the medical ICU at UNC with acute respiratory failure (functional lung impairment resulting in hypoxia, hypercapnia, or both) and\u002For sepsis with significant end organ dysfunction.\n* At least 18 years old\n* Survives to hospital discharge\n* Is expected to be discharged home or to an acute inpatient rehabilitation center with a clear plan to be subsequently discharged home\n* Capable of providing written informed consent\n* Has English language proficiency\n\nCaregiver Inclusion Criteria\n\n* Provides emotional, physical, and\u002For financial support to the patient in a non-professional, unpaid capacity\n* Must be related to the patient in one of the following ways: a spouse or domestic partner, an adult child, a parent, or a sibling\n* At least 18 years of age\n* Has English language proficiency\n* Must be the caregiver of a patient that meets the patient eligibility criteria listed above\n\nPatient Exclusion Criteria:\n\n* No available family caregiver\n* Lacks decision-making capacity\n* Under 18 years of age\n* Living at a location other than home prior to admission\n* Unhoused prior to admission\n* Receives extracorporeal membrane oxygenation (ECMO) during hospital stay\n* Expected to discharge to any location other than home or an acute inpatient rehabilitation center\n* Does not have English language proficiency\n\nCaregiver Exclusion Criteria\n\n* Does not provide emotional, physical, and\u002For financial support to the patient in a non-profession, unpaid capacity\n* Is not related to the patient in one of the following ways: a spouse or domestic partner, an adult child, a parent, or a sibling\n* Cannot complete surveys or engage in other study activities due to physical or cognitive limitations\n* Unhoused prior to admission\n* Is under 18 years of age\n* Does not have English language proficiency\n* Is not the caregiver of a patient that meets the patient eligibility criteria listed above","ALL","18 Years","99 Years",{"count":22,"type":23},144,"ESTIMATED","INTERVENTIONAL",[26],"NA","This study will investigate whether a family-centered intervention that has been adapted for patients with critical illness and their caregivers is possible, acceptable, and helpful",[29,30,31,32,33],"Acute Respiratory Failure","Critical Illness","Sepsis","Hypoxia","Hypercapnia",[29,35,36,31,37],"Family-Centered Intervention","Critical illness","Septic shock","NOT_YET_RECRUITING","2026-08-18",{"date":41,"type":42},"2026-08-21","ACTUAL",{"date":44,"type":23},"2026-09-01",{"date":46,"type":23},"2030-09-01",{"name":48,"class":49},"University of North Carolina, Chapel Hill","OTHER",1,{"id":52,"slug":53,"hasResults":12,"nctId":54,"briefTitle":55,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":57,"targetDuration":4,"studyType":59,"phases":4,"briefSummary":60,"conditions":61,"keywords":65,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":50},"100524389","novel-hypoxia-imaging-for-head-and-neck-cancer-imaging-phenotype-for-personalized-treatment-100524389","NCT06108089","Novel Hypoxia Imaging for Head and Neck Cancer: Imaging Phenotype for Personalized Treatment","Inclusion Criteria:\n\n* Newly diagnosed HNSCC (head and neck squamous cell carcinoma) by biopsy or fine needle aspiration originating from the oral cavity, larynx, hypopharynx, nasopharynx, and oropharynx\n* Patients are scheduled to undergo chemoradiotherapy or surgery\n* Able to provide informed consent and willing to sign an approved consent form that conforms to federal and institutional guidelines.\n\nExclusion Criteria:\n\n* Pregnant patients\n* Patients with claustrophobia\n* Patients with pacemaker, spinal stimulator, or cochlear implant that are not MR compatible or any other metallic objects in the body\n* Patients who had been treated for HNC, either surgery, radiation therapy, or chemotherapy\n* Patients with thyroid, skin, sinonasal, and salivary gland cancer.\n* Abnormal kidney function defined as estimated glomerular filtration rate (eGRF) \\\u003C 30 mL\u002Fmin\u002F1.73 m2\n* Patients with uncontrolled diabetes\n* Patients who obtained outside FDG-PET\u002FCT prior to initial treatment",{"count":58,"type":23},20,"OBSERVATIONAL","Tumor hypoxia is one of the physiological factors for treatment resistance and likely contributes to poor overall survival among patients with head and neck cancer (HNC). Identifying hypoxic features of HNC may allow the personalizing treatment plan. The investigators propose multiparametric Hypoxia MR (HMR) imaging using diffusion, perfusion, and oxygenation as non-invasive, in-vivo imaging components of a hypoxia phenotype. Assessing the hypoxia phenotypes' expression will be critically important for characterizing and predicting CRT response among patients with advanced HNC.\n\nA prospective cohort study will be conducted used multiparametric MR (MPMR) imaging correlated with treatment response assessed by 3 months fluorodeoxyglucose-positron emission tomography (FDG-PET). The image analysis approach will be developed to incorporate FDG-PET and quantitative MRI characteristics of tumor (ADC, oxygen-enhanced T1 and T2\\* maps, and volume transfer constant (Ktrans) to facilitate 3D visualization of multiparametric information. This proposed study's overarching goal is to develop and validate multiparametric HMR imaging using 18F - (fluoromisonidazole) FMISO-PET and immunohistochemistry (IHC) as the standard of references.",[62,32,63,64],"Head and Neck Cancer","Magnetic Resonance Imaging","Cancer Neck",[66,67,68,69],"hypoxia","precision medicine","imaging biomarker","prognosis","RECRUITING","2026-08-03",{"date":73,"type":42},"2026-08-05",{"date":75,"type":42},"2024-06-28",{"date":77,"type":23},"2027-12-01",{"name":79,"class":49},"University of Utah",{"id":81,"slug":82,"hasResults":12,"nctId":83,"briefTitle":84,"officialTitle":84,"acronym":85,"eligibilityCriteria":86,"healthyVolunteers":87,"sex":18,"minAge":19,"maxAge":88,"enrollmentInfo":89,"targetDuration":4,"studyType":24,"phases":91,"briefSummary":92,"conditions":93,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":50},"100644490","methodological-study-of-exercise-and-hypoxic-conditions-in-healthy-subjects-100644490","NCT07671638","Methodological Study of Exercise and Hypoxic Conditions in Healthy Subjects","ExHyp","Inclusion Criteria:\n\n* Healthy male or female volunteers\n* Aged 18-55\n* Body Mass Index \\\u003C30 kg\u002Fm²\n* Participants covered by a social security scheme\n* Participants capable of signing an informed consent form\n* Negative pregnancy test and highly effective contraception for women of childbearing age\n\nExclusion Criteria:\n\n* Cardiorespiratory, metabolic and neurological disorders, or other conditions assessed during the inclusion consultation that may affect physiological responses to exercise or hypoxia\n* Pharmacological treatment taken during the study, other than oral or implantable contraceptive medication for female volunteers of childbearing age",true,"55 Years",{"count":90,"type":23},305,[26],"The aim of this protocol is to assess physiological responses during various physical exercise protocols (whole-body exercise such as cycling or treadmill running, or localised exercise such as knee extension) and during inhalation of a gas mixtures with various oxygen contents (similar to exposure at high altitude).",[94,95,32],"Healthy Subjects (HS)","Exercise","2026-07-17",{"date":98,"type":42},"2026-07-21",{"date":100,"type":23},"2026-09-15",{"date":102,"type":23},"2032-03-31",{"name":104,"class":49},"University Hospital, Grenoble",{"id":106,"slug":107,"hasResults":12,"nctId":108,"briefTitle":109,"officialTitle":110,"acronym":4,"eligibilityCriteria":111,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":112,"targetDuration":4,"studyType":24,"phases":114,"briefSummary":115,"conditions":116,"keywords":4,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":130,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":50},"100569296","the-effects-of-endotracheal-suctioning-on-pain-and-serum-markers-100569296","NCT06692400","The Effects of Endotracheal Suctioning on Pain and Serum Markers","The Impact of Endotracheal Suctioning on Pain, Hypoxia, and Oxidative Stress Biomarkers in Intubated Adult ICU Patients: A Controlled Trial","Inclusion Criteria:\n\n* Adults (aged 18 years and older)\n* Current diagnosis of flu, pneumonia, COVID, or sepsis\n* Intubated and receiving mechanical ventilation.\n* Have arterial lines placed\n* Require endotracheal suctioning as part of their care\n\nExclusion Criteria:\n\n* Patients receiving neuromuscular blocking agents\n* Contraindications for blood draws (hemoglobin levels below 8.0 g\u002FdL; Jehovah's Witness)",{"count":113,"type":23},110,[26],"The goal of this experimental study is to understand if endotracheal tube (ETT) suctioning increases pain and causes stress on the body in intubated adult ICU patients. These patients are already on ventilators, which means they need suctioning to keep their airways clear, but this procedure may be uncomfortable and cause stress.\n\nThe main questions this study aims to answer are:\n\nDoes ETT suctioning raise pain levels as measured by the Critical-Care Pain Observation Tool (CPOT)? Does ETT suctioning increase certain chemicals in the blood (hypoxanthine, xanthine, and uric acid) that show stress and lack of oxygen in the body? Researchers will compare patients who have ETT suctioning (intervention group) with those who do not have suctioning during the study period (control group) to see if there are differences in pain and blood markers of stress.\n\nParticipants will:\n\nHave pain measured before and after suctioning using the CPOT. Have blood samples taken from an existing line at three time points: 5 minutes before, 5 minutes after, and 30 minutes after suctioning.\n\nProvide demographic information (like age, gender, and diagnosis) from medical records.\n\nThis research will help improve how pain is managed for ICU patients who cannot speak for themselves, potentially leading to better pain relief methods in the future.",[117,118,30,119,120,121,122,32,123,124,125,31,126,127,128],"Intensive Care Unit ICU","Intubation","Mechanical Ventilation","Pain Measurement","Pain, Procedural","Oxidative Stress","Biomarkers \u002F Blood","Adult","Uric Acid","COVID","Influenza","Pneumonia","2026-07-08",{"date":131,"type":42},"2026-07-10",{"date":133,"type":42},"2025-01-30",{"date":135,"type":23},"2026-12",{"name":137,"class":49},"Loma Linda University",{"id":139,"slug":140,"hasResults":12,"nctId":141,"briefTitle":142,"officialTitle":143,"acronym":144,"eligibilityCriteria":145,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":146,"enrollmentInfo":147,"targetDuration":4,"studyType":24,"phases":149,"briefSummary":150,"conditions":151,"keywords":155,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":163,"lastUpdatePostDateStruct":164,"startDateStruct":166,"completionDateStruct":167,"leadSponsor":169,"locationsCount":50},"100626126","effect-of-acute-hypoxia-on-right-ventricular-function-in-asthma-100626126","NCT07431580","Effect of Acute Hypoxia on RIght VEntRicular Function in Asthma.","Effect of Acute Hypoxia on RIght VEntRicular Function. A Single-Center, Double-Blind, Randomized Controlled Cross-Over Trial.","RIVER-Asthma","Inclusion Criteria:\n\n* Signed informed consent\n* Diagnosed and well controlled asthma bronchiale\n* 18-80 years (age group young: 18-39.99 years \u002F age group older: 40-80 years)\n* All sex and genders\n* Living \\\u003C800m and without altitude exposure \\> 2500 m and \\> 24h within the last three weeks\n\nExclusion Criteria:\n\n* \\\u003C18, \\>80 years old\n* Any other diagnosed cardiopulmonary condition including past HAPE\n* Other clinically significant severe concomitant disease states (e.g. renal, hepatic dysfunction, etc.)\n* Inability to follow the procedures of the study due to language problems, psychological neurological disorders or orthopaedic disorders\n* Participants permanently living \\>800m and altitude exposure \\> 2500 m and \\>24h within the last three weeks\n* Pregnancy: Participants will be asked if pregnant or not, no screening for undetected pregnancy\n* Lactating women\n* Participation in other study with active treatment","80 Years",{"count":148,"type":23},18,[26],"More and more people are engaging in sports in the mountains, including individuals with heart or lung diseases. At the same time, such diseases are becoming more common in Switzerland. At high altitude, less oxygen is available, which places stress on the body-particularly on the heart, which has to pump blood through the lungs. How the heart, especially the right ventricle, in people with asthma responds to this stress is still not well understood.\n\nTherefore, this study investigates how the heart responds to simulated altitudes of 2,500 m and 4,000 m, both at rest and during light physical activity in patients with asthma. The primary objective is to assess how right ventricular function changes under conditions of reduced oxygen availability.\n\nIn addition, vital signs, changes in blood gases, oxygen levels in blood and tissue and shortness of breath are assessed. The \"altitude\" is simulated using a special gas mixture that participants inhale. Participants undergo three altitude conditions (490, 2,500, and 4,000 m above sea level). The order of the altitude conditions is assigned at random.\n\nThe aim is to better understand how the right ventricle and other parameters respond to low-oxygen conditions and how affected patients can be better supported in the future.",[152,32,153,154],"Hypoxia, Altitude","Normobaric Hypoxia","Right Ventricular Function",[156,157,158,159,160,161,162],"right ventricular free wall strain","RVFWS","right ventricular function","tissue oxygenation","breathing difficulty","blood gas","heart rate","2026-05-26",{"date":165,"type":42},"2026-05-29",{"date":163,"type":42},{"date":168,"type":23},"2030-01",{"name":170,"class":49},"Mona Lichtblau",{"id":172,"slug":173,"hasResults":12,"nctId":174,"briefTitle":175,"officialTitle":176,"acronym":177,"eligibilityCriteria":178,"healthyVolunteers":87,"sex":18,"minAge":19,"maxAge":179,"enrollmentInfo":180,"targetDuration":4,"studyType":24,"phases":182,"briefSummary":183,"conditions":184,"keywords":191,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":195,"lastUpdatePostDateStruct":196,"startDateStruct":198,"completionDateStruct":200,"leadSponsor":202,"locationsCount":50},"100638153","study-of-the-effects-of-acute-exposure-to-moderate-altitude-hypoxia-on-prospective-memory-100638153","NCT07585227","Study of the Effects of Acute Exposure to Moderate Altitude Hypoxia on Prospective Memory.","Etude Des Effets d'Une Exposition aiguë à l'Hypoxie d'Altitude modérée Sur la mémoire Prospective (HYPRO)","HYPRO","Inclusion Criteria:\n\n* Healthy volunteer\n* Has provided informed consent\n\nExclusion Criteria:\n\n* Individuals who do not understand French\n* Pregnant or breastfeeding women\n* Cardiovascular risk factor\n* Infectious disease within the last 4 weeks\n* Chronic cardiovascular, respiratory, hematological, neurological, psychiatric, or metabolic disease\n* History of epileptic seizures, convulsions, or loss of consciousness\n* Individuals with migraines\n* History of a bleeding disorder\n* History of high blood pressure\n* Current medication use (excluding contraception)\n* History of episodes of altitude intolerance\n* Stay at high altitude (\\> 3,500 m) within the last 3 months\n* Anxiety score on the Hospital Anxiety and Depression (HAD) scale \\> 7\n* Depression score on the HAD scale \\> 7\n* Uncontrollable claustrophobia or a history of panic attacks","45 Years",{"count":181,"type":23},50,[26],"The goal of this study is to investigate whether prospective memory, i.e., memory for delayed intentions, is impaired at moderate altitude (4,000m).\n\nIt will also allow to study the effect of air and oxygen administration during hypoxia exposure.\n\nThe main questions it aims to answer are:\n\n* Does moderate acute hypoxia impair prospective memory ?\n* If so, does air or oxygen adminsitration induce a restoration of prospective memory? Researchers will compare cognitive performance during normobaric hypoxia exposure to cognitive performance during normoxia (control situation).\n\nParticipants will:\n\n* Session S0. Perform a battery of neuropsychological tests and questionnaires). EEG will be recorded during tests. A cheek swab will be performed.\n* Sessions S1 and S2. Perform several cognitive tasks while exposed to hypoxia and to normoxia (2 different sessions, randomized order) in a normobaric chamber. These are standardized cognitive tests administered on a computer and cognitive tests embedded in a flight simulator scenario. Various questionnaires will be performed on a regular basis. Several physiological measurements will be performed continuously: EEG, ECG, SpO2 and breathing rate. Blood pressure will be measured at the beginning and at the end of hypoxia\u002Fnormoxia exposure. A blood sample will also be performed. At last, participants will inhale air or oxygen through a mask while making a cognitive task in the chamber.",[32,185,186,187,152,188,189,190,153],"Hypoxia Brain","Hypoxia Altitude Simulation Test","Hypoxia in Healthy Individuals","Hypoxia, Brain","Altitude","Altitude Hypoxia",[192,193,194],"prospective memory","working memory","flight simulator","2026-05-09",{"date":197,"type":42},"2026-05-13",{"date":199,"type":23},"2026-05-06",{"date":201,"type":23},"2026-12-31",{"name":203,"class":49},"Direction Centrale du Service de Santé des Armées",{"id":205,"slug":206,"hasResults":12,"nctId":207,"briefTitle":208,"officialTitle":208,"acronym":4,"eligibilityCriteria":209,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":210,"targetDuration":4,"studyType":24,"phases":212,"briefSummary":213,"conditions":214,"keywords":4,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":220,"lastUpdatePostDateStruct":221,"startDateStruct":223,"completionDateStruct":225,"leadSponsor":227,"locationsCount":50},"100554594","optimizing-care-in-critically-ill-at-uchealth-by-liberalizing-the-target-o2-in-mechanically-ventilated-icu-patients-100554594","NCT06501118","Optimizing Care in Critically Ill at UCHealth by Liberalizing the Target O2 in Mechanically-ventilated ICU Patients","Inclusion Criteria:\n\n* Admission to ICU and requiring invasive mechanical ventilation\n\nExclusion Criteria:\n\n* Transferred patients from outside the UCHealth system\\*:\n* Patients with pre-existing disease that requires chronic use of positive pressure ventilation delivered through a tracheostomy\\*:\n* Pregnant women:\n* Prisoners\n* Patients receiving mechanical ventilation for less than twelve hours",{"count":211,"type":23},3600,[26],"A multimodal educational intervention to target an oxygen saturation target range (SpO2 90-96%) will reduce ventilator length of stay and reduce occult hypoxemia by increased awareness and adherence to a designated oxygen saturation target range.",[215,216,217,218,32,219],"Respiratory Failure","Acute Hypoxemic Respiratory Failure","Acute Hypoxic Respiratory Failure","Hypoxemia","Hypoxic Respiratory Failure","2026-05-04",{"date":222,"type":42},"2026-05-08",{"date":224,"type":42},"2024-09-01",{"date":226,"type":23},"2026-07-31",{"name":228,"class":49},"University of Colorado, Denver",{"id":230,"slug":231,"hasResults":12,"nctId":232,"briefTitle":233,"officialTitle":233,"acronym":234,"eligibilityCriteria":235,"healthyVolunteers":87,"sex":18,"minAge":236,"maxAge":146,"enrollmentInfo":237,"targetDuration":4,"studyType":24,"phases":239,"briefSummary":240,"conditions":241,"keywords":4,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":220,"lastUpdatePostDateStruct":247,"startDateStruct":248,"completionDateStruct":250,"leadSponsor":252,"locationsCount":50},"100442999","effect-of-hypoxic-conditioning-on-cerebrovascular-health-in-the-elderly-100442999","NCT05048680","Effect of Hypoxic Conditioning on Cerebrovascular Health in the Elderly","HYPOXAGE","Inclusion Criteria:\n\n* 60 to 80 years of age;\n* Being physically inactive (less than 150 min\u002Fweek of moderate to intense physical activity);\n* No chronic cardiovascular, respiratory, metabolic or neuromuscular disease counterindicating an exercise training or hypoxic conditioning program;\n* Health coverage;\n* Being able to provide written fully informed consent.\n\nExclusion Criteria:\n\n* Body-mass index \\>30 kg\u002Fm2;\n* Smoking (\\> cigarettes\u002Fday);\n* Alcohol use (\\> 10g\u002Fday);\n* Mental disorder or history of mental disorder;\n* Beta-blockade treatment;\n* Inability or refusal to provide informed consent;\n* No health coverage\n* People exceeding the annual ceiling of allowances received as a result of their participation in other clinical trials;\n* People deprived of freedom by judicial or administrative decision;\n* People subject to legal protection, who cannot be included in clinical trials.","60 Years",{"count":238,"type":23},64,[26],"In line with the ever-growing aging of Western populations, the development of preventive strategies to slow down the effects of aging on cardiovascular health represents a major challenge in order to preserve functional capacities and a sufficient quality of life in the elderly. The alteration of vascular function (at the cerebral and systemic level) with aging is an important feature in the clinical picture including a decrease in physical and cognitive capacities. Although physical activity is recognized as an essential means of combating the effects of aging, optimizing its effects by defining the most effective strategies of practice remains a key objective. Offering alternative interventions to exercise training is also necessary for people who are unwilling or unable to engage in a physical activity program. In this context, hypoxic conditioning, alone or in conjunction with rehabilitative exercise training, is a new therapeutic modality with strong preclinical validity, in particular from a cardiovascular standpoint, and used in other pathologies to improve cardiovascular function and exercise performance and quality of life. Our aim is, therefore, to investigate the effect of hypoxic conditioning (alone or in conjunction with exercise training) on cerebrovascular health in the elderly.",[32,242,243,95,244,245,246],"Cerebral Hypoxia","Brain Diseases","Aging","Cognitive Decline","Healthy Aging",{"date":222,"type":42},{"date":249,"type":42},"2021-10-13",{"date":251,"type":23},"2026-09",{"name":104,"class":49},{"id":254,"slug":255,"hasResults":12,"nctId":256,"briefTitle":257,"officialTitle":258,"acronym":4,"eligibilityCriteria":259,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":260,"targetDuration":4,"studyType":24,"phases":262,"briefSummary":263,"conditions":264,"keywords":268,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":271,"lastUpdatePostDateStruct":272,"startDateStruct":273,"completionDateStruct":275,"leadSponsor":277,"locationsCount":279},"100616588","high-flow-nasal-cannula-for-preventing-hypoxia-during-sedated-endoscopy-in-high-risk-obstructive-sleep-apnea-patients-100616588","NCT07307560","High-Flow Nasal Cannula for Preventing Hypoxia During Sedated Endoscopy in High-Risk Obstructive Sleep Apnea Patients","High-Flow Nasal Cannula for Preventing Hypoxia During Sedated Endoscopy in High-Risk Obstructive Sleep Apnea Patients: A Multicenter Randomized Trial","Inclusion Criteria:\n\n* Age ≥18 years.\n* STOP-Bang score ≥5.\n* Scheduled for sedated gastrointestinal endoscopy (gastroscopy, colonoscopy, or combined gastroscopy + colonoscopy).\n* The estimated duration of the procedure does not exceed 45 minutes.\n* Patients have signed the informed consent form.\n\nExclusion Criteria:\n\n* Coagulation disorders or bleeding tendency (e.g., oral\u002Fnasal bleeding risk, mucosal injury, space-occupying obstructions).\n* Active upper respiratory tract infection (oral, nasal, or pharyngeal), or fever (core temperature \\>37.5°C).\n* Chronic obstructive pulmonary disease or other acute\u002Fchronic pulmonary diseases requiring long-term or intermittent oxygen therapy, or preoperative SpO₂ ≤ 92% on room air.\n* Severe organ dysfunction, including: Cardiac insufficiency (\\\u003C4 METs), Severe renal insufficiency (requiring dialysis), Diagnosed severe hepatic insufficiency, Increased intracranial pressure, ASA physical status ≥ IV.\n* Confirmed pregnancy or current breastfeeding.\n* Known allergy to sedatives (e.g., propofol) or medical adhesives.\n* Multiple traumatic injuries.\n* Current participation in another clinical trial.\n* Other conditions deemed unsuitable by the investigator",{"count":261,"type":23},600,[26],"Hypoxia represents the most frequent adverse event during propofol-sedated gastrointestinal endoscopy. The STOP-BANG questionnaire serves as a widely adopted, straightforward tool for screening obstructive sleep apnea (OSA) risk, with a score ≥5 identifying high-risk OSA patients who are particularly susceptible to hypoxia under sedation. Although preliminary research from our team suggests that High-Flow Nasal Cannula (HFNC) may lower the incidence of hypoxemia, evidence remains limited and inconsistent in studies specifically targeting high-risk OSA populations. Therefore, this multicenter randomized controlled trial aims to evaluate whether HFNC can effectively reduce the occurrence of hypoxia during sedated gastrointestinal endoscopy in patients identified as high-risk for OSA.",[32,265,266,267],"Esophageal Cancer","Gastric Cancer (Diagnosis)","Obstructive Sleep Apnea (OSA)",[269,32,267,270],"Sedation","Gastrointestinal Endoscopy","2026-05-01",{"date":220,"type":42},{"date":274,"type":42},"2025-12-21",{"date":276,"type":23},"2026-12-01",{"name":278,"class":49},"Zhejiang University",3,{"id":281,"slug":282,"hasResults":12,"nctId":283,"briefTitle":284,"officialTitle":285,"acronym":4,"eligibilityCriteria":286,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":287,"enrollmentInfo":288,"targetDuration":4,"studyType":24,"phases":290,"briefSummary":291,"conditions":292,"keywords":296,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":271,"lastUpdatePostDateStruct":301,"startDateStruct":303,"completionDateStruct":305,"leadSponsor":307,"locationsCount":50},"100400773","structural-modification-in-supraglottic-airway-device-100400773","NCT04498598","Structural Modification In Supraglottic Airway Device","Structural Modification In Supraglottic Airway Device Enhances Exchange Between Supraglottic & Endotracheal Ventilation Modes","Inclusion Criteria:\n\n1. Adult patients\n2. scheduled for a general anesthesia procedure with ETT \\& muscle relaxation\n\nExclusion Criteria:\n\n1. Patients who are not able to consent\n2. Non English Speaking\n3. History of difficult airway\n4. Physical exam of airway which suggests difficulty in airway management or need to use special equipment\n5. BMI \\>35\n6. Gastroesophageal reflux disease\n7. Anesthetic plan other than general anesthesia\n8. Emergency procedures","100 Years",{"count":289,"type":23},100,[26],"The proposed A\u002FZ modification of a supraglottic airway (SGA) incorporates an opening in the SGA body that enables access to the endotracheal tube (ETT) through the body of the SGA without the need of using an exchange catheter, thus enabling an ETT to move in the body of the SGA and convert a supraglottic to endotracheal ventilation. In its original form an adaptor made from same material currently used in the endotracheal tubes can make ventilation through the proposed airway device possible in exactly the same manner of a conventional SGA currently used. This adapter also known as the R-piece can be replaced with an ETT. The modification also allows placement of SGA over an existing ETT to convert and endotracheal (ET) to supraglottic (SG) mode of ventilation without the need to use an exchange catheter.",[293,294,32,295],"Airway Complication of Anesthesia","Ventilation Therapy; Complications","Hypoventilation",[297,298,299,300],"Airway Management","Oxygenation and Ventilation","Airway Devices","Supraglottic Airway",{"date":302,"type":42},"2026-05-07",{"date":304,"type":42},"2020-09-30",{"date":306,"type":23},"2026-08-24",{"name":308,"class":49},"The Cleveland Clinic",{"id":310,"slug":311,"hasResults":12,"nctId":312,"briefTitle":313,"officialTitle":143,"acronym":314,"eligibilityCriteria":315,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":146,"enrollmentInfo":316,"targetDuration":4,"studyType":24,"phases":317,"briefSummary":318,"conditions":319,"keywords":320,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":321,"lastUpdatePostDateStruct":322,"startDateStruct":323,"completionDateStruct":325,"leadSponsor":326,"locationsCount":50},"100626124","effect-of-acute-hypoxia-on-right-ventricular-function-in-hape-100626124","NCT07431554","Effect of Acute Hypoxia on RIght VEntRicular Function in HAPE.","RIVER-HAPE","Inclusion Criteria:\n\n* Signed informed consent\n* Diagnosed or suspicion of past HAPE\n* 18-80 years (age group young: 18-39.99 years \u002F age group older: 40-80 years)\n* All sex and genders\n* Living \\\u003C800m and without altitude exposure \\> 2500 m and \\> 24h within the last three weeks\n\nExclusion Criteria:\n\n* \\\u003C18, \\>80 years old\n* Any other diagnosed cardiopulmonary condition\n* Other clinically significant severe concomitant disease states (e.g. renal, hepatic dysfunction, etc.)\n* Inability to follow the procedures of the study due to language problems, psychological neurological disorders or orthopaedic disorders\n* Participants permanently living \\>800m and altitude exposure \\> 2500 m and \\>24h within the last three weeks\n* Pregnancy: Participants will be asked if pregnant or not, no screening for undetected pregnancy\n* Lactating women\n* Participation in other study with active treatment",{"count":148,"type":23},[26],"More and more people are engaging in sports in the mountains, including individuals with heart or lung diseases. At the same time, such diseases are becoming more common in Switzerland. At high altitude, less oxygen is available, which places stress on the body-particularly on the heart, which has to pump blood through the lungs. How the heart, especially the right ventricle, in people with past HAPE responds to this stress is still not well understood. Therefore, this study investigates how the heart responds to simulated altitudes of 2,500 m and 4,000 m, both at rest and during light physical activity in patients with past HAPE. The primary objective is to assess how right ventricular function changes under conditions of reduced oxygen availability. In addition, vital signs, changes in blood gases, oxygen levels in blood and tissue and shortness of breath are assessed. The \"altitude\" is simulated using a special gas mixture that participants inhale. Participants undergo three altitude conditions (490, 2,500, and 4,000 m above sea level). The order of the altitude conditions is assigned at random. The aim is to better understand how the right ventricle and other parameters respond to low-oxygen conditions and how affected patients can be better supported in the future.",[190,32,153,154],[156,157,158,159,160,161,162],"2026-04-28",{"date":271,"type":42},{"date":324,"type":42},"2026-03-17",{"date":168,"type":23},{"name":170,"class":49},{"id":328,"slug":329,"hasResults":12,"nctId":330,"briefTitle":331,"officialTitle":332,"acronym":333,"eligibilityCriteria":334,"healthyVolunteers":12,"sex":18,"minAge":335,"maxAge":4,"enrollmentInfo":336,"targetDuration":4,"studyType":24,"phases":338,"briefSummary":339,"conditions":340,"keywords":342,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":321,"lastUpdatePostDateStruct":345,"startDateStruct":346,"completionDateStruct":348,"leadSponsor":350,"locationsCount":352},"100363070","nocturnal-hypoxia-in-geriatric-patients-after-hip-fracture-100363070","NCT04007432","Nocturnal Hypoxia in Geriatric Patients After Hip Fracture","Nocturnal Hypoxia in Patients Hospitalized in Orthogeriatrics After Hip Fracture","HIPOX","Inclusion Criteria:\n\n* age over 70 years old,\n* hospitalized in orthogeriatrics for hip fracture surgery\n* information about the study and expression of non opposition\n* Expected hospital stay of 5 nights or more\n\nExclusion Criteria:\n\n* patient under guardianship,\n* any other type of fracture associated,\n* oxymetry recording not possible (behavioral disorders, night stirring,...)","70 Years",{"count":337,"type":23},70,[26],"Delirium is a common complication following hip fracture surgery (HFS) in older people. Postoperative hypoxia has also been associated with delirium, but not specifically in geriatric patients. The aim of the study is to demonstrate that post-operative hypoxia is associated with in-hospital complications in patients with HFS.",[341,32],"Delirium",[343,344],"nocturnal hypoxia","delirum developpement",{"date":220,"type":42},{"date":347,"type":42},"2020-11-05",{"date":349,"type":23},"2028-11-05",{"name":351,"class":49},"Assistance Publique - Hôpitaux de Paris",2,{"id":354,"slug":355,"hasResults":12,"nctId":356,"briefTitle":357,"officialTitle":358,"acronym":4,"eligibilityCriteria":359,"healthyVolunteers":87,"sex":18,"minAge":19,"maxAge":236,"enrollmentInfo":360,"targetDuration":4,"studyType":24,"phases":362,"briefSummary":364,"conditions":365,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":367,"lastUpdatePostDateStruct":368,"startDateStruct":370,"completionDateStruct":372,"leadSponsor":374,"locationsCount":50},"100466123","early-phase-1-impact-of-iron-supplementation-on-right-ventricular-function-and-exercise-performance-in-hypoxia-100466123","NCT05349630","Impact of Iron Supplementation on Right Ventricular Function and Exercise Performance in Hypoxia","Impact of Iron Supplementation on Right Ventricular Function and Exercise Performance in Hypoxia (A Sub-Study)","Inclusion Criteria:\n\n* Age 18 - 60\n* For women, premenopausal status\n\nExclusion Criteria:\n\n* Active cardiovascular or pulmonary disease (e.g. hypertension, coronary artery disease, cardiomyopathy, arrhythmia, valvular abnormalities, diabetes, peripheral vascular disease, tobacco use, chronic obstructive pulmonary disease, asthma, interstitial lung disease, restrictive lung disease, or pulmonary hypertension)\n* Use of cardiac- or pulmonary-related medications\n* Prior history of high altitude pulmonary edema or high altitude cerebral edema\n* Body mass index \\\u003C 18.5 or \\> 30\n* Anemia\n* Iron deficiency\n* Iron supplementation (oral or intravenous) in the preceding 60 days\n* Systemic anticoagulation or aspirin use that cannot be temporarily held for the study\n* Pregnancy\n* Non-cardiopulmonary disorders that adversely influence exercise ability (e.g. arthritis or peripheral vascular disease)\n* Dedicated athletic training (defined here as spending \\>9 hours per week in vigorous physical activity \\[≥6 mets\\])\n* Regular high-altitude exercise (defined here as engaging in vigorous physical activity \\[≥1 hour at ≥6 mets\\] at ≥8,000 ft for \\>2 days per week over the preceding 4 weeks)\n* Residence at ≥8,000 ft for 3 or more consecutive nights in the preceding 30 days",{"count":361,"type":23},5,[363],"EARLY_PHASE1","The purpose of this study is to determine if taking iron supplement pills improves exercise performance in low-oxygen conditions.",[366,32],"Right Ventricular Dysfunction","2026-04-27",{"date":369,"type":42},"2026-04-29",{"date":371,"type":23},"2028-03",{"date":373,"type":23},"2030-05",{"name":228,"class":49},{"id":376,"slug":377,"hasResults":12,"nctId":378,"briefTitle":379,"officialTitle":379,"acronym":4,"eligibilityCriteria":380,"healthyVolunteers":87,"sex":18,"minAge":19,"maxAge":381,"enrollmentInfo":382,"targetDuration":384,"studyType":59,"phases":4,"briefSummary":385,"conditions":386,"keywords":388,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":391,"lastUpdatePostDateStruct":392,"startDateStruct":394,"completionDateStruct":396,"leadSponsor":398,"locationsCount":50},"100631629","hypoxia-and-hemodilution-testing-in-healthy-adult-volunteers-100631629","NCT07503171","Hypoxia and Hemodilution Testing in Healthy Adult Volunteers","Inclusion Criteria:\n\n1. In good general health with no evidence of significant medical problems.\n2. Fluent in both written and spoken English.\n\n4\\. Has provided written informed consent and is willing to comply with study procedures.\n\nExclusion Criteria:\n\n1. BMI above 30.\n2. History of heart, lung, kidney, or liver disease.\n3. Diagnosis of asthma, sleep apnea, or use of CPAP.\n4. Diabetes mellitus.\n5. Clotting disorders.\n6. Hemoglobinopathy or history of anemia (ctHb \\\u003C12 g\u002FdL for men, \\\u003C11 g\u002FdL for women, COHb \\>2%).\n7. Any serious systemic illness.\n8. Current smoker.\n9. Injury or abnormality at sensor sites interfering with measurements.\n10. History of fainting or vasovagal response.\n11. Sensitivity to local anesthesia.\n12. Diagnosis of Raynaud's disease.\n13. Unacceptable collateral circulation (Allen's test).\n14. Pregnant, lactating, or attempting to become pregnant.\n15. Unable or unwilling to provide informed consent or comply with study procedures.\n16. Any other condition deemed unsuitable by the investigator.","35 Years",{"count":383,"type":23},7,"1 Week","This study will collect physiological measurements in healthy adult volunteers under controlled hypoxia and hemodilution conditions.",[32,387],"Hemodilution",[389,390],"Pulse oximetry","Hb","2026-03-25",{"date":393,"type":42},"2026-03-31",{"date":395,"type":23},"2026-04-02",{"date":397,"type":23},"2028-01-31",{"name":399,"class":400},"Nihon Kohden","INDUSTRY",{"id":402,"slug":403,"hasResults":12,"nctId":404,"briefTitle":405,"officialTitle":143,"acronym":406,"eligibilityCriteria":407,"healthyVolunteers":87,"sex":18,"minAge":19,"maxAge":146,"enrollmentInfo":408,"targetDuration":4,"studyType":24,"phases":409,"briefSummary":410,"conditions":411,"keywords":413,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":414,"lastUpdatePostDateStruct":415,"startDateStruct":416,"completionDateStruct":418,"leadSponsor":419,"locationsCount":352},"100626125","effect-of-acute-hypoxia-on-right-ventricular-function-in-healthy-adults-100626125","NCT07431567","Effect of Acute Hypoxia on RIght VEntRicular Function in Healthy Adults.","RIVER-H","Inclusion Criteria:\n\n* Signed informed consent\n* 18-80 years (age group young: 18-39.99 years \u002F age group older: 40-80 years)\n* All sex and genders -Living \\\u003C800m and without altitude exposure \\> 2500 m and \\> 24h within the last three weeks\n\nExclusion Criteria:\n\n* \\\u003C18, \\>80 years old -Any diagnosed cardiopulmonary condition including past HAPE\n* Other clinically significant severe concomitant disease states (e.g. renal, hepatic dysfunction, etc.)\n* Inability to follow the procedures of the study due to language problems, psychological neurological disorders or orthopaedic disorders\n* Participants permanently living \\>800m and altitude exposure \\> 2500 m and \\>24h within the last three weeks\n* Pregnancy: Participants will be asked if pregnant or not, no screening for undetected pregnancy\n* Lactating women -Participation in other study with active treatment",{"count":148,"type":23},[26],"More and more people are engaging in sports in the mountains, including individuals with heart or lung diseases. At the same time, such diseases are becoming more common in Switzerland. At high altitude, less oxygen is available, which places stress on the body-particularly on the heart, which has to pump blood through the lungs. How the healthy heart, especially the right ventricle, responds to this stress is still not well understood. Therefore, this study investigates how the heart responds to simulated altitudes of 2,500 m and 4,000 m, both at rest and during light physical activity. The present investigation focuses on healthy individuals in order to establish a reference for future comparisons with patients suffering from cardiopulmonary diseases. The primary objective is to assess how right ventricular function changes under conditions of reduced oxygen availability. In addition, vital signs, changes in blood gases, oxygen levels in blood and tissue and shortness of breath are assessed. The \"altitude\" is simulated using a special gas mixture that participants inhale. Healthy participants undergo three altitude conditions (490, 2,500, and 4,000 m above sea level). The order of the altitude conditions is assigned at random. The aim is to better understand how the right ventricle and other parameters respond to low-oxygen conditions and how affected patients can be better supported in the future.",[32,153,190,412],"Right Heart Function",[156,157,158,159,160,161,162],"2026-03-13",{"date":324,"type":42},{"date":417,"type":42},"2026-03-11",{"date":168,"type":23},{"name":170,"class":49},{"id":421,"slug":422,"hasResults":12,"nctId":423,"briefTitle":424,"officialTitle":425,"acronym":4,"eligibilityCriteria":426,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":427,"targetDuration":4,"studyType":24,"phases":428,"briefSummary":429,"conditions":430,"keywords":433,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":439,"lastUpdatePostDateStruct":440,"startDateStruct":442,"completionDateStruct":444,"leadSponsor":446,"locationsCount":50},"100622858","the-efficacy-and-safety-of-the-supraglottic-oxygenation-via-nasotracheal-intubation-for-deep-sedation-fiberoptic-bronchoscopy-100622858","NCT07389083","The Efficacy and Safety of the Supraglottic Oxygenation Via Nasotracheal Intubation for Deep Sedation Fiberoptic Bronchoscopy","The Efficacy and Safety of the Supraglottic Oxygenation Via Nasotracheal Intubation Reduce the Incidence of Hypoxia in Patients Undergoing Sedated Fiberoptic Bronchoscopy.","Inclusion Criteria:\n\n* Undergoing fiberoptic bronchoscopy under deep sedation.\n* Written informed consent obtained from the patient or their legal representative.\n* Clear understanding of, and voluntary participation in, the study, with informed-consent form signed by the patient or their legal representative.\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years\n* BMI \\> 30 kg\u002Fm²\n* Previous history of abnormal recovery from anesthesia\u002Fsurgery\n* History of recurrent epistaxis, nasal bone fracture, nasal polyps, or sinus surgery\n* Chronic use of opioid analgesics, benzodiazepine hypnotics, or antidepressant medications\n* Known allergy to any of the anesthetic agents employed\n* Anticipated difficult airway\n* Increased intracranial pressure\n* Active upper-respiratory-tract infection of the oral, nasal, or pharyngeal regions\n* Severe cardiac insufficiency (functional capacity \\\u003C 4 METs)\n* Severe renal failure requiring dialysis prior to surgery\n* Pre-operative oxygen saturation on room air \\\u003C 92 %\n* Any condition that, in the opinion of the investigator, renders the patient unsuitable for participation in this trial",{"count":181,"type":23},[26],"Bronchoscopy is now widely used for the diagnosis and treatment of various respiratory diseases. However, the procedure is highly stimulating and provokes a strong stress response; because the airway is shared, patients are prone to hypoxia. With the growing emphasis on comfortable care, demand for anesthesia during bronchoscopy has increased. Deep sedation is the most common approach, but when administered in the supine position it often causes the tongue base to fall back. Both nasopharyngeal and oropharyngeal airways can relieve this obstruction, yet neither connects seamlessly to an oxygen supply line, resulting in insufficient oxygen delivery.We therefore replaced the nasopharyngeal airway with a wired endotracheal tube (size 4.0 or 4.5) inserted via the nose. This thinner tube couples easily to an oxygen line or ventilator circuit, partially relieves airway obstruction, and allows ample supraglottic oxygenation. The present study was designed to evaluate the feasibility and safety of this modified oxygen-delivery method in patients undergoing deep sedation for bronchoscopy.",[32,431,432],"Pulmonary Nodule","Pulmonary Infection",[434,32,435,436,437,438],"fiberoptic bronchoscopy","Deep sedation","supine position","tongue-base fallback","supraglottic oxygenation","2026-01-28",{"date":441,"type":42},"2026-02-05",{"date":443,"type":42},"2025-12-28",{"date":445,"type":23},"2026-03-30",{"name":447,"class":49},"First Affiliated Hospital of Zhejiang University",{"id":449,"slug":450,"hasResults":12,"nctId":451,"briefTitle":452,"officialTitle":453,"acronym":4,"eligibilityCriteria":454,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":455,"targetDuration":4,"studyType":24,"phases":457,"briefSummary":458,"conditions":459,"keywords":463,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":468,"lastUpdatePostDateStruct":469,"startDateStruct":471,"completionDateStruct":473,"leadSponsor":475,"locationsCount":50},"100615030","endotracheal-tube-suctioning-versus-no-suctioning-during-emergence-from-general-anesthesia-100615030","NCT07287293","Endotracheal Tube Suctioning Versus No Suctioning During Emergence From General Anesthesia","Comparison of Endotracheal Tube Suctioning Versus No Suctioning During Emergence From General Anesthesia With Endotracheal Intubation: A Randomized, Single-Blind Study","Inclusion Criteria:\n\n* Adults aged 18-90 years with American Society of Anesthesiologists (ASA) physical status I-III.\n* Scheduled for elective surgery under general anesthesia requiring endotracheal intubation.\n* Planned tracheal extubation in the operating room at the end of surgery.\n\nExclusion Criteria:\n\n* Inability to provide informed consent or the presence of a significant language barrier that prevents effective communication with the clinical team.\n* Known diagnosis of obstructive sleep apnea (OSA), active pneumonia, or chronic pulmonary disease (e.g., chronic obstructive pulmonary disease, restrictive lung disease).\n* Body mass index (BMI) \\>35 kg\u002Fm².\n* Pregnancy or increased aspiration risk (e.g., full stomach).\n* Scheduled for maxillofacial, head and neck, or airway surgery.\n* Anticipated surgical duration \\>3.5 hours.\n* Anticipated difficult airway, defined as the presence of ≥2 predictors of difficult mask ventilation (DMV) based on Langeron et al., or a documented history of difficult intubation.",{"count":456,"type":23},408,[26],"The goal of this study is to determine whether omitting tracheal suctioning immediately prior to extubation is non-inferior to routine tracheal suctioning with respect to early postoperative oxygenation among adult surgical patients (aged 18-90 years, American Society of Anesthesiologists \\[ASA\\] physical status I-III) undergoing elective surgery under general anesthesia with endotracheal intubation.\n\nThe study addresses the following questions:\n\n* Primary outcome (non-inferiority):\n* Is the risk of postoperative desaturation (oxygen saturation \\[SpO₂\\] \\\u003C92% within 60 minutes after extubation) in the no-suction group not worse than in the routine-suction group by more than 10 percentage points?\n* Secondary outcomes (superiority):\n* Does omitting tracheal suctioning reduce postoperative cough severity and sore throat?\n* Does omitting tracheal suctioning avoid increasing extubation-related adverse events?\n\nParticipants will be randomly assigned (1:1) to one of two groups:\n\n* Routine suctioning (SUC): Endotracheal suctioning plus oropharyngeal suctioning immediately before extubation\n* No suctioning (NON-SUC): Oropharyngeal suctioning only, without endotracheal suctioning\n\nAll participants will receive standard anesthetic care and postoperative monitoring in the post-anesthesia care unit (PACU) for 60 minutes. Follow-up for airway symptoms and patient satisfaction will be conducted at 24 hours after surgery.",[32,460,461,462],"Airway Obstruction, Postoperative","Sore Throat","Cough, Postoperative",[297,464,465,32,466,467],"Suctioning","Emergence from Anesthesia","Endotracheal Intubation","Postoperative Complications","2026-01-09",{"date":470,"type":42},"2026-01-12",{"date":472,"type":42},"2026-01-05",{"date":474,"type":23},"2027-03-31",{"name":476,"class":49},"Mahidol University",{"id":478,"slug":479,"hasResults":12,"nctId":480,"briefTitle":481,"officialTitle":481,"acronym":4,"eligibilityCriteria":482,"healthyVolunteers":12,"sex":483,"minAge":19,"maxAge":484,"enrollmentInfo":485,"targetDuration":4,"studyType":24,"phases":487,"briefSummary":488,"conditions":489,"keywords":492,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":496,"lastUpdatePostDateStruct":497,"startDateStruct":499,"completionDateStruct":501,"leadSponsor":503,"locationsCount":279},"100618739","the-efficacy-of-remimazolam-on-incidence-of-hypoxia-during-sedated-transvaginal-oocyte-retrieval-a-multicenter-randomized-controlled-trial-100618739","NCT07335536","The Efficacy of Remimazolam on Incidence of Hypoxia During Sedated Transvaginal Oocyte Retrieval: A Multicenter Randomized Controlled Trial.","Inclusion Criteria:\n\n* Subjects aged 18 to 50 years planning to undergo painless oocyte retrieval\n* Subjects classified as American Society of Anesthesiologists (ASA) physical status I-II\n\nExclusion Criteria:\n\n* Subjects with contraindications to general anesthesia, acute or severe cardiovascular disease history, acute upper respiratory infection, chronic obstructive pulmonary disease (COPD), asthma attacks, or uncontrolled hypertension\n* Subjects with alcohol abuse\n* Subjects with severe hepatic or renal insufficiency, severe cardiovascular disease, or psychiatric disorder history\n* Subjects with hearing impairment preventing communication\n* Subjects with a history of long-term sedative or opioid use, or allergies to benzodiazepines, flumazenil, opioids and their antidotes, propofol, eggs, or soy products\n* Subjects with SpO2 \\\u003C 95% while breathing room air after entering the room","FEMALE","50 Years",{"count":486,"type":23},400,[26],"Hypoxia is the most common adverse reaction during sedation outside the operating room.Exploring novel drug combinations to reduce the incidence of hypoxia during sedation in patients undergoing transvaginal oocyte retrieval procedures enhances patient safety and lowers perioperative adverse event rates. This multicenter, prospective, randomized, controlled clinical study will compare the hypoxia incidence rate of the remimazolam-alfentanil combination against the commonly used propofol-alfentanil combination.",[32,490,491],"Infertility","Infertility Assisted Reproductive Technology",[32,493,494,495],"oocyte retrieval","remimazolam","general anesthesia","2026-01-01",{"date":498,"type":42},"2026-01-13",{"date":500,"type":42},"2025-10-20",{"date":502,"type":23},"2026-12-30",{"name":504,"class":49},"Diansan Su",{"id":506,"slug":507,"hasResults":12,"nctId":508,"briefTitle":509,"officialTitle":510,"acronym":511,"eligibilityCriteria":512,"healthyVolunteers":87,"sex":18,"minAge":19,"maxAge":513,"enrollmentInfo":514,"targetDuration":4,"studyType":24,"phases":516,"briefSummary":517,"conditions":518,"keywords":520,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":524,"lastUpdatePostDateStruct":525,"startDateStruct":527,"completionDateStruct":529,"leadSponsor":531,"locationsCount":50},"100464143","going-to-altitude-with-anxious-depressive-symptoms-100464143","NCT05323864","Going to Altitude With Anxious-depressive Symptoms","Going to Altitude With Anxious-depressive Symptoms - a Randomised Cross Over Trial in Individuals With Mental Disorders and Healthy Controls","Psychoxie","Inclusion Criteria:\n\n* sufficient command of the German language\n* no psychotic or cognitive disorders\n* patients suffering from anxious-depressive symptoms (meeting the cut off points of light-medium in the screening for anxiety and depression symptoms)\n\nExclusion Criteria:\n\n* pregnant or breastfeeding\n* permanent residence above 1000m\n* overnight stays at altitudes above 2500m in the previous month\n* exposure to 2500m or higher two weeks prior to the six-hour hypoxic exposure","65 Years",{"count":515,"type":23},68,[26],"Introduction: Currently, there is a lack of international guidelines or clinical recommendations for individuals with mental illnesses (i.e., bipolar disorder, posttraumatic stress disorder) going on high altitude sojourns. However, these guidelines would be important considering that mental illnesses are among the most common disorders worldwide and millions of people are hiking at high altitudes in the Alps, being granted easy access up to 3800m by cable cars. Before conceptualizing these guidelines, it seems necessary to study the physiological and psychological effects of ambient pressure changes leading to oxygen deficiency (hypoxia) in individuals with mental illnesses when being exposed to hypoxic conditions. The investigators hypothesize a shift towards negative affective responses and state anxiety as well as increased levels of neurotransmitter precursor amino acids (PHE\u002FTYR and KYN\u002FTRP) in individuals with mental illnesses when being exposed to hypoxic conditions.\n\nMethods and Analysis: The investigators plan to perform a double-blind randomized controlled trial in a safe laboratory environment by using a normobaric hypoxic chamber. Participants suffering from depression and anxiety symptoms will be included as well as age and sex-matched healthy controls. They will attend a six-hour exposure equivalent to 3800m of altitude as well as a six-hour exposure to sham hypoxic conditions. Recruited participants will be screened by the Beck Anxiety and Depression Inventory, the Symptom Checklist (SCL-90) as well as an interview assessment. Affective responses in state anxiety will be assessed before, and during each hour of exposure by using the Feeling Scale (FS), Felt Arousal Scale (FAS), Positive and Negative Affect Schedule (PANAS), State-Anxiety Inventory (STAI) and subjective mental stress levels (Visual Analogue Scale; VAS). Physiological parameters will be assessed by venous blood sampling, pulse oximetry and oxidative stress level measurement before entering the chamber, after three and six hours of exposure. Additionally, symptoms of acute mountain sickness will be assessed by the Lake Louise Score before, after three and six hours of exposure. Follow-up measurements are planned one and seven days after the chamber visit, consisting of venous blood sampling, the Beck Anxiety and Depression Inventory.\n\nA series of univariate analyses of covariance (ANCOVA) for repeated measures will be used to test the three-way (i.e. \"group × condition × time\") and two-way (\"group × condition\" and \"group × time\") interactions. Analyses will be adjusted for possible confounding, by adding age, sex, smoking, prior AMS, and medication status in the models as covariates.\n\nEthics and dissemination: Ethical approval has been obtained from the ethics committee of the Medical University of Innsbruck (1250\u002F2021).",[32,519],"Mental Disorder",[521,522,523],"anxiety","depressive symptoms","high altitude","2025-12-02",{"date":526,"type":42},"2025-12-10",{"date":528,"type":42},"2023-04-14",{"date":530,"type":23},"2025-12",{"name":532,"class":49},"Universitaet Innsbruck",{"id":534,"slug":535,"hasResults":12,"nctId":536,"briefTitle":537,"officialTitle":538,"acronym":4,"eligibilityCriteria":539,"healthyVolunteers":12,"sex":18,"minAge":540,"maxAge":541,"enrollmentInfo":542,"targetDuration":4,"studyType":24,"phases":544,"briefSummary":545,"conditions":546,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":547,"lastUpdatePostDateStruct":548,"startDateStruct":550,"completionDateStruct":552,"leadSponsor":554,"locationsCount":4},"100610769","effect-of-different-positions-during-extubation-on-incidence-of-hypoxemia-in-the-peri-extubation-period-100610769","NCT07231887","Effect of Different Positions During Extubation on Incidence of Hypoxemia in the Peri Extubation Period","Effect of Different Positions During Extubation on Incidence of Hypoxemia in the Peri Extubation Period of Pediatric OSAS Surgery Under General Anesthesia, Randomized Controlled Trial","Inclusion Criteria:\n\n* Age 2-10 years\n* American Society of Anesthesiologists physical status classification (ASA) I - II\n* Patients scheduled for ENT procedures involving tonsillectomy, adenoidectomy or adenotonsillectomy\n\nExclusion Criteria:\n\n* • Patient legal guardian refusal to participate in the study.\n\n  * Children with cardio-pulmonary disease","2 Years","10 Years",{"count":543,"type":23},262,[26],"Pediatric Obstructive Sleep Apnea Syndrome (OSAS) is common, often due to enlarged tonsils\u002Fadenoids. Tonsillectomy\u002Fadenoidectomy frequently performed under GA with tracheal intubation due to the age of children. Risk of hypoxemia and respiratory complications during the peri-extubation period is high.",[32],"2025-11-15",{"date":549,"type":42},"2025-11-19",{"date":551,"type":23},"2026-01",{"date":553,"type":23},"2026-07",{"name":555,"class":49},"Assiut University",{"id":557,"slug":558,"hasResults":12,"nctId":559,"briefTitle":560,"officialTitle":561,"acronym":4,"eligibilityCriteria":562,"healthyVolunteers":87,"sex":18,"minAge":19,"maxAge":563,"enrollmentInfo":564,"targetDuration":4,"studyType":24,"phases":566,"briefSummary":567,"conditions":568,"keywords":4,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":576,"lastUpdatePostDateStruct":577,"startDateStruct":579,"completionDateStruct":581,"leadSponsor":583,"locationsCount":50},"100609605","effects-of-breathing-training-and-nitrate-on-exercise-at-simulated-altitude-100609605","NCT07216755","Effects of Breathing Training and Nitrate on Exercise at Simulated Altitude","Impact of Respiratory Muscle Training and Nitrate Therapy on Exercise Tolerance in Simulated Altitude","Inclusion Criteria:\n\n* Healthy adults between 18 and 40 years old.\n\nRecreationally active (performing ≥3 hours of structured physical activity per week).\n\nNon-smokers for at least the past 6 months.\n\nFree from any known cardiovascular, pulmonary, metabolic, or neuromuscular disease as determined by health screening questionnaire and medical history.\n\nAble to perform cycle ergometer exercise to volitional fatigue.\n\nWilling to abstain from high-nitrate foods and supplements (e.g., beets, spinach, arugula) for 48 hours prior to each testing session.\n\nAble and willing to provide written informed consent and comply with all study procedures.\n\nExclusion Criteria:\n\n* Diagnosis of or history of heart disease, hypertension, diabetes, or chronic respiratory disorders (e.g., asthma, COPD).\n\nCurrent use of medications or supplements known to affect cardiovascular, metabolic, or respiratory function (e.g., beta-blockers, nitrates, stimulants).\n\nSmoking, vaping, or tobacco use within the past 6 months.\n\nKnown allergy or intolerance to beetroot products or nitrates.\n\nParticipation in another interventional research study within the past 30 days.\n\nPregnant or breastfeeding women.\n\nAny orthopedic or musculoskeletal limitation preventing safe exercise testing.\n\nFailure to meet inclusion criteria or inability to complete familiarization and baseline testing.","40 Years",{"count":565,"type":23},80,[26],"This study investigates whether respiratory muscle training (RMT) and dietary nitrate supplementation can improve exercise tolerance under simulated moderate altitude conditions. Exposure to reduced oxygen availability at altitude places additional strain on the cardiovascular and respiratory systems, which may limit endurance performance. By combining RMT-designed to strengthen the muscles involved in breathing-with nitrate therapy, which enhances nitric oxide availability and vascular function, this study aims to determine whether these interventions independently or synergistically improve oxygen delivery, reduce physiological strain, and enhance exercise performance. The findings will help identify non-pharmacological strategies to improve physical performance and tolerance to hypoxia in both clinical and operational environments.",[569,570,32,571,572,573,574,575],"Healthy Adults","Mechanical Ventilation Dependence","Exercise Training","Exercise Intolerance","Dietary Supplement","Nitrate Supplementation","Inspiratory Muscle Training","2025-10-13",{"date":578,"type":42},"2025-10-15",{"date":580,"type":42},"2025-09-01",{"date":582,"type":23},"2028-08-31",{"name":584,"class":49},"Embry-Riddle Aeronautical University",{"id":586,"slug":587,"hasResults":12,"nctId":588,"briefTitle":589,"officialTitle":589,"acronym":4,"eligibilityCriteria":590,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":335,"enrollmentInfo":591,"targetDuration":4,"studyType":24,"phases":593,"briefSummary":594,"conditions":595,"keywords":597,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":600,"lastUpdatePostDateStruct":601,"startDateStruct":603,"completionDateStruct":605,"leadSponsor":607,"locationsCount":279},"100577320","combo-endoscopy-oropharyngeal-airway-reduces-hypoxia-during-sedated-gastrointestinal-endoscopy-in-obese-patients-a-multicenter-randomized-controlled-clinical-trial-100577320","NCT06796764","COMBO Endoscopy Oropharyngeal Airway Reduces Hypoxia During Sedated Gastrointestinal Endoscopy in Obese Patients: A Multicenter, Randomized, Controlled Clinical Trial","Inclusion Criteria:\n\n* Age 18≤ Age ≤70.\n* BMI ≥ 28 kg\u002Fm².\n* The ASA classification ranges from I to II.\n* Patients have signed the informed consent form.\n* Patients undergoing gastroendoscopy and colonoscopy procedure.\n* The estimated duration of the procedure does not exceed 45 minutes.\n\nExclusion Criteria:\n\n* Patients who exhibit contraindications to oropharyngeal airway ventilation, such as coagulation disorders, a predisposition to oral and nasal bleeding, mucosal damage, or anatomical constraints impeding oropharyngeal channel placement.\n* Severe cardiac insufficiency, defined as a maximal exercise capacity of less than 4 metabolic equivalents (METs).\n* Profound renal insufficiency necessitating preoperative dialysis.\n* A confirmed severe liver dysfunction.\n* Patients diagnosed with chronic obstructive pulmonary disease (COPD) or those presently experiencing other acute and chronic pulmonary conditions necessitating prolonged or intermittent oxygen therapy.\n* Elevated intracranial pressure.\n* Upper respiratory tract infections, encompassing the oral, nasal, and pharyngeal regions.\n* Fever, defined as a core body temperature exceeding 37.5 degrees Celsius.\n* Pregnancy or lactation.\n* Hypersensitivity reactions to sedatives like propofol or medical equipment such as adhesive tape.\n* Urgent surgical intervention.\n* Polytrauma.\n* Peripheral oxygen saturation (SpO2) levels below 95% while breathing room air preoperatively.\n* BMI\\\u003C28 kg\u002Fm².\n* Patients with a documented history of substance abuse, specifically drugs and\u002For alcohol, within the two years preceding the commencement of the screening period. Substance abuse in this context is defined as consuming more than three standard alcoholic beverages daily, roughly equivalent to 10g of alcohol or 50g of Chinese Baijiu.\n* Patients with a history of mental and neurological disorders, including but not limited to depression, severe central nervous system depression, Parkinson's disease, basal ganglia lesions, schizophrenia, epilepsy, Alzheimer's disease, and myasthenia gravis.\n* Presently engaged in concurrent participation in additional clinical trials.\n* Patients considered ineligible by researchers for inclusion in this clinical trial.",{"count":592,"type":23},580,[26],"Hypoxia represents the prevailing adverse occurrence during the sedation of patients undergoing gastrointestinal endoscopy with propofol. This is particularly true for obese patients, who have a higher incidence of hypoxia. A recent innovation in this domain is the COMBO Endoscopy Oropharyngeal Airway-a multifaceted device that encompasses capnography monitoring, bite block , oxygenation support, and oropharyngeal airway management. This device has been purposefully designed to cater to the unique requirements of endoscopic procedures. The principal objective of this study is to assess the efficacy and safety of the COMBO Endoscopy Oropharyngeal Airway in reducing the incidence of hypoxia in obese patients undergoing gastrointestinal endoscopy under sedation.",[32,265,596],"Gastric Cancer",[598,599,32,269,270],"Obese Patients","The COMBO Endoscopy Oropharyngeal Airway","2025-09-09",{"date":602,"type":42},"2025-09-10",{"date":604,"type":42},"2025-04-11",{"date":606,"type":23},"2025-12-04",{"name":278,"class":49},{"id":609,"slug":610,"hasResults":12,"nctId":611,"briefTitle":612,"officialTitle":612,"acronym":4,"eligibilityCriteria":613,"healthyVolunteers":87,"sex":483,"minAge":19,"maxAge":335,"enrollmentInfo":614,"targetDuration":4,"studyType":24,"phases":616,"briefSummary":617,"conditions":618,"keywords":4,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":621,"lastUpdatePostDateStruct":622,"startDateStruct":623,"completionDateStruct":625,"leadSponsor":626,"locationsCount":50},"100548144","early-phase-1-impact-of-early-aging-and-menopause-on-the-vascular-responses-to-hypoxia-100548144","NCT06417177","Impact of Early Aging and Menopause on the Vascular Responses to Hypoxia","Inclusion Criteria:\n\n* Female assigned at birth\n* Pre, peri- or post-menopausal\n* Healthy weight (BMI ≥18 and ≤30 kg\u002Fm2)\n\nExclusion Criteria:\n\n* Male (assigned at birth)\n* Pregnancy, breastfeeding\n* Use of hormone replacement therapies\n* Hysterectomy\n* Body mass index \\>30 kg\u002Fm2\n* Diagnosed sleep apnea\n* Current smoking\u002FNicotine\u002FDrug use\n* Nerve\u002Fneurologic disease\n* Cardiovascular, hepatic, renal, respiratory disease\n* Blood pressure ≥140\u002F90 mmHg\n* Diabetes, Polycystic ovarian syndrome\n* Communication barriers\n* Prescription medications\n* Malignant cancer",{"count":615,"type":23},75,[363],"The purpose of this study is to examine hypoxic vasodilation and the role of beta-adrenergic receptors in younger premenopausal, perimenopausal, and older postmenopausal women.",[244,619,32,620],"Menopause","Vasodilation","2025-09-08",{"date":600,"type":42},{"date":624,"type":42},"2024-06-03",{"date":553,"type":23},{"name":627,"class":49},"University of Missouri-Columbia",{"id":629,"slug":630,"hasResults":12,"nctId":631,"briefTitle":632,"officialTitle":633,"acronym":4,"eligibilityCriteria":634,"healthyVolunteers":12,"sex":18,"minAge":635,"maxAge":20,"enrollmentInfo":636,"targetDuration":4,"studyType":24,"phases":637,"briefSummary":638,"conditions":639,"keywords":4,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":580,"lastUpdatePostDateStruct":641,"startDateStruct":642,"completionDateStruct":644,"leadSponsor":646,"locationsCount":352},"100502882","hfnc-compared-with-facial-mask-in-patients-with-chest-trauma-patients-100502882","NCT05828030","HFNC Compared With Facial Mask in Patients With Chest Trauma Patients","Noninvasive Ventilation With High Flow Nasal Cannula Compared With Facial Mask in Patients With Chest Trauma: a Randomized Controlled Study","Inclusion Criteria:\n\nPatients who have the following condition within 72 hours of chest trauma despite receiving standard nasal cannula oxygen therapy \\[≥10 L\u002Fmin\\], are eligible for inclusion.\n\n* severe hypoxemic respiratory failure \\[Arterial partial pressure of oxygen (PaO2)\u002Ffraction of inspired oxygen fraction(FiO2) \\\u003C300 mmHg\\]\n* with a respiratory rate \\>25 breaths\u002Fminute and difficulty breathing, or respiratory distress\n* PaCO2 of 45 mmHg or higher (if the patient requires emergency surgery with endotracheal intubation and mechanical ventilation, the time of inclusion will be the start of the post-extubation period. (Note: For patients who receive emergency trauma surgery with endotracheal intubation and mechanical ventilation, the time of inclusion assessment will be 72 hours after extubation.)\n\nExclusion Criteria:\n\n1. Patients with a Glasgow Coma Scale less than 8 or severe brain injury.\n2. Patients with any contraindications to non-invasive ventilation, including acute gastrointestinal bleeding, upper airway obstruction, or hemodynamic instability.\n3. Facial trauma involving skull base fractures, facial bone fractures, or orbital floor fractures.\n4. Severe injuries involving the nasal sinuses.\n5. Patients with cervical spine injuries.\n6. Patients with increased intracranial pressure.\n7. Patients with facial, nasal, or airway structural abnormalities or surgery that prevents the use of appropriate nasal cannula.\n8. Patients after upper airway surgery.\n9. Patients who are unable to clearly express their willingness to sign informed consent.","20 Years",{"count":289,"type":23},[26],"Guidelines for noninvasive ventilation (NIV) recommend continuous positive airway pressure in patients with thoracic trauma who remain hypoxic . However, no any suggestion was applied for high flow nasal cannula (HFNC). Therefore, Our aim was to determine whether HFNC reduces intubation in severe trauma-related hypoxemia.",[640,32],"Chest Trauma",{"date":621,"type":42},{"date":643,"type":42},"2023-04-26",{"date":645,"type":23},"2027-12-31",{"name":647,"class":49},"National Taiwan University Hospital",{"id":649,"slug":650,"hasResults":12,"nctId":651,"briefTitle":652,"officialTitle":652,"acronym":4,"eligibilityCriteria":653,"healthyVolunteers":87,"sex":18,"minAge":19,"maxAge":484,"enrollmentInfo":654,"targetDuration":4,"studyType":59,"phases":4,"briefSummary":656,"conditions":657,"keywords":4,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":659,"lastUpdatePostDateStruct":660,"startDateStruct":662,"completionDateStruct":664,"leadSponsor":666,"locationsCount":50},"100526997","pulse-oximeter-accuracy-in-healthy-humans-during-hypoxia-100526997","NCT06142019","Pulse Oximeter Accuracy in Healthy Humans During Hypoxia","Inclusion Criteria:\n\n1. The subject is male or female, aged ≥18 and \\\u003C50.\n2. The subject is in good general health with no evidence of any medical problems.\n3. The subject is fluent in both written and spoken English.\n4. The subject has provided informed consent and is willing to comply with the study procedures.\n\nExclusion Criteria:\n\n1. The subject is obese (BMI\\>35).\n2. The subject has a known history of heart disease, lung disease, kidney or liver disease.\n3. Diagnosis of asthma, sleep apnea, or use of CPAP.\n4. Subject has diabetes.\n5. Subject has a clotting disorder.\n6. The subject a hemoglobinopathy or history of anemia, per subject report or the first blood sample, that in the opinion of the investigator, would make them unsuitable for study participation.\n7. The subject has any other serious systemic illness.\n8. The subject is a current smoker.\n9. Any injury, deformity, or abnormality at the sensor sites that in the opinion of the investigators' would interfere with the sensors working correctly.\n10. The subject has a history of fainting or vasovagal response.\n11. The subject has a history of sensitivity to local anesthesia.\n12. The subject has a diagnosis of Raynaud's disease.\n13. The subject has unacceptable collateral circulation based on exam by the investigator (Allen's test).\n14. The subject is pregnant, lactating or trying to get pregnant.\n15. The subject is unable or unwilling to provide informed consent, or is unable or unwilling to comply with study procedures.\n16. The subject has any other condition, which in the opinion of the investigators' would make them unsuitable for the study.",{"count":655,"type":23},10000,"The aim of this project is to test the accuracy of pulse oximeters during mild, moderate and severe hypoxia. This is done by comparing the reading of the pulse oximeter during brief, steady state hypoxia with a gold-standard measurement of blood oxygen. This study will be done on healthy male or females between the age group of 18-50.",[32,658],"Skin Pigmentation","2025-08-29",{"date":661,"type":42},"2025-09-02",{"date":663,"type":42},"2021-11-29",{"date":665,"type":23},"2028-09-01",{"name":667,"class":49},"University of California, San Francisco"]