[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"icp-intracranial-pressure-increase\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:icp-intracranial-pressure-increase":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":5},"100653313","comparison-of-hyperosmolar-agent-in-reduction-of-increased-intracranial-pressure-in-patients-with-traumatic-brain-injury-using-ultrasonography-100653313",false,"NCT07786324","Comparison of Hyperosmolar Agent in Reduction of Increased Intracranial Pressure in Patients With Traumatic Brain Injury Using Ultrasonography","Comparison of 3% Hypertonic Saline Versus 20% Mannitol in Reduction of Increased Intracranial Pressure in Patients With Traumatic Brain Injury Using Optic Nerve Sheath Diameter Measurements''","MHTS-ONSD","Inclusion Criteria:\n\n* • Age ≥18 years.\n\n  * Acute severe traumatic brain injury (TBI) (GCS 3-8) confirmed by CT brain.\n  * Elevated ONSD suggestive of raised ICP (ONSD cutoff value ≥5.6 mm ).(14)\n  * Initiation of hyperosmolar therapy within 24 hours of injury.\n\nExclusion Criteria:\n\n* • Penetrating head injury.\n\n  * Hypotension.\n  * Previous ocular trauma or orbital surgery.\n  * Glaucoma or optic nerve pathology.\n  * Bilateral ocular injuries preventing ultrasound assessment.\n  * Pregnancy.\n  * Chronic renal failure requiring dialysis.\n  * Initial serum sodium \\>150mmol\u002FL or Patients reaching a sodium level \\>160mmol\u002FL during hypertonic administration.\n  * Previous hyperosmolar therapy before enrollment.\n  * Refusal of consent by legal surrogate.","ALL","18 Years",{"count":20,"type":21},100,"ESTIMATED","INTERVENTIONAL",[24],"NA","The aim of this study to compare the efficacy of hypertonic saline and mannitol in reducing intracranial pressure, as assessed by serial optic nerve sheath diameter (ONSD) ultrasound measurements, in patients with traumatic brain injury.",[27,28,29],"TBI (Traumatic Brain Injury)","ICP (Intracranial Pressure) Increase","Optic Nerve Sheath Diameter Measurement",[31,32,33,34,35],"mannitol","hypertonic saline","ICP","ONSD","TBI","NOT_YET_RECRUITING","2026-08-21",{"date":39,"type":40},"2026-08-25","ACTUAL",{"date":42,"type":21},"2026-10-01",{"date":44,"type":21},"2029-09-30",{"name":46,"class":47},"Assiut University","OTHER"]