[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"impacted-mandibular-third-molar-extraction\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:impacted-mandibular-third-molar-extraction":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,53],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":52},"100650047","comparison-of-prf-and-corticosteroids-in-impacted-third-molar-surgery-100650047",false,"NCT07742826","Comparison of PRF and Corticosteroids in Impacted Third Molar Surgery","Comparison of Postoperative Effects of PRF and Corticosteroid Treatments in Impacted Third Molar Surgery","Inclusion Criteria:\n\n* Patients aged 18 years and older.\n* Patients with good general health\n* Patients with complete clinical and radiographic examination (panoramic radiograph\u002FCBCT if applicable)\n* Patients willing and able to attend all postoperative follow-up visits\n\nExclusion Criteria:\n\n* Patients with systemic diseases that may impair wound healing (e.g., uncontrolled diabetes, immunodeficiency).\n* Pregnant or breastfeeding women.\n* Patients with acute infection, abscess, or pericoronitis at the surgical site.\n* Patients with a history of allergy or contraindication to corticosteroids, local anesthetics, or prescribed medications.\n* Patients using corticosteroids, anticoagulants, immunosuppressive drugs, or bisphosphonates.\n* Patients with bleeding disorders.\n* Patients with previous radiotherapy to the head and neck region.\n* Patients unable or unwilling to comply with the study protocol or attend follow-up visits.",true,"ALL","18 Years",{"count":20,"type":21},60,"ESTIMATED","INTERVENTIONAL",[24],"NA","This prospective, randomized interventional study aims to compare the postoperative effects of standard treatment (control), platelet-rich fibrin (PRF), and PRF combined with corticosteroid treatment in patients undergoing impacted mandibular third molar surgery. A total of 60 participants will be randomly assigned to one of three treatment groups according to the study protocol. Postoperative pain, facial swelling, and trismus will be evaluated on postoperative days 1, 2, 3, and 7. The findings of this study are expected to provide evidence regarding the effectiveness of PRF alone and PRF combined with corticosteroid treatment in reducing postoperative complications following impacted mandibular third molar surgery.",[27,28,29],"Impacted Mandibular Third Molar Extraction","Impacted Lower Third Molar","Impacted Wisdom Tooth",[31,32,33,34,35,36,37,38,39],"Third Molar Surgery","Impacted Third Molar","Platelet-Rich Fibrin","Corticosteroids","Postoperative Pain","Facial Swelling","Trismus","Oral Surgery","Postoperative Complications","RECRUITING","2026-07-29",{"date":43,"type":44},"2026-08-03","ACTUAL",{"date":46,"type":44},"2024-09-03",{"date":48,"type":21},"2026-08",{"name":50,"class":51},"Final International University","OTHER",1,{"id":54,"slug":55,"hasResults":11,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":4,"eligibilityCriteria":59,"healthyVolunteers":11,"sex":17,"minAge":60,"maxAge":4,"enrollmentInfo":61,"targetDuration":4,"studyType":22,"phases":63,"briefSummary":64,"conditions":65,"keywords":4,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":52},"100620805","autologous-dentine-graft-compared-to-xenograft-in-managing-periodontally-compromised-second-molar-after-third-molar-removal-100620805","NCT07362394","Autologous Dentine Graft Compared to Xenograft in Managing Periodontally Compromised Second Molar After Third Molar Removal","Autologous Dentine Graft Compared to Xenograft in Managing Periodontally Compromised Second Molar After Third Molar Removal - A Split-Mouth Randomized Controlled Trial","Inclusion Criteria:\n\n* Adult patients aged 26 years and above who can give informed consent and are scheduled for bilateral surgical removal of mesioangular or horizontally impacted mandibular M3s\n* Present with a periodontally compromised mandibular second molar, defined by the presence of probing pocket depth (PPD) greater than 4 mm on the distal aspect\n* Type of impaction of M3s on both sides must be symmetrical\n* Consent to the use of xenograft as control\n\nExclusion Criteria:\n\n* Smokers\n* Poor oral hygiene with \\>30% full mouth plaque score (FMPS)\n* Pregnant or lactating mothers\n* Have uncontrolled systemic conditions such as diabetes or immunodeficiency disorders\n* On medications that affect bone metabolism, including bisphosphonates or corticosteroids\n* History of periodontal surgery or grafting at the intended surgical site\n* Presence of acute infection and M2s with distal caries and Grade III mobility","26 Years",{"count":62,"type":21},34,[24],"The goal of this study is to evaluate the efficacy of autologous dentin graft (ADG) in treating periodontal defects on the distal aspect of mandibular 2nd molar (M2) after surgical removal of impacted mandibular 3rd molar (M3) by improving periodontal and radiological outcomes when compared with a xenograft, which is commercially available. The main questions it aims to answer are:\n\n1. How does the clinical efficacy of ADG compare to xenografts, regarding wound healing and periodontal parameters at the distal aspect of periodontally compromised mandibular M2 following impacted M3 extraction?\n2. How does the radiological bone regeneration at ADG-grafted sites differ from that at xenograft-grafted sites?\n3. How do the post-operative patient-reported outcomes at sites receiving ADG differ from those at sites receiving xenografts?\n\nResearchers will compare ADG to xenograft to see if ADG is more efficacious in managing periodontal defects on distal aspect of M2 after surgical removal of M3.\n\nParticipants will\n\n1. Undergo bilateral surgical removal of M3 under general anaesthesia\n2. Receive ADG on test site and xenograft on contralateral control site\n3. Come back for clinical assessments, wound healing assessments and radiographic assessments for 5 times after the surgery (2 weeks, 1 month, 3 months, 6 months and 12 months)",[27,66,67,68],"Dentin Graft","Xenograft","Bone Defects","NOT_YET_RECRUITING","2026-01-15",{"date":72,"type":44},"2026-01-23",{"date":74,"type":21},"2026-06-01",{"date":76,"type":21},"2028-06-30",{"name":78,"class":51},"National University of Malaysia"]