[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"incomplete-spinal-cord-injury-sci\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:incomplete-spinal-cord-injury-sci":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,53,75,101],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":32,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":52},"100650564","zepu-2000-limb-rehabilitation-trainer-study-zepu2000rct-100650564",false,"NCT07749612","ZEPU-2000 Limb Rehabilitation Trainer Study (ZEPU2000RCT)","Feasibility, Safety and Efficacy of ZEPU-2000A, ZEPU-2000D and ZEPU-2000E Upper and Lower Limb Active and Passive Rehabilitation Trainer Systems in Patients With Upper and Lower Limb Motor Dysfunction","Inclusion Criteria:\n\n* Presence of upper-limb motor dysfunction, with or without concurrent lower-limb impairment, due to one of the following: stroke with onset between 2 and 24 months prior to enrolment; incomplete spinal cord injury (neurological level C5 and below), classified as ASIA Impairment Scale C or D; traumatic brain injury with persistent upper-limb functional limitation; or orthopedic\u002Fpost-surgical conditions involving the shoulder, elbow, wrist, or hand with persistent functional impairment for more than 3 months\n* Age between 18 and 60 years\n* Ability to understand study procedures and follow instructions, and to provide written informed consent (or assent with guardian consent where applicable)\n* Body weight and limb anthropometry compatible with ZEPU-2000A, ZEPU-2000D, and ZEPU-2000E systems, per manufacturer specifications\n* Medically stable and cleared by a physician for robotic rehabilitation, with no active infection, uncontrolled cardiac or respiratory disease, severe osteoporosis, uncontrolled epilepsy, or untreated deep vein thrombosis\n\nExclusion Criteria:\n\n* Complete spinal cord injury or profound motor paralysis preventing safe interaction with robotic devices\n* Severe cognitive impairment, defined as a Mini-Mental State Examination (MMSE) score less than 24, that would compromise safe participation Severe spasticity of the upper limb, defined as a Modified Ashworth Scale score greater than 3\n* Unstable fractures, severe fixed joint contractures of the shoulder, elbow, wrist, or hand (e.g., greater than 30 degrees), or severe pain limiting safe robotic training\n* Uncontrolled cardiac arrhythmia, or presence of a pacemaker or other implanted electronic medical device incompatible with robotic sensors\n* Pregnancy","ALL","18 Years","60 Years",{"count":20,"type":21},36,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to learn whether the ZEPU-2000A, ZEPU-2000D and ZEPU-2000E robotic rehabilitation trainers help people with weakness or movement problems in their arms and legs. These devices are used to guide repeated arm and leg movements as part of rehabilitation therapy. The study will also look at whether the devices are safe to use.\n\nThe main questions it aims to answer are:\n\nIs training with the ZEPU-2000 devices safe, and how well do patients tolerate and stick with the training sessions? Does adding robotic training to usual rehabilitation improve muscle strength, joint movement, balance, walking, and daily function more than usual rehabilitation alone?\n\nResearchers will compare a group receiving robotic-assisted rehabilitation plus usual care to a group receiving usual rehabilitation care alone, to see whether the robotic devices provide added benefit.\n\nParticipants will:\n\nBe adults aged 18-60 with arm and\u002For leg movement problems caused by stroke, incomplete spinal cord injury, traumatic brain injury, or an orthopedic condition Attend training sessions 3 times a week for 12 weeks (about 36 sessions total), each lasting approximately 45 minutes Undergo assessments of strength, movement, balance, and daily function at the start of the study and every 2 weeks throughout the 12-week period Be monitored for any side effects or safety concerns, such as skin irritation, falls, or discomfort, at every session",[27,28,29,30,31],"Stroke","Incomplete Spinal Cord Injury (SCI)","Traumatic Brain Injury","Upper Extremity Motor Dysfunction","Lower Extremity Motor Dysfunction",[33,34,35,36,37,38,39],"Robotic rehabilitation","ZEPU-2000A","ZEPU-2000D","ZEPU-2000E","Active and passive rehabilitation","Neurorehabilitation","Musculoskeletal rehabilitation","NOT_YET_RECRUITING","2026-08-04",{"date":43,"type":44},"2026-08-06","ACTUAL",{"date":46,"type":21},"2026-08",{"date":48,"type":21},"2026-12",{"name":50,"class":51},"Bangladesh Medical University","OTHER",1,{"id":54,"slug":55,"hasResults":11,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":59,"eligibilityCriteria":60,"healthyVolunteers":11,"sex":16,"minAge":61,"maxAge":4,"enrollmentInfo":62,"targetDuration":4,"studyType":22,"phases":64,"briefSummary":65,"conditions":66,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":71,"leadSponsor":73,"locationsCount":4},"100641670","effect-of-antigravity-treadmill-training-on-cardiorespiratory-fitness-and-lower-limb-function-in-incomplete-spinal-cord-injury-100641670","NCT07653529","Effect of Antigravity Treadmill Training on Cardiorespiratory Fitness and Lower Limb Function in Incomplete Spinal Cord Injury","Effect of Antigravity Treadmill Locomotor Training on Cardiorespiratory Fitness and Lower Limb Function in Patients With Incomplete Spinal Cord Injury","Antigravity","Inclusion Criteria:\n\nIncomplete spinal cord injury (ASIA C or D)\n\n* Injury duration more than 3 months\n* Ability to stand with or without assistance\n* Medically stable condition\n\nExclusion Criteria:\n\n* Complete spinal cord injury\n\n  * Severe cardiopulmonary disorders\n  * Severe osteoporosis or fractures\n  * Severe cognitive impairment\n  * Other neurological disorders affecting gait","40 Years",{"count":63,"type":21},60,[24],"This study aims to investigate the effect of locomotor training using an antigravity treadmill on cardiorespiratory fitness and lower limb function in patients with incomplete spinal cord injury.",[28],"2026-06-12",{"date":69,"type":44},"2026-06-17",{"date":67,"type":21},{"date":72,"type":21},"2026-12-15",{"name":74,"class":51},"Middle East University",{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":83,"targetDuration":4,"studyType":22,"phases":85,"briefSummary":86,"conditions":87,"keywords":88,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":52},"100627211","transcutaneous-spinal-cord-stimulation-tscs-during-assisted-cycling-training-for-incomplete-spinal-cord-injury-100627211","NCT07445685","Transcutaneous Spinal Cord Stimulation (tSCS) During Assisted Cycling Training for Incomplete Spinal Cord Injury.","Transcutaneous Spinal Cord Stimulation (tSCS) During Assisted Cycling Training for Incomplete Spinal Cord Injury: a Randomized, Double-blind Study.","tSCS_SJD_PMI_1","Inclusion Criteria:\n\n* Age at least 18.\n* Diagnosis of spinal cord injury at levels C2-T11, classified as ASIA Impairment Scale grades B, C, or D.\n* Less than 1 year since the injury.\n* Ability to follow instructions and tolerate the intervention.\n\n  .-Spasticity grade less than 3 on the Modified Ashworth Scale.\n* Signed informed consent.\n\nExclusion Criteria:\n\n* Comorbidities that limit active participation (severe heart disease, serious active infections, pressure ulcers in the area).\n* Use of devices incompatible with electrical stimulation.\n* Metallic implant in the T11-T12 area.\n* History of epilepsy.\n* Fixed joint contractures limiting range of motion.\n* Significantly reduced bone density (osteoporosis).\n* Unhealed fractures.\n* Pregnancy.\n* Active tumor process.",{"count":84,"type":21},40,[24],"The goal of this clinical trial is to learn if transcutaneous spinal cord stimulation works to improve lower limb motor function in adults with incomplete spinal cord injury. It will also learn about the safety of transcutaneous spinal cord stimulation when combined with assisted cycling training.\n\nThe main questions it aims to answer are:\n\nDoes transcutaneous spinal cord stimulation while training with assisted cycling improve lower limb motor function? Does transcutaneous spinal cord stimulation while training with assisted cycling reduce muscle spasms or improve bladder or bowel function?\n\nResearchers will compare transcutaneous spinal cord stimulation to a sham (a look-alike stimulation that does not deliver therapeutic electrical current) to see if transcutaneous spinal cord stimulation during assisted cycling improves motor function in people with incomplete spinal cord injury.\n\nParticipants will:\n\nParticipate in the training program with assisted cycling. Receive active stimulation or placebo stimulation during this training. Undergo motor function assessments, and be monitored about muscle spasms, bladder and bowel function and side effects.\n\nThe study will include 40 participants with incomplete spinal cord injury with less than 12 months since injury.",[28],[89,90,91],"Incomplete Spinal Cord Injury","Transcutaneous Electrical Spinal Cord Stimulation","Cycling","2026-03-02",{"date":94,"type":44},"2026-03-04",{"date":96,"type":21},"2026-03-01",{"date":98,"type":21},"2027-12",{"name":100,"class":51},"Fundació Sant Joan de Déu",{"id":102,"slug":103,"hasResults":11,"nctId":104,"briefTitle":105,"officialTitle":105,"acronym":106,"eligibilityCriteria":107,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":108,"enrollmentInfo":109,"targetDuration":4,"studyType":22,"phases":111,"briefSummary":112,"conditions":113,"keywords":116,"overallStatus":123,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":52},"100613207","effect-of-hybrid-functional-electrical-stimulation-and-augmented-reality-based-gait-training-on-gait-parameters-among-incomplete-spinal-cord-injury-patients-100613207","NCT07263581","Effect of Hybrid Functional Electrical Stimulation and Augmented Reality-Based Gait Training on Gait Parameters Among Incomplete Spinal Cord Injury Patients","FES AR SCI","Inclusion Criteria:\n\n* Diagnosed with incomplete spinal cord injury (ASIA Impairment Scale C or D)\n* Neurological level of injury between T10 and L2\n* Aged 18 to 45 years\n* Medically stable with no acute complications\n* Able to walk with or without assistive devices\n* Cognitively intact\n* Capable of providing written informed consent\n* Stable physical and emotional health\n* No history of seizures\n* No major urinary or bowel dysfunction\n\nExclusion Criteria:\n\n* Severe spasticity or contractures in the lower limbs\n* Significant pain or joint instability in the lower limbs\n* Presence of other neurological (e.g., stroke, multiple sclerosis) or musculoskeletal disorders\n* Open skin lesions or ulcerations\n* History of fractures or orthopedic surgery in the lower limbs\n* Severe cardiovascular conditions","45 Years",{"count":110,"type":21},70,[24],"The goal of this clinical trial is to determine whether combining Functional Electrical Stimulation (FES) with Augmented Reality (AR)-based gait training can improve walking ability in individuals with incomplete spinal cord injury (SCI). The study aims to identify the most effective rehabilitation approach for enhancing gait performance and functional independence among these patients.\n\nIn this study, participants will include:\n\n* Adults aged 18-45 years\n* Diagnosed with incomplete spinal cord injury (ASIA Impairment Scale grades C or D)\n* Neurological level of injury between T10 and L2\n* Medically stable and able to walk with or without assistive devices\n* Cognitively intact and capable of providing informed consent\n\nExclusion Criteria:\n\n* Severe spasticity or contractures in the lower limbs\n* Significant pain or joint instability\n* Other neurological or musculoskeletal disorders (e.g., stroke, multiple sclerosis)\n* Recent lower limb fractures or orthopedic surgeries\n* Cardiovascular instability or open skin lesions Two treatment groups will be formed: Group A and Group B.\n* Group A will receive Hybrid FES-AR gait training, which combines electrical stimulation of muscles with visual, task-specific feedback provided through augmented reality.\n* Group B will receive conventional gait training, which includes standard physiotherapy methods such as strength, balance, and mobility exercises without FES or AR.\n\nBoth interventions will be delivered over 12 weeks, with 3 sessions per week, each lasting approximately 40 minutes.\n\nBaseline assessments will be conducted before starting therapy, followed by evaluations at 6 weeks and 12 weeks. The outcome measures will include improvements in gait speed, step length, stride length, cadence, and gait symmetry, using validated clinical tools such as the JAKC Observational Gait Analysis, Walking Index for Spinal Cord Injury II (WISCI II), and the Functional Gait Assessment (FGA).\n\nThis study seeks to determine whether the hybrid approach (FES + AR) leads to greater improvement in walking ability compared to traditional gait training. The findings may help guide future rehabilitation strategies and support the integration of technology-based interventions into spinal cord injury management.",[28,114,115],"ASIA C and D Classification of SCI","Gait Dysfunction",[117,118,119,38,120,121,122],"Spinal Cord Injury (SCI)","Functional Electrical Stimulation (FES)","Augmented Reality (AR)","Gait Training","Lower Limb Rehabilitation","T10-L2 Injury","RECRUITING","2026-01-13",{"date":126,"type":44},"2026-01-15",{"date":128,"type":21},"2026-01-10",{"date":130,"type":21},"2026-03-10",{"name":132,"class":51},"Lahore University of Biological and Applied Sciences"]