[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"incomplete-spinal-cord-injury\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:incomplete-spinal-cord-injury":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,51,69,93,125,153,185,213],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":32,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100649757","zepu-sgi1plus-hand-training-study-zepusgi1rct-100649757",false,"NCT07739264","ZEPU-SGI1PLUS Hand Training Study (ZEPUSGI1RCT)","Feasibility, Safety and Efficacy of ZEPU-SGI1PLUS Hand Functional Comprehensive Training Systems in Patients With Upper Limb Motor Dysfunction","Inclusion Criteria:\n\n* Presence of upper-limb motor dysfunction, with or without concurrent lower-limb impairment, due to one of the following conditions: (a) stroke, with onset between 2 and 24 months prior to enrollment; (b) incomplete spinal cord injury (neurological level C5 and below), classified as ASIA Impairment Scale C or D; (c) traumatic brain injury with persistent upper-limb functional limitation; or (d) orthopedic or post-surgical conditions involving the shoulder, elbow, wrist, or hand with persistent functional impairment for \\> 3 months\n* Age between 18 and 60 years, inclusive\n* Ability to understand study procedures and follow instructions, and to provide written informed consent (or assent with guardian consent where applicable)\n* Body weight and limb anthropometry compatible with the ZEPU-SG1PLUS Hand Functional Comprehensive Training System per manufacturer specifications\n* Medically stable and cleared by a physician for robotic rehabilitation, with no active infection, uncontrolled cardiac or respiratory disease, severe osteoporosis, uncontrolled epilepsy, or untreated deep vein thrombosis\n\nExclusion Criteria:\n\n* Complete spinal cord injury or profound motor paralysis preventing safe interaction with robotic devices\n* Severe cognitive impairment, defined as a Mini-Mental State Examination (MMSE) score \\\u003C 24, that would compromise safe participation\n* Severe spasticity of the upper limb, defined as a Modified Ashworth Scale score \\> 3\n* Unstable fractures, severe fixed joint contractures of the shoulder, elbow, wrist, or hand (e.g., \\> 30°), or severe pain limiting safe robotic training\n* Uncontrolled cardiac arrhythmia, presence of a pacemaker, or other implanted electronic medical device incompatible with robotic sensors\n* Pregnancy","ALL","18 Years","60 Years",{"count":20,"type":21},36,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this pilot randomized controlled trial is to learn whether the ZEPU-SG1PLUS Hand Functional Comprehensive Training System - a robotic device used alongside standard rehabilitation - is safe, feasible, and helpful for people with upper limb (arm\u002Fhand) motor problems caused by stroke, incomplete spinal cord injury, traumatic brain injury, or orthopedic conditions.\n\nThe main questions it aims to answer are:\n\nIs robotic-assisted hand training well tolerated by patients, and can it be safely added to standard rehabilitation, with acceptable rates of device-related side effects? Does adding robotic hand training to standard rehabilitation improve arm and hand strength, range of motion, and functional ability compared with standard rehabilitation alone? Is it practical to fit this type of robotic training into everyday rehabilitation services at Bangladesh Medical University?\n\nResearchers will compare a robotic-augmented rehabilitation group to a standard-care (control) group to see whether adding robotic hand training works better than usual rehabilitation alone.\n\nParticipants will:\n\nBe randomly assigned to one of two groups: one receiving standard rehabilitation plus robotic hand training with the ZEPU-SG1PLUS device, and one receiving standard rehabilitation alone If assigned to the robotic training group, attend three training sessions per week for 12 weeks, each lasting about 30-45 minutes, at the Robotic Rehabilitation Centre, BMU Undergo assessments at the start of the study and at two-week intervals during the 12-week program and follow-up period, including tests of muscle strength, joint movement, hand function, and daily activity ability Be monitored throughout for any side effects or safety concerns related to the training",[27,28,29,30,31],"Upper Limb Motor Dysfunction","Stroke","Incomplete Spinal Cord Injury","Traumatic Brain Injury","Upper Limb Orthopedic Trauma",[33,34,35,36,37],"Robotic Rehabilitation","ZEPU-SG1PLUS","Hand Function Training","Neurorehabilitation","Musculoskeletal Rehabilitation","NOT_YET_RECRUITING","2026-07-29",{"date":41,"type":42},"2026-07-31","ACTUAL",{"date":44,"type":21},"2026-07",{"date":46,"type":21},"2026-11",{"name":48,"class":49},"Bangladesh Medical University","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":4,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":58,"targetDuration":4,"studyType":22,"phases":59,"briefSummary":60,"conditions":61,"keywords":63,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":65,"startDateStruct":66,"completionDateStruct":67,"leadSponsor":68,"locationsCount":50},"100649645","zepu-ai5-strength-training-study-zepuai5rct-100649645","NCT07735702","ZEPU-AI5 Strength Training Study (ZEPUAI5RCT)","Safety, Feasibility and Efficacy of ZEPU AI5 Lower Limb Muscle Strength Training and Evaluation Robot","Inclusion Criteria:\n\n* Lower-limb motor dysfunction due to one of the following: (a) stroke (onset 2-24 months), (b) incomplete spinal cord injury (neurological level T12 or below, ASIA Impairment Scale C or D), or (c) orthopedic surgery (e.g., knee\u002Fhip replacement) with persistent gait impairment more than 3 months post-surgery\n* Age greater than 18 years and up to 60 years\n* Medically stable and able to provide informed consent\n* Able to meet device anthropometric criteria for use of the ZEPU-AI5 system\n\nExclusion Criteria:\n\n* Complete spinal cord injury with inability to bear any weight\n* Severe cognitive impairment (Mini-Mental State Examination score less than 24) preventing safe participation\n* Severe spasticity of the lower limbs (Modified Ashworth Scale greater than 3)\n* Unstable fractures, severe hip\u002Fknee contractures (greater than 30 degrees fixed flexion), or severe osteoarthritis requiring imminent surgery\n* Uncontrolled cardiac arrhythmia, pacemaker incompatibility, or any implanted electronic device incompatible with the robot's sensors\n* Pregnancy",{"count":20,"type":21},[24],"The goal of this clinical trial is to learn if robot-assisted lower-limb strength and gait training can improve safety, feasibility, and functional recovery in adults aged 18-60 years with lower-limb motor dysfunction due to stroke, incomplete spinal cord injury, or persistent gait impairment following orthopedic surgery. The main questions it aims to answer are:\n\nIs robot-assisted training using the ZEPU-AI5 device safe and well-tolerated, with an acceptable rate of device-related adverse events? Does adding ZEPU-AI5-assisted training to standard-of-care rehabilitation improve functional outcomes (such as walking distance, muscle strength, balance, and mobility) compared to standard-of-care rehabilitation alone?\n\nResearchers will compare an intervention group receiving standard-of-care rehabilitation combined with ZEPU-AI5-assisted training to a control group receiving standard-of-care rehabilitation alone, to see if the addition of robotic training leads to greater improvements in safety, functional recovery, and quality of life.\n\nParticipants will:\n\nUndergo a baseline assessment before starting the study Receive either robot-assisted training plus standard-of-care rehabilitation, or standard-of-care rehabilitation alone, three times per week for 12 weeks Complete follow-up assessments every two weeks to evaluate safety, functional outcomes, and durability of any benefits",[28,29,62],"Gait Impairment Following Orthopedic Surgery",[33,36,64],"Muscle Strength",{"date":41,"type":42},{"date":44,"type":21},{"date":46,"type":21},{"name":48,"class":49},{"id":70,"slug":71,"hasResults":11,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":4,"eligibilityCriteria":75,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":76,"enrollmentInfo":77,"targetDuration":4,"studyType":22,"phases":79,"briefSummary":80,"conditions":81,"keywords":4,"overallStatus":83,"whyStopped":4,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":50},"100450242","effectiveness-of-virtual-bodily-illusion-intervention-in-upper-limb-motor-function-in-people-with-incomplete-spinal-cord-injury-100450242","NCT05142943","Effectiveness of Virtual Bodily Illusion Intervention in Upper Limb Motor Function in People With Incomplete Spinal Cord Injury.","Effectiveness of Virtual Bodily Illusion Intervention in Upper Limb Motor Function, Sensibility and Pain in People With Incomplete Spinal Cord Injury.","Inclusion Criteria:\n\n* Incomplete cervical spinal cord injury (AIS C, D or E).\n* Ability to understand instructions (Mini-Mental State Examination\\> 23 points)\n\nExclusion Criteria:\n\n* Traumatic pathology in upper limbs.\n* Other alterations of the central nervous system or peripheral\n* Alterations in the vestibular system.\n* Concomitant diseases.","99 Years",{"count":78,"type":21},80,[24],"Previous studies have shown that the neuroplasticity of the residual corticospinal fibers, the motor cortex and the spinal neurons plays an important role in the spontaneous functional recovery of people with neurological or musculoskeletal pathology. However, it is also possible to stimulate the neuroplasticity mechanisms of these structures through techniques aimed at rehabilitating different deficits (for example, motor function or sensitivity). In general, intervention programs are usually carried out, in most cases, using low-cost strategies such as therapeutic physical exercise programs.\n\nThe objective of this study is to analyze the effectiveness of visual illusion therapies in combination with conventional exercises on the symptoms and signs related to incomplete spinal cord injury that affects the upper limb.\n\nThe study will include the realization of three measurements that will be carried out one day before starting the program, one day after finishing it, and one month later (follow-up).\n\nThe clinical assessment will be composed of the study of the following variables: Motor function and motor skills, Upper limb isometric force, Muscle activation, Muscle tone, Quality of life, Functionality. All interventions will last eight weeks and will be planned according to the availability of volunteers. In each session, it will be recorded if any type of adverse effect occurs. There will be four types of interventions: i. Visual Illusion (IV) and therapeutic exercise program (PE), ii.placebo and PE, iii. IV, iv. IV placebo.",[29,82],"Spinal Cord Injury","RECRUITING","2026-07-06",{"date":86,"type":42},"2026-07-07",{"date":88,"type":42},"2021-11-01",{"date":90,"type":21},"2026-12-31",{"name":92,"class":49},"University of Valencia",{"id":94,"slug":95,"hasResults":11,"nctId":96,"briefTitle":97,"officialTitle":98,"acronym":99,"eligibilityCriteria":100,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":101,"enrollmentInfo":102,"targetDuration":4,"studyType":22,"phases":104,"briefSummary":105,"conditions":106,"keywords":110,"overallStatus":83,"whyStopped":4,"lastUpdateSubmitDate":116,"lastUpdatePostDateStruct":117,"startDateStruct":119,"completionDateStruct":121,"leadSponsor":123,"locationsCount":50},"100603366","non-invasive-interventions-for-respiratory-recovery-in-chronic-spinal-cord-injury-100603366","NCT07135583","Non-Invasive Interventions for Respiratory Recovery in Chronic Spinal Cord Injury","Non-Invasive Interventions and Biomarker Identification for Respiratory Recovery in Chronic Spinal Cord Injury","Combinatorial","Inclusion Criteria:\n\n1. adults 18 to 70 years of age (the latter to reduce likelihood of cardiovascular disease);\n2. chronic SCI for ≥ 1 year at or below C-3 to T-8\n3. incomplete SCI based on classification of incomplete-B, C or D\n4. medically stable with clearance from physician\n5. SCI due to non-progressive etiology\n6. \\>20% impairment in maximal inspiratory or expiratory pressure generation\n\nExclusion Criteria:\n\n* Individuals will be excluded due to (1) current diagnosis of an additional neurologic condition (eg. multiple sclerosis or stroke) (2) loss of diaphragm EMG activity on forced respiratory tests; (3) severe illness or infection (4) non-healing decubitus ulcers (5) untreated bladder or urinary infections (6) cardiovascular disease (7) lung disease (8) active heterotopic ossification (9) uncontrolled hypertension; (10) severe neuropathic pain; (11) pregnancy (5) severe recurrent and uncontrolled autonomic dysreflexia (6) history of seizure disorder.","70 Years",{"count":103,"type":21},20,[24],"Spinal cord injuries (SCI) can seriously affect a person's ability to breathe. This happens because the injury can damage the nerves that control the muscles used for breathing. As a result, people with SCI often face breathing problems, a higher risk of lung infections, and even early death. While breathing exercises can help strengthen these muscles, they often aren't intense enough to make a big difference, especially in people with long-term injuries.\n\nThis research project is exploring a new way to improve breathing in people with chronic SCI. The goal is to \"wake up\" the remaining nerve pathways that still connect the brain and spinal cord to the breathing muscles. By doing this, the investigators hope to make breathing exercises more effective and improve overall respiratory health.\n\nThe investigators are testing a combination of two non-invasive (non-surgical) techniques:\n\nTranscutaneous Spinal Cord Stimulation (tSCS): This uses small electrical pulses delivered through the skin to stimulate the spinal cord and help activate the muscles used for breathing.\n\nHypercapnic-Hypoxia Protocol (HiCO₂-AIH): This involves breathing air with lower oxygen and higher carbon dioxide for short periods. This naturally increases the brain's drive to breathe and may help strengthen the breathing muscles.\n\nThe investigators believe that using these two techniques together will \"prime\" the nervous system, making it more responsive to breathing exercises. This could lead to better outcomes for people with SCI.\n\nIn addition to testing this treatment, the investigators are also collecting saliva and blood samples to look for biomarkers-biological clues that might help predict who will benefit most from this therapy. These include genetic markers and signs of nerve damage in the blood.\n\nWho Can Participate\n\nThe investigators are looking for adults aged 18 to 70 who:\n\nHave had a spinal cord injury for at least one year. Have an injury between the neck and upper back (from C3 to T8). Have an incomplete injury (some nerve function remains). Are medically stable and cleared by a doctor. Have at least a 20% reduction in breathing strength. What Participants Will Do\n\nEach participant will complete four rounds of treatment. Each round includes four days in a row of therapy, followed by a three-week break before the next round.\n\nEach daily session lasts about two hours and includes:\n\nBreathing special air mixtures (low oxygen and high carbon dioxide) for short periods, followed by normal air.\n\nA short break. Then, spinal cord stimulation combined with breathing exercises that use resistance (like breathing through a straw).\n\nWhat the Investigators Will Measure\n\nThe investigators will track:\n\nBreathing ability using lung function tests and pressure measurements. Nerve activity using brain and spinal cord stimulation to see how well the diaphragm (the main breathing muscle) responds.\n\nSafety by monitoring oxygen levels, heart rate, blood pressure, and breathing responses during each session.\n\nBiological Samples\n\nParticipants will provide:\n\nA one-time saliva sample for genetic testing. A one-time blood sample to look for markers of nerve injury. Why This Matters\n\nThis study could lead to new, non-invasive treatments that improve breathing and quality of life for people living with spinal cord injuries. By identifying who is most likely to benefit from this therapy, the investigators can also move toward more personalized and effective care in the future.",[107,108,109,29],"Spinal Cord Injury, Chronic","Spinal Cord Injury Cervical","Spinal Cord Injury Thoracic",[111,112,113,114,115],""Spinal Cord Stimulation" [MeSH]","acute intermittant hypoxia","respiratory resistance training","Genetic Biomarker","Blood biomarker","2026-02-02",{"date":118,"type":42},"2026-02-05",{"date":120,"type":42},"2025-09-18",{"date":122,"type":21},"2027-08-15",{"name":124,"class":49},"Thomas Jefferson University",{"id":126,"slug":127,"hasResults":11,"nctId":128,"briefTitle":129,"officialTitle":129,"acronym":4,"eligibilityCriteria":130,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":131,"targetDuration":4,"studyType":22,"phases":133,"briefSummary":134,"conditions":135,"keywords":137,"overallStatus":83,"whyStopped":4,"lastUpdateSubmitDate":144,"lastUpdatePostDateStruct":145,"startDateStruct":147,"completionDateStruct":149,"leadSponsor":151,"locationsCount":50},"100611192","comparing-the-ceriter-stride-one-a-pressure-sensitive-smart-insole-with-gait-parameters-measured-on-the-grail-in-neurological-populations-100611192","NCT07237386","Comparing the Ceriter Stride One, a Pressure-sensitive Smart Insole, With Gait Parameters Measured on the GRAIL in Neurological Populations","Inclusion Criteria:\n\n* Persons suffering a lesion of the central nervous system (stroke, incomplete spinal cord injury, acquired brain injury) who are admitted to the rehabilitation center of the Ghent University hospital or who follow therapy at the rehabilitation center of the Ghent University hospital as outpatients.\n* Patients need to be able to walk independently during at least 6 minutes without the need of an extra person (Functional ambulation category 3 or higher).\n\nExclusion Criteria:\n\n* Severe orthopedic trauma or acute trauma of the lower limbs influencing walking\n* body weight that exceeds 120 kg.\n* severe dizziness that makes exercising in standing position impossible\n* severe cardio-pulmonary disorders that require monitoring during exercising\n* patients who do not understand the task that needs to be performed in this study.",{"count":132,"type":21},30,[24],"Ceriter Stride-One soles have been available on the market for several years. One of the features of these soles is that they can measure gait parameters while patients walk around in a functional environment. This can provide a more realistic picture of gait patterns compared to measurements taken in a laboratory setting.\n\nAt UZ Ghent, we use an advanced gait lab to measure gait parameters before and after a training period on this system, the GRAIL system. We measure similar parameters to the Ceriter Stride-One soles (support phase, swing phase, pressure on the left leg and on the right leg). In this study, we would apply these insoles to patients who are tested on the GRAIL system, according to standard care, during the test in order to compare the parameters measured by the insoles and the parameters measured by the GRAIL system. This information will give us more insight into the accuracy of the data measured with these soles so that we can apply them in future studies conducted not in the gait lab but in functional environments.\n\nPatients who are eligible for GRAIL therapy and are therefore routinely tested are patients who are admitted or undergoing outpatient rehabilitation at the rehabilitation centre of UZ Ghent after a brain injury, stroke, spinal cord injury or amputation. Given the subject of the research and the difficulty of fitting a sole into the shoe of a prosthetic leg, only people with brain and spinal cord injuries are asked to participate in the study.\n\nParticipants must be able to step onto the GRAIL treadmill with the help of one therapist and must be able to walk for at least six minutes. Participants have to weigh less than 120 kg (treadmill safety system restriction).\n\nAs standard in our setting, participants train for 5 weeks, twice a week for 30 minutes on the GRAIL treadmill. Before and after their training period, they walk on the GRAIL for about 2 minutes and we measure a number of gait parameters: speed, step width, step length, duration of the support phase and swing phase, and how much they support on their left and right legs.\n\nSome of these parameters can also be measured by the Ceriter Stride One sole. The aim is to investigate how comparable these data are. If these data are sufficiently comparable, the soles can be used to measure the ratio of the support and swing phases during walking in everyday tasks or in environments other than a laboratory setting.",[28,29,30,136],"Acquired Brain Injury",[138,139,140,141,142,143],"Gait","stroke","spinal cord injury","brain injury","smart insoles","spatiotemporal","2025-11-14",{"date":146,"type":42},"2025-11-19",{"date":148,"type":42},"2025-10-15",{"date":150,"type":21},"2026-10-01",{"name":152,"class":49},"University Hospital, Ghent",{"id":154,"slug":155,"hasResults":11,"nctId":156,"briefTitle":157,"officialTitle":158,"acronym":4,"eligibilityCriteria":159,"healthyVolunteers":11,"sex":16,"minAge":160,"maxAge":161,"enrollmentInfo":162,"targetDuration":4,"studyType":22,"phases":164,"briefSummary":165,"conditions":166,"keywords":170,"overallStatus":83,"whyStopped":4,"lastUpdateSubmitDate":175,"lastUpdatePostDateStruct":176,"startDateStruct":178,"completionDateStruct":180,"leadSponsor":182,"locationsCount":50},"100495085","evaluating-long-term-use-of-a-pediatric-robotic-exoskeleton-prexagilik-to-improve-gait-in-children-with-movement-disorders-100495085","NCT05726591","Evaluating Long-term Use of a Pediatric Robotic Exoskeleton (P.REX\u002FAgilik) to Improve Gait in Children With Movement Disorders","A Phase I\u002FII Trial Evaluating Long-Term Use of a Pediatric Robotic Exoskeleton (P.REX\u002FAgilik) to Improve Gait in Children With Movement Disorders","* INCLUSION CRITERIA:\n\nIn order to be eligible to participate in this study, an individual must meet all of the following criteria:\n\n* Provision of signed and dated separate informed consent and assent forms for screening purposes. Upon inclusion in the protocol, provision of signed and dated informed consent and assent forms to begin participation in the study will be necessary.\n* Stated willingness to comply with all study procedures and availability for the duration of the study, or alternatively, ability to do so based on parent report and physician observation during history and physical examination.\n* Age 3 to 17 years old.\n* Have a gait pathology involving the knee joint, from a diagnosis of cerebral palsy, muscular dystrophy, spina bifida, or incomplete spinal cord injury.\n* Knee joint range of motion of at least 25 degrees in the sagittal plane (knee extension\u002Fflexion) assessed with hip extended in supine position. Hamstring contracture as assessed by straight leg raising test does not limit ability to participate in the study.\n* Ankle joint range of motion of at least 15 degrees in the sagittal plane (dorsi-plantar flexion) with the foot in neutral alignment.\n* A measured foot-thigh angle of -15 to 30 degrees in prone position.\n* Able to walk at least 10 feet without stopping with or without a walking aid.\n\nEXCLUSION CRITERIA:\n\nAn individual who meets any of the following criteria will be excluded from participation in this study:\n\n* Any neurological, musculoskeletal or cardiorespiratory injury, health condition, or diagnosis other than cerebral palsy, muscular dystrophy, spina bifida, or incomplete spinal cord injury that would affect the ability to walk as directed with the robotic exoskeleton.\n* A history of uncontrolled seizure in the past year.\n* Pregnancy. A urine test will be performed for all participants who are able to become pregnant at the initial screening visit and in the case of a positive test, the participant will be excluded from participation. Further monitoring will rely on self-reporting of interruption in menstruation that would require re-testing for pregnancy at the next visit.\n* Any acute cardiopulmonary condition which limits exercise to less than 60 minutes per session or less than 5 days per week.","3 Years","17 Years",{"count":163,"type":21},44,[24],"Background:\n\nPeople with cerebral palsy, spina bifida, muscular dystrophy, or spinal cord injury often have muscle weakness and problems controlling how their legs move. This can affect how they walk. The NIH has designed a robotic device (exoskeleton) that can be worn on the legs while walking. The wearable robot offers a new form of gait training.\n\nObjective:\n\nTo learn whether a robotic device worn on the legs can improve walking ability in those with a gait disorder.\n\nEligibility:\n\nPeople aged 3 to 17 years with a gait disorder involving the knee joint.\n\nDesign:\n\nParticipants will be screened. They will have a physical exam. Their walking ability will be tested.\n\nParticipants will have markers taped on their body; they will walk while cameras record their movements. They will undergo other tests of their motor function and muscle strength.\n\nThe study will be split into three 12-week phases. During 1 phase, participants will continue with their standard therapy.\n\nDuring another phase, participants will work with the exoskeleton in a lab setting. Their legs will be scanned to create an exoskeleton with a customized fit. The exoskeleton operates in different modes: in exercise mode, it applies force that makes it difficult to take steps; in assistance mode, it applies force meant to aid walking; in combination mode, it alternates between these two approaches.\n\nDuring the third phase, participants may take the exoskeleton home. They will walk in the device at least 1 hour per day, 5 days per week, for 12 weeks.\n\nParticipants walking ability will be retested after each phase....",[167,168,169,29],"Cerebral Palsy","Muscular Dystrophy","Spina Bifida",[171,172,167,173,174],"EEG","Muscular Dystophies","Knee","incomplete spinal cord injury","2025-10-24",{"date":177,"type":42},"2025-10-27",{"date":179,"type":42},"2023-05-02",{"date":181,"type":21},"2027-10-31",{"name":183,"class":184},"National Institutes of Health Clinical Center (CC)","NIH",{"id":186,"slug":187,"hasResults":11,"nctId":188,"briefTitle":189,"officialTitle":190,"acronym":4,"eligibilityCriteria":191,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":192,"targetDuration":4,"studyType":22,"phases":194,"briefSummary":195,"conditions":196,"keywords":197,"overallStatus":83,"whyStopped":4,"lastUpdateSubmitDate":204,"lastUpdatePostDateStruct":205,"startDateStruct":207,"completionDateStruct":209,"leadSponsor":211,"locationsCount":50},"100514216","non-invasive-brain-stimulation-paired-with-fes-cycling-post-sci-100514216","NCT05975606","Non-invasive Brain Stimulation Paired With FES Cycling Post SCI","Exploring the Effect of Non-invasive Brain Stimulation Paired With Functional Electrical Stimulation to Improve Lower Extremity Function Following Incomplete Spinal Cord Injury","Inclusion Criteria:\n\n* adult\n* having motor incomplete SCI with level C or D on the American Spinal Injury Association Impairment Scale (AIS) with the lesion at any level of the cord resulting from either traumatic or non-traumatic etiology who are at least one-year post-injury.\n* having non-progressive SCI\n* being able to walk independently for 10 meters without help from another person\n\nExclusion Criteria:\n\n* other orthopedic or neurological implications that affect the lower extremity function\n* contraindications to FES (e.g., implanted electronic devices, unhealed bone fractures, sever contractures, extreme osteoporosis or osteoarthritis)\n* contraindications to rTMS (e.g., metal implants, history of seizure, cochlear implants)",{"count":193,"type":21},14,[24],"This project is randomized controlled trial which will explore the effect of pairing repetitive Transcranial Magnetic Stimulation (rTMS) with Functional Electrical Stimulation (FES) Cycling on lower extremity function in people with incomplete spinal cord injury and compare the effects to each one of these interventions alone.",[29],[174,198,199,200,201,202,203],"repetitive transcranial magnetic stimulation","functional electrical stimulation cycling","lower extremity function","walking speed","muscle strength","feasibility","2025-04-09",{"date":206,"type":42},"2025-04-13",{"date":208,"type":42},"2023-09-19",{"date":210,"type":21},"2025-12",{"name":212,"class":49},"Western University, Canada",{"id":214,"slug":215,"hasResults":11,"nctId":216,"briefTitle":217,"officialTitle":217,"acronym":4,"eligibilityCriteria":218,"healthyVolunteers":219,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":220,"targetDuration":4,"studyType":22,"phases":222,"briefSummary":223,"conditions":224,"keywords":229,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":231,"lastUpdatePostDateStruct":232,"startDateStruct":234,"completionDateStruct":236,"leadSponsor":238,"locationsCount":4},"100558545","the-outcome-of-injured-cervical-spinal-cord-with-uncontrolled-swelling-under-duraplasty-100558545","NCT06552507","The Outcome of Injured Cervical Spinal Cord with Uncontrolled Swelling Under Duraplasty","Inclusion Criteria:\n\n* Age ≥18 years\n* Severe cervical (C2 - T1) traumatic spinal cord injury (AIS grade A-C)\n* Deemed to require and be suitable for surgery that includes laminectomy or diskectomy by local surgeon\n* Surgery within 72 hours of traumatic spinal cord injury\n* Able to provide informed consent or consultee declaration or proxy consent\n\nExclusion Criteria:\n\n* Life-limiting or rehabilitation-restricting co-morbidities\n* Thoracic or lumbar traumatic spinal cord injury\n* Probable dural tear due to injury\n* Other central nervous system disease",true,{"count":221,"type":21},104,[24],"Overall Objective: To assess whether incorporating duraplasty alongside bony decompression enhances motor function outcomes in individuals following Traumatic Spinal Cord Injury (TSCI).\n\nRationale for Research:\n\nIn a systematic review, individuals suffering from cervical Traumatic Spinal Cord Injuries (TSCIs) identified specific priorities for improvement in their quality of life. These priorities encompassed enhanced arm and hand function, improved bladder and bowel control, sexual function, and the nurturing of personal relationships with their families and friends.\n\nIn this context, the investigators posit that augmenting standard treatment with expansion duraplasty has the potential to address several critical aspects of TSCI. Our hypothesis centers on the idea that the incorporation of duraplasty into the treatment regimen can lead to a reduction in spinal cord compression, an enhancement in Spinal Cord Perfusion Pressure (SCPP), an amelioration in spinal cord metabolism, and a mitigation of inflammation at the injury site. The investigatorsanticipate that these physiological and metabolic enhancements will contribute to increased neuronal survival, ultimately resulting in improved motor outcomes. These improved motor outcomes, in turn, are expected to translate into enhanced limb function, superior bladder and bowel control, and an overall improvement in the quality of life for the patients.\n\nOur investigative focus encompasses a comprehensive examination of the impact of duraplasty on various facets of spinal cord physiology, metabolism, inflammation, motor and sensory performance, and Health-Related Quality of Life (HRQoL) measures. These HRQoL measures encompass aspects such as hand function, ambulation, bladder and bowel function, as well as the mental, emotional, and social well-being of the patients.\n\nIn the north area of R.O.C, individuals with TSCI are initially admitted to Linkou Chang Guan Memorial Hospital, where they typically undergo surgery involving spinal instrumentation (e.g., screws and rods) to address deformities and instability. Bony decompression, typically carried out through laminectomy, is a common surgical intervention aimed at addressing the adverse effects of bony compression on the spinal cord. It is worth noting that a significant majority of surgeons (ranging from 85% to 96%) advocate for bony decompression as a primary treatment for TSCI, as recommended by the National Institute for Health and Care Excellence (NICE) guidelines in 2016. However, the effectiveness of bony decompression in improving outcomes following TSCI remains a topic of debate and uncertainty, largely due to the absence of robust evidence from randomized controlled trials (RCTs).\n\nOur proposal suggests that bony decompression in isolation may offer only partial relief to the swollen and injured spinal cord, which continues to experience compression against the dura. This may explain the persisting uncertainty surrounding the benefits of bony decompression in TSCI treatment. Achieving adequate cord decompression through surgical intervention assumes particular importance in this context, given the lack of pharmaceutical treatments proven to enhance outcomes in individuals with acute and severe TSCI. While the administration of methylprednisolone initially showed promise, subsequent trials, observational studies, and meta-analyses have cast doubt on its efficacy and raised concerns about potential harm.\n\nThe management of TSCI in the R.O.C is characterized by considerable variation among major trauma centers, encompassing diverse practices related to factors such as target blood pressure, choice of anesthetic agents, extent of monitoring (including the use of arterial and central lines), and timing of surgery. To circumvent these controversies and differences in practice, the \"The outcome of Injured cervical Spinal Cord with Uncontrolled Swelling under Duraplasty\" trial has been meticulously designed in a single major trauma center to allow participating surgeon can follow the same protocol about time to surgery and medically management.\n\nThe \"The outcome of Injured cervical Spinal Cord with Uncontrolled Swelling under Duraplasty\" trial was conceived with the aim of addressing these critical questions surrounding TSCI management, ultimately seeking to improve the outcomes and quality of life for individuals grappling with this challenging condition.",[225,226,227,29,228],"Spine Injury","Cord Injury, Spinal","Cord Infarction Spinal","Complete Spinal Cord Injury",[230],"Duroplasty; spinal cord injury; Dura augmentation","2025-02-06",{"date":233,"type":42},"2025-02-10",{"date":235,"type":21},"2025-03-01",{"date":237,"type":21},"2026-08-01",{"name":239,"class":49},"Chang Gung Memorial Hospital"]