[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"inferior-alveolar-nerve-injury\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:inferior-alveolar-nerve-injury":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":4},"100653772","ndyag-laser-photobiomodulation-for-neurosensory-recovery-following-bimaxillary-orthognathic-surgery-100653772",false,"NCT07789821","Nd:YAG Laser Photobiomodulation for Neurosensory Recovery Following Bimaxillary Orthognathic Surgery","Nd:YAG Laser Photobiomodulation for Neurosensory Recovery Following Bimaxillary Orthognathic Surgery: A Randomised Sham-Controlled Double-Blinded Clinical Trial","Inclusion Criteria:\n\n1. Age 21-80 years and above at time of orthognathic surgery.\n2. Underwent bimaxillary orthognathic surgery (SSRO and Le Fort I osteotomy)\n3. Willing and able to comply with the full 12-month follow-up schedule comprising 12 visits.\n\nExclusion Criteria:\n\n1. Systemic diseases known to impair peripheral nerve regeneration, including diabetes mellitus (any type), peripheral neuropathy of any aetiology, multiple sclerosis, or other demyelinating disorders.\n2. Pregnant women are excluded\n3. Patients with cognitive impairment are excluded\n4. History of hypersensitivity or adverse reaction to laser therapy of any type.\n5. Surgical complication directly attributable to the orthognathic procedure that required reoperation or microsurgical nerve repair, as these represent a fundamentally different injury severity and recovery trajectory from the neurapraxic and axonotmetic injuries targeted by this study.","ALL","21 Years","80 Years",{"count":20,"type":21},36,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study investigates whether low-energy laser light therapy applied to the skin (photobiomodulation, PBM) can speed up recovery of sensation in the lower lip, chin, and cheek area following jaw surgery (bimaxillary orthognathic surgery). Numbness and altered sensation in these areas are common and expected side effects of jaw surgery, affecting approximately one third of patients at 12 months without active treatment. There is currently no proven non-invasive treatment to accelerate nerve recovery after jaw surgery.\n\nEligible participants who develop numbness after jaw surgery will be randomly assigned to receive either active PBM laser treatment or an inactive sham laser treatment (6 sessions over 3 weeks). Neither the participant nor the assessor measuring recovery will know which treatment was received. All participants also receive standard postoperative care.\n\nThe study aims to determine whether active PBM significantly reduces the time to functional sensory recovery compared with sham treatment, and to characterise recovery patterns using a standardised multicomponent neurosensory assessment battery over 12 months.",[27,28,29,30],"Infraorbital Nerve Injury","Inferior Alveolar Nerve Injury","Neurosensory Disturbance Following Orthognathic Surgery","Photobiomodulation",[32,33,34,35],"inferior alveolar nerve injury","photobiomodulation","Neurosensory disturbance following orthognathic surgery","Infraorbital nerve injury","NOT_YET_RECRUITING","2026-09-21",{"date":39,"type":40},"2026-09-24","ACTUAL",{"date":42,"type":21},"2026-09-01",{"date":44,"type":21},"2028-12-31",{"name":46,"class":47},"National University Hospital, Singapore","OTHER"]