[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"inflammatory-biomarkers\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:inflammatory-biomarkers":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,48,74,102],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100651541","silver-nanoparticle-reinforced-double-antibiotic-paste-in-symptomatic-apical-periodontitis-a-randomized-controlled-trial-100651541",false,"NCT07762599","Silver Nanoparticle-Reinforced Double Antibiotic Paste in Symptomatic Apical Periodontitis: A Randomized Controlled Trial","Evaluation of Effect of Silver Nanoparticles Reinforced Double Antibiotic Paste on Inflammatory Biomarkers , Post Endodontic Pain and Periapical Healing in Teeth With Symptomatic Apical Periodontitis :a Parallel, Double-blind, Randomized Controlled Trial.","Inclusion Criteria:\n\n1. Adult participants (aged 18-60 years) with SAP and Periapical Pathology in single rooted teeth.\n2. Preoperative pain score will be assessed and recorded using the NRS on a scale 0 to 10. Patients will be asked to mark their current pain level on the scale of 0-10. Patients with pain level ≥7 will be included in the study (NRS categorized as none (0), mild (1-3), moderate (4-6), and severe (7-10).\n3. Periapical pathology will be diagnosed according to PAI and patient with PAI ≥3 will be included in the study (PAI -Score 1 Normal periapical structure, Score2: Minor changes in bone structure, Score 3 Changes in bone structure with some mineral loss, Score4: A well-defined radiolucent area, Score 5 Severe periodontitis with exacerbated features)\n4. Systemic Health will be assessed using ASA. Patient with ASA II will be included in the study.\n\nExclusion Criteria:\n\n1. Previous endodontic treatment\n2. Absence of antagonist tooth\n3. Teeth with Immature apex\n4. Severe periodontal disease or root resorption\n5. Use of antibiotics within 1 month or analgesics within 3 days\n6. Pregnancy or lactation.\n7. Allergy to study medicaments","ALL","18 Years","60 Years",{"count":20,"type":21},50,"ESTIMATED","INTERVENTIONAL",[24],"NA","Background Apical periodontitis (AP) is an inflammatory condition of the periapical tissues. The Symptomatic Apical periodontitis (SAP) represents the active phase of the disease, presenting with pain and tenderness. In SAP, levels of inflammatory mediators such as Interleukin-1β (IL-1β) and Matrix Metalloproteinase-9 (MMP-9) are elevated in gingival crevicular fluid (GCF). Assessing these biomarkers in GCF provides a novel, non-invasive method to evaluate periapical inflammation and healing. Due to the polymicrobial nature of root canal infections, the use of Intracanal medicaments (ICM) has been recommended to achieve effective disinfection. Traditionally used ICMs have their own inherent limitations. Hence, ICMs such as Triple antibiotic paste (TAP), double antibiotic paste (DAP), Silver nanoparticles (AgNPs) and their various combinations are gaining popularity. Currently, various combinations of AgNPs with other agents such as chitosan, calcium hydroxide, antibiotics and various herbal products are being tried to improve its effectiveness when used as an ICM. However, to the best of investigators knowledge, no study reinforced the DAP with AgNPs. Hence, the current double-blind, randomized, parallel clinical trial is planned to compare the effects of DAP with and without reinforcement of AgNPs on inflammatory biomarkers (IL-1β and MMP-9), postendodontic pain, and periapical healing in SAP. Moreover, this DAP+AgNPs formulation will undergo characterization such as FTIR, TEM\u002FSEM, Zeta potential to assess its properties.\n\nMethods A total of 50 adult participants with SAP in single-rooted teeth were randomly divided into two groups based on the type of ICM used: Group I received DAP, while Group II received DAP reinforced with AgNPs. Before starting the root canal treatment, GCF will be collected and marked as baseline. Then under rubber dam isolation all teeth underwent root canal treatment and ICM will be placed according to the specific group. Patient will be recalled after 14 days and again GCF sample will be collected after removal of the ICM. The samples will be stored at -800C for analysis. All samples will undergo enzyme-linked immunosorbent assay (ELISA) to estimate IL1β and MMP-9 levels. Pain levels will be recorded using the Numerical Rating scale (NRS) at various intervals. Data will be analyzed using STATA, SPSS or R. P value \\\u003C 0.05 will be considered statistically significant.\n\nDiscussion Most conventional ICM have limited ability to penetrate where residual microorganisms often persist. Nanoparticle-based formulations such as AgNPs have gained attention because of their extremely small size, surface charge, and potent antimicrobial activity, which enable them to penetrate dentinal tubules and disrupt bacterial biofilms that are resistant to conventional antibiotics. Incorporating AgNPs into DAP could therefore enhance their antibacterial efficacy. Furthermore, since most endodontic pathogens cannot be routinely cultivated, monitoring the changes in inflammatory biomarkers in GCF provides a reliable and non-invasive method to assess the biological response and healing. Hence, the current double-blind, randomized, parallel clinical trial is planned to compare the effects of DAP with and without reinforcement of AgNPs on inflammatory biomarkers (IL-1β and MMP-9), postendodontic pain, and periapical healing in SAP. The findings may support the use of nanoparticle-assisted ICM as a safer and more effective approach for endodontic disinfection and healing",[27,28,29,30],"Apical Periodontitis","Post Endodontic Pain","Periapical Healing","Inflammatory Biomarkers",[32,33,34],"silver nanoparticles","Double antibiotic paste","Intracanal Medicament","NOT_YET_RECRUITING","2026-08-09",{"date":38,"type":39},"2026-08-13","ACTUAL",{"date":41,"type":21},"2026-08-30",{"date":43,"type":21},"2027-12-30",{"name":45,"class":46},"All India Institute of Medical Sciences","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":16,"minAge":55,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":58,"phases":4,"briefSummary":59,"conditions":60,"keywords":4,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":73},"100563308","frailty-hip-fractures-and-inflammatory-biomarkers-100563308","NCT06614478","Frailty, Hip Fractures and Inflammatory Biomarkers","Frailty in Hip Fracture Patients Treated With Surgery; the Role of Simple Inflammatory Biomarkers. An Observational Study","Inclusion Criteria:\n\n* age \\>65 years, ASA PS I-III, non- institutionalized, able to communicate patients\n\nExclusion Criteria:\n\n* Patients with severe cognitive dysfunction, those treated conservatively, those with pathological fractures and patients who refused to participate","65 Years",{"count":57,"type":21},200,"OBSERVATIONAL","We ought to investigate if hip fracture patients suffering from frailty have higher inflammatory burden according to simple inflammatory biomarkers.",[61,62,30],"Frailty","Hip Fracture","RECRUITING","2026-05-03",{"date":66,"type":39},"2026-05-05",{"date":68,"type":39},"2023-04-01",{"date":70,"type":21},"2027-04-12",{"name":72,"class":46},"University of Thessaly",2,{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":4,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":16,"minAge":81,"maxAge":82,"enrollmentInfo":83,"targetDuration":4,"studyType":58,"phases":4,"briefSummary":85,"conditions":86,"keywords":89,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":97,"leadSponsor":99,"locationsCount":47},"100604326","inflammatory-biomarkers-as-predictors-of-ponv-following-pediatric-orchiopexy-100604326","NCT07148063","Inflammatory Biomarkers as Predictors of PONV Following Pediatric Orchiopexy","Association of Preoperative Inflammatory Biomarkers With Postoperative Nausea and Vomiting in Children Undergoing Orchiopexy","Inclusion Criteria:\n\n* Patients aged between 1 and 8 years\n* Patients with ASA physical status I-II\n* Patients scheduled for elective orchiopexy\n* Obtained written informed consent from parents\u002Fguardians\n\nExclusion Criteria:\n\n* Patients younger than 1 year or older than 8 years\n* Patients with ASA physical status III or higher\n* Presence of acute infection signs\n* History of previous nausea or vomiting","1 Year","8 Years",{"count":84,"type":21},170,"Orchiopexy is a common surgical procedure for the treatment of cryptorchidism in the pediatric population, with a high incidence of postoperative nausea and vomiting (PONV).\n\nRecent evidence suggests that systemic inflammation may contribute to PONV pathogenesis, and preoperative inflammatory biomarkers such as NLR, PLR, SII, MLR, and SIRI could serve as predictive indicators.\n\nThis prospective observational study aims to evaluate the relationship between these biomarkers and PONV incidence in children undergoing orchiopexy.",[87,88,30],"Pediatric Anesthesia","Postoperative Nausea and Vomiting (PONV)",[90,91,88,92],"Pediatric anesthesia","Orchiopexy","Inflammatory biomarkers","2025-09-08",{"date":95,"type":39},"2025-09-09",{"date":93,"type":39},{"date":98,"type":21},"2026-03-27",{"name":100,"class":101},"Diskapi Yildirim Beyazit Education and Research Hospital","OTHER_GOV",{"id":103,"slug":104,"hasResults":11,"nctId":105,"briefTitle":106,"officialTitle":107,"acronym":108,"eligibilityCriteria":109,"healthyVolunteers":11,"sex":16,"minAge":110,"maxAge":111,"enrollmentInfo":112,"targetDuration":4,"studyType":22,"phases":114,"briefSummary":115,"conditions":116,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":120,"lastUpdatePostDateStruct":121,"startDateStruct":123,"completionDateStruct":125,"leadSponsor":127,"locationsCount":4},"100596495","effects-os-physiotherapeutic-rehabilitation-on-function-autonomic-and-inflammatory-in-patients-with-long-covid-100596495","NCT07046208","Effects os Physiotherapeutic Rehabilitation on Function Autonomic and Inflammatory in Patients With Long Covid","Effects os Physiotherapeutic Rehabilitation on Cardiovascular Autonomic Modulation and Biomarkers Inflammatory and Cardiac Conditions in Patients With Long Covid","LongCovidRehab","Inclusion Criteria:\n\n* both sexes\n* aged 20 and 59 years\n* clinical evaluation and undergoing clinical follow-up of Post COVID-19.\n* least one persistent COVID-19-related symptom.\n\nExclusion Criteria:\n\n* incomplete data.\n* presence of a pacemaker\n* use of antihypertensive drugs that alter HRV\n* persistent pulmonary alterations\n* persistent desaturation\n* anaemia or presence of reinfection.","20 Years","59 Years",{"count":113,"type":21},58,[24],"Introduction: Long COVID is characterized by persistent symptoms that persist for weeks or months after the acute phase of infection, with a significant impact on the cardiovascular and autonomic systems. Objectives: This study aims to evaluate the effects of a physiotherapeutic rehabilitation protocol on cardiovascular autonomic modulation and on inflammatory and cardiac biomarkers in patients with Long COVID. Methodology: This is a controlled clinical trial, carried out in a cardiorespiratory rehabilitation outpatient clinic, involving individuals with a clinical diagnosis of Long COVID undergoing a protocol of 20 aerobic, anaerobic and respiratory rehabilitation sessions. Heart rate variability (HRV) variables will be analyzed using linear and non-linear methods, in addition to serum levels of CKMB, LDH, ferritin and C-reactive protein. Expected results: Rehabilitation is expected to provide an improvement in autonomic function and a reduction in inflammatory and cardiac markers, contributing to the understanding of the pathophysiological mechanisms of Long COVID and helping to propose evidence-based therapeutic strategies.",[117,118,119,30],"Long COVID","Heart Rate Variability (HRV)","Cardiac Biomarkers","2025-06-29",{"date":122,"type":39},"2025-07-01",{"date":124,"type":21},"2025-08-11",{"date":126,"type":21},"2026-09-30",{"name":128,"class":46},"Universidade do Estado do Pará"]