[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"inspiratory-strength-training-ist\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:inspiratory-strength-training-ist":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,51],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100646800","early-phase-1-breathing-for-two-inspiratory-muscle-strength-training-for-supporting-healthy-blood-pressure-in-pregnancy-100646800",false,"NCT07687745","Breathing for Two: Inspiratory Muscle Strength Training for Supporting Healthy Blood Pressure in Pregnancy","Inclusion Criteria:\n\n* Female sex\n* Pregnant (32 to 34 weeks of gestation, confirmed by ultrasound, at the time of first training session, eligible patients may consent\u002Fenrolled earlier in pregnancy)\n* Singleton pregnancy\n* Age 18 to 55\n* Able to read English and provide consent\n* Possess smartphone for syncing the AiroFit and Omron devices using Bluetooth and completing online surveys\n* Smartphone updated to iOS 12+ or Android 11+\n* No contraindication for moderate exercise at time of enrollment\n* Not planning delivery for at least one month at time of enrollment (\\\u003C 38 weeks of gestation)\n* Willing to adhere to AiroFit device use throughout study period\n* Must already be scheduled, or in the process of scheduling, for weekly NST appointments by 32 to 34 weeks gestational age (per provider order \u002F due to obstetric indication)\n\nLower-Risk Pregnancy Cohort Inclusion Criteria:\n\n* No history or evidence of hypertensive disorders of pregnancy\n* May be undergoing antenatal testing for:\n* Conception via in vitro fertilization, BMI ≥ 35, an advanced maternal age (age \\>\u002F=35), or other condition not listed in exclusion criteria or 'higher risk for HDP group' but is recommended for antenatal testing.\n\nHigher-Risk Pregnancy Cohort Inclusion Criteria:\n\n* Conditions associated with higher risk of developing HDP, including:\n* Gestational diabetes mellitus, chronic hypertension, gestational hypertension, or a history of preeclampsia in a previous pregnancy\n\nExclusion Criteria:\n\n* Younger than 18 or older than 55 years of age\n* Multiple gestation (twin or higher-order pregnancy)\n* Fetal chromosomal abnormalities or major anatomical anomalies\n* Planning to deliver earlier than 38 weeks or within 4 weeks of study enrollment\n* Any contraindication for moderate exercise (e.g., cardiomyopathy, congenital cardiac conditions)\n* Deep vein thrombosis\n* Complications in current pregnancy including intrauterine growth restriction (IUGR), oligohydramnios, preeclampsia, or severe-range blood pressures (\\>\u002F=160\u002F110 or \\\u003C100\u002F60)\n* Active vaginal bleeding, or history of coagulopathy\n* Placenta previa or other placental abnormalities (including placental cyst or abruption)\n* Signs of labor\n* Current substance use disorder\n* History of neurological, respiratory, head\u002Fneck, or thoracic surgeries, or conditions such as collapsed lung or perforated eardrum\n* Individuals with any of the following:\n* Chronic obstructive pulmonary disorder (COPD)\n* Severe asthma\n* Severe ischemic heart disease\n* Left-sided heart failure\n* Chronic laryngitis, chronic bronchitis, emphysema, pneumonia\n* Latent or active tuberculosis\n* Chronic cough\n* Neurological problems (e.g. seizure disorder)\n* Severe scoliosis with no history of surgical correction or management.\n* Organ transplant\n* HIV or other immunocompromising conditions\n* Autoimmune disease with possible vascular complications (e.g. Lupus)\n* Significant respiratory compromise (e.g., severe dyspnea, O₂ saturation \\\u003C95%, uncontrolled asthma, history of pneumothorax)",true,"FEMALE","18 Years","55 Years",{"count":20,"type":21},80,"ESTIMATED","INTERVENTIONAL",[24],"EARLY_PHASE1","This is an interventional study that will test whether a breathing exercise called Inspiratory Muscle Strength Training (IMST) can safely and effectively lower blood pressure during late pregnancy. The goal is to see if a home-based breathing training can help prevent or reduce high blood pressure disorders in pregnancy. The main objectives are to make sure the training is safe and tolerable for pregnant women and to examine blood pressure and blood vessel health. Participants in their third trimester will be randomly assigned to either do moderate resistance IMST or a minimal resistance sham IMST, for 5 to 8 minutes a day over six weeks.",[27,28,29,30],"Hypertension Disorders in Pregnancy","Blood Pressure Measurement in Pregnancy","Inspiratory Strength Training (IST)","Pregnancy",[32,33,34,35,36,37],"pregnancy","blood pressure","hypertensive disorders of pregnancy","imst","hdp","inspiratory muscle strength training","RECRUITING","2026-07-01",{"date":41,"type":42},"2026-07-07","ACTUAL",{"date":44,"type":42},"2026-06-08",{"date":46,"type":21},"2027-09-30",{"name":48,"class":49},"University of Arizona","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":15,"sex":59,"minAge":60,"maxAge":61,"enrollmentInfo":62,"targetDuration":4,"studyType":22,"phases":64,"briefSummary":66,"conditions":67,"keywords":70,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":50},"100625783","rehab-and-mechanical-ventilation-100625783","NCT07427121","Rehab and Mechanical Ventilation","Rehabilitation-based Approaches to Prevent Mechanical Ventilation-induced Breathing Dysfunction","REHAB-MV","Inclusion Criteria:\n\nNon-smokers Sedentary or recreationally active Normal lung function No history of claustrophobia\n\nExclusion Criteria:\n\nCurrent smoking or vaping Obstructive lung disease Use of antibiotics or systemic corticosteroids to treat an acute condition History of sepsis or metastatic disease Post infectious conditions that affect breathing Diagnosed with a neurological or neuromuscular condition Any use of supplemental oxygen, continuous positive airway pressure (CPAP), or other positive pressure ventilation to treat sleep apnea Cardiac disease Orthopedic conditions that impair lung expansion Pregnancy Implanted metallic devices within 10 cm of the cervical spine","ALL","25 Years","80 Years",{"count":63,"type":21},16,[65],"NA","The goal of this research study is to evaluate the effects of a single session of rehabilitation in healthy adults, before noninvasive mechanical ventilation (MV). MV can help support breathing function during sleep or illness. High levels of MV support have been reported to alter the function of the diaphragm muscle, the primary breathing muscle, in people with compromised health. However, rehabilitation may have some potential to improve diaphragm function in advance of using MV. This study will test different rehabilitation interventions, including (1) inspiratory strength training (IST), (2) transcutaneous spinal cord stimulation (TSCS), or sham TSCS. Before and after MV, participants will complete breathing strength tests and responses to phrenic nerve stimulation.",[29,68,69],"Transcutaneous Spinal Stimulation","Sham Spinal Stimulation",[71,72,73,74],"diaphragm","phrenic nerve","maximal inspiratory pressure","mechanical ventilation","2026-04-29",{"date":77,"type":42},"2026-05-05",{"date":79,"type":42},"2026-03-30",{"date":81,"type":21},"2027-12-31",{"name":83,"class":49},"University of Florida"]