[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"insulin-stimulated\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:insulin-stimulated":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":5},"100652826","genetic-of-skeletal-muscle-insulin-resistance-100652826",false,"NCT07780513","Genetic of Skeletal Muscle Insulin Resistance","Identification of Cell Type-Specific Insulin Responsive Quantitative Trait Loci in Human Skeletal Muscle","Inclusion Criteria:\n\n* Males and Females Age 18-75\n* Body Mass Index (BMI) \\> 18\n* Normal glucose tolerance as defined by:\n\nFasting blood sugar \\\u003C 100 mg\u002FdL 2-hour Oral Glucose Tolerance Test (OGTT) \\\u003C 140mg\u002FdL Stable weight over the past 3 months defined as \\>±5% change in body weight\n\n* Hemoglobin A1c \\\u003C 5.7\n* Creatinine \\\u003C 2\n* Aspartate aminotransferase\u002FAlanine transaminase (AST\u002FALT) \\\u003C 75\n* Blood sodium 135 to 145 mEq\u002FL\n* Blood potassium 3.6 to 5.2 mmol\u002FL\\[MH1.1\\]\n\nExclusion Criteria:\n\n* Urine albumin excretion\\>300mg\u002Fday\n* Partial thromboplastin time (PTT) \\>35International normalized ratio (INR) \\> 1.2\n* No oral corticosteroids for 1 month\n* No Sodium-glucose co-transporter 2 (SGLT2) inhibitor for 3 months\n* No glucagon-like peptide-1 (GLP-1) receptor agonist for 6 months\n* Any anti-platelet or anti-coagulation medication other than as needed for Pain Management\n* No alcohol 4 days before the insulin clamp and biopsy procedure\n* No acute structural knee injuries\n* No Rheumatologic muscular or nervous system disease\n* Pregnancy, Intentions to become pregnant, or Breastfeeding\n* Blood Pressure \\>170\u002F110\n* Temperature \\> 100F\n* Triglycerides \\> 400 by lipid panel\n* Hemoglobin \\\u003C10g\u002FdL\n* 1+ or greater Blood on Urinalysis\n* 2+ or greater Protein on Urinalysis\n* Electrocardiogram (EKG) abnormalities, including but not limited to ST elevations, T wave abnormalities, evidence of recent prior infarct",true,"ALL","18 Years","75 Years",{"count":21,"type":22},100,"ESTIMATED","INTERVENTIONAL",[25],"NA","In this study, we will use euglycemic\u002Fhyperinsulinemic clamps, longitudinal skeletal muscle biopsies, and single nucleus RNA- and ATAC- sequencing to reveal cell type-specific molecular response Quantitative trait loci (rQTLs) acutely regulated by insulin signaling and glucose uptake.",[28],"Insulin Stimulated",[30,31,32],"Insulin","Skeletal muscle","Quantitative trait loci (QTL)","RECRUITING","2026-08-18",{"date":36,"type":37},"2026-08-21","ACTUAL",{"date":39,"type":22},"2026-08-31",{"date":41,"type":22},"2031-07-31",{"name":43,"class":44},"The University of Texas Health Science Center at San Antonio","OTHER"]