[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"intensive-care-unit-survivors\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:intensive-care-unit-survivors":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,46],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":21,"conditions":22,"keywords":28,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100651960","supply-induced-demand-in-intensive-care-unit-a-retrospective-trial-100651960",false,"NCT07768410","Supply Induced Demand in Intensive Care Unit: a Retrospective Trial","Inclusion Criteria:\n\n* Patients admitted to the ICU from November 2018 to November 2025\n\nExclusion Criteria:\n\n* Incomplete documentation","ALL","18 Years",{"count":18,"type":19},1500,"ESTIMATED","OBSERVATIONAL","Intensive Care Unit (ICU) represents a high-level healthcare and expensive resource in hospitals. The causes of hospitalization in critical care are therefore multiple, and over the years numerous prognostic scores have been proposed, which therefore correlate the severity of the pathology with the predicted mortality from a statistical point of view. The function of the scores is also to assist the physician in clinical choices. The two most frequently used prognostic scores in critical care are the Acute Physiology And Chronic Health Evaluation (APACHE) II score and the Simplified Acute Physiology Score (SAPS) II.\n\nThe choice to admit a patient to Intensive Care, therefore, is a clinical, economic and managerial choice. Due to the costs of the ICU beds, as well as to the fact that shortage of beds may have a significant clinical impact on patients, many studies addressed the issue of supply-induced scarcity (SIS), i.e. scarcity due to a lack of supply and not to an excess of demand. On the other side, Health Economics has demonstrated that often an increase in supply can generate an increase in demand, even when this increase is not strictly necessary or appropriate. This phenomenon, called supply-induced demand (SID), to the best of our knowledge, few studies have been conducted in critical care settings; moreover, the correlation between SID and outcomes, specifically mortality, has never been demonstrated.\n\nThe aim of this retrospective, single-center study, therefore, is to investigate the presence of SID, and the consequent effects on mortality outcome, in a multispecialty Postoperative Intensive Care Unit.",[23,24,25,26,27],"Intensive Care (ICU)","Intensive Care Unit (ICU) Admission","Intensive Care Unit Survivors","SID","Health and Social Services",[29,30,31,32,26],"Intensive Care Unit","ICU","Intensive Care Unit Admission","Supply Induced Demand","NOT_YET_RECRUITING","2026-08-14",{"date":36,"type":37},"2026-08-17","ACTUAL",{"date":39,"type":19},"2026-08-20",{"date":41,"type":19},"2026-09-20",{"name":43,"class":44},"Saint Camillus International University of Health Sciences","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":55,"phases":56,"briefSummary":58,"conditions":59,"keywords":64,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":4},"100615649","accelerating-recovery-after-icu-admission-post-discharge-supplementation-with-pasteurized-akkermansia-muciniphila-100615649","NCT07295353","Accelerating Recovery After ICU Admission: Post-discharge Supplementation With Pasteurized Akkermansia Muciniphila.","PAM-ICU","Inclusion Criteria:\n\n* Age ≥18 years\n* Treated in the ICU for at least 2 days and discharged to a regular clinical ward\n* Diagnosed with sepsis during ICU admission\n* Received selective digestive decontamination (SDD) or cephalosporin\n* Capable of giving written informed consent\n\nExclusion Criteria:\n\n* Recent major gastrointestinal surgery\n* Diagnosed with ulcerative colitis or Crohn's disease\n* Presence of a hematological malignancy and\u002For current use of immunomodulatory therapy (e.g., CAR-T cell therapy or immune checkpoint inhibitors) Use of systemic immunomodulatory drugs or corticosteroids (defined as ≥10 mg prednisone equivalent daily at ICU discharge), at the time of inclusion.\n* History of solid organ or stem cell transplantation\n* Pregnancy or lactation\n* Donation of blood or plasma within 30 days prior to inclusion or planned donation during the intervention period\n* Any other condition that, in the opinion of the investigator, could pose a risk to the subject or interfere with study result",{"count":54,"type":19},50,"INTERVENTIONAL",[57],"NA","The goal of this clinical trial is to learn if daily oral supplementation with pasteurized Akkermansia muciniphila (PAM), an EFSA-approved food supplement, can support recovery in adults who have recently been treated in the ICU for sepsis.\n\nThe main questions it aims to answer are:\n\n* Is PAM safe to take for 56 days after ICU discharge?\n* Does PAM increase the abundance of beneficial butyrate-producing bacteria in the gut?\n\nResearchers will compare PAM to a placebo (a capsule that looks the same but has no active ingredient) to see if PAM improves gut microbiota and immune recovery.\n\nParticipants will:\n\n* Take PAM or placebo capsules once daily for 56 days\n* Provide stool and blood samples at baseline, day 28, and day 56\n* Receive a follow-up phone call about their health 1 year after starting the study",[60,61,62,63,25],"Sepsis","Post Intensive Care Unit Syndrome","Critical Illness","Microbiome Dysbiosis",[65,66,67,68,69,70,71,72],"Pasteurized Akkermansia muciniphila","Akkermansia muciniphila","Postbioticum","Microbiome","PAM","Gut Barrier Function","Post-Sepsis Recovery","Randomized Controlled Trial","2025-12-08",{"date":75,"type":37},"2025-12-19",{"date":77,"type":19},"2026-01",{"date":79,"type":19},"2028-01",{"name":81,"class":44},"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)"]