[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"interscalene-blocks\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:interscalene-blocks":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,52,80],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":34,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100652223","continuous-interscalene-blocks-and-rebound-pain-100652223",false,"NCT07770165","Continuous Interscalene Blocks and Rebound Pain","Evaluation of the Effect of Continuous Interscalene Blocks on Rebound Pain Compared to Single-Shot Interscalene Blocks in Total Shoulder Arthroplasty : A Randomized-Controlled Trial","Inclusion Criteria:\n\n* Adults aged \\>18 years of age\n* ASA I-III\n* Scheduled for elective ambulatory total shoulder arthroplasty.\n\nExclusion Criteria:\n\n* ASA IV\n* Revision surgery\n* Contraindication to regional anesthesia (such as allergy to local anesthetics, systemic anticoagulation, local infection)\n* Preoperative chronic pain or opioid use\n* Preoperative drug dependency\n* Severe respiratory disease or contralateral diaphragmatic paralysis\n* Patient refusal.","ALL","18 Years",{"count":19,"type":20},154,"ESTIMATED","INTERVENTIONAL",[23],"NA","The primary objectives of this present study are to examine whether a continuous interscalene block of a total duration of 48 hours reduces the incidence of rebound pain comparatively to single-shot interscalene block, through the evaluation of the NRS scores at rest and on movement in the postoperative period at 24, 48, 72 and 96 hours as well as the total opioid consumption in the same timeframe for patients undergoing total shoulder arthroplasty.\n\nRebound pain has been defined in some studies as the \"the transition from well-controlled pain (numerical rating scale \\[NRS\\] ≤3) while the block is working to severe pain (NRS ≥7) within 24 h of block performance.\"",[26,27,28,29,30,31,32,33],"Total Shoulder Arthroplasty","Reverse Total Shoulder Arthroplasty","Interscalene Analgesia","Interscalene Blocks","Interscalene Nerve Block","Orthopedic Surgery Patients","Locoregional Anaesthesia","Rebound Pain",[35,36,37,38,26,27,33],"Interscalene","Nerve Block","Catheter","Continuous Interscalene Block","NOT_YET_RECRUITING","2026-08-17",{"date":42,"type":43},"2026-08-19","ACTUAL",{"date":45,"type":20},"2026-10",{"date":47,"type":20},"2027-05",{"name":49,"class":50},"University of Calgary","OTHER",1,{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":4,"eligibilityCriteria":58,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":59,"enrollmentInfo":60,"targetDuration":4,"studyType":21,"phases":62,"briefSummary":63,"conditions":64,"keywords":68,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":51},"100617890","effect-of-dexamethasone-on-plasma-levels-of-bupivacaine-and-dexamethasone-after-a-single-injection-interscalene-nerve-block-100617890","NCT07324499","Effect of Dexamethasone on Plasma Levels of Bupivacaine and Dexamethasone After a Single-injection Interscalene Nerve Block.","Effect of Dexamethasone on Plasma Levels of Bupivacaine and Dexamethasone Following a Single-injection Interscalene Nerve Block: A Randomized Controlled Study","Inclusion Criteria:\n\n\\- ASA I-II patients, with a body mass index (BMI) between 20 and 34 kg\u002Fm2 scheduled for shoulder surgery requiring single-needle interscalene block\n\nExclusion Criteria:\n\n\\- Chronic opioid use, liver failure, kidney failure, allergy to protocol drugs","90 Years",{"count":61,"type":20},40,[23],"Recent studies have highlighted the comparative advantages of perineural dexamethasone, particularly regarding its safety profile and its ability to prolong analgesia in various peripheral nerve blocks. A recent systematic review demonstrated that perineural administration of dexamethasone significantly extends the duration of analgesia compared to intravenous administration.\n\nThe mechanism of action of perineural dexamethasone remains unclear. Moreover, there is a lack of research comparing the systemic absorption of local anesthetics administered perineurally with or without dexamethasone, and the systemic absorption and bioavailability of dexamethasone when used as a perineural adjuvant have not been studied.\n\nObjective: This study aims to compare plasma concentrations of bupivacaine following a single-shot interscalene block with dexamethasone administered either perineurally or intravenously.\n\nMethodology: A prospective, randomized, double-blind trial will be conducted involving 40 patients undergoing shoulder surgery requiring a single-shot interscalene block. Each patient will receive 20 mL of 0.25% bupivacaine combined with 8 mg of dexamethasone administered either perineurally or intravenously. Venous blood samples (5 mL) will be collected at 5, 10, 20, 40, 80, 120, and 240 minutes post-block, and one sample at discharge, to measure plasma concentrations of both enantiomers of bupivacaine (D(+)-bupivacaine and L(-)-bupivacaine) and dexamethasone.\n\nOutcomes: The study will compare plasma levels of bupivacaine between groups, characterize the pharmacokinetics of bupivacaine and dexamethasone, and assess block duration and opioid consumption.",[65,29,66,67],"Pain","Dexamethasone","Bupivacaine",[66,67,65,69],"Interscalene blocks","RECRUITING","2026-08-09",{"date":73,"type":43},"2026-08-12",{"date":75,"type":43},"2026-05-19",{"date":77,"type":20},"2027-12-01",{"name":79,"class":50},"Pontificia Universidad Catolica de Chile",{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":86,"eligibilityCriteria":87,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":88,"targetDuration":90,"studyType":91,"phases":4,"briefSummary":92,"conditions":93,"keywords":96,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":51},"100646553","preoperative-versus-postoperative-interscalene-block-in-arthroscopic-rotator-cuff-repair-100646553","NCT07689448","Preoperative Versus Postoperative Interscalene Block in Arthroscopic Rotator Cuff Repair","Pre-Procedure Versus Post-Procedure Administration of Interscalene Block in Arthroscopic Rotator Cuff Repair: Effects on Early Pain Control and Functional Outcomes","ISB-ARCR","Inclusion Criteria:\n\n* Adults aged 18 years or older.\n* Patients undergoing primary arthroscopic rotator cuff repair.\n* Presence of a repairable small-, medium-, or large-sized rotator cuff tear confirmed by clinical and imaging evaluation.\n* Receipt of an ultrasound-guided interscalene nerve block as part of perioperative pain management.\n* Ability to provide informed consent and comply with study follow-up requirements.\n\nExclusion Criteria:\n\n* Irreparable rotator cuff tears.\n* Partial-thickness rotator cuff tears not requiring repair.\n* Revision rotator cuff repair procedures.\n* Concomitant shoulder procedures that could substantially influence postoperative pain or functional outcomes (e.g., shoulder arthroplasty, fracture fixation).\n* Previous surgery on the affected shoulder.\n* Contraindications to interscalene nerve block, including local anesthetic allergy, infection at the injection site, or severe neurologic disease affecting the brachial plexus.\n* Chronic opioid use or opioid dependence before surgery.\n* Inability to complete study questionnaires or follow the postoperative rehabilitation protocol.\n* Missing baseline or follow-up data required for outcome assessment.",{"count":89,"type":20},42,"6 Months","OBSERVATIONAL","This study is evaluating whether the timing of an interscalene nerve block affects pain control and recovery after arthroscopic rotator cuff repair surgery.\n\nAn interscalene block is commonly used to reduce pain after shoulder surgery. However, it is not known whether administering the block before surgery or after surgery provides better outcomes. Participants undergoing arthroscopic rotator cuff repair are assigned to receive the interscalene block either before the surgical incision or after completion of the procedure.\n\nThe study compares postoperative pain levels, opioid medication use, length of hospital stay, and ultrasound imaging quality during block administration between the two groups. Functional recovery is also assessed using patient-reported outcome measures during follow-up.\n\nThe investigators hypothesize that administration of the interscalene block before surgery may provide superior early pain control and reduce postoperative opioid requirements while maintaining similar functional outcomes compared with administration after surgery.",[94,29,95],"Rotator Cuff Tear Repair","Rotator Cuff Tears",[95,97,30,98,99,100,101],"Arthroscopic Rotator Cuff Repair","Regional Anesthesia","Postoperative Pain","Preemptive Analgesia","Pain Management","2026-07-07",{"date":104,"type":43},"2026-07-08",{"date":106,"type":20},"2026-07-13",{"date":108,"type":20},"2026-10-20",{"name":110,"class":50},"Istinye University"]