[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"intestinal-failure\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:intestinal-failure":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,46,76,102,125,148,173],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":4},"100651510","effects-of-whey-protein-and-resistance-training-on-muscle-mass-in-patients-with-intestinal-failure-100651510",false,"NCT07759271","Effects of Whey Protein and Resistance Training on Muscle Mass in Patients With Intestinal Failure","Effect of Whey Protein Supplementation Combined With Resistance Training on Muscle Mass in Patients With Intestinal Failure: A Randomized Controlled Trial","Inclusion Criteria:\n\n1. Patients with chronic intestinal failure and low muscle mass.\n2. Willing to participate in the study and provide written informed consent.\n3. Able to complete the assigned 6-week intervention and the assessments at baseline, week 6, and week 8.\n\nExclusion Criteria:\n\n1. Known allergy to whey protein.\n2. Severe renal dysfunction.","ALL","18 Years","65 Years",{"count":20,"type":21},72,"ESTIMATED","INTERVENTIONAL",[24],"NA","This single-center, prospective, four-arm randomized controlled trial will enroll 72 adults with chronic intestinal failure and low muscle mass. All participants will receive standardized basic nutritional support and will be randomly assigned to one of four groups: usual care, whey protein supplementation, resistance training, or whey protein supplementation combined with resistance training.\n\nParticipants assigned to whey protein supplementation will receive 20 g of whey protein daily for 6 weeks. Participants assigned to resistance training will complete moderate-intensity resistance exercises for approximately 30 minutes, 3 to 5 times per week, for 6 weeks. Participants in the combined group will receive both interventions.\n\nBody composition, appendicular skeletal muscle mass index, phase angle, handgrip strength, 6-meter walking speed, laboratory indicators, and quality of life will be assessed at baseline, week 6, and week 8. The study aims to evaluate the effectiveness and safety of whey protein supplementation and resistance training, alone or in combination, for improving muscle mass and physical function in patients with chronic intestinal failure.",[27,28],"Intestinal Failure","Low Muscle Mass",[30,28,31,32,33],"Chronic Intestinal Failure","Resistance Training","Appendicular Skeletal Muscle Mass Index","Physical Function","NOT_YET_RECRUITING","2026-08-11",{"date":37,"type":38},"2026-08-12","ACTUAL",{"date":40,"type":21},"2026-08-28",{"date":42,"type":21},"2027-10-28",{"name":44,"class":45},"Wang Xinying","OTHER",{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":53,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":54,"targetDuration":4,"studyType":22,"phases":56,"briefSummary":57,"conditions":58,"keywords":60,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":75},"100647980","resting-energy-expenditure-by-gastrointestinal-functional-status-100647980","NCT07714499","Resting Energy Expenditure by Gastrointestinal Functional Status","Comparison of Resting Energy Expenditure According to Gastrointestinal Functional Status","Inclusion Criteria:\n\nGroup A - Healthy Controls:\n\n* Age 18 to 65 years\n* No diagnosed chronic diseases\n* No hospitalization within the previous 30 days\n* No acute illness within the previous 14 days\n\nGroup B - Participants With Intestinal Failure:\n\n* Age 18 to 65 years\n* Diagnostically confirmed intestinal failure\n* Stable clinical condition\n\nExclusion Criteria:\n\n* Uncontrolled hyperthyroidism or hypothyroidism\n* Diabetes mellitus with poor glycemic control\n* Adrenal gland disease\n* Active inflammatory bowel disease, including Crohn's disease or ulcerative colitis\n* Celiac disease\n* Chronic pancreatitis\n* Active gastric or esophageal disease\n* Irritable bowel syndrome with significant symptoms\n* History of major abdominal surgery that permanently affects gastrointestinal function, except in participants with intestinal failure when this forms part of the condition under study\n* Heart failure\n* Active ischemic heart disease or recent myocardial infarction\n* Chronic obstructive pulmonary disease\n* Respiratory failure or need for long-term oxygen therapy\n* Progressive neurodegenerative disease\n* Dementia impairing the ability to participate\n* Severe stroke with significant functional impairment\n* Active tuberculosis\n* HIV\u002FAIDS with clinically significant immunosuppression\n* Active systemic autoimmune disease\n* Active malignant disease\n* Advanced liver cirrhosis\n* Chronic kidney disease\n* Treatment with hemodialysis or peritoneal dialysis\n* Pregnancy or breastfeeding",true,{"count":55,"type":21},92,[24],"This prospective, comparative interventional study will evaluate resting energy expenditure in adults with different gastrointestinal functional status. A total of 92 participants aged 18 to 65 years will be included: 30 healthy adults with normal gastrointestinal function and 62 patients with clinically confirmed intestinal failure. The intestinal failure group will include patients with short bowel syndrome and patients with other causes of intestinal failure.\n\nParticipants will be assigned to one of two protocol-defined groups according to their gastrointestinal functional status. Each participant will attend one study visit lasting approximately 90 to 120 minutes. The research procedures will include measurement of resting energy expenditure by indirect calorimetry after an overnight fast, assessment of body composition by dual-energy X-ray absorptiometry and bioelectrical impedance analysis, and blood sampling for inflammatory markers.\n\nThe primary objective is to compare resting energy expenditure between healthy participants and patients with intestinal failure and to determine whether resting energy expenditure differs according to the underlying cause of intestinal failure. Secondary objectives are to evaluate the associations between resting energy expenditure, lean body mass, fat mass, phase angle, and inflammatory markers. The results may contribute to more individualized nutritional management of patients with intestinal failure.",[27,59],"Short Bowel Syndrome",[61,62,63,64],"Resting Energy Expenditure","Indirect Calorimetry","Body Composition","Dual-Energy X-Ray Absorptiometry","RECRUITING","2026-07-15",{"date":68,"type":38},"2026-07-20",{"date":70,"type":38},"2025-10-01",{"date":72,"type":21},"2026-10-01",{"name":74,"class":45},"Institute of Oncology Ljubljana",1,{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":16,"minAge":83,"maxAge":17,"enrollmentInfo":84,"targetDuration":4,"studyType":86,"phases":4,"briefSummary":87,"conditions":88,"keywords":90,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":75},"100556488","weaning-is-winning-wewin-study-100556488","NCT06525753","Weaning is Winning? (WeWin Study)","Weaning is Winning? (WeWin Study): Are Parenteral Nutrition (PN) Graduates Growing up Healthy?","Inclusion Criteria:\n\n* Parenteral Nutrition graduates for at least 1 year, with a history of intestinal failure.\n* Age \\\u003C18 years at time of inclusion.\n\nExclusion criteria:\n\n* No consent provided.","0 Years",{"count":85,"type":21},120,"OBSERVATIONAL","We propose a multicenter prospective study on pediatric patients with intestinal failure (IF) who weaned off parenteral nutrition (PN).",[27,89],"Parenteral Nutrition",[91,92],"Quality of Life","Pediatric","2026-06-19",{"date":95,"type":38},"2026-06-24",{"date":97,"type":38},"2024-06-01",{"date":99,"type":21},"2034-06-01",{"name":101,"class":45},"The Hospital for Sick Children",{"id":103,"slug":104,"hasResults":11,"nctId":105,"briefTitle":106,"officialTitle":107,"acronym":4,"eligibilityCriteria":108,"healthyVolunteers":53,"sex":16,"minAge":109,"maxAge":4,"enrollmentInfo":110,"targetDuration":4,"studyType":22,"phases":112,"briefSummary":113,"conditions":114,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":115,"lastUpdatePostDateStruct":116,"startDateStruct":118,"completionDateStruct":120,"leadSponsor":122,"locationsCount":124},"100600193","the-lift-echo-last-mile-project-100600193","NCT07094308","The LIFT-ECHO Last Mile Project","Improving Outcomes in Chronic Intestinal Failure Using the ECHO Model: The LIFT-ECHO Last Mile Project","Inclusion Criteria:\n\n* CIF patient participants must meet the following criteria in order to be considered eligible for participation:\n\n  * Individuals of adult age (18 years or older), including pregnant women or Individuals of age \\> 5 years with parental consent and patient assent.\n  * Diagnosis of chronic intestinal failure (ie. on PN \\>6 months with no malignancy, no HIV and a malabsorption or post-surgical diagnosis)\n  * Currently receiving PN from a homecare infusion service company\n* Physician Inclusion Criteria:\n\n  * Physician participants must meet the following criteria in order to be considered eligible for participation:\n\n    * Individuals of adult age (18 years or older), including pregnant women\n    * Hold an MD or DO degree\n    * Be a licensed physician prescriber with a homecare infusion service company\n\nExclusion Criteria:\n\n* Participants meeting one or more of the following criteria will be excluded from participation:\n\n  * Adults unable to consent (individuals with impaired decision-making capacity)\n  * Prisoners\n  * Children \\> 5 years who dissent","5 Years",{"count":111,"type":21},150,[24],"This is a multi-site research study to evaluate the efficacy and effectiveness of the LIFT-ECHO program to improve clinical outcomes in patients and improve patient reported quality of life (PRQOL). LIFT-ECHO (Learn Intestinal Failure Tele-ECHO) is a tele-health learning program whereby non-specialist clinicians meet with and learn from CIF specialist teams with the goal of improving the knowledge of CIF. LIFT-ECHO sessions consist of group discussion of anonymized real-world patient cases, followed by a didactic presentation from an expert in intestinal failure. Sessions are held twice a month and last 60-90 minutes. The study will proceed in three distinct phases, correlating with Project Aims. During phase 1 (Aim 1), an intestinal failure disease activity index (IF-DAI) will be developed as a measure of short- to medium-term clinical activity in CIF patients; this phase will be undertaken through Delphi Rounds. During Phase 2 (corresponding to project Aim 2), the researchers will evaluate the impact of physician participation in LIFT-ECHO on patients with CIF on PN. Lastly, Phase 3, corresponding to Aim 3 will be the dissemination of LIFT-ECHO nationally. For Phase 2, the researchers had originally proposed that patients and physicians will be recruited from the records of Optum Home Infusion services. Patient reported quality of life and clinical status will be assessed using surveys at baseline. Physicians will then be invited to participate in a module of LIFT-ECHO consisting of 8 one- hour-long sessions held over the course of 2-4 months. Patients will then be followed for 12 months to assess if physician participation in LIFT-ECHO improves patient reported quality of life and\u002For treatment efficacy and effectiveness. The main procedures for physician participants in the study include: completion of baseline and monthly surveys, possible participation in an appreciative inquiry workshop and possible participation in a focus group discussion, optional, but encouraged, participation in LIFT-ECHO. The main procedures for patient participants include: completion of surveys at baseline, participation in 12 monthly follow-up phone calls with a study team member. The proposed trial has a total length of 34 months.",[27],"2026-03-10",{"date":117,"type":38},"2026-03-12",{"date":119,"type":21},"2026-07-01",{"date":121,"type":21},"2030-06-30",{"name":123,"class":45},"Icahn School of Medicine at Mount Sinai",5,{"id":126,"slug":127,"hasResults":11,"nctId":128,"briefTitle":129,"officialTitle":130,"acronym":4,"eligibilityCriteria":131,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":132,"targetDuration":4,"studyType":22,"phases":134,"briefSummary":135,"conditions":136,"keywords":138,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":140,"lastUpdatePostDateStruct":141,"startDateStruct":143,"completionDateStruct":145,"leadSponsor":147,"locationsCount":75},"100625450","anabolic-response-to-intravenous-amino-acids-in-chronic-intestinal-failure-patients-100625450","NCT07422792","Anabolic Response To Intravenous Amino Acids In Chronic Intestinal Failure Patients","Anabolic Response To Protein And Assessment Of Metabolic Phenotype In Patients With Home Parenteral Nutrition And Chronic Intestinal Failure","Inclusion Criteria:\n\n\\- Patients with chronic intestinal failure (CIF) receiving home parenteral nutrition.",{"count":133,"type":21},40,[24],"The purpose of this study is to gain insight into the actual protein requirements of patients with chronic intestinal failure (CIF) receiving home parenteral nutrition, which could improve clinical management of these patients. Based on collected data on protein kinetics, the study aims to further refine and personalize nutritional mixtures in patients with CIF. Additional aims include assessment of short-chain fatty acid metabolism and evaluation of gut microbiota function in patients with CIF.",[30,27,137],"Home Parenteral Nutrition",[89,139],"Intravenous Amino Acids","2026-02-13",{"date":142,"type":38},"2026-02-20",{"date":144,"type":38},"2022-04-01",{"date":146,"type":21},"2027-12-31",{"name":74,"class":45},{"id":149,"slug":150,"hasResults":11,"nctId":151,"briefTitle":152,"officialTitle":153,"acronym":4,"eligibilityCriteria":154,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":155,"enrollmentInfo":156,"targetDuration":4,"studyType":22,"phases":158,"briefSummary":159,"conditions":160,"keywords":161,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":163,"lastUpdatePostDateStruct":164,"startDateStruct":166,"completionDateStruct":168,"leadSponsor":170,"locationsCount":75},"100624818","ai-driven-total-parenteral-nutrition-platform-100624818","NCT07414576","AI-driven Total Parenteral Nutrition Platform","Clinical Decision Support for Total Parenteral Nutrition Constituents in Neonatal Intensive Care Unit (NICU) Patients: A Pilot Study","Inclusion Criteria:\n\n* Any newborns or infants requiring total parenteral nutrition in a neonatal ICU that performs daily laboratory tests\n* 6-month old at the time of admission\n* Any gestational age or birthweight\n* Any race or sex\n\nExclusion Criteria:\n\n\\- Infants deem unfit for the suggested TPN due to safety concerns by physicians","6 Months",{"count":157,"type":21},260,[24],"This study tests whether an artificial intelligence (AI) tool can help doctors order total parenteral nutrition (TPN) for babies in the neonatal intensive care unit (NICU). Premature babies often cannot eat by mouth and need nutrition delivered through an IV. Ordering TPN is complex, time-consuming, and mistakes can happen. This study will test an AI tool that suggests TPN formulas to doctors based on each baby's lab values and health information. Doctors can accept, change, or reject the suggestions at any time. The main goal is to measure how often doctors accept the AI suggestions. The study will also track time to complete TPN orders, weight changes, days on TPN, whether lab values stay in normal ranges, provider satisfaction, and baby health outcomes including complications such as lung disease, brain bleeding, infections, and other conditions common in premature babies. Babies admitted to the NICU who need TPN may participate if their doctors agree to use the tool. Each baby will be in the study while they need TPN, typically about 14 days. The AI tool only makes suggestions and does not replace doctor decision-making. All other care remains the same as standard practice.",[27],[162],"parenteral nutrition","2026-02-10",{"date":165,"type":38},"2026-02-17",{"date":167,"type":38},"2026-01-21",{"date":169,"type":21},"2027-02-21",{"name":171,"class":172},"Takeoff41, Inc.","INDUSTRY",{"id":174,"slug":175,"hasResults":11,"nctId":176,"briefTitle":177,"officialTitle":178,"acronym":4,"eligibilityCriteria":179,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":180,"targetDuration":4,"studyType":86,"phases":4,"briefSummary":182,"conditions":183,"keywords":185,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":190,"lastUpdatePostDateStruct":191,"startDateStruct":193,"completionDateStruct":195,"leadSponsor":197,"locationsCount":75},"100608780","effect-of-parenteral-support-on-fibroscan-in-short-bowel-syndrome-100608780","NCT07206004","Effect of Parenteral Support on FibroScan in Short Bowel Syndrome","Effect of Parenteral Nutrition\u002FFluids on FibroScan Results in Patients With Short Bowel Syndrome","Inclusion Criteria:\n\n* Adult patients (≥18 years) with short bowel syndrome with capacity to give consent\n* Patients receiving regular PS (≥4 days\u002Fweek and ≥10 liters\u002Fweek)\n* Stable clinical condition\n\nExclusion Criteria:\n\n* Known liver cirrhosis\n* Active infection, severe dehydration, or electrolyte disturbances\n* Pregnancy\n* Receiving IV fluids or medications on study day\n* Tapered infusion rate prior to disconnection",{"count":181,"type":21},20,"Home Parenteral Support (HPS) is a life-sustaining treatment for patients with short bowel syndrome and intestinal failure. This study aims to investigate how administration of parenteral support affects FibroScan results in order to determine optimal timing of liver assessment in this patient population.",[59,27,184],"Liver Diseases",[186,187,162,188,189],"FibroScan","transient elastography","intestinal failure","hepatic fibrosis","2025-09-25",{"date":192,"type":38},"2025-10-03",{"date":194,"type":21},"2026-02",{"date":196,"type":21},"2027-08",{"name":198,"class":45},"Rigshospitalet, Denmark"]