[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"intracranial-atherosclerosis-icas\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:intracranial-atherosclerosis-icas":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100628792","phase-4-pcsk9-inhibitor-for-intracranial-atherosclerosis-related-acute-ischemic-stroke-100628792",false,"NCT07466251","PCSK9 Inhibitor for Intracranial Atherosclerosis Related Acute Ischemic Stroke","PCSK9 Inhibitor for Intracranial Atherosclerosis Related Acute Ischemic Stroke (PISTIAS-3): a Randomized, Double-blind, Placebo-controlled Trial","PISTIAS-3","Inclusion Criteria\n\n1. Age 30 to 80 years, inclusive.\n2. Acute ischemic stroke with symptom onset within 72 hours before screening, diagnosed on the basis of neurological deficits and CT or MRI findings.\n3. National Institutes of Health Stroke Scale (NIHSS) score of 4 to 25 at hospital admission.\n4. CTA, DSA, or MRA evidence that the culprit intracranial artery has atherosclerotic stenosis of 50% to 99%.\n\nExclusion Criteria\n\n1. Intracranial arterial stenosis attributable to a nonatherosclerotic cause, such as arterial dissection, moyamoya disease, or systemic vasculitis.\n2. Any definite source of cardioembolism, such as atrial fibrillation, a mechanical prosthetic heart valve, left ventricular thrombus, or patent foramen ovale.\n3. Clinical and imaging findings suggesting that the index ischemic event is primarily attributable to cerebral small vessel disease.\n4. Pre-stroke disability, defined as a modified Rankin Scale score of 2 or higher before the index ischemic event.\n5. Extensive cerebral infarction on CT or MRI, such as an Alberta Stroke Program Early CT Score (ASPECTS) below 6 or an infarct volume of 70 mL or greater.\n6. Previous stent implantation in the culprit vessel or planned stent implantation in the culprit vessel within 3 months after enrollment.\n7. Any intracranial hemorrhage within 3 months before enrollment.\n8. An intracranial tumor; or a cerebral aneurysm or arteriovenous malformation judged to require interventional treatment.\n9. Severe active bleeding tendency or coagulation disorder.\n10. Severe cardiac, hepatic, renal, or other major organ dysfunction.\n11. Treatment with a PCSK9 monoclonal antibody inhibitor within 1 month before enrollment or with a PCSK9-targeting small interfering RNA therapy within 6 months before enrollment.\n12. A definite contraindication to statin therapy or a history of statin intolerance.\n13. Pregnant or breastfeeding, or planning to become pregnant during the study.\n14. Current participation in another clinical trial.","ALL","30 Years","80 Years",{"count":21,"type":22},1212,"ESTIMATED","INTERVENTIONAL",[25],"PHASE4","This study is a prospective, multicenter, double-blind, randomized, placebo-controlled clinical trial designed to evaluate whether early administration of PCSK9 inhibitors can effectively improve functional outcomes at 90 days in patients with ischemic stroke (AIS) associated with intracranial atherosclerotic stenosis (ICAS), primarily assessed using the modified Rankin Scale at 90 days.",[28,29,30],"Acute Ischemic Stroke AIS","Intracranial Atherosclerosis ICAS","Atherosclerotic Plaque",[32,33,34,35,36],"Intracranial Atherosclerosis","intracranial artery stenosis","atherosclerotic plaque","PCSK9 inhibitor","Recaticimab","NOT_YET_RECRUITING","2026-07-14",{"date":40,"type":41},"2026-07-15","ACTUAL",{"date":43,"type":22},"2026-09-01",{"date":45,"type":22},"2029-12-31",{"name":47,"class":48},"Peking Union Medical College Hospital","OTHER",19]