[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"intracranial-stenosis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:intracranial-stenosis":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,48],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100651627","this-prospective-observational-study-aims-to-evaluate-the-capability-of-ultra-high-resolution-photon-counting-ct-angiography-uhr-pcd-cta-for-noninvasive-evaluation-of-intracranial-venous-sinus-stents-the-study-will-compare-image-quality-stent-visualization-metal-related-artifacts-and-diagnosti-100651627",false,"NCT07762677","This Prospective Observational Study Aims to Evaluate the Capability of Ultra-high-resolution Photon-counting CT Angiography (UHR PCD-CTA) for Noninvasive Evaluation of Intracranial Venous Sinus Stents. The Study Will Compare Image Quality, Stent Visualization, Metal-related Artifacts, and Diagnosti","Evaluation of Ultra-High-Resolution Photon-Counting CT Angiography for Intracranial Venous Sinus Stent Assessment","Inclusion Criteria:\n\n* Adults aged ≥18 years.\n* History of intracranial venous sinus stent implantation.\n* Undergoing follow-up contrast-enhanced CT angiography after stent -placement.\n* Available clinical and imaging data.\n\nExclusion Criteria:\n\n* Severe motion artifacts affecting image interpretation.\n* Contraindication to iodinated contrast media.\n* Severe renal impairment preventing contrast-enhanced CT examination.\n* Incomplete imaging data.\n* Other conditions preventing reliable assessment of the venous sinus stent.","ALL","18 Years","90 Years",{"count":20,"type":21},200,"ESTIMATED","OBSERVATIONAL","This prospective observational study aims to evaluate the effectiveness of ultra-high-resolution photon-counting CT angiography (UHR PCD-CTA) for noninvasive assessment of intracranial venous sinus stents. The study will compare image quality, stent visualization, metal-related artifacts, and diagnostic accuracy between PCD-CTA and conventional energy-integrating detector CT angiography (EID-CTA).",[25,26,27,28,29],"Intracranial Stenosis","Venous Sinus Stenosis","Stent Implantation","Intracranial Venous Pressures","Intracranial Venous Sinus Stenosis",[31,32,33,34],"Photon-counting CT","Intracranial venous sinus stent","Ultra-high-resolution CT","CT angiography","RECRUITING","2026-08-19",{"date":38,"type":39},"2026-08-20","ACTUAL",{"date":41,"type":39},"2026-01-07",{"date":43,"type":21},"2029-01-07",{"name":45,"class":46},"Xin Lou","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":58,"conditions":59,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":5},"100598479","endovascular-recanalization-for-symptomatic-chronic-intradural-occlusions-100598479","NCT07072026","Endovascular Recanalization for Symptomatic Chronic Intradural Occlusions","Feasibility of Endovascular Recanalization for Symptomatic Chronic Intradural Large Vessel Occlusions - Re-CHILL Study","Re-CHILL","Inclusion Criteria:\n\n* all consecutive patients who undergone endovascular recanalization for chronic intradural large vessel occlusions between January 1st, 2020, and December 31st, 2024 involving the following locations: internal carotid artery (ICA), middle cerebral artery (MCA), vertebral artery (VA), and basilar artery (BA)\n\nExclusion Criteria:\n\n* presence of documented written or verbal refusal",{"count":57,"type":21},80,"Background: Chronic intracranial large vessel occlusion (LVO), resulting from progressive atherosclerosis or thrombosis, contributes significantly to ischemic strokes, 8-10% in North America and up to 50% in the Chinese population. This condition leads to cerebral hypoperfusion, brain ischemia, and potentially cognitive impairment. While extra-to-intracranial bypass surgery has shown limited benefit, recent advances in endovascular treatment (EVT) for acute ischemic stroke show promise. Preliminary reports suggest EVT may be feasible for chronic intracranial artery occlusions. Still, outcomes vary and perioperative risks remain high, particularly for intradural occlusions, which are technically more challenging and less studied.\n\nObjectives: This study aims to evaluate the feasibility, safety, and clinical outcomes of EVT for symptomatic chronic intradural large vessel occlusions. Primary endpoints include technical success, complication rates, and functional outcomes, as measured by the modified Rankin Scale (mRS) at 3 months and the last follow-up. Safety endpoints include mortality, ischemic stroke, and periprocedural complications.\n\nDesign: A multicenter, retrospective and prospective observational study involving 10-20 experienced centers worldwide. Data from approximately 40-80 patients treated between January 2020 and December 2024 will be collected by local neuroradiologists, neurologists, or neurosurgeons. Clinical data (demographics, comorbidities, symptoms, outcomes), imaging data (pre-, post-, and follow-up), procedural details, and medication regimens will be collected. Inclusion criteria target adult patients with symptomatic chronic intradural occlusions of key intracranial arteries (ICA, MCA, VA, BA). Symptomatic occlusion is defined by neurological deficits or imaging evidence of ischemia. The data analysis will be performed by the local team at the Inselspital, Bern, Switzerland.\n\nAim: To descriptively analyze patient characteristics, treatment approaches, complications, and hemodynamic changes post-EVT to inform future therapeutic strategies for this challenging condition.",[25,60],"Intracranial Atherosclerotic Disease","2025-07-08",{"date":63,"type":39},"2025-07-18",{"date":65,"type":39},"2025-05-15",{"date":67,"type":21},"2025-12-31",{"name":69,"class":46},"Insel Gruppe AG, University Hospital Bern"]