[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"intraoperative-blood-loss\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:intraoperative-blood-loss":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,50,93],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":32,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":4},"100646727","effect-of-obesity-phenotype-on-intraabdominal-pressure-and-bleeding-in-major-lumbar-spinal-surgery-100646727",false,"NCT07688265","Effect of Obesity Phenotype on Intraabdominal Pressure and Bleeding in Major Lumbar Spinal Surgery","Effect of Obesity Phenotype on Intraabdominal Pressure, Intraoperative Bleeding, and Perioperative Complications in Patients Undergoing Major Lumbar Spinal Surgery: A Prospective Observational Study","OBESPINE","Inclusion Criteria:\n\n* Age 18-80 years\n* ASA Physical Status Classification I-III\n* Scheduled for elective major lumbar spinal surgery (canal stenosis decompression and\u002For instrumented fusion)\n* No prior lumbar spinal surgery\n* Written informed consent obtained\n\nExclusion Criteria:\n\n* \\- Pediatric patients (\\\u003C18 years)\n* Pregnancy\n* Emergency surgical procedures\n* Pre-existing renal failure\n* Coagulation disorder\n* Pre-existing anemia\n* Known drug allergy relevant to study medications\n* Inability to obtain written informed consent","ALL","18 Years","80 Years",{"count":21,"type":22},90,"ESTIMATED","OBSERVATIONAL","Obesity is prevalent among patients with lumbar degenerative disease and is a known risk factor for perioperative complications in spinal surgery. However, most existing evidence relies solely on body mass index (BMI) without distinguishing between central and peripheral obesity phenotypes. Central and peripheral fat distribution may have distinct biomechanical and hemodynamic consequences, particularly with respect to intraabdominal pressure (IAP) changes during prone positioning and intraoperative blood loss.\n\nThis prospective single-center observational study aims to evaluate the effect of obesity phenotype - classified as non-obese, centrally obese, or peripherally obese based on BMI and waist-to-hip ratio - on intraabdominal pressure, intraoperative blood loss, and other perioperative outcomes in adult patients undergoing major lumbar spinal surgery (decompression and\u002For instrumentation)",[26,27,28,29,30,31],"Lumbar Spinal Stenosis","Lumbar Degenerative Disease","Obesity","Intraabdominal Hypertension","Intraoperative Blood Loss","Perioperative Complications",[33,34,35,36,37],"major spinal surgery","obesity phenotype","intraabdominal pressure","intraoperative blood loss","perioperative hemorrhage","NOT_YET_RECRUITING","2026-07-05",{"date":41,"type":42},"2026-07-07","ACTUAL",{"date":44,"type":22},"2026-06-15",{"date":46,"type":22},"2027-06-01",{"name":48,"class":49},"Marmara University Pendik Training and Research Hospital","OTHER",{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":57,"sex":58,"minAge":18,"maxAge":59,"enrollmentInfo":60,"targetDuration":4,"studyType":62,"phases":63,"briefSummary":65,"conditions":66,"keywords":70,"overallStatus":82,"whyStopped":4,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":86,"completionDateStruct":87,"leadSponsor":89,"locationsCount":92},"100620851","early-phase-1-topical-tranexamic-acid-to-reduce-blood-loss-during-cesarean-delivery-100620851","NCT07362992","Topical Tranexamic Acid to Reduce Blood Loss During Cesarean Delivery","Does Topical Use of Tranexamic Acid During a Cesarean Delivery Reduce Intra-surgical Bleeding? A Randomized ,Multi-center Trial","Inclusion Criteria:\n\n* Women aged 18 to 51 years\n* Singleton pregnancy\n* Elective cesarean delivery scheduled at ≥37+0 weeks of gestation\n* First or second cesarean delivery only\n* Low transverse uterine incision planned\n* Double-layer uterine closure using 1-0 Vicryl sutures\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Known allergy or hypersensitivity to tranexamic acid (TXA)\n* History of bleeding or coagulation disorders\n* Previous postpartum hemorrhage\n* Placenta previa or placenta accreta spectrum\n* Presence of uterine myomas\n* Current use of anticoagulant or antiplatelet medications\n* Planned or intraoperative conversion to general anesthesia\n* Known uterine malformations\n* Known bleeding tendency or thromboembolic disease",true,"FEMALE","51 Years",{"count":61,"type":22},112,"INTERVENTIONAL",[64],"EARLY_PHASE1","The goal of this clinical trial is to learn whether applying topical tranexamic acid (TXA) directly to the uterine incision during cesarean delivery can reduce surgical bleeding compared to placebo. The study will include pregnant women aged 18-51 undergoing elective cesarean delivery at term (37 weeks or more).\n\nThe main questions it aims to answer are:\n\n* Does topical TXA shorten uterine closure time?\n* Does topical TXA reduce the need for additional hemostatic sutures? Researchers will compare women receiving topical TXA to those receiving placebo (normal saline) to see if TXA reduces intraoperative bleeding and improves surgical outcomes.\n\nParticipants will:\n\n* Be randomly assigned to receive either topical TXA or placebo during cesarean delivery.\n* Have standard surgery and postoperative care identical in both groups.\n* Provide routine clinical data, including hemoglobin levels and recovery outcomes, from their medical records.",[67,68,30,69],"Cesarean Delivery","Postpartum Hemorrhage (PPH)","Hemostasis",[71,72,73,67,74,75,76,77,78,79,80,81],"Tranexamic Acid","Topical Tranexamic Acid","Hexakapron","Cesarean Section","Elective Cesarean","Postpartum Hemorrhage","Intraoperative Bleeding","Blood Loss Prevention","Uterine Closure","Randomized Controlled Trial","Maternal Outcomes","RECRUITING","2026-07-01",{"date":85,"type":42},"2026-07-02",{"date":83,"type":42},{"date":88,"type":22},"2028-12-31",{"name":90,"class":91},"Wolfson Medical Center","OTHER_GOV",4,{"id":94,"slug":95,"hasResults":11,"nctId":96,"briefTitle":97,"officialTitle":98,"acronym":4,"eligibilityCriteria":99,"healthyVolunteers":11,"sex":17,"minAge":100,"maxAge":18,"enrollmentInfo":101,"targetDuration":4,"studyType":62,"phases":103,"briefSummary":105,"conditions":106,"keywords":4,"overallStatus":82,"whyStopped":4,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":118},"100424777","tranexamic-acid-in-pediatric-undergoing-proximal-femoral-osteotomies-andor-acetabular-osteotomy-100424777","NCT04811313","Tranexamic Acid in Pediatric Undergoing Proximal Femoral Osteotomies and\u002For Acetabular Osteotomy","Impact of Tranexamic Acid Use on Blood Loss and Transfusion Rates After Hip Reconstruction in Children, A Randomized Controlled Trial","Inclusion Criteria:\n\n* ASA I - II\n* Scheduled for acetabular osteotomy and\u002For proximal femoral derotation osteotomies.\n\nExclusion Criteria:\n\n* Patient's guardian refusal to participate in the study.\n* Children known to have pre-existing bleeding or coagulation disorders.\n* Children with anemia; defined according to (WHO ) cutoffs as Hb level\\\u003C11g\u002Fdl for girls and \\\u003C12g\u002Fdl for boys\n* History of epilepsy.\n* History of renal insufficiency or failure","1 Year",{"count":102,"type":22},400,[104],"NA","Surgical hip reconstruction reduces the hip joint through soft tissue releases and osteotomies of the femur and\u002For pelvis. Blood loss and subsequent blood transfusion are normal consequences of hip reconstruction.",[30,107,108],"Pediatric","Orthopedic Disorder","2025-11-14",{"date":111,"type":42},"2025-11-17",{"date":113,"type":42},"2025-04-03",{"date":115,"type":22},"2026-03",{"name":117,"class":49},"Assiut University",1]